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1. 发明授权

US10301615B2 Genes expressed in mental illness and mood disorders 有权
公开(公告)号：US10301615B2
公开(公告)日：2019-05-28
申请号：US14763706
申请日：2014-01-30
申请人： PSYCHNOSTICS, LLC
发明人： Alagu P. Thiruvengadam , Krish Chandrasekaran
IPC分类号： C12N15/10 , C12Q1/68 , C40B30/04 , C40B40/06 , C12Q1/6883 , C12Q1/6806
摘要： The present invention relates to a composition comprising a plurality of cDNA molecules for use in methods of detecting changes in expression of genes encoding proteins that are associated with mental illnesses and which are differentially expressed in patients with mental illnesses, such as bipolar I disorder, bipolar II disorder, unipolar disorder, schizophrenia, attention deficit hyperactive disorders, obsessive compulsive disorders, anxiety disorders or other related mood disorders. The composition and the cDNA molecules may be used in their entirety or in part as to diagnose, to stage, to treat, and/or to monitor the treatment of a subject with mental illness.

2. 发明申请

US20190309285A1 GENES EXPRESSED IN MENTAL ILLNESS AND MOOD DISORDERS 审中-公开
公开(公告)号：US20190309285A1
公开(公告)日：2019-10-10
申请号：US16378233
申请日：2019-04-08
申请人： PsychNostics, LLC
发明人： Alagu P. THIRUVENGADAM , Krish CHANDRASEKARAN
IPC分类号： C12N15/10 , C12Q1/6806 , C12Q1/6883
摘要： The present invention relates to a composition comprising a plurality of cDNA molecules for use in methods of detecting changes in expression of genes encoding proteins that are associated with mental illnesses and which are differentially expressed in patients with mental illnesses, such as bipolar I disorder, bipolar II disorder, unipolar disorder, schizophrenia. attention deficit hyperactive disorders, obsessive compulsive disorders, anxiety disorders or other related mood disorders. The composition and the cDNA molecules may be used in their entirety or in part as to diagnose. to stage, to treat. and/or to monitor the treatment of a subject with mental illness.

3. 发明申请

US20160084826A1 METHODS FOR TREATING ADHD AND BIPOLAR DISORDER USING A MEMBRANE POTENTIAL RATIO TEST 审中-公开
标题翻译：使用膜可能比率测试治疗ADHD和双极性疾病的方法
公开(公告)号：US20160084826A1
公开(公告)日：2016-03-24
申请号：US14888720
申请日：2014-05-15
申请人： PSYCHNOSTICS, LLC
发明人： Alagu P. THIRUVENGADAM , Douglas B. WOODRUFF
IPC分类号： G01N33/50
CPC分类号： G01N33/5035 , G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2800/304 , G01N2800/305
摘要： The present invention relates to a method for optimizing drug therapy treatment of patients with Attention Deficit Hyperactivity Disorder (ADHD) or Bipolar Disorder (BD), a method of optimizing drug dosage for treatment of ADHD and BD, a method of treating ADHD and BD, and a kit. The present method may also be used to adjust medication doses for individual patients.
摘要翻译：本发明涉及一种优化注意缺陷多动障碍（ADHD）或双相障碍（BD）患者药物治疗的方法，优化药物用量治疗ADHD和BD的方法，一种治疗ADHD和BD的方法，和一个工具包。本方法也可用于调整个体患者的药物剂量。

4. 发明申请

US20190302102A1 COMBINATION THERAPIES FOR TREATING BIPOLAR DISORDER, AND METHODS FOR USING THE SAME 审中-公开
公开(公告)号：US20190302102A1
公开(公告)日：2019-10-03
申请号：US16346212
申请日：2017-10-26
申请人： PsychNostics, LLC
发明人： Alagu P. THIRUVENGADAM
IPC分类号： G01N33/50 , A61K33/06 , A61K45/06 , G16H20/10
摘要： The present invention relates to pharmaceutical combinations and compositions, and methods of using the same for treatment of Bipolar Disorder (BD). More specifically, the invention relates to combination therapies for the treatment of BD, and methods for treating BD using such therapies. The present invention also relates to methods of determining an optimal combination drug treatment therapy for BD, methods of optimizing a combination drug treatment therapy for BD, methods of optimizing dosage of a drug in a combination drug treatment therapy for BD, as well as methods for monitoring the efficacy of a combination therapy for the treatment of BD. The present invention involves analyzing the membrane potential of cells isolated from a BD patient treated with the combination therapy, and calculating a membrane potential ratio therefrom.

