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1. 发明授权

US5944670A Breath test for the diagnosis of bacterial infection 失效
标题翻译：呼吸试验用于诊断细菌感染
公开(公告)号：US5944670A
公开(公告)日：1999-08-31
申请号：US759340
申请日：1996-12-02
申请人： Daniel E. Katzman
发明人： Daniel E. Katzman
IPC分类号： G01N33/497 , A61K51/12 , A61B5/00
CPC分类号： A61K51/1206
摘要： A breath test for diagnosing the presence of Chlamydia species, such as Chlamydia pneumoniae, in a subject is described. The method of diagnosing Chlamydia species in a subject is performed as follows. First, a safe and effective amount of a substrate, preferably appropriately labelled, is administered to the subject. Second, the exhaled breath of the subject is analyzed to detect the concentration of a cleavage product or products, produced when an enzyme from Chlamydia bacteria cleaves the substrate. The presence of the cleavage product or products indicates a positive diagnosis of Chlamydia species in the subject. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of diagnosing Chlamydia species in a subject. For example, such a breath test kit could include a substrate to be administered to the subject.
摘要翻译：描述了用于诊断衣原体物种如肺炎衣原体的存在的呼吸试验。诊断受试者中衣原体物种的方法如下进行。首先，向对象施用安全有效量的底物，优选适当标记。第二，分析受试者的呼出气体以检测当来自衣原体细菌的酶切割底物时产生的切割产物或产物的浓度。切割产物或产物的存在表明受试者中衣原体物种的阳性诊断。还描述了呼吸测试试剂盒。这样的呼吸测试试剂盒将包括执行受试者中至少一种诊断衣原体物种的方法所需的物品或物品。例如，这种呼吸测试试剂盒可以包括要施用于受试者的底物。

2. 发明申请

US20070272247A1 Oral nasal cannula 审中-公开
标题翻译：口腔鼻插管
公开(公告)号：US20070272247A1
公开(公告)日：2007-11-29
申请号：US11410503
申请日：2006-04-25
申请人： Ron Porat
发明人： Ron Porat
IPC分类号： A62B18/02
CPC分类号： A61M16/0666 , A61M16/0672 , A61M16/085 , A61M2210/0625 , A61M2230/432
摘要： There is provided a cannula which may include a spacer adapted to maintain a minimum distance between at least a portion of an oral cavity and at least a portion of an oral breath collector and at least one nasal breath collector. There is also provided a method for sampling exhaled breath including positioning a cannula on a face of a subject, wherein the cannula may include a spacer adapted to maintain a minimum distance between at least a portion of an oral cavity and at least a portion of an oral breath collector and at least one nasal breath collector.
摘要翻译：提供了一种插管，其可以包括间隔件，其适于保持口腔的至少一部分与至少一部分口腔呼吸收集器和至少一个鼻呼吸收集器之间的最小距离。还提供了一种用于对呼出气体进行采样的方法，包括将套管定位在受试者的脸部上，其中插管可包括间隔物，其适于在口腔的至少一部分与至少一部分口腔之间保持最小距离口腔呼吸器和至少一个鼻呼吸器。

