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1. 发明申请

US20100152210A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：US20100152210A1
公开(公告)日：2010-06-17
申请号：US12593218
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/52 , C07D473/40 , A61P11/00 , A61P25/00 , A61P25/08 , A61P13/00 , A61P15/00 , A61P9/00 , A61P1/00 , A61P3/10 , A61P37/00 , A61P25/30 , A61P25/28
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

2. 发明申请

US20080119110A1 Beehive Lid 有权
标题翻译：蜂箱盖
公开(公告)号：US20080119110A1
公开(公告)日：2008-05-22
申请号：US11814192
申请日：2006-02-08
申请人： Ioannis Katsampis
发明人： Ioannis Katsampis
IPC分类号： A01K47/06 , A01K47/00
CPC分类号： A01K53/00 , A01K47/00
摘要： The lid of the beehive has a split open top (10) held by a mechanism to the one side of the body (99) of the lid. By opening the top (10) of the lid a surface is revealed which has containers (8) on the one side and an easily open cover (48) on the other, which enables immediate access into the internal of the hive. On the top (10) of the lid there are shutters (11) that open and close the air intake holes (12). The hive has a folding take off board (85) on its bottom reducing space during transportation. It uses dovetail (15,16) joints to withhold the sidewalls (94). This makes it very durable.
摘要翻译：蜂巢的盖具有通过机构保持在盖的主体（99）的一侧的开口顶部（10）。通过打开盖的顶部（10），可以看出表面上有容器（8），另一侧有容易打开的盖子（48），可以立即进入蜂巢内部。在盖的顶部（10）上有开闭空气进入孔（12）的百叶窗（11）。蜂巢在运输过程中的底部减少空间具有折叠起飞板（85）。它使用燕尾（15,16）接头来挡住侧壁（94）。这使得它非常耐用。

3. 发明申请

US20100160315A1 NOVEL 2, 3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE 失效
标题翻译：新二氨基喹诺酮酮衍生物及其医学用途
公开(公告)号：US20100160315A1
公开(公告)日：2010-06-24
申请号：US12601124
申请日：2008-05-22
申请人： Carsten Jessen , William Dalby Brown , Joachim Demnitz , Dorte Strobaek , Mads P.G. Korsgaard , Palle Christophersen
发明人： Carsten Jessen , William Dalby Brown , Joachim Demnitz , Dorte Strobaek , Mads P.G. Korsgaard , Palle Christophersen
IPC分类号： A61K31/517 , C07D239/95 , C07D403/02 , C07D413/02 , A61K31/5377 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/02
CPC分类号： C07D239/95 , C07D403/04 , C07D405/12
摘要： This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3-diamino-quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.
摘要翻译：本发明涉及具有医疗效用的新的2,3-二氨基 - 喹唑啉酮衍生物，其用于制备药物的2,3-二氨基 - 喹唑啉酮衍生物，包含2,3-二氨基 - 本发明的喹唑啉酮衍生物，以及治疗受试者的疾病，疾病或病症的方法，所述疾病，疾病或病症对Kv7通道的激活有反应。

4. 发明申请

US20100029711A1 NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效
标题翻译：新颖的2-酮衍生物及其作为单胺神经递质抑制剂的用途
公开(公告)号：US20100029711A1
公开(公告)日：2010-02-04
申请号：US12520236
申请日：2007-12-18
申请人： Dan Peter , John Paul Redrobe , Gunnar M. Olsen , Elsebet Østergaard Nielsen
发明人： Dan Peter , John Paul Redrobe , Gunnar M. Olsen , Elsebet Østergaard Nielsen
IPC分类号： A61K31/439 , C07D451/00
CPC分类号： C07D451/06
摘要： This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的式（I）的新型色烯-2-酮衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

