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1. 发明公开

US20230324397A1 Antibody composition for immunotyping of myeloid tumor and use thereof 审中-公开
公开(公告)号：US20230324397A1
公开(公告)日：2023-10-12
申请号：US18172516
申请日：2023-02-22
申请人： Peking University People's Hospital
发明人： Yanrong LIU , Yazhe WANG
IPC分类号： G01N33/574 , G01N33/569 , C07K16/28
CPC分类号： G01N33/57492 , G01N33/57426 , G01N33/56972 , C07K16/2866 , C07K16/2896
摘要： The present disclosure relates to the field of antibody medicine and in particular to an antibody composition for immunotyping of myeloid neoplasms and use thereof, the antibody composition comprising panels of 22-24 antibodies. In the disclosure, combinations of antibodies and corresponding fluorescent labels as well as the method for interpreting the results are optimized, which, with only one tube of 22 or 24 antibodies and one tube of cells at a time, allows for comprehensive and efficient subtyping of acute myeloid leukaemia (AML) and chronic myeloid neoplasms, prediction of CML and part of AML with recurrent genetical abnormalities, and thus a high sensitivity for the diagnosis of myelodysplasia (MDS). It is also possible to identify leukaemia-associated immunophenotypes (LAIP) in this composition that can be used for post-treatment minimal residual disease (MRD) monitoring.

2. 发明申请

US20100055674A1 UTILIZING LIVER CELL LINE QSG-7701 TO BE INFECTED WITH HEPATITIS B VIRUS 失效
标题翻译：利用肝细胞系QSG-7701感染乙型肝炎病毒
公开(公告)号：US20100055674A1
公开(公告)日：2010-03-04
申请号：US12523085
申请日：2008-01-29
申请人： Xiaoben Pan , Lai Wei
发明人： Xiaoben Pan , Lai Wei
IPC分类号： C12Q1/70 , C12N5/00
CPC分类号： C12N7/00 , C12N2730/10151
摘要： The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not require pre-differentiation induction and is naturally susceptible for HBV infection. This cell line provides near normal physiological conditions for HBV infection, especially the infection conditions that are characterized with Chinese origin. This cell line is suitable for investigating the life cycle of HBV. Therefore, this cell line is useful for the investigation of viral infection processes and for the development of drugs that specifically target these processes.
摘要翻译：肝细胞系QSG-7701用于HBV感染的方法包括以下步骤：用纯化的HBV颗粒直接感染QSG-7701细胞，并促进通过DMSO和/或PEG处理的感染。容易获得的QSG-7701肝细胞系可能不需要预分化诱导，并且对HBV感染天然易感。该细胞系为HBV感染提供接近正常的生理条件，特别是以中国血清为特征的感染病症。该细胞系适用于调查HBV的生命周期。因此，这种细胞系可用于病毒感染过程的研究和用于开发专门针对这些过程的药物。

3. 发明公开

US20230167404A1 Urine-Derived Mesenchymal Stem Cell Mitochondria as Well as Transplantation Method and Use Thereof 审中-公开
公开(公告)号：US20230167404A1
公开(公告)日：2023-06-01
申请号：US17574634
申请日：2022-01-13
申请人： Peking University People's Hospital
发明人： Huan Shen , Zhixin Jiang , Cheng Shi , Yanbin Wang , Xi Chen , Hongjing Han , Min Fu , Jia Fei
IPC分类号： C12N5/075 , C12N5/0775
CPC分类号： C12N5/0609 , C12N5/0668
摘要： A urine-derived mesenchymal stem cell mitochondria as well as a transplantation method and use thereof. The urine-derived mesenchymal stem cell mitochondrion is extracted from urine to be used for improving the quality of oocytes. The transplantation method comprises: jointly injecting sperms and the urine-derived mesenchymal stem cell mitochondria into mature oocytes for blastaea culture during the intracytoplasmic sperm microinjection. The present disclosure has the beneficial effects: during the traditional ICSI in combination with the transplantation of the urine-derived mesenchymal stem cell mitochondria, the fertilization rate of human in-vitro fertilization and the quality of embryos are significantly improved; the urine-derived mesenchymal stem cell mitochondria of the present disclosure can be used for in-vitro fertilization of low-prognosis patients with infertility with a good treatment effect; the problem of an autologous mitochondrion source in the prior art is solved without involving the introduction of a third-party genetic material and ethical issues.

