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1. 发明授权

US4886789A Peritoneal dialysis and compositions for use therein 失效
标题翻译：腹膜透析及其中使用的组合物
公开(公告)号：US4886789A
公开(公告)日：1989-12-12
申请号：US335778
申请日：1989-04-10
申请人： Jeremiah Milner
发明人： Jeremiah Milner
IPC分类号： A61K31/718 , A61K45/06 , A61M1/28
CPC分类号： A61M1/287 , A61K31/718 , A61K45/06
摘要： A peritoneal dialysis composition containing an osmotic agent comprising a glucose polymer mixture, said mixture including at least 15% by weight of glucose polymers having a D.P. (degree of polymerization) greater than 12. A method is provided for preparing the glucose polymers and a defined sterile aqueous solution of the same for use in peritoneal dialysis by introduction into the abdominal cavity. Also disclosed are methods of treating toxaemia caused by toxins arising from internal disorders of the body, such as hepatic encephalopathy, or which arise from external sources such as poisoning by overdoses of drugs or industrial and agricultural chemicals, e.g., paraquat.
摘要翻译：一种含有包含葡萄糖聚合物混合物的渗透剂的腹膜透析组合物，所述混合物包含至少15重量％的具有D.P.的葡萄糖聚合物。（聚合度）大于12.提供了通过引入腹腔中制备葡萄糖聚合物和其定义的用于腹膜透析的无菌水溶液的方法。还公开了治疗由身体内部疾病引起的毒素引起的毒血症的方法，例如肝性脑病，或由外部来源产生，例如过量的药物或工业和农业化学品例如百草枯中毒。

2. 发明授权

US5439894A Dextrin derivatives for the treatment of acidic conditions 失效
标题翻译：糊精衍生物用于处理酸性条件
公开(公告)号：US5439894A
公开(公告)日：1995-08-08
申请号：US150717
申请日：1993-11-12
申请人： Donald S. Davies
发明人： Donald S. Davies
IPC分类号： A61K31/715 , A61P3/06 , A61P7/00 , C08B31/00 , C08B31/12 , A61K31/73
CPC分类号： C08B31/125 , Y10S514/819 , Y10S514/823
摘要： Disclosed is a pharmaceutical composition comprising a dextrin derivative in which a proportion of the hydroxyl groups of dextrin are replaced by basic groups. Such compositions are useful for the treatment of acidic conditions.
摘要翻译：公开了包含糊精衍生物的药物组合物，其中糊精的一部分羟基被碱性基团代替。这些组合物可用于治疗酸性条件。

3. 发明授权

US5280017A Use of dextrin derivatives for the treatment of acidic conditions 失效
标题翻译：糊精衍生物用于治疗酸性条件
公开(公告)号：US5280017A
公开(公告)日：1994-01-18
申请号：US640313
申请日：1991-01-29
申请人： Donald S. Davies
发明人： Donald S. Davies
IPC分类号： A61K31/715 , A61P3/06 , A61P7/00 , C08B31/00 , C08B31/12 , A61K31/73
CPC分类号： C08B31/125 , Y10S514/819 , Y10S514/823
摘要： A method of treating acid poisoning in mammals or of lowering blood cholesterol levels in mammals, which involves administering to the mammals a pharmaceutically effective amount of an aminated dextrin where amine groups or residues are present in an amount of from 0.5 to 2 groups per glucose unit.
摘要翻译： PCT No.PCT / GB89 / 00858 Sec。 371 1991年1月29日第 102（e）日期1991年1月29日PCT提交1989年7月28日PCT公布。第WO90 / 01499号公报日期1990年2月22日。一种治疗哺乳动物中的酸中毒或降低哺乳动物血中胆固醇含量的方法，其涉及向哺乳动物施用药学有效量的胺化糊精，其中胺基或残基以每个葡萄糖单位0.5至2个组。

4. 发明授权

US06881556B2 Polynucleotide 有权
标题翻译：多核苷酸
公开(公告)号：US06881556B2
公开(公告)日：2005-04-19
申请号：US10225073
申请日：2002-08-21
申请人： Michael Antoniou , Robert Crombie
发明人： Michael Antoniou , Robert Crombie
IPC分类号： A61K48/00 , C12N1/21 , C12N15/11 , C12N15/85 , C12P21/02
CPC分类号： C12N15/11 , A01K2217/05 , A61K48/00 , C12N15/85 , C12N2799/021 , C12N2799/027 , C12N2800/108 , C12N2830/008 , C12N2830/205 , C12N2830/42 , C12N2830/46 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.
摘要翻译：本发明涉及包含不衍生自13的普遍存在的染色质开放元件（UCOE）的多核苷酸。8.权利要求1至7中任一项的多核苷酸，其中所述UCOE包含图1的序列。 20个核苷酸1至7627之间或其功能同系物或其片段。一个LCR。本发明还涉及包含多核苷酸序列的载体，包含载体的宿主细胞，治疗和测定中多核苷酸，载体或宿主细胞的用途以及鉴定UCOE的方法。 UCOE打开染色质或维持染色质处于开放状态，并且促进可操作地连接的基因在至少两种不同组织类型的细胞中的表达。

5. 发明授权

US5258175A Treatment of poisoning and compositions for use therein 失效
标题翻译：治疗中毒及其中使用的组合物
公开(公告)号：US5258175A
公开(公告)日：1993-11-02
申请号：US646939
申请日：1991-01-25
申请人： Donald S. Davies
发明人： Donald S. Davies
IPC分类号： A61K31/715 , A61F2/02 , A61K9/14 , A61K47/36 , A61P39/02
CPC分类号： A61K31/715 , Y10S514/823
摘要： A dextrin derivative, in which a proportion of the hydroxyl groups in the dextrin have been replaced by strongly acidic groups, is useful in treatment of poisoning or drug overdose, particularly by compounds having basic groups. Dextrin sulphate is a preferred derivative for use in the treatment of paraquat poisoning.

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