3. 发明授权

US06926005B1 Neonatal airway adaptor 有权
标题翻译：新生儿气道适配器
公开(公告)号：US06926005B1
公开(公告)日：2005-08-09
申请号：US10009847
申请日：2000-06-07
申请人： Lewis Colman , Gershon Levitsky
发明人： Lewis Colman , Gershon Levitsky
IPC分类号： A61M16/04 , A61M16/08 , A61M16/00
CPC分类号： A61M16/08 , A61M16/085 , A61M2230/43 , Y10S128/911 , Y10S128/912
摘要： This invention is a neonatal airway adapter (10) with a sliding internal passage (54), which virtually eliminates void volumes (112) within the bore (76) of the airways, such that mixing of the exhaled gases with void gases is reduced, and the waveform of the breath is maintained without undue distortion. Furthermore, the virtual elimination of void volumes reduces the level of re-breathing. The neonatal airway adapter connects to endotracheal tube adapters in such a way as to nullify the effect of the differing internal diameters (20) and internal lengths which are used in ET adapters currently available. The cross section of the internal bore of the airway through which the breath flows from the ET adapter to the connector of the ventilator is maintained almost constant, especially in the region of the gas sampling point (66), to ensure that reasonable conditions of laminar flow, and accurate sampling are maintained.
摘要翻译：本发明是具有滑动内部通道（54）的新生儿气道适配器（10），其实质上消除了气道孔（76）内的空隙体积（112），使得呼出气体与空气气体的混合减少，并且保持呼吸的波形而没有不适当的失真。此外，虚拟消除空隙体积减少了再呼吸的水平。新生儿气道适配器连接到气管插管适配器，以消除在当前可用的ET适配器中使用的不同内径（20）和内部长度的影响。呼吸道从ET适配器流到呼吸机连接器的呼吸道内孔的截面几乎保持不变，特别是在气体采样点（66）的区域，以确保合理的层流条件流量和精确采样。

4. 发明授权

US5857461A Multiple channel sample port 失效
标题翻译：多通道采样端口
公开(公告)号：US5857461A
公开(公告)日：1999-01-12
申请号：US912776
申请日：1997-08-18
申请人： Gershon Levitsky , Joshua L. Colman
发明人： Gershon Levitsky , Joshua L. Colman
IPC分类号： A61M16/04 , A61B5/083 , A61B5/087 , A61B5/097 , A61M16/00
CPC分类号： A61B5/087 , A61B5/083 , A61B5/097
摘要： A multiple channel sample port for an airway adaptor, which includes a substantially spherical projection with a plurality of inlet tubes and an outlet, which is designed to be placed substantially within the main channel of the airway adaptor through an opening in the side wall of main channel of the airway adaptor. The outlet is connected to, or integrally formed with, one end of a substantially cylindrical chamber. The opposite end of the substantially cylindrical chamber is adapted to be connected to a gas analyzer. When a pressure reduced below atmospheric pressure is applied at the gas analyzer, gas flows from the main channel of the airway adaptor into the inlets of the substantially spherical projection, through the spherical projection into the substantially cylindrical projection, and from thence to the gas analyzer.
摘要翻译：用于气道适配器的多通道采样端口，其包括具有多个入口管和出口的基本上球形的突出部，其被设计成通过主体侧壁中的开口基本位于气道适配器的主通道内气道适配器通道。出口连接到基本上圆柱形的腔室的一端或与其一体形成。基本上圆柱形的腔室的相对端适于连接到气体分析器。当在气体分析器处施加低于大气压力的压力时，气体从气道适配器的主通道流入基本上球形的突起的入口，通过球形突起进入基本上圆柱形的突起，并且从那里流到气体分析器。

5. 再颁专利

USRE38728E1 Breath test analyzer 有权
标题翻译：呼吸试验分析仪
公开(公告)号：USRE38728E1
公开(公告)日：2005-04-19
申请号：US10122341
申请日：2002-04-16
申请人： Daniel E. Katzman , Ephraim Carlebach
发明人： Daniel E. Katzman , Ephraim Carlebach
IPC分类号： A61B5/083 , G01N21/35 , G01N33/00 , A61B5/08
CPC分类号： G01N21/3504 , A61B5/0836 , A61B5/7239 , G01N33/0006
摘要： A breath test analyzer, which analyzes exhaled breadths of a patient for isotope labeled products generated in the patient's body after ingestion by the patient of an isotope labeled substance, where the presence of these isotope labeled products provide an indication of a medical condition in the patient. The analyzer uses a very sensitive infra-red spectrophotometer, which enables it to continuously collect and analyze multiple samples of the patient's breath, and process the outputs in real time, while the patient is still connected to the analyzer, such that a definitive result is obtained within a short time, such as the order of a few minutes. The breath test analyzer is sufficiently small in that it can be easily accommodated in the office of a physician. The breath test analyzer can be utilized for a number of diagnostic breath tests, according to the isotope labeled substance ingested by the patient and the gases detected in the patient's breath.
摘要翻译：一种呼吸测试分析仪，其分析由患者摄取同位素标记物质后在患者体内产生的同位素标记产物的呼出宽度，其中这些同位素标记的产物的存在提供患者的医疗状况的指示。分析仪使用非常敏感的红外分光光度计，使得它能够连续收集和分析患者呼吸的多个样本，并且在患者仍然连接到分析仪的同时对实时输出进行处理，从而确定结果为在短时间内获得，如几分钟的顺序。呼吸测试分析仪足够小，因为它可以容易地容纳在医生的办公室中。根据患者摄取的同位素标记物质和患者呼吸中检测到的气体，呼吸测试分析仪可用于多项诊断性呼吸试验。

