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1. 发明授权

US07989000B2 Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects 有权
标题翻译：可吸收的油灰状植入物及其用于骨骼机械止血和治疗骨缺损的方法
公开(公告)号：US07989000B2
公开(公告)日：2011-08-02
申请号：US10941889
申请日：2004-09-16
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： A61L24/0042 , A61L24/043 , A61L27/425 , A61L27/46 , A61L2400/04 , A61L2430/02
摘要： Disclosed are body-implantable, appropriately absorbable, biocompatible, putty-like compositions useful as mechanical hemostatic tamponades for the control of osseous hemorrhage arising from surgical intervention or trauma and for providing an osteoinductive matrix to foster improved bone healing.
摘要翻译：公开了可用作机械止血填塞物的可植入植入物，适当吸收的，生物相容性的油灰状组合物，用于控制由外科手术或创伤引起的骨出血并提供骨诱导基质以促进改善的骨愈合。

2. 发明申请

US20120027817A1 Absorbable Implants and Methods for Their Use in Hemostasis 审中-公开
标题翻译：可吸收植入物及其用于止血的方法
公开(公告)号：US20120027817A1
公开(公告)日：2012-02-02
申请号：US13223611
申请日：2011-09-01
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61K31/715 , A61B19/02 , A61P7/04 , A61K31/717 , A61K9/00
CPC分类号： A61K31/19 , A61L24/0042 , A61L24/08 , A61L2400/04 , A61L2400/06 , A61L2430/02 , C08L1/26
摘要： The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered polysaccharide and a biocompatible liquid comprising one or more block copolymers of ethylene oxide and propylene oxide.
摘要翻译：本发明涉及具有腻子状稠度的机械止血体吸收性组合物，其包含细粉状多糖和包含环氧乙烷和环氧丙烷的一种或多种嵌段共聚物的生物相容性液体。

3. 发明申请

US20110280970A1 ABSORBABLE PUTTY-LIKE IMPLANTS AND METHODS FOR THEIR USE FOR MECHANICAL HEMOSTASIS OF BONE AND FOR THE TREATMENT OF OSSEOUS DEFECTS 有权
标题翻译：可吸收的类似植入物及其用于机械性骨质疏松症和治疗OSSEOUS缺陷的方法
公开(公告)号：US20110280970A1
公开(公告)日：2011-11-17
申请号：US13173719
申请日：2011-06-30
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61K31/355 , A61P19/00 , A61K36/47 , A61K36/81 , A61K31/225 , A61K31/737
CPC分类号： A61L24/0042 , A61L24/043 , A61L27/425 , A61L27/46 , A61L2400/04 , A61L2430/02
摘要： The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered, carboxylic acid salt, a liquid block copolymer of ethylene oxide and propylene oxide, and a tocopherol.
摘要翻译：本发明涉及具有油灰状稠度的机械止血体吸收性组合物，其包含细粉状羧酸盐，环氧乙烷和环氧丙烷的液体嵌段共聚物和生育酚。

4. 发明申请

US20120189671A1 Absorbable Implants and Methods for their use in Hemostasis 审中-公开
标题翻译：可吸收植入物及其用于止血的方法
公开(公告)号：US20120189671A1
公开(公告)日：2012-07-26
申请号：US13410995
申请日：2012-03-02
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61K31/717 , A61K38/18 , A61K38/17 , B67D7/60 , A61K9/00 , A61P7/04 , A61P31/00 , A61K35/32 , A61K33/42
CPC分类号： A61K31/19 , A61L24/0042 , A61L24/08 , A61L2400/04 , A61L2400/06 , A61L2430/02 , C08L1/26
摘要： The invention provides body absorable, mechanically hemostatic putty compositions comprising carboxymethyl cellulose and one or more of polyhydroxy compounds, fatty acids, and esters thereof for use in controlling the bleeding of bone.
摘要翻译：本发明提供了包含羧甲基纤维素和一种或多种多羟基化合物，脂肪酸和酯的可吸收的机械止血油灰组合物，其用于控制骨的出血。

5. 发明授权

US08105628B2 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 有权
标题翻译：可吸收植入物及其用于止血和治疗骨质缺陷的方法
公开(公告)号：US08105628B2
公开(公告)日：2012-01-31
申请号：US10941890
申请日：2004-09-16
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： A61K31/19 , A61L24/0042 , A61L2400/04 , A61L2430/02
摘要： Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, polydioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; alkyl aryl ethers and ketones, polyhydroxy compounds and esters and ethers thereof; (ethylene oxide/propylene oxide copolymers), oils e.g. olive oil, castor oil and triglycerides.
摘要翻译：两种（或多种）组合的植入体，可吸收的，生物相容的，油灰和非油腻的止血栓塞用于手术。组分1是细粉状填充材料，优选小于50微米。含有约6至22个碳原子的饱和或不饱和羧酸的钙，镁，铝或钡盐，羟基磷灰石，DBM，聚乙交酯，聚丙交酯，聚二恶英酮，聚己内酯，可吸收的玻璃，明胶，胶原，单糖和多糖淀粉。组分2，分散载体，可以是C 8 -C 18一元醇与C 2 -C 6脂族一元羧酸的酯; C2-C18一元醇与多元羧酸; C8-C30一元醇; 生育酚及其酯与C 2 -C 10脂族一元羧酸或多元羧酸; 可吸收的10-14C碳氢化合物; 游离羧酸如油酸，癸酸和月桂酸; 二烷基醚和酮; 烷基芳基醚和酮，多羟基化合物及其酯和醚; （环氧乙烷/环氧丙烷共聚物），例如油。橄榄油，蓖麻油和甘油三酯。

