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1. 发明授权

US08461419B2 Plant height regulatory gene and uses thereof 有权
标题翻译：植物高度调节基因及其用途
公开(公告)号：US08461419B2
公开(公告)日：2013-06-11
申请号：US12672803
申请日：2008-08-11
申请人： Zuhua He , Yingying Zhang , Qun Li
发明人： Zuhua He , Yingying Zhang , Qun Li
IPC分类号： C12N15/87 , A01H5/00 , A01H1/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N9/0077 , C12N15/8225 , C12N15/8226 , C12N15/827 , Y02A40/146
摘要： Provided are a crop height regulatory gene from Arabidopsis thaliana, expression regulatory sequences thereof and uses thereof. The crop regulatory gene can be used to regulate the plant height, volume, tiller, yield, flower organ size, or seed size of crops.
摘要翻译：提供拟南芥的作物高度调节基因，其表达调控序列及其用途。作物调节基因可用于调节作物的植物高度，体积，分蘖，产量，花器官大小或种子大小。

2. 发明申请

US20110245145A1 METHODS AND REAGENTS FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INSULIN RESISTANCE 有权
标题翻译：诊断，预防和治疗胰岛素抵抗的方法和试剂
公开(公告)号：US20110245145A1
公开(公告)日：2011-10-06
申请号：US13132750
申请日：2009-12-03
申请人： Gang Pei , Bing Luan , Jian Zhao
发明人： Gang Pei , Bing Luan , Jian Zhao
IPC分类号： A61K38/02 , C12N15/63 , C07K14/47 , G01N33/566 , C12Q1/68 , A61K31/7088 , C07K16/18 , C07H21/00 , A61P3/10 , A61P3/08 , A61P3/04 , A61P9/12 , A61P9/00 , A61P19/06
CPC分类号： A61K38/1709
摘要： The present invention provides the use of βarrestin2 protein or its up-regulators for manufacturing a composition for the prevention or treatment of insulin resistance or related disease in mammals. The reagents and the kits for the specific identification of βarrestin2 protein or its coding gene or transcript are also provided which can be used in diagnosis of insulin resistance or related diseases.
摘要翻译：本发明提供了用于制备用于预防或治疗哺乳动物的胰岛素抵抗或相关疾病的组合物的抑制蛋白2或其上调节剂的用途。还提供了用于特异性鉴定和抑制蛋白2或其编码基因或转录物的试剂和试剂盒，其可用于胰岛素抵抗或相关疾病的诊断。

3. 发明授权

US07939497B2 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof 有权
标题翻译：狭缝和圆形（robo）介导的血管发生的检测和调节及其用途
公开(公告)号：US07939497B2
公开(公告)日：2011-05-10
申请号：US10386386
申请日：2003-03-10
申请人： Jian-Guo Geng
发明人： Jian-Guo Geng
IPC分类号： A61K38/16 , A61K39/395 , C07K14/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/76
摘要： This invention is generally in the field of methods for diagnosis, treatment and prevention of various disorders involving the Slit2 mediated angiogenesis.
摘要翻译：本发明通常涉及用于诊断，治疗和预防涉及Slit2介导的血管生成的各种疾病的方法领域。

4. 发明申请

US20100279976A1 USE OF ARTEMISININ AND ITS DERIVATIVES IN CANCER THERAPY 审中-公开
标题翻译：阿司匹林及其衍生物在癌症治疗中的应用
公开(公告)号：US20100279976A1
公开(公告)日：2010-11-04
申请号：US12769263
申请日：2010-04-28
申请人： Hui Wang , Tao Chen , Junmei Hou , Mian Li
发明人： Hui Wang , Tao Chen , Junmei Hou , Mian Li
IPC分类号： A61K31/7068 , A61K31/366 , A61P35/00 , A61P15/00 , A61P1/16
CPC分类号： A61K31/555 , A61K31/357 , A61K31/366 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： A method for treating cancer in a mammal includes administering to the mammal in need thereof a therapeutically effective amount of artemisinin (ART) or its derivative, such as dihydroartemisinin (DHA), artemether (ARM), or artesunate (ARS) alone or in combination with a chemotherapeutic agent, such as gemcitabine and carboplatin. A method for inhibiting tumor cell proliferation includes contacting a tumor cell with ART or its derivative, such as DHA, ARM, and ARS, in an amount effective to inhibit tumor cell proliferation or in combination with a chemotherapeutic agent, such as gemcitabine and carboplatin.
摘要翻译：用于治疗哺乳动物癌症的方法包括向有需要的哺乳动物施用单独或组合的治疗有效量的青蒿素（ART）或其衍生物，例如二氢青蒿素（DHA），蒿甲醚（ARM）或青蒿琥酯（ARS）与化疗剂，如吉西他滨和卡铂。抑制肿瘤细胞增殖的方法包括以有效抑制肿瘤细胞增殖的量或与化疗药物如吉西他滨和卡铂组合的方式使肿瘤细胞与ART或其衍生物如DHA，ARM和ARS接触。

