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1. 发明申请

US20070298031A1 Methods for preventing or treating neuromuscular or muscular conditions by peripherally administered erythropoietin 审中-公开
标题翻译：通过外周给予的促红细胞生成素预防或治疗神经肌肉或肌肉状况的方法
公开(公告)号：US20070298031A1
公开(公告)日：2007-12-27
申请号：US11881759
申请日：2007-07-26
申请人： Michael Brines , Anthony Cerami , Carla Cerami Hand
发明人： Michael Brines , Anthony Cerami , Carla Cerami Hand
IPC分类号： A61K38/19 , A61K35/00 , A61K39/395 , A61P21/00 , A61P29/00 , A61P9/10
CPC分类号： A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.
摘要翻译：通过全身给予促红细胞生成素受体活性调节剂如红细胞生成素，通过EPO激活的受体信号调节可兴奋组织的功能，提供了用于保护或增强哺乳动物可激发组织功能的方法和组合物。可兴奋组织包括中枢神经元组织，如脑，周围神经元组织，视网膜和心脏组织。保护可兴奋组织提供治疗缺氧，癫痫发作，神经退行性疾病，低血糖症和神经毒素中毒。功能的增强在学习和记忆中是有用的。本发明还涉及通过分子与促红细胞生成素受体活性调节剂如红细胞生成素的缔合促进分子穿过内皮细胞紧密连接屏障（例如血脑屏障）的转运的组合物和方法。

2. 发明申请

US20090004202A1 METHODS FOR TREATMENT OF NEURODEGENERATIVE CONDITIONS BY PERIPHERALLY ADMINISTERED ERYTHROPOIETIN 审中-公开
标题翻译：通过外周血管内皮细胞生长因子治疗神经营养因子的方法
公开(公告)号：US20090004202A1
公开(公告)日：2009-01-01
申请号：US12123828
申请日：2008-05-20
申请人： MICHAEL BRINES , Anthony Cerami , Carla Cerami Hand
发明人： MICHAEL BRINES , Anthony Cerami , Carla Cerami Hand
IPC分类号： A61K39/395 , A61K31/7048
CPC分类号： A61K38/1816
摘要： Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.
摘要翻译：通过全身给予促红细胞生成素受体活性调节剂如红细胞生成素，通过EPO激活的受体信号调节可兴奋组织的功能，提供了用于保护或增强哺乳动物可激发组织功能的方法和组合物。可兴奋组织包括中枢神经元组织，如脑，周围神经元组织，视网膜和心脏组织。保护可兴奋组织提供治疗缺氧，癫痫发作，神经退行性疾病，低血糖症和神经毒素中毒。功能的增强在学习和记忆中是有用的。本发明还涉及通过分子与促红细胞生成素受体活性调节剂如红细胞生成素的缔合促进分子穿过内皮细胞紧密连接屏障（例如血脑屏障）的转运的组合物和方法。

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