4. 发明申请

US20120141977A1 HEPATITIS B VIRUS MUTATION STRAIN WITH RESISTANCE TO ADEFOVIR DIPIVOXIL AND THE USES THEREOF 审中-公开
标题翻译：乙型肝炎病毒乙型肝炎病毒株对抗ADIVOVIR DIPIVOXIL及其用途
公开(公告)号：US20120141977A1
公开(公告)日：2012-06-07
申请号：US13318783
申请日：2009-10-20
申请人： Lai Wei , Shaocai Du , Lijun Liu , Jianghua Wang
发明人： Lai Wei , Shaocai Du , Lijun Liu , Jianghua Wang
IPC分类号： C12N7/01 , C12N1/21 , G01N21/64 , C12Q1/70 , C07H21/04
CPC分类号： C12N7/00 , C12N9/1241 , C12N2730/10122 , C12Q1/706 , C12Q2600/136
摘要： A HBV mutation strain is provided, wherein rtE218G mutation occurs at the polymerase region of the mutation strain. The use of the HBV strain in screening anti-HBV drugs and related detection reagents used to detect rtE218G mutation are also provided.
摘要翻译：提供HBV突变株，其中rtE218G突变发生在突变株的聚合酶区域。还提供了HBV筛选抗HBV药物和用于检测rtE218G突变的相关检测试剂的应用。

5. 发明公开

US20230333110A1 REAGENT COMPOSITION FOR IMMUNOPHENOTYPING OF B LYMPHOBLASTIC LEUKEMIA/LYMPHOMA AND USE THEREOF 审中-公开
公开(公告)号：US20230333110A1
公开(公告)日：2023-10-19
申请号：US18300028
申请日：2023-04-13
申请人： Peking University People's Hospital
发明人： Yanrong LIU , Yazhe WANG
IPC分类号： G01N33/574 , G01N15/14
CPC分类号： G01N33/57426 , G01N15/14 , G01N2333/70503 , G01N2800/7028
摘要： Provided is a reagent composition for immunophenotyping and MRD monitoring of B lymphoblastic leukemia/lymphoma (B-ALL/LBL). The reagent composition includes a 20-antibody combination. In the present disclosure, the antibody combination, the fluorescent labeling combination for the corresponding antibody, and the result interpretation methods are optimized. It only needs to use 20 kinds of antibodies in a single tube of cells for one sample loading, allowing for comprehensively and efficiently performing subtype typing on B lymphoblastic leukemia/lymphoma. In addition, it enables to predict part of recurrent genetically abnormal B-ALL/LBL and has high sensitivity and specificity for the diagnosis of the subtype of BCR/ABL1 gene. Meanwhile, it enables to determine the leukemia-related immunophenotype (LAIP) for minimal residual disease (MRD) monitoring after treatment by using the combination and used for MRD monitoring and CAR-T post-treatment monitoring.

6. 发明授权

US08124409B2 Utilizing liver cell line QSG-7701 to be infected with hepatitis B virus 失效
标题翻译：利用肝细胞系QSG-7701感染乙型肝炎病毒
公开(公告)号：US08124409B2
公开(公告)日：2012-02-28
申请号：US12523085
申请日：2008-01-29
申请人： Xiaoben Pan , Lai Wei
发明人： Xiaoben Pan , Lai Wei
IPC分类号： C12N5/10 , C07N7/06
CPC分类号： C12N7/00 , C12N2730/10151
摘要： The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not require pre-differentiation induction and is naturally susceptible for HBV infection. This cell line provides near normal physiological conditions for HBV infection, especially the infection conditions that are characterized with Chinese origin. This cell line is suitable for investigating the life cycle of HBV. Therefore, this cell line is useful for the investigation of viral infection processes and for the development of drugs that specifically target these processes.
摘要翻译：肝细胞系QSG-7701用于HBV感染的方法包括以下步骤：用纯化的HBV颗粒直接感染QSG-7701细胞，并促进通过DMSO和/或PEG处理的感染。容易获得的QSG-7701肝细胞系可能不需要预分化诱导，并且对HBV感染天然易感。该细胞系为HBV感染提供接近正常的生理条件，特别是以中国血清为特征的感染病症。该细胞系适用于调查HBV的生命周期。因此，这种细胞系可用于病毒感染过程的研究和用于开发专门针对这些过程的药物。

7. 发明申请

US20100310605A1 ANTI-HCV VACCINE AND PREPARATION METHODS AND USES THEREOF 审中-公开
标题翻译：抗HCV疫苗及其制备方法及其用途
公开(公告)号：US20100310605A1
公开(公告)日：2010-12-09
申请号：US12809132
申请日：2007-12-18
申请人： Lai Wei , Yuan Tian
发明人： Lai Wei , Yuan Tian
IPC分类号： A61K39/29 , A61P31/14
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： An anti-HCV vaccine, which is prepared through recombination of an NS gene in series, including NS3/NS4 and NS4/NS5, with an adenovirus vector. The preparation methods and uses of the anti-HCV vaccine.
摘要翻译：通过将NS基因（包括NS3 / NS4和NS4 / NS5）与腺病毒载体重组而制备的抗HCV疫苗。抗HCV疫苗的制备方法和用途。

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