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1. 发明授权

US12123061B2 Method for the detection of legionella 有权
公开(公告)号：US12123061B2
公开(公告)日：2024-10-22
申请号：US16339968
申请日：2017-10-04
申请人： National University of Ireland, Galway
发明人： Thomas Barry , Kate Reddington , Elizabeth Minogue
IPC分类号： C12Q1/68 , C12Q1/689
CPC分类号： C12Q1/689 , C12Q2600/112 , C12Q2600/16 , Y02A50/30
摘要： This invention relates to the detection of Legionella, more specifically Legionella pneumophila, more specifically Legionella pneumophila serogroup 1, in a sample. Methods of detection, and assays and kits useful for detection, are also disclosed. The invention provides a method for identifying the presence, absence, or quantity of Legionella pneumophila serogroup 1 in a sample, the method comprising the steps of detecting the presence, absence, or quantity of at least part of the nucleic acid sequence of the lpg0768 gene or an expression product thereof, and correlating the presence, absence, or quantity of the at least part of the nucleic acid sequence of the lpg0768 gene or an expression product thereof, to the presence, absence, or quantity of Legionella pneumophila serogroup 1 in the sample.

2. 发明公开

US20240307110A1 DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：US20240307110A1
公开(公告)日：2024-09-19
申请号：US18678536
申请日：2024-05-30
申请人： National University of Ireland, Galway
发明人： David Townley , Brian Shields , Ivan Keogh , Michele Qi Zhan , Conor Farrell
IPC分类号： A61B18/14 , A61B17/00 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/18 , A61B18/20 , A61B34/00 , A61B90/00
CPC分类号： A61B18/1485 , A61B18/1206 , A61B34/25 , A61B2017/00199 , A61B2017/00292 , A61B2017/00862 , A61B2017/00867 , A61B2018/00273 , A61B2018/00327 , A61B2018/00434 , A61B2018/00577 , A61B2018/00648 , A61B2018/00672 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B18/02 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1807 , A61B2018/1823 , A61B18/20 , A61B2090/3735 , A61B2090/376 , A61B2090/3762 , A61B2090/378
摘要： Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

3. 发明公开

US20230405182A1 ANTI-MICROBIAL COATING FOR OBJECTS SUCH AS PROSTHETIC IMPLANTS 审中-公开
公开(公告)号：US20230405182A1
公开(公告)日：2023-12-21
申请号：US18319216
申请日：2023-05-17
申请人： National University of Ireland, Galway
发明人： Firas Awaja , Giorgio Speranza
IPC分类号： A61L27/30 , A61L27/06 , A61L27/54
CPC分类号： A61L27/303 , A61L27/06 , A61L27/54 , A61L2300/404 , A61L2400/18
摘要： A method of providing an anti-microbial coating on an object, comprises the steps of pre-treating the object in a first oxygen plasma to graft oxygen-based functional groups on the surface of the object by plasma enhanced chemical vapour deposition, coating the pre-treated object with a suspension of particulate graphene oxide to provide a graphene oxide coating on the object, treating the object in a hydrocarbon plasma to deposit an amorphous hydrocarbon film on the graphene oxide coating by plasma enhanced chemical vapour deposition, and treating the object in a second oxygen plasma configured to etch and flatten the coatings on the surface of the object. A prosthetic implant having a metal or metal alloy surface and an anti-microbial coating on all or part of the surface is also described.

4. 发明公开

US20230255512A1 DIAGNOSIS AND TREATMENT OF PELVIC CONDITIONS 审中-公开
公开(公告)号：US20230255512A1
公开(公告)日：2023-08-17
申请号：US18133137
申请日：2023-04-11
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： Sinead HUGHES , Siobhan KELLEHER
IPC分类号： A61B5/11 , A61B5/053 , A61B5/00 , G16H10/60 , G16H50/20
CPC分类号： A61B5/1107 , A61B5/053 , A61B5/4836 , G16H10/60 , G16H50/20
摘要： A system to determine status of a pelvic condition in a subject characterised by abnormal contractility activity of a target pelvic structure is described. The system comprises a sensing module to measure electrical activity of the subject's pelvis at a plurality of time points during the subject's hormonal cycle, a signal processing module configured to receive electrical activity measurements from the sensing module and isolate from the electrical activity measurements electrical contractility parameter measurements representative of the target pelvic structure, and a processor module operably connected to the signal processing module. The processor is configured to receive as an input the electrical contractility parameter measurements representative of the target pelvic structure, generate a data profile of the subject comprising the electrical contractility parameter measurements representative of the target pelvic structure, compare the data profile with a database of reference data profiles comprising reference data profiles of subjects with different pelvic condition status, output the status of the pelvic condition in the subject based on the comparison. In any embodiment, the signal processing module is configured to isolate from the electrical activity measurements slow wave electrical contractility parameter measurements representative of the target pelvic structure. Systems and methods for treating pelvic conditions comprising stimulation of a pelvic structure to normalise pelvic structure contractility are also described.