5. 发明申请

US20090209455A1 VITREOUS ADMINISTRATION OF ERYTHROPOIETIN 审中-公开
标题翻译：艾滋病毒的维权管理
公开(公告)号：US20090209455A1
公开(公告)日：2009-08-20
申请号：US12299006
申请日：2007-04-28
申请人： Guotong Xu , Weiye Li , Stephen H. Sinclair
发明人： Guotong Xu , Weiye Li , Stephen H. Sinclair
IPC分类号： A61K38/22 , C07K14/505 , A61P27/02
CPC分类号： A61K38/1816 , A61K9/0048
摘要： A therapeutic composition for treating and/or preventing retinal disorder includes intravitreally or transsclerally administered erythropoietin.
摘要翻译：用于治疗和/或预防视网膜病变的治疗组合物包括玻璃体内或经transsclerally施用的促红细胞生成素。

6. 发明申请

US20140143906A1 METHOD FOR IMPROVING PLANT RESISTANCE TO INSECTS 审中-公开
标题翻译：改善植物抗药性的方法
公开(公告)号：US20140143906A1
公开(公告)日：2014-05-22
申请号：US14008436
申请日：2012-03-31
申请人： Xiaoya Chen , Xiuming Wu , Yingbo Mao , Changqing Yang , Lingjian Wang
发明人： Xiaoya Chen , Xiuming Wu , Yingbo Mao , Changqing Yang , Lingjian Wang
IPC分类号： C12N15/82 , C12N15/113
CPC分类号： C12N15/8286 , C12N15/113 , C12N15/8218 , Y02A40/162
摘要： A method for improving plant insect resistance includes providing target genes derived from insects. Constructs based on the nucleotide sequences of these target genes are designed to form interfering molecules. After being eating by insects, the plant can significantly inhibit expression of corresponding genes in insects. This inhibition is not affected by barrier of the insect digestive systems. The method can improve the insect resistance of plants, reduce pesticide applications, lower the costs of agricultural production, and protect the environment.
摘要翻译：提高植物抗虫性的方法包括提供源于昆虫的靶基因。基于这些靶基因的核苷酸序列的构建体被设计成形成干扰分子。昆虫食用后，能显着抑制昆虫中相应基因的表达。这种抑制作用不受昆虫消化系统的屏障影响。该方法可以提高植物的抗虫性，减少农药应用，降低农业生产成本，保护环境。

7. 发明申请

US20130065814A1 INDUCTIVE PRODUCTION OF PLURIPOTENT STEM CELLS USING SYNTHETIC TRANSCRIPTION FACTORS 审中-公开
标题翻译：使用合成转录因子诱导生产干细胞干细胞
公开(公告)号：US20130065814A1
公开(公告)日：2013-03-14
申请号：US13583829
申请日：2011-03-07
申请人： Guoliang Xu , Yang Wang
发明人： Guoliang Xu , Yang Wang
IPC分类号： C12N5/071 , C12N15/86 , A61K31/7088 , C12N15/62 , A61K38/02 , C12N15/85 , C07K19/00
CPC分类号： C07K14/52 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2510/00
摘要： The present invention relates to use of synthetic factors in reprogramming somatic cells to become induced pluripotent stem cells and other cell lineages. Specifically, the present application relates to fusion proteins containing proteins encoded by cell totipotency-related genes and transcription regulatory domains, their coding sequences, expression vectors, and compositions. The present application also relates to methods for reprogramming somatic cells to become induced pluripotent stem cells and other cell lineages, and cells containing the fusion proteins or the coding sequences.
摘要翻译：本发明涉及合成因子在重编程体细胞中成为诱导多能干细胞和其他细胞谱系的用途。具体地，本申请涉及含有由细胞全能相关基因和转录调控结构域编码的蛋白质，其编码序列，表达载体和组合物的融合蛋白。本申请还涉及用于重编程体细胞以成为诱导多能干细胞和其他细胞谱系的方法，以及含有融合蛋白或编码序列的细胞。

