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1. 发明申请

US20160155228A1 MEDICAL IMAGE GENERATION APPARATUS, METHOD, AND PROGRAM 审中-公开
标题翻译：医学图像生成装置，方法和程序
公开(公告)号：US20160155228A1
公开(公告)日：2016-06-02
申请号：US14953224
申请日：2015-11-27
申请人： KABUSHIKI KAISHA TOSHIBA , National Institute of Radiological Sciences
发明人： Yukinobu SAKATA , Ryusuke HIRAI , Kyoka SUGIURA , Yasunori TAGUCHI , Tomoyuki TAKEGUCHI , Shinichiro MORI , Fumi MARUYAMA
IPC分类号： G06T7/00 , G06K9/46 , A61B6/00 , G06T11/00
CPC分类号： A61B6/5205 , A61B6/0421 , A61B6/0457 , A61B6/4266 , A61B6/4464 , A61B6/5223 , A61B6/5252 , A61B34/10 , A61B2034/107 , A61N5/1049 , A61N2005/1061 , A61N2005/1062 , G06K9/00208 , G06K9/2018 , G06K2209/05 , G06T7/11 , G06T7/194 , G06T11/008 , G06T2207/10081 , G06T2207/30196
摘要： A medical image generation apparatus includes: a three-dimensional image acquisition unit that acquires a three-dimensional image in which a space including a patient is captured; an imparting unit that imparts, to each of voxels constituting the three-dimensional image, a living-body likelihood coefficient indicating a likelihood of being a living-body region of the patient; an updating unit that updates a luminance value of the voxel in which the imparted living-body likelihood coefficient shows a given value, through predetermined processing; a virtual viewpoint setting unit that sets a virtual viewpoint for transforming the three-dimensional image into a two-dimensional radiation image; and a radiation image generation unit that calculates a luminance value of a pixel constituting the radiation image based on the luminance value of the voxel existing along a line connecting each of the corresponding pixels and the virtual viewpoint.
摘要翻译：一种医用图像生成装置，包括：三维图像获取单元，其获取包含患者的空间的三维图像; 赋予构成所述三维图像的体素的每个体素赋予表示患者的生物体区域的可能性的生物体似然系数的赋予单位; 更新单元，通过预定处理来更新所赋予的生物体似然系数显示给定值的体素的亮度值; 虚拟视点设置单元，其将用于将所述三维图像变换为二维辐射图像的虚拟视点; 以及放射线图像生成单元，其基于沿着连接各个像素和虚拟视点的线存在的体素的亮度值来计算构成放射线图像的像素的亮度值。

2. 发明申请

US20150299280A1 MEDICAL TREATMENT USE OF CELL-MEMBRANE-PERMEABLE FIBROBLAST GROWTH FACTOR 审中-公开
标题翻译：细胞膜渗透性成纤维细胞生长因子的医疗处理
公开(公告)号：US20150299280A1
公开(公告)日：2015-10-22
申请号：US14647634
申请日：2013-11-11
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人： Fumiaki NAKAYAMA , Sachiko UMEDA , Takeshi YASUDA , Mayumi FUJITA , Takashi IMAI
IPC分类号： C07K14/50 , C07K14/705
CPC分类号： C07K14/50 , A61K38/00 , C07K14/501 , C07K14/503 , C07K14/705 , C07K2319/10
摘要： The present invention relates to a chimeric protein formed by fusing a CPP containing a CPP-C domain in any of an FGF11, FGF12, FGF13, and FGF14 to an FGF1 or an FGF2, or DNA molecules that contain DNA sequences coding the FGF1 or the FGF2 and DNA sequences coding a CPP-C or vectors containing these DNA sequences. These chimeric protein, DNA molecules, or vectors can be used for a medicine or a method of treatment effective to a tissue on which an expression of an FGFR is low or becomes low due to any cause, a medicine or a method of treatment that can further dynamize bioactivity of the FGF1 or the FGF2 via the FGFR, or a medicine or a method of treatment that protects a stem cell against an influence from radiation exposure, a chemotherapy, or a similar treatment.
摘要翻译：本发明涉及通过将含有FGF11，FGF12，FGF13和FGF14中的任一种中的CPP-C结构域的CPP融合到FGF1或FGF2而形成的嵌合蛋白，或含有编码FGF1或 FGF2和编码CPP-C的DNA序列或含有这些DNA序列的载体。这些嵌合蛋白质，DNA分子或载体可以用于药物或治疗方法，对于FGFR的表达低或由于任何原因，药物或治疗方法可能会降低的组织有效通过FGFR进一步动力FGF1或FGF2的生物活性，或通过保护干细胞免受辐射暴露，化疗或类似治疗影响的药物或治疗方法。

