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1. 发明授权

US07384913B2 PT32 sperm protein, sperm c-Yes, oocyte cytoplasmic c-Yes, and uses thereof 有权
标题翻译： PT32精子蛋白，精子c-是，卵母细胞胞质c-是，及其用途
公开(公告)号：US07384913B2
公开(公告)日：2008-06-10
申请号：US11224577
申请日：2005-09-12
申请人： Richard Oko , Peter Sutovsky
发明人： Richard Oko , Peter Sutovsky
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K2319/00
摘要： The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing agents. Transgenic, non-human animals also are disclosed.
摘要翻译：披露核周核32（PT32）蛋白并显示与酪氨酸激酶c-Yes相互作用。 PT32，c-是，其片段和与其结合的分子可用于增强生育力，治疗或诊断生育能力下降和异常精子发生，提供避孕方法以及鉴定避孕和生育力增强剂的方法。转基因非人类动物也被公开。

2. 发明申请

US20060240512A1 PT32 sperm protein, sperm c-Yes, oocyte cytoplasmic c-Yes, and uses thereof 有权
标题翻译： PT32精子蛋白，精子c-是，卵母细胞胞质c-是，及其用途
公开(公告)号：US20060240512A1
公开(公告)日：2006-10-26
申请号：US11224577
申请日：2005-09-12
申请人： Richard Oko , Peter Sutovsky
发明人： Richard Oko , Peter Sutovsky
IPC分类号： C12P21/06 , C07K14/47 , C07K7/06
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K2319/00
摘要： The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing agents. Transgenic, non-human animals also are disclosed.
摘要翻译：披露核周核32（PT32）蛋白并显示与酪氨酸激酶c-Yes相互作用。 PT32，c-是，其片段和与其结合的分子可用于增强生育力，治疗或诊断生育能力下降和异常精子发生，提供避孕方法以及鉴定避孕和生育力增强剂的方法。转基因非人类动物也被公开。

3. 发明申请

US20050214845A1 Small and intermediate conductance, calcium-activated potassium channels and uses thereof 失效
标题翻译：小和中间电导，钙激活钾通道及其用途
公开(公告)号：US20050214845A1
公开(公告)日：2005-09-29
申请号：US11116760
申请日：2005-04-27
申请人： John Adelman , James Maylie , Chris Bond , Christopher Silvia
发明人： John Adelman , James Maylie , Chris Bond , Christopher Silvia
IPC分类号： G01N33/50 , A61K38/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/68 , G06F17/30
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , C07K2299/00 , G01N2500/04
摘要： This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
摘要翻译：本发明涉及小和中等电导，钙激活的钾通道蛋白。更具体地，本发明涉及用于制备和检测钙激活的钾通道蛋白的组合物和方法以及编码钙激活的钾通道蛋白的核酸。本发明还提供了用于测定通过钙激活的钾通道增加或减少钾离子通量的化合物的方法和组合物。

4. 发明申请

US20030044910A1 Small and intermediate conductance, calcium-activated potassium channels and uses thereof 失效
标题翻译：小和中间电导，钙激活钾通道及其用途
公开(公告)号：US20030044910A1
公开(公告)日：2003-03-06
申请号：US10115671
申请日：2002-04-03
申请人： Oregon Health Sciences University
发明人： John P. Adelman , James Maylie , Chris T. Bond , Christopher P. Silvia
IPC分类号： C07K014/435 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , C07K2299/00 , G01N2500/04
摘要： This invention relates to small and intermediate conductance, calcium-acaivated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositons for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
摘要翻译：本发明涉及小和中等电导，钙激活钾通道蛋白。更具体地，本发明涉及用于制备和检测钙激活的钾通道蛋白的组合物和方法以及编码钙激活的钾通道蛋白的核酸。本发明还提供了用于测定通过钙激活的钾通道增加或减少钾离子通量的化合物的方法和组合物。

