专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090221575A1 Sulfonamide derivatives and use thereof for the modulation of metalloproteinases 有权
标题翻译：磺酰胺衍生物及其用于金属蛋白酶调节的用途
公开(公告)号：US20090221575A1
公开(公告)日：2009-09-03
申请号：US12091582
申请日：2006-10-24
申请人： Patrick Gerber , Dominique Swinnen , Agnes Bombrun
发明人： Patrick Gerber , Dominique Swinnen , Agnes Bombrun
IPC分类号： A61K31/4725 , C07D217/22 , C07D405/12 , C07D209/44 , C07D413/12 , C07D401/12 , A61K31/472 , A61K31/4035 , A61K31/5377 , A61K31/506
CPC分类号： C07D209/44 , C07D217/08 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： The present invention is related to sulfonamide derivatives of Formula (Ia) where the groups are as defined in the description, and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.
摘要翻译：本发明涉及式（Ia）的磺酰胺衍生物，其中基团如说明书中所定义，特别是其用于治疗和/或预防自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多发性硬化，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。

2. 发明授权

US07507707B2 Methods of inducing ovulation using a non-polypeptide camp level modulator 有权
标题翻译：使用非多肽血浆调节剂诱导排卵的方法
公开(公告)号：US07507707B2
公开(公告)日：2009-03-24
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

3. 发明申请

US20090018169A1 Sulfonamide Derivatives for the Treatment of Bacterial Infections 审中-公开
标题翻译：用于治疗细菌感染的磺酰胺衍生物
公开(公告)号：US20090018169A1
公开(公告)日：2009-01-15
申请号：US12278831
申请日：2007-02-09
申请人： Jerome Gonzalez , Dominique Swinnen , Agnes Bombrun , Rob Hooft Van Huijsduijnen , Timothy Wells
发明人： Jerome Gonzalez , Dominique Swinnen , Agnes Bombrun , Rob Hooft Van Huijsduijnen , Timothy Wells
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61P31/04 , C07D333/04
CPC分类号： A61K31/381 , A61K31/4436
摘要： This present invention is related to sulfonamide derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of bacterial infections such as tuberculosis.
摘要翻译：本发明涉及式（I）的磺酰胺衍生物，其药物组合物，其制备方法及其用于治疗和/或预防细菌感染如结核病的用途。

4. 发明授权

US07465441B2 Use of gp130 activators in diabetic neuropathy 有权
标题翻译：在糖尿病性神经病变中使用gp130激活剂
公开(公告)号：US07465441B2
公开(公告)日：2008-12-16
申请号：US10492087
申请日：2002-10-10
申请人： Michel Dreano , Pierre-Alain Vitte
发明人： Michel Dreano , Pierre-Alain Vitte
IPC分类号： A61K38/20 , A61K38/16 , A61K38/17 , A61K38/19
CPC分类号： A61K38/204 , A61K38/1793 , C07K2319/02 , C07K2319/30 , C12N2750/10011 , A61K2300/00
摘要： The invention relates to the use a substance signaling through gp130 for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy. The use of IL-6 is preferred.
摘要翻译：本发明涉及通过gp130信号传导的物质用于制备用于治疗和/或预防糖尿病性神经病的药物。优选使用IL-6。

5. 发明申请

US20080305078A1 Soluble Il-17Rc Variant and Uses Thereof 审中-公开
标题翻译：可溶性Il-17Rc变体及其用途
公开(公告)号：US20080305078A1
公开(公告)日：2008-12-11
申请号：US12158572
申请日：2006-12-22
申请人： Laurent Magnenat , Christine Power
发明人： Laurent Magnenat , Christine Power
IPC分类号： A61K38/20 , C07K14/54 , C12N15/24 , C12P21/02 , A61P29/00 , A61P37/00 , C12N5/10 , C12N15/85 , C07K16/24
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/01
摘要： The present invention relates to a new soluble IL-17RC variant and its therapeutic uses thereof, in particular for treating or preventing inflammatory or autoimmune disorders or neurological diseases.
摘要翻译：本发明涉及新的可溶性IL-17RC变体及其治疗用途，特别是用于治疗或预防炎性或自身免疫疾病或神经疾病。

6. 发明申请

US20080286824A1 System for Screening Cells for High Expression of a Protein of Interest (Poi) 审中-公开
标题翻译：筛选高表达兴趣蛋白（Poi）的细胞系统
公开(公告)号：US20080286824A1
公开(公告)日：2008-11-20
申请号：US12064287
申请日：2006-08-25
申请人： Philippe Dupraz , Michel Kobr
发明人： Philippe Dupraz , Michel Kobr
IPC分类号： C12Q1/02 , C07K14/00 , C07H21/04 , C12N15/63 , C12P21/04 , C12P21/06 , C12N15/00 , C12N5/08 , C12N5/00
CPC分类号： C12N9/1205 , C07K2319/20 , C07K2319/60 , C12N9/1029 , C12N15/64 , G01N33/5023
摘要： This invention refers to industrial production of proteins. More particularly, the invention refers to a fusion protein as a novel chimeric selection marker comprising a peptide conferring resistance to an antibiotic, or a fragment, allelic variant, splice variant or mutein thereof, and at least one sequence comprising SEQ ID NO: 1, 2 or 3, preferably for producing a protein of interest (POI). The inventive chimeric selection marker exhibits: (i) a resistance to an antibiotic; and (ii) a fluorescence activity upon binding of a ligand to the sequence comprising SEQ ID NO: 1, 2 or 3. The invention further refers to nucleic acids encoding the inventive fusion protein and to expression vectors, comprising the inventive fusion protein and additionally the protein of interest (POI). Finally, uses of the inventive chimeric selection marker for screening cells for high expression of a protein of interest (POI) are disclosed.
摘要翻译：本发明涉及蛋白质的工业化生产。更具体地，本发明涉及作为新型嵌合选择标记的融合蛋白，其包含赋予抗生素或其片段等位基因变体，剪接变体或突变蛋白的抗性的肽，以及至少一个包含SEQ ID NO：1， 2或3，优选用于产生感兴趣的蛋白质（POI）。本发明的嵌合选择标记显示：（i）对抗生素的抗性; 和（ii）在将配体结合到包含SEQ ID NO：1,2或3的序列时的荧光活性。本发明还涉及编码本发明融合蛋白的核酸和包含本发明融合蛋白的另外的表达载体感兴趣的蛋白质（POI）。最后，公开了本发明的嵌合选择标记用于筛选高表达目标蛋白（POI）的细胞的用途。