3. 发明申请

US20130241555A1 PET-MRI APPARATUS 有权
标题翻译： PET-MRI装置
公开(公告)号：US20130241555A1
公开(公告)日：2013-09-19
申请号：US13874795
申请日：2013-05-01
申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES , TOSHIBA MEDICAL SYSTEMS CORPORATION
发明人： Takayuki OBATA , Taiga YAMAYA , Iwao KANNO , Hitoshi YAMAGATA , Takuzo TAKAYAMA , Kazuya OKAMOTO
IPC分类号： G01R33/28
CPC分类号： G01R33/28 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4417 , G01R33/481 , G01T1/1603
摘要： In a PET (Positron Emission Tomography)-MRI (Magnetic Resonance Imaging) apparatus of an embodiment, a magnet that is a seamless structure generates a static magnetic field in a bore having a cylindrical shape. First detectors and second detectors are each formed in a ring shape and detect gamma rays emitted from positron emitting radionuclides injected into a subject. The first detectors and the second detectors are disposed with a space therebetween in an axial direction of the bore so as to interpose the magnetic field center of the static magnetic field therebetween.
摘要翻译：在实施例的PET（正电子发射断层摄影）-MRI（磁共振成像）装置中，作为无缝结构的磁体在具有圆柱形状的孔中产生静磁场。第一检测器和第二检测器各自形成为环形，并且检测从注射到受试者中的正电子发射放射性核素发射的γ射线。第一检测器和第二检测器在孔的轴向方向上设置有空间，以将静磁场的磁场中心插入其间。

4. 发明申请

US20130211233A1 INTEGRATED PET/MRI SCANNER 有权
标题翻译：集成PET / MRI扫描仪
公开(公告)号：US20130211233A1
公开(公告)日：2013-08-15
申请号：US13880842
申请日：2010-10-25
申请人： Taiga Yamaya , Fumihiko Nishikido , Takayuki Obata , Mikio Suga , Kazuyuki Saito , Mitsuo Watanabe , Eiichi Tanaka
发明人： Taiga Yamaya , Fumihiko Nishikido , Takayuki Obata , Mikio Suga , Kazuyuki Saito , Mitsuo Watanabe , Eiichi Tanaka
IPC分类号： A61B6/00 , A61B5/055 , A61B6/03
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4258 , A61B6/501 , A61B6/5247 , G01R33/34076 , G01R33/481 , G01T1/1603
摘要： In the integrated PET/MRI scanner provided with an RF coil for MRI and a plurality of PET detectors in the measuring port of the MRI scanner, the PET detectors are disposed with spaces therebetween and at least the transmitting coil elements of the RF coil for MRI are disposed between adjacent PET detectors. Here, the PET detectors are disposed in the circumferential direction of the measuring port with spaces therebetween and the transmitting coil elements are disposed in the axial direction of the measuring port. Alternatively, at least some of the PET detectors are disposed in the axial direction of the measuring port with spaces therebetween and the transmitting coil elements are disposed between adjacent PET detectors. The PET detectors can be DOI-type detectors capable of detecting position in the depth direction.
摘要翻译：在具有用于MRI的RF线圈和在MRI扫描仪的测量端口中的多个PET检测器的集成PET / MRI扫描仪中，PET检测器设置有空间，并且至少用于MRI的RF线圈的发射线圈元件设置在相邻的PET检测器之间。这里，PET检测器沿测量端口的圆周方向设置有空间，并且发送线圈元件沿测量端口的轴向设置。或者，至少一些PET检测器沿测量口的轴向设置，其间具有空间，并且发射线圈元件设置在相邻的PET检测器之间。 PET检测器可以是能够在深度方向上检测位置的DOI型检测器。

