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    • 4. 发明授权
    • Process for the producing of alkylcyclopentanone derivatives
    • 制备烷基环戊酮衍生物的方法
    • US5681979A
    • 1997-10-28
    • US609374
    • 1996-03-01
    • Hajime HoshiSatoru Kumazawa
    • Hajime HoshiSatoru Kumazawa
    • C07C67/343C07B61/00C07C69/757C07C201/12C07C205/61C07C253/30C07C255/57C07D233/60C07D249/08C07C69/76
    • C07C69/757
    • The present invention provides a process for producing alkylcyclopentanone derivatives of formula (1) by reacting alkyl cyclopentanone derivatives of formula (2) and alkyl halides of formula (3) in an organic solvent in the presence of molecular sieves and an alkaline metal hydroxide: ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl group; R.sup.2 is hydrogen atom or C.sub.1 -C.sub.5 alkyl group; R.sup.3 is C.sub.1 -C.sub.5 alkyl group; Y is halogen atom, C.sub.1 -C.sub.5 alkyl group, C.sub.1 -C.sub.5 haloalkyl group, phenyl group, cyano group or nitro group; n is an integer from 0 to 5; when n is 2 or greater, Y's may be identical or different; R.sup.3 in formula (3) is the same as R.sup.3 in formula (1); and a process for preparing alkylcyclopentanone derivatives of formula (5) by reacting cyclopentanone derivatives of formula (4) and alkyl halides of formula (6) in an organic solvent in the presence of molecular sieves and an alkaline metal hydroxide: ##STR2## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl group; R.sup.4 is hydrogen atom or C.sub.1 -C.sub.5 alkyl group; R.sup.5 is C.sub.1 -C.sub.5 alkyl group; R.sup.k is either R.sup.4 or R.sup.5 ; Y is halogen atom, C.sub.1 -C.sub.5 alkyl group, C.sub.1 -C.sub.5 haloalkyl group, phenyl group, cyano group or nitro group; n is an integer from 0 to 5; when n is 2 or greater, Y's may be identical or different.
    • 本发明提供了在分子筛和碱金属氢氧化物的存在下,通过使式(2)的烷基环戊酮衍生物与式(3)的烷基卤衍生物在有机溶剂中反应制备式(1)的烷基环戊酮衍生物的方法: (1)图像(2)R3X(3)其中R1是C1-C4烷基; R2是氢原子或C1-C5烷基; R3是C1-C5烷基; Y是卤素原子,C1-C5烷基,C1-C5卤代烷基,苯基,氰基或硝基; n为0〜5的整数, 当n为2以上时,Y可以相同或不同; 式(3)中的R 3与式(1)中的R 3相同; (4)的环戊酮衍生物和式(6)的烷基卤在有机溶剂中在分子筛和碱金属氢氧化物存在下制备式(5)的烷基环戊酮衍生物的方法: (5)RkX(6)其中R1是C1-C4烷基; R4是氢原子或C1-C5烷基; R5是C1-C5烷基; Rk是R4或R5; Y是卤素原子,C1-C5烷基,C1-C5卤代烷基,苯基,氰基或硝基; n为0〜5的整数, 当n为2以上时,Y可以相同也可以不同。