5. 发明授权

US09523673B2 Methods for diagnosing and identifying modulators of membrane potentials in bipolar disorder and attention deficit hyperactivity disorder 有权
标题翻译：诊断和鉴别双相障碍和注意缺陷多动障碍的膜电位调节剂的方法
公开(公告)号：US09523673B2
公开(公告)日：2016-12-20
申请号：US14236787
申请日：2012-09-14
申请人： Alagu P. Thiruvengadam
发明人： Alagu P. Thiruvengadam
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5041 , G01N33/5008 , G01N33/502 , G01N33/6872 , G01N2333/912 , G01N2333/91215 , G01N2800/304 , G01N2800/305
摘要： The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD. Methods of identifying effective compounds responsible for membrane potentials and excitabilities influencing bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods of identifying an effective compound that modulates the activity of Ca2+/CaM enzyme and compounds involved in changing the K+ gradient across the plasma membrane thereby increasing or decreasing the membrane potential ratio (MPR™) values. The invention provides methods of identifying a compound that modulates the activity of PKC which is an important protein of the DAG signaling pathway. Methods of identifying a compound that modulates DAG and its related enzymes along the DAG signaling pathway are provided. These compounds decrease or increase the membrane potential ratio (MPR™) in BD and ADHD patients.
摘要翻译：本发明提供了调节沿着DAG信号通路的关键元件的方法以及使用该方法诊断双相情感障碍（BD）和注意缺陷多动障碍（ADHD）的诊断测定，装置和方法。识别BD和ADHD的诊断标志物和药物靶标的方法。鉴定负责影响双相情感障碍（BD）和注意缺陷多动障碍（ADHD）的膜电位和兴奋性的有效化合物的方法。鉴定调节Ca2 + / CaM酶的活性的有效化合物的方法和涉及改变跨越质膜的K +梯度的化合物，从而增加或降低膜电位比（MPR TM）值。本发明提供了鉴定调节作为DAG信号通路的重要蛋白质的PKC的活性的化合物的方法。提供了鉴定沿着DAG信号通路调节DAG及其相关酶的化合物的方法。这些化合物降低或增加BD和ADHD患者的膜电位比（MPR™）。

6. 发明授权

US10082498B2 Methods for treating ADHD and bipolar disorder using a membrane potential ratio test 有权
公开(公告)号：US10082498B2
公开(公告)日：2018-09-25
申请号：US14888720
申请日：2014-05-15
申请人： PSYCHNOSTICS, LLC.
发明人： Alagu P. Thiruvengadam , Douglas B. Woodruff
IPC分类号： A61K39/00 , A61K31/00 , G01N33/566 , C12Q1/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5035 , G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2800/304 , G01N2800/305
摘要： The present invention relates to a method for optimizing drug therapy treatment of patients with Attention Deficit Hyperactivity Disorder (ADHD) or Bipolar Disorder (BD), a method of optimizing drug dosage for treatment of ADHD and BD, a method of treating ADHD and BD, and a kit. The present method may also be used to adjust medication doses for individual patients.

7. 发明申请

US20140248652A1 METHODS FOR DIAGNOSING AND IDENTIFYING MODULATORS OF MEMBRANE POTENTIALS IN BIPOLAR DISORDER AND ATTENTION DEFICIT HYPERACTIVITY DISORDER 有权
标题翻译：用于诊断和识别双极细胞膜中电位的调节剂的方法和注意缺陷性高血压病
公开(公告)号：US20140248652A1
公开(公告)日：2014-09-04
申请号：US14236787
申请日：2012-09-14
申请人： Alagu P. Thiruvengadam
发明人： Alagu P. Thiruvengadam
IPC分类号： G01N33/50 , G06F19/00
CPC分类号： G01N33/5041 , G01N33/5008 , G01N33/502 , G01N33/6872 , G01N2333/912 , G01N2333/91215 , G01N2800/304 , G01N2800/305
摘要： The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD. Methods of identifying effective compounds responsible for membrane potentials and excitabilities influencing bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods of identifying an effective compound that modulates the activity of Ca2+/CaM enzyme and compounds involved in changing the K+ gradient across the plasma membrane thereby increasing or decreasing the membrane potential ratio (MPR™) values. The invention provides methods of identifying a compound that modulates the activity of PKC which is an important protein of the DAG signaling pathway. Methods of identifying a compound that modulates DAG and its related enzymes along the DAG signaling pathway are provided. These compounds decrease or increase the membrane potential ratio (MPR™) in BD and ADHD patients.
摘要翻译：本发明提供了调节沿着DAG信号通路的关键元件的方法以及使用该方法诊断双相情感障碍（BD）和注意缺陷多动障碍（ADHD）的诊断测定，装置和方法。识别BD和ADHD的诊断标志物和药物靶标的方法。鉴定负责影响双相情感障碍（BD）和注意缺陷多动障碍（ADHD）的膜电位和兴奋性的有效化合物的方法。鉴定调节Ca2 + / CaM酶的活性的有效化合物的方法和涉及改变跨越质膜的K +梯度的化合物，从而增加或降低膜电位比（MPR TM）值。本发明提供了鉴定调节作为DAG信号通路的重要蛋白质的PKC的活性的化合物的方法。提供了鉴定沿着DAG信号通路调节DAG及其相关酶的化合物的方法。这些化合物降低或增加BD和ADHD患者的膜电位比（MPR™）。