5. 发明申请

US20110124735A1 CARBONYLAMINO DERIVATIVES USEFUL FOR THE TREATMENT OF CERTAIN INFLAMMATORY DISORDERS 有权
标题翻译：用于治疗某些炎症性疾病的碳云母衍生物
公开(公告)号：US20110124735A1
公开(公告)日：2011-05-26
申请号：US12674746
申请日：2008-08-21
申请人： Lars Siim Madsen , Palle Christophersen
发明人： Lars Siim Madsen , Palle Christophersen
IPC分类号： A61K31/165 , A61P29/00 , A61P25/28 , A61P1/00
CPC分类号： A61K31/165
摘要： The present invention relates to the use of a particular group of carbonylamino derivatives for the treatment or alleviation of a disease or condition relating to certain inflammatory disorders.
摘要翻译：本发明涉及特定的一组羰基氨基衍生物用于治疗或减轻与某些炎性疾病有关的疾病或病症的用途。

6. 发明申请

US20100144809A1 NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：新型苯扎明明衍生物作为钾通道调节剂有用
公开(公告)号：US20100144809A1
公开(公告)日：2010-06-10
申请号：US12599196
申请日：2008-05-07
申请人： Antonio Nardi , Joachim Demnitz , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Joachim Demnitz , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/41 , C07D257/04 , A61P11/00 , A61P25/08 , A61P25/00 , A61P13/10 , A61P15/10 , A61P15/00 , A61P13/00 , A61P25/18 , A61P25/16 , A61P25/24 , A61P27/00 , A61P17/14
CPC分类号： C07D257/04 , C07D403/10
摘要： This invention relates to novel benzamidine derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels. A stereoisomer or a mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically-acceptable addition salt thereof, wherein B may be absent (i.e. no heterocyclic ring is formed); and when absent, the nitrogen next to B holds a hydrogen (i.e. “NH”), and A represents NH2 or OH; or B may be present (i.e. forms part of a heterocyclic ring); and when present, B represents C═O or C═S; and A represents NH or O; and wherein the rest of variables are as specified in claim 1.
摘要翻译：本发明涉及式（I）的新型苄脒衍生物，其被发现是钾通道的有效调节剂，因此是治疗与钾通道调节有关的疾病或病症多种多样的有价值的候选物。其立体异构体或其立体异构体或其N-氧化物或其药学上可接受的加成盐的混合物，其中B可以不存在（即没有形成杂环）; 当不存在时，B旁边的氮保持氢（即“NH”），A表示NH 2或OH; 或B可以存在（即形成杂环的一部分）; 当存在时，B表示C = O或C = S; A表示NH或O; 并且其中其余的变量如权利要求1所述。

7. 发明申请

US20090227613A1 Novel 3-Aza-Spiro[5.5]Undecane Derivatives and Their Use As Monoamine Neurotransmitter Re-Uptake Inhibitors 失效
标题翻译：新型3-氮杂螺[5.5]十一烷衍生物及其用作单胺神经递质重吸收抑制剂
公开(公告)号：US20090227613A1
公开(公告)日：2009-09-10
申请号：US11922917
申请日：2006-06-28
申请人： Birgitte L. Eriksen , Dan Peters , Elsebet Ostergaard Nielsen , John Paul Redrobe
发明人： Birgitte L. Eriksen , Dan Peters , Elsebet Ostergaard Nielsen , John Paul Redrobe
IPC分类号： A61K31/438 , C07D221/20 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/16
CPC分类号： C07D221/20 , C07D491/10
摘要： This invention relates to novel 3-aza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的新型3-氮杂 - 螺[5.5]十一烷衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

8. 发明申请

US20080200529A1 Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels 有权
标题翻译：新型2-氨基苯并咪唑衍生物及其作为小电导钙活化钾通道调节剂的用途
公开(公告)号：US20080200529A1
公开(公告)日：2008-08-21
申请号：US11795018
申请日：2006-01-10
申请人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/30 , A61P25/16 , A61P25/08 , A61P9/10
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

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