5. 发明授权

US08461539B2 Combined radiation therapy/pet apparatus 有权
标题翻译：联合放射治疗/宠物器械
公开(公告)号：US08461539B2
公开(公告)日：2013-06-11
申请号：US12996471
申请日：2008-08-01
申请人： Taiga Yamaya , Hideo Murayama , Taku Inaniwa
发明人： Taiga Yamaya , Hideo Murayama , Taku Inaniwa
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037 , A61B6/583 , A61N5/1048 , A61N2005/1052 , A61N2005/1087
摘要： A combined radiation therapy/PET apparatus includes: an open PET device having multi-ring detector rings that are opposed to each other in the direction of the body axis so as to leave a gap therebetween; and a radiation therapy apparatus for performing radiation therapy through the gap. When imaging the condition of an affected area and a treatment beam for monitoring in radiation therapy of irradiating the affected area with X-rays, gamma rays, or particle beams, the apparatus covers a region of interest in the irradiation field of the radiation therapy with the field-of-view of the open PET device, thereby making possible the positioning of the irradiation field and treatment monitoring using PET images.
摘要翻译：组合放射治疗/ PET装置包括：开放式PET装置，其具有多个环形探测器环，所述多环检测器环在体轴方向上彼此相对以在其间留有间隙; 以及用于通过间隙进行放射治疗的放射线治疗装置。当对X射线，γ射线或粒子束照射受影响的区域进行辐射治疗的受影响区域状况和治疗束进行成像时，该装置覆盖放射治疗的照射场中的感兴趣区域，开放的PET装置的视野，从而可以定位照射场和使用PET图像的处理监视。

6. 发明授权

US08436312B2 DOI type radiation detector 有权
标题翻译： DOI型辐射探测器
公开(公告)号：US08436312B2
公开(公告)日：2013-05-07
申请号：US12999041
申请日：2008-10-08
申请人： Naoko Inadama , Hideo Murayama , Kengo Shibuya , Fumihiko Nishikido , Taiga Yamaya , Eiji Yoshida
发明人： Naoko Inadama , Hideo Murayama , Kengo Shibuya , Fumihiko Nishikido , Taiga Yamaya , Eiji Yoshida
IPC分类号： G01T1/20
CPC分类号： G01T1/1644 , G01T1/2008
摘要： This aims to provide a DOI type radiation detector in which scintillation crystals arranged two-dimensionally on a light receiving surface to form rectangular section groups in extending directions of the light receiving surface of a light receiving element are stacked up to make a three-dimensional arrangement and responses of the crystals that have detected radiation are made possible to identify at response positions on the light receiving surface, so that a three-dimensional radiation detection position can be obtained. In the DOI type radiation detector, scintillation crystals are right triangle poles extending upwards from the light receiving surface and the response positions on the light receiving surface are characterized. With this structure, DOI identification of a plurality of layers can be carried out by simply performing an Anger calculation of a light receiving element signal.
摘要翻译：其目的在于提供一种DOI型放射线检测器，其中，在光接收表面上二维布置的闪烁晶体在光接收元件的光接收表面的延伸方向上形成矩形截面组，以形成三维布置并且能够检测到辐射的晶体的响应可以在光接收表面上的响应位置处识别，从而可以获得三维辐射检测位置。在DOI型辐射检测器中，闪烁晶体是从光接收表面向上延伸的直角三角形磁极，并且在光接收表面上的响应位置被表征。利用这种结构，可以通过简单地执行光接收元件信号的愤怒计算来执行多个层的DOI识别。

7. 发明授权

US08299437B2 Gamma ray detector and gamma ray reconstruction method 失效
标题翻译：伽马射线检测器和伽马射线重建方法
公开(公告)号：US08299437B2
公开(公告)日：2012-10-30
申请号：US12600216
申请日：2007-05-15
申请人： Hidehito Nakamura
发明人： Hidehito Nakamura
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037 , G01T1/1603
摘要： Provided are a gamma ray detector and a gamma ray reconstruction method which can be used in SPECT and PET and which combine and reconstruct the information on “Compton-scattered” gamma rays, thereby remarkably increasing gamma ray detection sensitivity, decreasing the amount of a radioactive substance given to a subject, and remarkably reducing the concern about the amount of radiation exposure. The gamma ray detector comprises an absorber scintillator 12 made from an absorptive substance exhibiting a high rate of absorption with respect to gamma rays 1 in an energy region, emitted from a subject, a Compton scattering scintillator 14 made from a Compton scattering substance exhibiting a high probability of Compton scattering, and an energy detector 16 which combines the amounts of gamma ray energy absorption simultaneously measured by the two types of scintillators to reconstruct the gamma rays emitted from the subject. The two types of scintillators 12 and 14 are arranged in multiple layers so as to absorb or Compton-scatter the whole energy of the gamma rays 1.
摘要翻译：提供了可用于SPECT和PET中的伽马射线检测器和伽马射线重建方法，其组合并重建关于康普顿散射伽马射线的信息，从而显着增加伽马射线检测灵敏度，减少给定的放射性物质的量并且显着地减少了对辐射暴露量的担忧。伽马射线检测器包括由吸收物质制成的吸收体闪烁体12，该吸收物质表现出相对于从被检体发射的能量区域中的γ射线1的高吸收率，由康普顿散射物质表现出高的康普顿散射闪烁体14 康普顿散射的概率和能量检测器16，其结合由两种类型的闪烁体同时测量的伽马射线能量吸收量，以重构从被摄体发射的伽马射线。两种类型的闪烁体12和14被布置成多层，以便吸收或康普顿散射伽马射线1的全部能量。