8. 发明申请

US20210196697A1 COMBINATION THERAPIES FOR TREATING BIPOLAR DISORDER AND ADHD, AND METHODS FOR USING THE SAME 有权
公开(公告)号：US20210196697A1
公开(公告)日：2021-07-01
申请号：US16756960
申请日：2018-10-24
申请人： PsychNostics, LLC
发明人： Alagu P. THIRUVENGADAM
IPC分类号： A61K31/4458 , A61K31/55 , A61P25/28 , G01N33/50
摘要： The present invention relates to pharmaceutical combinations and compositions, and methods of using the same for treatment of attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BD). The invention relates to combination therapies for the treatment of BD and for ADHD, and methods for treating BD and ADHD using such therapies. The present invention also relates to methods of determining an optimal combination drug treatment therapy for BD and for ADHD, methods of optimizing a combination drug treatment therapy for BD and for ADHD, methods of optimizing dosage of a drug in a combination drug treatment therapy for BD and for ADHD, as well as methods for monitoring the efficacy of a combination therapy for the treatment of BD and for ADHD. The present invention involves analyzing the membrane potential of cells isolated from a BD patient treated with the combination therapy and from an ADHD patient treated with the combination therapy, and calculating a membrane potential ratio therefrom.

9. 发明申请

US20190293633A1 METHODS FOR IDENTIFYING MODULATORS OF MEMBRANE POTENTIALS IN BIPOLAR DISORDER AND ATTENTION DEFICIT HYPERACTIVITY DISORDER 审中-公开
公开(公告)号：US20190293633A1
公开(公告)日：2019-09-26
申请号：US16439084
申请日：2019-06-12
申请人： PsychNostics, LLC
发明人： Alagu P. THIRUVENGADAM
IPC分类号： G01N33/50 , G01N33/68
摘要： The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD. Methods of identifying effective compounds responsible for membrane potentials and excitabilities influencing bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods of identifying an effective compound that modulates the activity of Ca2+/CaM enzyme and compounds involved in changing the K+ gradient across the plasma membrane thereby increasing or decreasing the membrane potential ratio (MPR™) values. The invention provides methods of identifying a compound that modulates the activity of PKC which is an important protein of the DAG signaling pathway. Methods of identifying a compound that modulates DAG and its related enzymes along the DAG signaling pathway are provided. These compounds decrease or increase the membrane potential ratio (MPR™) in BD and ADHD patients.

10. 发明授权

US10365268B2 Methods for identifying modulators of membrane potentials in bipolar disorder and attention deficit hyperactivity disorder 有权
公开(公告)号：US10365268B2
公开(公告)日：2019-07-30
申请号：US15276088
申请日：2016-09-26
申请人： PsychNostics, LLC
发明人： Alagu P. Thiruvengadam
IPC分类号： G01N33/50 , G01N33/68
摘要： The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD. Methods of identifying effective compounds responsible for membrane potentials and excitabilities influencing bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods of identifying an effective compound that modulates the activity of Ca2+/CaM enzyme and compounds involved in changing the K+ gradient across the plasma membrane thereby increasing or decreasing the membrane potential ratio (MPR™) values. The invention provides methods of identifying a compound that modulates the activity of PKC which is an important protein of the DAG signaling pathway. Methods of identifying a compound that modulates DAG and its related enzymes along the DAG signaling pathway are provided. These compounds decrease or increase the membrane potential ratio (MPR™) in BD and ADHD patients.

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