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1. 发明申请

US20160287729A1 SMALL MOLECULE IMAGING OF FUNGI BY POSITRON EMISSION TOMOGRAPHY SCANNING 审中-公开
标题翻译：通过POSITRON排放测量扫描进行真菌小分子成像
公开(公告)号：US20160287729A1
公开(公告)日：2016-10-06
申请号：US15030554
申请日：2014-10-23
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV , THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
发明人： Peter R. WILLIAMSON , Dale O. KIESEWETTER , John PANEPINTO , Jin QIU
IPC分类号： A61K51/04 , C07D251/68 , C07B59/00
CPC分类号： A61K51/0461 , A61K31/53 , C07B59/002 , C07D251/68
摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl ; R2 is —NHC(O)—R3—L or —C(O)NH—R3—L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
摘要翻译：其中R1是胺，羟基，硫化物，羧酸，酰胺，烷基或芳基; R2是-NHC（O）-R3-L或-C（O）NH-R3-L，其中R3是芳基或脂族基团（例如烷基）; 每个R 4独立地可以选自卤素，脂族（例如烷基），芳基，胺，羟基，卤代烷基，羧酸，酰胺，芳烷基，氰基，酯，硫醇，硫醚或烷氧基; 每个R 5独立地可以选自氢，芳烷基，烷基或芳基，任意一个芳烷基，烷基或芳基任选被提供给R 4的任何取代基取代; 每个n独立地为1,2,3,4或5; L为18F或能够螯合放射性标记的螯合剂（例如[18F] AlF，64Cu，68Ga）的螯合剂，1,4,7,10-四氮杂环十二烷四乙酸（DOTA）或1,4,7-三氮杂环壬烷 - 三乙酸（NOTA）。

2. 发明申请

US20140030285A1 Altered OSPA of Borrelia Burgdorferi 有权
标题翻译：改变了Borurgia Burgdorferi的OSPA
公开(公告)号：US20140030285A1
公开(公告)日：2014-01-30
申请号：US13944078
申请日：2013-07-17
申请人： Brookhaven Sciences Associates, LLC , Research Foundation of the State University of New York , University of Rochester
发明人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
IPC分类号： C07K14/20
CPC分类号： C07K14/20 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
摘要翻译：本文提供了具有某些改变的来自莱姆病引起的疏螺旋体的OspA多肽。在一个实施方案中，所述改变增加含有所述改变的OspA多肽的构象稳定性，同时保持相应未改变的OspA多肽的至少一些抗原性。在另一个实施方案中，与相应的未改变的OspA多肽相比，改变的OspA多肽具有降低的与hLFA-1的交叉反应性。

3. 发明授权

US08460647B2 Pre-ligand assembly domain of the IL-17 receptor 失效
标题翻译： IL-17受体的前配体组装结构域
公开(公告)号：US08460647B2
公开(公告)日：2013-06-11
申请号：US12595585
申请日：2008-04-20
申请人： Sarah L. Gaffen , Fang Shen , Walter Hanel , Jill Kramer , James P. Malone , Michael Wittekind , Raymond Paxton
发明人： Sarah L. Gaffen , Fang Shen , Walter Hanel , Jill Kramer , James P. Malone , Michael Wittekind , Raymond Paxton
IPC分类号： C07K14/7155 , C07K2319/00 , C07K2319/33
CPC分类号： C07K14/47 , C07K14/7155 , C07K2319/00 , C07K2319/30
摘要： The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided.
摘要翻译：本发明提供了包含IL-17受体（IL-17R）家族成员的结构域（例如，纤连蛋白III样结构域）的氨基酸序列的分离的前配体组装域（PLAD）多肽，其中PLAD多肽抑制包含IL-17R家族成员的受体复合物的多聚化。还提供了分离的PLAD结合多肽，例如特异性结合本文所述的PLAD多肽的抗体和avim。本文提供了相关嵌合蛋白，缀合物，核酸，载体和宿主细胞。还提供了治疗炎性或自身免疫性疾病的方法，抑制IL-17介导的信号转导的方法，抑制IL-17配体结合的方法，抑制IL-17R复合物多聚化的方法，以及抑制IL-17介导的信号转导的方法提供了至少一种细胞因子，趋化因子，基质金属蛋白酶或与IL-17信号转导相关的其它分子。