5. 发明授权

US11672984B2 Apparatus for management of a Parkinson's disease patient's gait 有权
公开(公告)号：US11672984B2
公开(公告)日：2023-06-13
申请号：US16938606
申请日：2020-07-24
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： Gearóid Ó Laighin , Leo Quinlan , Dean Sweeney , Gavin Corley , James Feehilly , Patrick Browne
IPC分类号： A61N1/36 , A61H3/00
CPC分类号： A61N1/36067 , A61H3/00 , A61N1/36003 , A61H2003/007 , A61H2201/165 , A61H2201/5023 , A61H2201/5079 , A61H2201/5084 , A61H2230/105
摘要： A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.

6. 发明公开

US20230173148A1 A BREAST PUMP 审中-公开
公开(公告)号：US20230173148A1
公开(公告)日：2023-06-08
申请号：US17906544
申请日：2021-03-18
申请人： National University of Ireland, Galway
发明人： Eva Nagy-Gannon , Sandra Ganly , Yuqi Shaughnessy , Faisal Sharif , Genevieve Becker , Roy Phillip , Migle Dominica Make-Lyte , Morven Gannon , Kealan Devlin
IPC分类号： A61M1/06
CPC分类号： A61M1/064 , A61M1/06935
摘要： A biomechanical breast pump mechanism (1) for expressing breastmilk comprising a biomimetic funnel (2), at least two active actuation areas (23,24) on the funnel (2) and stationary areas (25), the active actuation areas (23,24) being actuatable by a driving mechanism or mechanisms (3) and being configured to replicate the complex functions of the infant's tongue during suckling namely the physical stimulation of the areola (17)/nipple (16); nipple positioning; creating and maintaining low-level baseline vacuum to create air-seal on the breast; generating sub-atmospheric pressure inside the funnel (2); creating and maintaining close-to-zero-air environment in the funnel (2); and control of the vacuum oscillation within predefined ranges coordinated negative and positive actuation (41,42) of one or both actuation areas (23,24) independently or simultaneously.

7. 发明申请

US20220275431A1 PRIMERS FOR ISOTHERMAL AMPLIFICATION 有权
公开(公告)号：US20220275431A1
公开(公告)日：2022-09-01
申请号：US17627166
申请日：2020-07-14
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： OWEN HIGGINS , TERRY SMITH
IPC分类号： C12Q1/6827 , C12Q1/6858
摘要： The present invention relates to primers for isothermal amplification, in particular primers for loop-mediated isothermal amplification (LAMP). Also disclosed are methods for identifying a target nucleic acid, and methods for identifying a nucleic acid modification or substitution of a target nucleic acid. The invention finds utility in the diagnosis of diseases or disorders.

8. 发明申请

US20220133286A1 DEVICES AND METHODS FOR TREATING A VESSEL IN A SUBJECT 有权
公开(公告)号：US20220133286A1
公开(公告)日：2022-05-05
申请号：US17547723
申请日：2021-12-10
申请人： National University of Ireland, Galway
发明人： Sean CUMMINS , Nigel PHELAN , Stephen COX , Martin O'HALLORAN
IPC分类号： A61B17/00 , A61B17/3207 , A61B18/14
摘要： A method of treating a vessel in a subject comprises the steps of advancing a device distally across a treatment zone in a vessel, wherein the device comprises an elongated catheter having a lumen and a distal end, and a radially expansive treatment element disposed in the lumen and configured for axial movement relative to the catheter; deploying the radially expansive treatment element proud of the distal end of the catheter to radially expand and circumferentially impress against the vessel lumen at a distal end of the treatment zone; and withdrawing the deployed radially expansive treatment element proximally along the treatment zone with the treatment element circumferentially impressed against the vessel lumen to mechanically and circumferentially denude the treatment zone of the vessel. The radially expansive treatment element is then recaptured into the lumen of the catheter, before the device is withdrawn from the treated vessel.

9. 发明申请

US20210236692A1 REGENERATION OF DISEASES INTERVERTEBRAL DISCS 有权
公开(公告)号：US20210236692A1
公开(公告)日：2021-08-05
申请号：US17088234
申请日：2020-11-03
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： Abhay PANDIT , Isma Liza MOHD ISA
IPC分类号： A61L27/20 , A61L27/52 , A61L27/54
摘要： A hydrogel composition for use in a method of regeneration of an intervertebral disc, or suppression of discogenic pain, in a mammal with intervertebral disc degeneration is described. The hydrogel composition comprises cross-linked high molecular weight hyaluronan. The hydrogel composition is implanted in the mammal at a site of intervertebral disc degeneration.

10. 发明授权

US11067054B2 Vortex generator 有权
公开(公告)号：US11067054B2
公开(公告)日：2021-07-20
申请号：US16626205
申请日：2018-06-21
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： Eoghan Clifford , Sean Mulligan
IPC分类号： F03B3/18 , B01F3/04
摘要： A vortex generator apparatus including a fluid intake duct, a fluid tank including: a first fluid inlet port, a second fluid inlet port, and a fluid outlet port. A turbine is provided outside of the fluid tank in fluid communication with the fluid outlet port.

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