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1. 发明申请

US20100267056A1 DIFFERENTIAL LABELLING METHOD 审中-公开
标题翻译：差分标签方法
公开(公告)号：US20100267056A1
公开(公告)日：2010-10-21
申请号：US12767157
申请日：2010-04-26
申请人： Eduard Gerhard Talman , Robertus Petrus Maria van Gijlswijk , Robert Jochem Heetebrij , Jacky Theo Maria Veuskens
发明人： Eduard Gerhard Talman , Robertus Petrus Maria van Gijlswijk , Robert Jochem Heetebrij , Jacky Theo Maria Veuskens
IPC分类号： G01N33/53 , C07K14/765 , C07K16/00 , C07K14/485 , C07K14/00 , C07H21/04 , C12N9/96 , G01N33/553
CPC分类号： G01N33/84 , G01N33/58
摘要： The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.
摘要翻译：本发明涉及用于差异地标记一个或多个实体的方法，一起包括不同的反应位点。本发明还涉及已经通过根据本发明的方法标记的实体以及包含标记实体的诊断试剂盒和使用根据本发明的方法的诊断试剂盒。

2. 发明申请

US20050118621A1 Methods for labeling nucleotides, labeled nucleotides and useful intermediates 有权
标题翻译：标记核苷酸，标记核苷酸和有用中间体的方法
公开(公告)号：US20050118621A1
公开(公告)日：2005-06-02
申请号：US10950985
申请日：2004-09-27
申请人： Hendrick Houthoff , Jan Reedijk , Tinka Jelsma , Robert Heetebrij , Herman Volkers
发明人： Hendrick Houthoff , Jan Reedijk , Tinka Jelsma , Robert Heetebrij , Herman Volkers
IPC分类号： C12N15/09 , C07F15/00 , C07H21/00 , C07H23/00 , C12Q1/68
CPC分类号： C07H23/00 , C07H21/00 , Y10S436/80 , Y10T436/143333
摘要： The present invention provides a labeled nucleoside having formula: where X represents an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four carbon atoms and at least one oxygen atom in the chain. The invention further provides a method for labeling a nucleoside, kits for labeling a nucleoside, and kits for producing a labeled nucleic acid.
摘要翻译：本发明提供了具有下式的标记核苷：其中X表示脂族二胺，标记部分包含标记和间隔基，其中间隔物一端与铂原子结合，另一端与标记偶联，间隔基包含链中具有至少四个碳原子和至少一个氧原子的链。本发明还提供了用于标记核苷的方法，用于标记核苷的试剂盒和用于产生标记的核酸的试剂盒。

3. 发明申请

US20040132106A1 Method for identifying a mycobacterium species 审中-公开
标题翻译：鉴定分枝杆菌种的方法
公开(公告)号：US20040132106A1
公开(公告)日：2004-07-08
申请号：US10739457
申请日：2003-12-17
申请人： Kreatech Biotechnology B.V.
发明人： Hendrik-Jan Houthoff , Saskia Kroon-Swart , Remco Van Der Meulen , Soenita Goerdayal , Arend Kolk , Lenka Pereira Arias-Bouda , Sjoukje Kuyper
IPC分类号： C12Q001/68 , G01N033/53
CPC分类号： G01N33/5695
摘要： The invention relates to a method for identifying a Mycobacterium species comprising the steps of: a) contacting at least one immuno-cross reactive antigen component of a mycobacterial species with a sample of a body fluid of a human or animal individual; b) contacting at least one antibody, which is capable of reacting with a mycobacterial antigen, with said body fluid sample; c) detecting the presence of antigen-antibody complexes, and identifying the Mycobacterium species present in said body fluid sample.
摘要翻译：本发明涉及鉴定分枝杆菌物种的方法，包括以下步骤：a）使分枝杆菌物种的至少一种免疫交叉反应性抗原成分与人或动物个体的体液样品接触; b）使能够与分枝杆菌抗原反应的至少一种抗体与所述体液样品接触; c）检测抗原 - 抗体复合物的存在，以及鉴定存在于所述体液样品中的分枝杆菌属物种。