4. 发明授权

US08110181B2 Method of treating tuberculosis with interferons 有权
标题翻译：用干扰素治疗结核病的方法
公开(公告)号：US08110181B2
公开(公告)日：2012-02-07
申请号：US12154158
申请日：2008-05-19
申请人： Rany Condos , Gerald Smaldone
发明人： Rany Condos , Gerald Smaldone
IPC分类号： A61K38/00 , A61K38/21 , C07K14/00
CPC分类号： A61K9/0078 , A61K31/00 , A61K38/21 , A61K2300/00
摘要： A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.
摘要翻译：一种治疗结核病的方法，包括施用雾化干扰素，例如干扰素α，干扰素＆bgr; 或治疗有效量的干扰素γ。而且，提供了一种或多种雾化干扰素的药物组合物。

5. 发明授权

US08105571B2 Method of treating pulmonary disease with interferons 有权
标题翻译：用干扰素治疗肺部疾病的方法
公开(公告)号：US08105571B2
公开(公告)日：2012-01-31
申请号：US12460376
申请日：2009-07-17
申请人： Gerald Smaldone , Rany Condos
发明人： Gerald Smaldone , Rany Condos
IPC分类号： A61K38/00 , A61K38/21 , C07K14/00
CPC分类号： A61K38/217 , A61K9/0073
摘要： A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.
摘要翻译：本文提供了治疗肺部疾病的方法，例如特发性肺纤维化（IPF），混合性结缔组织病和哮喘，包括以治疗有效量施用雾化干扰素如干扰素γ。此外，提供了一种或多种雾化干扰素单独或与其它治疗剂组合的药物组合物。

6. 发明申请

US20110130538A1 PHOTOLYTIC ACID-GENERATING POLYMERS AND MONOMERS FOR THEIR CONSTRUCTION 有权
标题翻译：用于其构造的光致酸性聚合物和单体
公开(公告)号：US20110130538A1
公开(公告)日：2011-06-02
申请号：US12869308
申请日：2010-08-26
申请人： Robert L. BRAINARD
发明人： Robert L. BRAINARD
IPC分类号： C08G75/30 , C07D403/12 , C07D487/04 , C07D209/48 , C07D207/40 , C08G75/24
CPC分类号： C07D487/04 , C07D207/46 , C07D209/48 , C07D519/00 , C08G75/24 , C08G75/30
摘要： Polymers for photoresists and monomers for incorporation into those polymers are disclosed. The polymers comprise a photoacid generator (PAG) component and at least a second component that is photolytically stable and acid-stable. The polymers may also contain a third, acid-labile component. The photoacid generator is based on N-sulfoxyimides and related moieties that contain photolabile oxygen-heteroatom and oxygen-aromatic carbon bonds.
摘要翻译：公开了用于结合到这些聚合物中的光致抗蚀剂和单体的聚合物。聚合物包含光致酸产生剂（PAG）组分和至少一种光解稳定和酸稳定的第二组分。聚合物还可以含有第三种酸不稳定组分。光致酸发生器是基于N-亚磺酰氧基和含有光不稳定氧 - 杂原子和氧 - 芳族碳键的相关部分。

7. 发明授权

US07545945B2 Comb sense microphone 有权
标题翻译：梳感麦克风
公开(公告)号：US07545945B2
公开(公告)日：2009-06-09
申请号：US11198370
申请日：2005-08-05
申请人： Ronald Miles
发明人： Ronald Miles
IPC分类号： H04R25/00
CPC分类号： H04R19/04
摘要： There is provided a rigid hinged substrate, which forms a diaphragm for miniature microphones. A series of fingers disposed radially around the perimeter of the diaphragm interacts with mating fingers disposed adjacent the diaphragm with a small gap in between. The fingers are interdigitated. The movement of the diaphragm fingers relative to the fixed fingers varies the capacitance, thereby allowing creation of an electrical signal responsive to varying sound pressure at the diaphragm. Because the fingers may be formed with great stiffness, the classic problem in typical capacitive microphones of attraction of the diaphragm to the back plate is effectively overcome. The multiple fingers allow the creation of a microphone having a high output voltage relative to conventional microphones. This yields a very low noise microphone. The diaphragm may be readily formed using well known silicon microfabrication techniques so as to reduce manufacturing costs.
摘要翻译：提供了刚性铰链基板，其形成用于微型麦克风的隔膜。围绕隔膜的周边径向设置的一系列指状物与邻近隔膜设置的配合指针相互作用，其间具有小的间隙。手指交错。光镊指相对于固定指的移动改变电容，从而允许响应于隔膜处的变化的声压产生电信号。因为手指可能形成很大的刚度，所以有效克服了隔膜吸引到背板的典型的电容式麦克风的经典问题。多个手指允许创建相对于传统麦克风具有高输出电压的麦克风。这产生非常低噪音的麦克风。可以使用公知的硅微细加工技术容易地形成隔膜，以降低制造成本。