7. 发明申请

US20080188531A1 Thiazole Derivatives and Use Thereof 有权
标题翻译：噻唑衍生物及其用途
公开(公告)号：US20080188531A1
公开(公告)日：2008-08-07
申请号：US11915476
申请日：2006-05-24
申请人： Anna Quattropani , Jerome Dorbais , David Covini , Gwenaelle Desforges , Thomas Rueckle
发明人： Anna Quattropani , Jerome Dorbais , David Covini , Gwenaelle Desforges , Thomas Rueckle
IPC分类号： A61K31/427 , C07D417/04 , A61P25/28 , A61P25/00 , A61P9/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译：本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症，移植，移植排斥或肺部损伤。

8. 发明授权

US07393660B2 CC-chemokine binding tick proteins 失效
标题翻译： CC-趋化因子结合蜱蛋白
公开(公告)号：US07393660B2
公开(公告)日：2008-07-01
申请号：US10583218
申请日：2004-12-21
申请人： Christine Power , Amanda Proudfoot , Achim Frauenschuh
发明人： Christine Power , Amanda Proudfoot , Achim Frauenschuh
IPC分类号： C12N15/62 , C12N15/63 , A61K38/00 , C07K14/00 , C07H21/04
CPC分类号： C07K14/43527
摘要： A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus. Compounds prepared in accordance with the present invention can be used as anti-inflammatory compounds and in the treatment or prevention of CC-chemokine-related diseases.
摘要翻译：从R us唾液中分离出一种新型CC-趋化因子结合蛋白。根据本发明制备的化合物可用作抗炎化合物和用于治疗或预防CC趋化因子相关疾病。

9. 发明授权

US07312358B2 Pharmaceutically active sulfanilide derivatives 有权
标题翻译：药物活性磺酰苯胺衍生物
公开(公告)号：US07312358B2
公开(公告)日：2007-12-25
申请号：US10399040
申请日：2001-10-15
申请人： Anna Quattropani , Matthias Schwarz , Catherine Joran-Lebrun , Dennis Church , Alexander Scheer
发明人： Anna Quattropani , Matthias Schwarz , Catherine Joran-Lebrun , Dennis Church , Alexander Scheer
IPC分类号： C07C303/00
CPC分类号： C07D213/53 , A61K31/18 , A61K31/4045 , A61K31/437 , A61K31/4402 , A61K31/4439 , A61K31/4706 , A61K31/472 , A61K31/5377 , A61K38/00 , C07D207/16 , C07D209/20 , C07D209/40 , C07D209/44 , C07D217/16 , C07D217/26 , C07D233/64 , C07D471/04 , C07K5/06026 , C07K5/06191
摘要： The present invention relates to sulfanilide derivatives of formula (I), in which R1 and R2 are optionally substituted aryl and heteroaryl groups and the other variables are as defined in the claims, for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such sulfanilide derivatives. Said derivatives are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to sulfanilide derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin and/or vasopressin, including preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. The present invention is furthermore related to novel sulfanilide derivatives as well as to methods of their preparation.
摘要翻译：本发明涉及式（I）的磺酰苯胺衍生物，其中R 1和R 2是任选取代的芳基和杂芳基，其它变量如用作药物活性化合物，以及含有这种磺酰苯胺衍生物的药物制剂。所述衍生物可用于治疗和/或预防早产，早产，痛经，不适当的血管加压素分泌，充血性心力衰竭，动脉高血压，肝硬化，肾病综合征和高眼压症。特别地，本发明涉及展示催产素和/或加压素受体的实质性调节，特别是拮抗活性的磺酰苯胺衍生物。更优选地，所述化合物可用于治疗和/或预防催产素和/或加压素介导的疾病状态，包括早产，早产，痛经，不适当的血管加压素分泌，充血性心力衰竭，动脉高血压，肝硬化，肾病综合征和高眼压症。本发明还涉及新的磺酰苯胺衍生物及其制备方法。

10. 发明申请

US20100303760A9 TREATMENT AND/OR PREVENTION OF CANCER AND/OR ARTHRITIS 审中-公开
标题翻译：治疗和/或预防癌症和/或神经病
公开(公告)号：US20100303760A9
公开(公告)日：2010-12-02
申请号：US11912432
申请日：2006-04-20
申请人： Christine Power , Melanie Yorke-Smith
发明人： Christine Power , Melanie Yorke-Smith
IPC分类号： A61K38/21 , A61K38/00 , A61K31/7088 , A61P31/00 , A61P19/00 , A61K39/395 , A61K35/12
CPC分类号： A61K38/191 , A61K38/1793 , A61K2300/00
摘要： The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.
摘要翻译：本发明涉及INSP163用于治疗和/或预防癌症和/或肌肉骨骼/结缔组织病症，特别是肺癌和/或骨关节炎的用途。 INSP163与干扰素，TNF拮抗剂或其它抗癌或抗关节炎药物的组合也在本发明的范围内。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式