6. 发明授权

US07955616B2 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 有权
标题翻译：可吸收植入物及其用于止血和治疗骨质缺陷的方法
公开(公告)号：US07955616B2
公开(公告)日：2011-06-07
申请号：US11224650
申请日：2005-09-12
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61F2/02
CPC分类号： A61K31/717 , A61K31/19 , A61L24/0042
摘要： The present application is directed to compositions and methods for mechanically controlling the bleeding of bone. The compositions comprise in intimate admixture the following Components 1, 2 and 3: (1) a finely powdered, carboxylic acid salt comprising a carboxylate anion and a metallic cation, (2) a composition comprising pyrrolidone or an N-alkyl pyrrolidone wherein alkyl is a C1-C12 alkyl radical and an optional, biocompatible liquefying agent if the composition is in solid form at room temperature, and (3) an optional analgesic, wherein the analgesic is present in a free base and salt form.
摘要翻译：本申请涉及用于机械控制骨的出血的组合物和方法。组合物包括以下组分1,2和3的紧密混合物：（1）包含羧酸根阴离子和金属阳离子的细粉末状羧酸盐，（2）包含吡咯烷酮或N-烷基吡咯烷酮的组合物，其中烷基是 C1-C12烷基和任选的生物相容性液化剂，如果组合物在室温下为固体形式，和（3）任选的止痛剂，其中止痛剂以游离碱和盐形式存在。

7. 发明申请

US20130109651A1 Absorbable Implants And Methods Of Their Use In Hemostasis And In The Treatment Of Osseous Defects 审中-公开
标题翻译：可吸收植入物及其用于止血和治疗骨质缺损的方法
公开(公告)号：US20130109651A1
公开(公告)日：2013-05-02
申请号：US13716339
申请日：2012-12-17
申请人： Orthocon, Inc.
发明人： Richard L. Kronenthal
IPC分类号： A61K31/717
CPC分类号： A61K31/717 , A61K31/19 , A61L24/0042
摘要： The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency which demonstrate excellent water resistance. The compositions are useful as mechanical hemostatic tamponades for the control of osseous hemorrhage. The compositions comprise carboxymethyl cellulose and one or more compounds selected from polyhydroxy compounds, esters of polyhydroxy compounds, fatty acids, esters of fatty acids, and mixtures of the foregoing.
摘要翻译：本发明涉及具有优异耐水性的油灰状稠度的机械性止血体吸收性组合物。该组合物可用作用于控制骨出血的机械性止血填塞物。组合物包含羧甲基纤维素和一种或多种选自多羟基化合物，多羟基化合物的酯，脂肪酸，脂肪酸的酯和上述混合物的化合物。

8. 发明授权

US08337879B2 Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects 有权
标题翻译：可吸收植入物及其用于止血和治疗骨质缺陷的方法
公开(公告)号：US08337879B2
公开(公告)日：2012-12-25
申请号：US13087584
申请日：2011-04-15
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61F2/02
CPC分类号： A61K31/717 , A61K31/19 , A61L24/0042
摘要： The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency. The compositions preferably comprise a finely powdered, carboxylic acid salt and a liquid block copolymer of ethylene oxide and propylene oxide.
摘要翻译：本发明涉及具有油灰状稠度的机械性止血体吸收性组合物。组合物优选包含细粉末状的羧酸盐和环氧乙烷和环氧丙烷的液体嵌段共聚物。

9. 发明授权

US08309131B2 Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects 有权
标题翻译：可吸收的油灰状植入物及其用于骨骼机械止血和治疗骨缺损的方法
公开(公告)号：US08309131B2
公开(公告)日：2012-11-13
申请号：US13173719
申请日：2011-06-30
申请人： Richard L. Kronenthal
发明人： Richard L. Kronenthal
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： A61L24/0042 , A61L24/043 , A61L27/425 , A61L27/46 , A61L2400/04 , A61L2430/02
摘要： The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered, carboxylic acid salt, a liquid block copolymer of ethylene oxide and propylene oxide, and a tocopherol.
摘要翻译：本发明涉及具有油灰状稠度的机械止血体吸收性组合物，其包含细粉状羧酸盐，环氧乙烷和环氧丙烷的液体嵌段共聚物和生育酚。

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