5. 发明申请

US20020192757A1 Small and intermediate conductance, calcium-activated potassium channels and uses thereof 失效
标题翻译：小和中间电导，钙激活钾通道及其用途
公开(公告)号：US20020192757A1
公开(公告)日：2002-12-19
申请号：US10115695
申请日：2002-04-03
申请人： Oregon Health Sciences University
发明人： John P. Adelman , James Maylie , Chris T. Bond , Christopher P. Silvia
IPC分类号： C07K014/435 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , C07K2299/00 , G01N2500/04
摘要： This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated proteins. The invention also provides methods for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
摘要翻译：本发明涉及小和中等电导，钙激活的钾通道蛋白。更具体地，本发明涉及用于制备和检测钙激活的钾通道蛋白质和编码钙激活蛋白质的核酸的组合物和方法。本发明还提供了测定通过钙激活钾通道增加或减少钾离子通量的化合物的方法。

6. 发明申请

US20020123096A1 Dopamine receptors and genes 失效
公开(公告)号：US20020123096A1
公开(公告)日：2002-09-05
申请号：US09934358
申请日：2001-08-21
申请人： Oregon Health Sciences University.
发明人： Olivier Civelli , James R. Bunzow , David K. Grandy , Curtis A. Machida
IPC分类号： C07K014/705 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , C07K16/286 , C12N15/00 , C12Q1/6876 , C12Q2600/158
摘要： A mammalian D2 dopamine receptor gene has been cloned. Thus, DNA sequences encoding all or a part of the dopamine receptor are provided, as well as the corresponding polypeptide sequences and methods for producing the same both synthetically and via expression of a corresponding sequence from a host transformed with a suitable vector carrying the corresponding DNA sequence. The various structural information provided by this invention enables the preparation of labeled or unlabeled immunospecific species, particularly antibodies, as well as nucleic acid probes labeled in conventional fashion. Pharmaceutical compositions and methods of using various products of this invention are also provided.

7. 发明授权

US6090560A Amino acid transporters and uses 失效
公开(公告)号：US6090560A
公开(公告)日：2000-07-18
申请号：US188496
申请日：1998-11-09
申请人： Susan G. Amara , Jeffrey L. Arriza , Wendy A. Fairman
发明人： Susan G. Amara , Jeffrey L. Arriza , Wendy A. Fairman
IPC分类号： A61K38/00 , C07K14/47 , C12P21/04 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to novel mammalian amino acid transporter proteins and the genes that encode such proteins. The invention is directed toward the isolation, characterization and pharmacological use of a human amino acid transporter protein termed EAAT4 and genes encoding such a transporter. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to this transporter gene. Also provided are recombinant expression constructs capable of expressing this amino acid transporter gene in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human amino acid transporter protein encoded therein. The invention also provides methods for screening in vitro compounds having transport-modulating properties using preparations of transporter proteins from such cultures of cells transformed with recombinant expression constructs.

8. 发明授权

US6020479A Amino acid transporters and uses 失效
公开(公告)号：US6020479A
公开(公告)日：2000-02-01
申请号：US198650
申请日：1998-11-24
申请人： Susan G. Amara , Jeffrey L. Arriza
发明人： Susan G. Amara , Jeffrey L. Arriza
IPC分类号： A61K38/00 , C07K14/47 , C12P21/04 , C07H21/04 , C12Q1/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to novel mammalian amino acid transporter proteins and the genes that encode such proteins. The invention is directed toward the isolation, characterization and pharmacological use of the human amino acid transporter proteins EAAT1, EAAT2, EAAT3 and ASCT1. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to each of these transporter genes. Also provided are recombinant expression constructs capable of expressing each of the amino acid transporter genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human amino acid transporter proteins encoded therein. The invention also provides methods for screening in vitro compounds having transport-modulating properties using preparations of transporter proteins from such cultures of cells transformed with recombinant expression constructs.