8. 发明授权

US07803563B2 Method for screening the receptor-ligand binding in live cell 有权
标题翻译：筛选活细胞中受体 - 配体结合的方法
公开(公告)号：US07803563B2
公开(公告)日：2010-09-28
申请号：US12298988
申请日：2007-04-29
申请人： Zhuan Zhou , Hoping Cheng
发明人： Zhuan Zhou , Hoping Cheng
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/5035 , G01N33/566 , G01N2333/726
摘要： The invention relates to methods and system for detecting ligand binding to membrane receptors and endocytosis. A method for detecting ligand binding to a membrane receptor includes the steps of: incubating the cell with a dye and a ligand; and detecting dye-containing endocytic vesicles in the cell. A system for screening ligand binding to membrane receptors includes an automatic liquid handling device; an x-y stage for positioning a plate; a microscope configured to image endocytic vesicles of a cell; a software for automatic analysis of FM spots (endocytic vesicles); and a control unit configured to control the movement of the x-y stage and the microscope.
摘要翻译：本发明涉及检测配体结合膜受体和内吞作用的方法和系统。检测配体与膜受体结合的方法包括以下步骤：将细胞与染料和配体一起孵育; 并检测细胞中含有染料的内吞囊泡。用于筛选与膜受体结合的配体的系统包括自动液体处理装置; 用于定位板的x-y台; 显微镜，配置成图像细胞的胞吞泡; 用于自动分析FM斑点（内吞囊泡）的软件; 以及控制单元，被配置为控制x-y台和显微镜的移动。

9. 发明授权

US08193162B2 Human liver regeneration associated protein and the use thereof 有权
标题翻译：人肝再生相关蛋白及其用途
公开(公告)号：US08193162B2
公开(公告)日：2012-06-05
申请号：US12766613
申请日：2010-04-23
申请人： Mujun Zhao , Zhanwu Liu , Jie Qiu , Zaiping Li
发明人： Mujun Zhao , Zhanwu Liu , Jie Qiu , Zaiping Li
IPC分类号： A61K48/00 , C07H21/04 , C07H21/02 , C07K16/00
CPC分类号： C07H21/00 , A61K31/713 , A61K38/00 , C07K14/47 , C07K16/18
摘要： This invention provides a novel human liver regeneration associated protein hLRTM4 and the polynucleotide which encodes the hLRTM4 protein. Furthermore, this invention provides a method of preparing and using hLRTM4 protein, and its polynucleotides. hLRTM4 protein can be used to treat liver injury, and its antagonists (e.g. antisense nucleic acids and antibodies) can be used to treat hepatocellular carcinoma. This invention also provides the corresponding pharmaceutical compositions.
摘要翻译：本发明提供了一种新型人肝再生相关蛋白hLRTM4和编码hLRTM4蛋白的多核苷酸。此外，本发明提供了制备和使用hLRTM4蛋白及其多核苷酸的方法。 hLRTM4蛋白可用于治疗肝损伤，其拮抗剂（例如反义核酸和抗体）可用于治疗肝细胞癌。本发明还提供相应的药物组合物。

10. 发明申请

US20060039884A1 Baldness related gene and the polypeptide encoded thereby , and uses 有权
标题翻译：秃发相关基因及其编码的多肽及其用途
公开(公告)号：US20060039884A1
公开(公告)日：2006-02-23
申请号：US10534894
申请日：2003-11-13
申请人： Xiangyin Kong , Shanru Li , Landian Hu , Yaozhou Shi , Xiaokun Teng
发明人： Xiangyin Kong , Shanru Li , Landian Hu , Yaozhou Shi , Xiaokun Teng
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , A61K8/64
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention has disclosed a baldness-related gene and the encoded polypeptide, and a process for producing the polypeptide by recombinant methods. It has also disclosed the use of Rhor gene and protein in the diagnosis and treatment of baldness.
摘要翻译：本发明公开了一种与秃头相关的基因和编码的多肽，以及通过重组方法制备该多肽的方法。还公开了Rhor基因和蛋白质在秃发诊断和治疗中的应用。

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