4. 发明授权

US07217813B2 Methods for labeling nucleotides, labeled nucleotides and useful intermediates 有权
标题翻译：标记核苷酸，标记核苷酸和有用中间体的方法
公开(公告)号：US07217813B2
公开(公告)日：2007-05-15
申请号：US10950985
申请日：2004-09-27
申请人： Hendrick Jan Houthoff , Jan Reedijk , Tinka Jelsma , Robert Jochem Heetebrij , Herman Hendricus Volkers
发明人： Hendrick Jan Houthoff , Jan Reedijk , Tinka Jelsma , Robert Jochem Heetebrij , Herman Hendricus Volkers
IPC分类号： C07H21/00 , C07H19/04 , C12Q1/68 , G01N33/53
CPC分类号： C07H23/00 , C07H21/00 , Y10S436/80 , Y10T436/143333
摘要： The present invention provides a labeled nucleoside having formula: where X represents an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four carbon atoms and at least one oxygen atom in the chain. The invention further provides a method for labeling a nucleoside, kits for labeling a nucleoside, and kits for producing a labeled nucleic acid.
摘要翻译：本发明提供了具有下式的标记核苷：其中X表示脂族二胺，标记部分包含标记和间隔基，其中间隔物一端与铂原子结合，另一端与标记偶联，间隔基包含链中具有至少四个碳原子和至少一个氧原子的链。本发明还提供了用于标记核苷的方法，用于标记核苷的试剂盒和用于产生标记的核酸的试剂盒。

5. 发明申请

US20090023910A1 Applications with and Methods for Producing Selected Interstrand Cross-Links in Nucleic Acids 审中-公开
标题翻译：用于生产核酸中选择的跨链跨链的应用和方法
公开(公告)号：US20090023910A1
公开(公告)日：2009-01-22
申请号：US12197590
申请日：2008-08-25
申请人： Herman Volkers , Robert Heetebrij , Hendrik-Jan Houthoff , R.P.M. van Gijlswijk , Hendrikus Johannes Tanke , Anton Klaas Raap
发明人： Herman Volkers , Robert Heetebrij , Hendrik-Jan Houthoff , R.P.M. van Gijlswijk , Hendrikus Johannes Tanke , Anton Klaas Raap
IPC分类号： C07H21/00 , C07K1/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6832 , C07H21/04 , C12Q1/6816 , C12Q1/6841 , C12Q1/686 , C12Q2563/137 , C12Q2523/101 , C12Q2525/151 , C12Q2525/107 , C12Q2565/102 , C12Q2525/186
摘要： The invention provides a method for stably cross-linking a first nucleic acid sequence selected for being stably cross-linked in the presence of a second nucleic acid sequence selected for not being stably cross-linked in a nucleic acid molecule. The method comprises providing a nucleic acid sequence that is complementary to the first nucleic acid sequence; hybridizing the first nucleic acid sequence to its complementary sequence; and stably cross-linking the first nucleic acid sequence to the complementary sequence.
摘要翻译：本发明提供了在核酸分子中存在选择为不稳定交联的第二核酸序列的情况下，稳定交联选择用于稳定交联的第一核酸序列的方法。该方法包括提供与第一核酸序列互补的核酸序列; 将第一核酸序列与其互补序列杂交; 并将第一核酸序列稳定交联至互补序列。

6. 再颁专利

USRE40557E1 Methods for labeling nucleotides, labeled nucleotides and useful intermediates 有权
标题翻译：标记核苷酸，标记核苷酸和有用中间体的方法
公开(公告)号：USRE40557E1
公开(公告)日：2008-10-28
申请号：US10900902
申请日：1997-10-08
申请人： Jan Hendrick Houthoff , Jan Reedijk , Tinka Jelsma , Robert Jochem Heetebrij , Herman Hendricus Volkers
发明人： Jan Hendrick Houthoff , Jan Reedijk , Tinka Jelsma , Robert Jochem Heetebrij , Herman Hendricus Volkers
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/00 , G01N33/53 , C07K1/00 , C07H21/04
CPC分类号： C07H23/00 , C07H21/00 , Y10S436/80 , Y10T436/143333
摘要： The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which linker is a platinum compound having a stabilizing bridge and two reactive moieties, with an electron donating moiety of a spacer, which spacer comprises a chain having at least four atoms and at least one heteroatom in the chain, which spacer further comprises said electron donating moiety at one end of the chain and a reactive moiety at the other end of the chain; reacting the reactive moiety of said spacer with a label; reacting the other reactive moiety of said linker with a nucleotide. A major advantage of the invention is that all nucleotides can be labeled by the method of the invention, whereas until now the attachment of a label was mostly restricted to one or certain nucleotides.
摘要翻译：本发明提供了用于标记核苷酸的改进方法。用于标记核苷酸的本发明的方法包括以下步骤：使接头的反应性部分（该接头是具有稳定桥和两个反应性部分的铂化合物）与间隔基的给电子部分反应，该间隔基包括链在链中具有至少四个原子和至少一个杂原子，该间隔基进一步包含链一端的所述给电子部分和链的另一端的反应性部分; 使所述间隔物的反应性部分与标记反应; 使所述接头的另一反应性部分与核苷酸反应。本发明的主要优点是所有的核苷酸都可以通过本发明的方法进行标记，而到目前为止，标记的连接主要限于一个或某些核苷酸。