8. 发明授权

US08299277B2 Radiation protection drug containing tocopherol or tocotrienol compound ester derivative as active ingredient 有权
标题翻译：含有生育酚或生育三烯酚化合物酯衍生物的放射防护药物为活性成分
公开(公告)号：US08299277B2
公开(公告)日：2012-10-30
申请号：US12516722
申请日：2007-11-14
申请人： Kazunori Anzai , Megumi Ueno , Haruko Yakumaru , Junichi Ueda , Makoto Akashi , Shizuko Kobayashi , Jiro Takata , Nobuo Ikota
发明人： Kazunori Anzai , Megumi Ueno , Haruko Yakumaru , Junichi Ueda , Makoto Akashi , Shizuko Kobayashi , Jiro Takata , Nobuo Ikota
IPC分类号： C07D311/00
CPC分类号： A61K31/355 , C07D311/76
摘要： Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.
摘要翻译：在暴露于辐射之前或之后施用由通式（1）表示的生育酚或生育三烯酚化合物酯衍生物在预防或治疗由辐射暴露引起的健康障碍中是有效的。

9. 发明授权

US08222608B2 PET scanner and method for deciding arrangement of detectors 有权
标题翻译： PET扫描仪及其检测方法
公开(公告)号：US08222608B2
公开(公告)日：2012-07-17
申请号：US12936464
申请日：2008-04-14
申请人： Taiga Yamaya , Hideo Murayama
发明人： Taiga Yamaya , Hideo Murayama
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037 , A61B6/4258 , A61B6/4266 , A61B6/44 , A61B6/508
摘要： A PET scanner in which detector rings are arrayed in a multilayered manner so as to oppose each other in the body axis direction is provided. In the PET scanner, a predetermined number of detector units, each of which is made up of a predetermined number of detector rings, are arrayed so as to give each other a clearance, and a first ring set in which the clearance is less than or equal to a mean value of widths of two detector units forming each clearance and a second ring set constituted with a predetermined number of detector units are arrayed apart so as to give a clearance which is less than or equal to a mean value of the width of the first ring set and that of the second ring set, thereby imaging a field-of-view including the clearance and continuing in the body axis direction to an entire length of the first ring set and that of the second ring set.
摘要翻译：提供了一种PET扫描仪，其中检测器环以多层方式排列成在体轴方向上彼此相对。在PET扫描器中，排列有预定数量的检测器单元，每个检测器单元由预定数量的检测器环构成，以便彼此给予间隙;第一环组，其中间隙小于或等于等于形成每个间隙的两个检测器单元的宽度的平均值，并且由预定数量的检测器单元构成的第二环组排列成分开，以便产生小于或等于宽度的平均值的间隙所述第一环组和所述第二环组的第一环组和所述第二环组的整个长度成像为包括所述间隙的视场，并且在所述体轴方向上延伸到所述第一环组和所述第二环组的整个长度。

10. 发明授权

US08067648B2 Method for synthesizing radioactive ligand having 18F-labeled fluorobenzene ring 有权
标题翻译：合成具有18 F标记氟苯环的放射性配体的方法
公开(公告)号：US08067648B2
公开(公告)日：2011-11-29
申请号：US12161974
申请日：2006-11-29
申请人： Kazutoshi Suzuki , Ming-Rong Zhang , Katsushi Kumata
发明人： Kazutoshi Suzuki , Ming-Rong Zhang , Katsushi Kumata
IPC分类号： C07B59/00 , C07C231/12 , C07C233/25 , C07C303/26 , C07C309/73
CPC分类号： C07B59/001 , C07B2200/05 , C07C233/88 , C07C309/00 , Y10T436/196666
摘要： A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a 18F-labeled ligand having various functional groups and a [18F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [18F]F−.
摘要翻译：通过使用具有各种官能团的衍生物和溴或碘 - 苯环作为放射性配体的标记材料来合成苯基锡化合物。另一方面，通过氧化具有一个或多个给电子基团的碘苯并将其与甲苯磺酸反应得到具有给电子基团的新的羟基苯基碘苯化合物。然后，通过使所得化合物与各种苯基锡化合物反应来合成作为标记前体的二苯基碘鎓盐。最后，通过使得到的二苯基碘鎓盐与[18 F] F- - 反应合成具有各种官能团和[18 F]氟苯环的18 F标记的配体。

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