6. 发明授权

US6067989A Breath test for the diagnosis of Helicobacter pylori infection in the gastrointestinal tract 失效
标题翻译：呼吸试验用于诊断胃肠道幽门螺杆菌感染
公开(公告)号：US6067989A
公开(公告)日：2000-05-30
申请号：US805415
申请日：1997-02-26
申请人： Daniel E. Katzman
发明人： Daniel E. Katzman
IPC分类号： A61B5/083 , A61B10/00 , A61B19/00 , C07C2/02
CPC分类号： A61B5/42 , A61B5/0836 , A61B5/411 , A61B2010/0087
摘要： A breath test for diagnosing the presence of Helicobacter pylori in a subject is described. The method of diagnosing Helicobacter pylori is performed as follows. First, a safe and effective amount of urea, preferably appropriately labelled, is administered to the subject. Second, a plurality of the exhaled breaths of the subject is analyzed to detect the concentration of a cleavage product or products, produced when urease cleaves the substrate. The measured concentrations are then fitted to a curve, and the derivative is then calculated, to indicate the presence or absence of Helicobacter pylori infection in the subject.
摘要翻译：描述了用于诊断幽门螺杆菌存在的呼吸试验。诊断幽门螺杆菌的方法如下进行。首先，向对象施用安全有效量的尿素，优选适当标记。第二，分析受试者的多个呼出的呼吸以检测当脲酶切割底物时产生的切割产物或产物的浓度。然后将测量的浓度拟合到曲线上，然后计算衍生物，以指示受试者中幽门螺杆菌感染的存在或不存在。

7. 发明授权

US5962335A Breath test for detection of drug metabolism 失效
标题翻译：用于检测药物代谢的呼吸试验
公开(公告)号：US5962335A
公开(公告)日：1999-10-05
申请号：US778589
申请日：1997-01-03
申请人： Daniel E. Katzman
发明人： Daniel E. Katzman
IPC分类号： A61K47/48 , A61K51/12 , G01N33/497 , G01N1/22
CPC分类号： A61K51/1206 , A61K47/48961 , B82Y5/00 , Y10S436/90 , Y10T436/13 , Y10T436/204998 , Y10T436/24 , Y10T436/25875
摘要： A breath test for determining the rate of metabolism of a drug is described. First, a safe and effective amount of the drug, preferably appropriately labelled and most preferably isotopically-labelled, is administered to a subject. After a suitable time period, the exhaled breath of the subject is analyzed to determine the concentration of a metabolite. The concentration of the metabolite is then used to determine the rate of metabolism of the drug. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of determining the rate of metabolism of a drug in a subject. For example, such a breath test kit could include an isotopically-labelled drug to be administered to the subject.
摘要翻译：描述了用于确定药物代谢速率的呼气试验。首先，对受试者施用安全有效量的药物，优选适当标记，最优选同位素标记。在合适的时间段后，分析受试者的呼出气体以确定代谢物的浓度。然后使用代谢物的浓度来确定药物的代谢速率。还描述了呼吸测试试剂盒。这样的呼吸测试试剂盒将包括执行测定受试者中药物的代谢速率的方法中的至少一种方法所需的物品或物品。例如，这种呼吸测试试剂盒可以包括要给受试者施用的同位素标记的药物。

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