7. 发明授权

US5302347A Apparatus for cyclincial temperature process with automatic monitoring and adjusting of the temperature of a water bath 失效
标题翻译：用于循环温度过程的设备，具有自动监测和调节水浴温度
公开(公告)号：US5302347A
公开(公告)日：1994-04-12
申请号：US923938
申请日：1992-09-03
申请人： Van Den Berg , Heiman H. Volkens
发明人： Van Den Berg , Heiman H. Volkens
IPC分类号： B01L7/02 , B01L7/00 , B01L7/04 , C12M1/36 , G01N35/00 , G05D23/00 , G05D23/19 , H05B6/68 , H05B6/80 , G01N21/00
CPC分类号： H05B6/666 , B01L7/52 , G05D23/1919
摘要： An apparatus for cyclical temperature processes with automatic monitoring and adjusting of the temperature of a water bath, including a reactor space with a water bath in which a plurality of sample containers with samples to be examined can be placed. The desired temperatures and periods during which each adjusted temperature should be maintained are adjustable by an adjustment means, wherein a temperature sensor for measuring the temperature of the water bath is provided and a control unit controls the temperature of the water bath in dependence on the measured temperature and time. At least one magnetron tube is provided in the reactor space for heating the water bath and the sample containers placed in the same. The water bath is connectable to a water conduit through a water supply conduit wherein the control unit controls the magnetron tube and the valve in dependence on the desired temperature and time.
摘要翻译： PCT No.PCT / NL91 / 00034 Sec。 371日期：1992年9月3日 102（e）日期1992年9月3日PCT 1991年2月28日PCT PCT。公开号WO91 / 12888 日期1991年9月5日。一种用于循环温度过程的装置，其具有自动监测和调节水浴的温度，包括具有水浴的反应器空间，其中可以放置多个具有待检测样品的样品容器。每个调节温度应保持的期望温度和时间可以通过调节装置来调节，其中提供了用于测量水浴温度的温度传感器，并且控制单元根据所测量的温度和温度来控制水浴的温度温度和时间。在反应器空间中设置至少一个磁控管，用于加热水浴和放置在其中的样品容器。水浴可通过供水管连接到水管，其中控制单元根据期望的温度和时间来控制磁控管和阀。

8. 发明申请

US20110104103A1 Method of conjugating therapeutic compounds to cell targeting devices via metal complexes 审中-公开
标题翻译：通过金属络合物将治疗化合物与细胞靶向装置缀合的方法
公开(公告)号：US20110104103A1
公开(公告)日：2011-05-05
申请号：US11995960
申请日：2006-07-20
申请人： Robert Jochem Heetebrij , Robbert Jan Kok , Eduard Gerhard Talman , Klaas Poelstra , Grietje Molema
发明人： Robert Jochem Heetebrij , Robbert Jan Kok , Eduard Gerhard Talman , Klaas Poelstra , Grietje Molema
IPC分类号： A61K31/555 , C07K16/00 , C07K14/765 , C07K14/77 , C07K14/00 , C07K14/475 , C07K14/54 , C12N9/36 , C12N9/16 , C12N9/02 , C07K14/52 , C07K14/525 , C07F15/00 , A61K39/395 , A61K38/47 , A61K38/46 , A61K38/44 , A61K38/19 , A61K38/20 , A61K38/18 , A61K38/02 , A61P29/00 , A61P9/12
CPC分类号： A61K47/62 , A61K47/549 , A61K47/61
摘要： The present invention relates to a cell-targeting complex comprising a targeting moiety and a deliverable compound, wherein said targeting moiety and said deliverable compound are joined by means of a (transition) metal ion complex having at least a first reactive moiety for forming a coordination bond with a reactive site of said targeting moiety and having at least a second reactive moiety for forming a coordination bond with a reactive site of said deliverable compound, and wherein said deliverable compound is a therapeutic compound.
摘要翻译：本发明涉及包含靶向部分和可递送化合物的细胞靶向复合物，其中所述靶向部分和所述可递送化合物通过具有至少第一反应性部分的（过渡）金属离子络合物连接以形成配位体与所述靶向部分的反应位点键合并且具有至少第二反应性部分，用于与所述可递送化合物的反应性位点形成配位键，并且其中所述可递送化合物是治疗性化合物。