8. 发明申请

US20090117471A1 LITHIUM ION BATTERY ELECTRODE AND METHOD FOR MANUFACTURE OF SAME 审中-公开
标题翻译：锂离子电池电极及其制造方法
公开(公告)号：US20090117471A1
公开(公告)日：2009-05-07
申请号：US12261715
申请日：2008-10-30
申请人： Clare P. GREY , Hailong Chen
发明人： Clare P. GREY , Hailong Chen
IPC分类号： H01M4/40
CPC分类号： H01M4/525 , C01G45/1228 , C01G45/1242 , C01G49/0027 , C01G51/42 , C01G51/50 , C01P2002/72 , C01P2002/77 , C01P2002/85 , C01P2002/86 , C01P2004/03 , C01P2004/04 , C01P2006/40 , H01M4/505
摘要： Disclosed is a method for synthesizing a lithium transition metal oxide nanostructure for the cathode material LiCoO2, by using a molten salts/hydroxides flux method, and a device thereof.
摘要翻译：公开了通过使用熔融盐/氢氧化物通量法合成阴极材料LiCoO 2的锂过渡金属氧化物纳米结构体的方法及其装置。

9. 发明授权

US07524064B2 Apparatus and method for assessing retinal damage 失效
标题翻译：用于评估视网膜损伤的装置和方法
公开(公告)号：US07524064B2
公开(公告)日：2009-04-28
申请号：US10972613
申请日：2004-10-25
申请人： Harry J. Wyatt
发明人： Harry J. Wyatt
IPC分类号： A61B3/10
CPC分类号： A61B3/112 , A61B3/024
摘要： The invention administers an objective clinical test to an eye that measures the visual sensitivity of the superior retina and the inferior retina, by alternately presenting a stimulus pair comprising a shaped superior light stimulus and a shaped inferior light stimulus that are horizontal mirror images of one another and have shapes encompassing visual field defects. The shaped superior and inferior light stimuli stimulate pupillary responses whose amplitudes are measured. A cycle-averaged pupillary response balance and a luminance ratio are computed for each presentation of a stimulus pair. A stimulus pair response curve is computed by fitting cycle-averaged pupillary response balances to a sigmoid function of the luminance ratios. A balanced luminance ratio at which the cycle-averaged pupillary response balance is equal to about zero is computed from the sigmoid function. The balanced luminance ratio is indicative of the presence and location of retinal nerve damage.
摘要翻译：本发明通过交替地呈现包括彼此为水平镜像的成形的优良光刺激和形状的下光刺激的刺激对，来对眼睛进行客观的临床测试，以测量上视网膜和下视网膜的视觉灵敏度并且具有包含视野缺陷的形状。成形的上下光刺激刺激测量幅度的瞳孔反应。针对刺激对的每个呈现计算周期平均瞳孔响应平衡和亮度比。通过将周期平均瞳孔响应平衡拟合到亮度比的S形函数来计算刺激对响应曲线。从S形函数计算周期平均瞳孔响应平衡等于约零的平衡亮度比。平衡亮度比表示视网膜神经损伤的存在和位置。

10. 发明授权

US07370357B2 Specification-based anomaly detection 失效
标题翻译：基于规范的异常检测
公开(公告)号：US07370357B2
公开(公告)日：2008-05-06
申请号：US10298826
申请日：2002-11-18
申请人： Ramasubramanian Sekar
发明人： Ramasubramanian Sekar
IPC分类号： G06F11/00
CPC分类号： H04L63/1425 , H04L43/00 , H04L43/14 , H04L69/03
摘要： A method for network intrusion detection on a network comprising a plurality of state machines for passing a plurality of network packets comprises determining frequency distributions for each transition within each state machine, determining the distributions of values of each state machine on each transition, and comparing the distributions to observed statistics in the network, and upon determining that the observed statistics are outside defined limits, detecting an anomaly.
摘要翻译：一种用于在包括用于传递多个网络分组的多个状态机的网络上进行网络入侵检测的方法包括：确定每个状态机内的每个转换的频率分布，确定每个转换时每个状态机的值的分布，在网络中观察统计数据的分布情况，以及在确定观察到的统计数据超出限定值时，检测到异常。

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