9. 发明授权

US5998188A Mitogen activated protein kinase phosphatase cDNAS and their biologically active expression products 失效
标题翻译：丝裂原活化蛋白激酶磷酸酶cDNAs及其生物活性表达产物
公开(公告)号：US5998188A
公开(公告)日：1999-12-07
申请号：US990379
申请日：1997-12-15
申请人： Philip J. S. Stork , Anita Misra-Press
发明人： Philip J. S. Stork , Anita Misra-Press
IPC分类号： A61K38/00 , C12N9/16
CPC分类号： C12N9/16 , A61K38/00
摘要： The invention relates to a novel mitogen-activated protein kinase phosphatase, MKP-2. The invention further relates to methods and means for preparing and to nucleic acids encoding this protein. The MKP-2 of the present invention is useful in the control of cell growth, differentiation and apoptosis.
摘要翻译：本发明涉及新型丝裂原活化蛋白激酶磷酸酶MKP-2。本发明还涉及用于制备和编码该蛋白质的核酸的方法和手段。本发明的MKP-2可用于控制细胞生长，分化和凋亡。

10. 发明授权

US5922855A Mammalian DNA mismatch repair genes MLH1 and PMS1 失效
标题翻译：哺乳动物DNA错配修复基因MLH1和PMS1
公开(公告)号：US5922855A
公开(公告)日：1999-07-13
申请号：US209521
申请日：1994-03-08
申请人： Robert M. Liskay , C. Eric Bronner , Sean M. Baker , Roni J. Bollag , Richard D. Kolodner
发明人： Robert M. Liskay , C. Eric Bronner , Sean M. Baker , Roni J. Bollag , Richard D. Kolodner
IPC分类号： C07K14/47 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156
摘要： We have discovered two human genes, hMLH1 and hPMS1, each of which apparently encodes for a protein involved in DNA mismatch repair. The hMLH1 gene encodes for a protein which is homologous to the bacterial DNA mismatch repair protein MutL, and is located on human chromosome 3p21.3-23. We believe that mutations in the hMLH1 gene cause hereditary non-polyposis colon cancer (HNPCC) in some individuals based upon the similarity of the hMLH1 gene product to the yeast DNA mismatch repair protein MLH1, the coincident location of the hMLH1 gene and the HNPCC locus on chromosome 3, and hMLH1 missense mutations in affected individuals from a chromosome 3-linked HNPCC family. The human hPMS1 gene is homologous to the yeast DNA mismatch repair gene PMS1, and is located on human chromosome 7q. We believe that the hPMS1 gene is a strong candidate for HNPCC testing because the yeast proteins MLH1 and PMS1 have been shown to be involved in the same DNA repair pathway and because hMLH1 and hMSH2 have both been implicated in HNPCC families. The most immediate use for hMLH1 and hPMS1 will be in screening tests on individuals who are members of families which exhibit high frequencies of early onset cancer. We have also isolated and sequenced mouse MLH1 and PMS1 genes. We have produced chimeric mice with a mutant form of the PMS1 gene that will enable us to derive mice that are heterozygous or homozygous for mutation in mPMS1. These mice will be useful for cancer research. We have also produced and isolated antibodies directed to hPMS1 which are useful in assays to detect the presence of protein in tumor samples.
摘要翻译：我们已经发现了两个人基因hMLH1和hPMS1，每个基因都显然编码参与DNA错配修复的蛋白质。 hMLH1基因编码与细菌DNA错配修复蛋白MutL同源的蛋白质，位于人染色体3p21.3-23上。我们认为，基于hMLH1基因产物与酵母DNA错配修复蛋白MLH1的相似性，hMLH1基因和HNPCC基因座的重合位点，hMLH1基因突变导致遗传性非息肉病结肠癌（HNPCC）在一些个体中在3号染色体上，并且来自染色体3连接的HNPCC家族的受影响个体中的hMLH1错义突变。人hPMS1基因与酵母DNA错配修复基因PMS1同源，位于人染色体7q上。我们认为，hPMS1基因是HNPCC检测的有力候选者，因为酵母蛋白MLH1和PMS1已显示参与相同的DNA修复途径，并且因为hMLH1和hMSH2均与HNPCC家族有关。用于hMLH1和hPMS1的最直接用途将是对具有高频早期癌症的家庭成员的个体进行筛选测试。我们还分离和测序小鼠MLH1和PMS1基因。我们已经产生了具有突变形式的PMS1基因的嵌合小鼠，这将使得我们能够导出在mPMS1中突变是杂合的或纯合的小鼠。这些小鼠可用于癌症研究。我们还生产和分离了针对hPMS1的抗体，它们可用于检测肿瘤样品中蛋白质的存在。

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