9. 发明授权

US07704755B2 Differential labelling method 有权
标题翻译：差示贴标法
公开(公告)号：US07704755B2
公开(公告)日：2010-04-27
申请号：US10156730
申请日：2002-05-28
申请人： Eduard Gerhard Talman , Robertus Petrus Maria van Gijlswijk , Robert Jochem Heetebrij , Jacky Theo Maria Veuskens
发明人： Eduard Gerhard Talman , Robertus Petrus Maria van Gijlswijk , Robert Jochem Heetebrij , Jacky Theo Maria Veuskens
IPC分类号： G01N33/543 , G01N33/553 , C07F15/00
CPC分类号： G01N33/84 , G01N33/58
摘要： The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.
摘要翻译：本发明涉及用于差异地标记一个或多个实体的方法，一起包括不同的反应位点。本发明还涉及已经通过根据本发明的方法标记的实体以及包含标记实体的诊断试剂盒和使用根据本发明的方法的诊断试剂盒。

10. 发明授权

US5817473A Method and device for identifying a mycobacterium species responsible for a mycobacterial infection 失效
标题翻译：用于鉴定负责分枝杆菌感染的分枝杆菌物种的方法和装置
公开(公告)号：US5817473A
公开(公告)日：1998-10-06
申请号：US454122
申请日：1995-11-20
申请人： Pranab Khumar Das , Remco Maria Van Es , Hendrik Jan Houthoff
发明人： Pranab Khumar Das , Remco Maria Van Es , Hendrik Jan Houthoff
IPC分类号： G01N33/543 , G01N33/569 , G01N33/53
CPC分类号： G01N33/54366 , G01N33/5695
摘要： A method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respectively antigen preparation; binding the antigen, respectively the antigen preparation to a suitable carrier, causing the binding antigen to react with antibodies from serum of an individual infected with a Mycobacterium species; making visible antigen-antibody reactions for a suitable antibody (sub-)class; and identifying the responsible Mycobacterium on the basis of the reactions which are made visible. The invention further provides a diagnostic kit which takes the form of a dip-stick on which is arranged a carrier strip with mycobacterial antigens binding thereto, and visualizing reagents antigen-antibody reactions occurring on the carrier after contact with the serum for testing. In another embodiment, the diagnostic kit comprises a micro titer plate, in the wells of which a specified antibody is arranged, and reagents for making visible antigen-antibody reactions occurring in the wells after contact with the serum for testing. The third embodiment is an immunoblot with mycobacterial antigens separated by electrophoresis binding thereto, and reagents for visualizing antigen-antibody reactions occurring on the immunoblot after contact with the serum for testing.
摘要翻译： PCT No.PCT / NL93 / 00270 Sec。 371日期：1995年11月20日 102（e）1995年11月20日日期PCT 1993年12月17日PCT PCT。 WO94 / 14069 PCT出版物日期1994年6月23日一种用于鉴定负责人或动物中分枝杆菌感染的分枝杆菌物种的方法，包括选择合适的分枝杆菌物种和菌株; 制备至少一种分枝杆菌抗原，分别制备抗原制剂; 将抗原分别将抗原制剂结合到合适的载体上，使结合抗原与受分枝杆菌感染的个体血清的抗体反应; 对合适的抗体（亚类）进行可见的抗原 - 抗体反应; 并根据可见的反应鉴定负责的分枝杆菌。本发明还提供一种诊断试剂盒，其采用浸棒的形式，其上布置有与分枝杆菌抗原结合的载体条带，以及在与血清接触后在载体上显现试剂抗原 - 抗体反应以进行测试。在另一个实施方案中，诊断试剂盒包括在其中布置指定抗体的孔中的微量滴定板和用于在与血清接触以进行测试之后在孔中发生可见的抗原 - 抗体反应的试剂。第三个实施方案是具有通过电泳结合分离的分枝杆菌抗原的免疫印迹，以及在用于测试的血清接触后在免疫印迹上发生的抗原 - 抗体反应的试剂。

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