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1. 发明授权

US08894824B2 Porous coatings for biomedical implants 有权
标题翻译：用于生物医学植入物的多孔涂层
公开(公告)号：US08894824B2
公开(公告)日：2014-11-25
申请号：US11168050
申请日：2005-06-28
申请人： David A. Glocker , Mark M. Romach
发明人： David A. Glocker , Mark M. Romach
IPC分类号： C23C14/00 , C23C14/32 , C23C14/22 , A61L27/30 , A61F2/30
CPC分类号： C23C14/225 , A61F2/30767 , A61F2002/30929 , A61F2002/3098 , A61F2310/00407 , A61F2310/00449 , A61F2310/00485 , A61F2310/00497 , A61F2310/00544 , A61F2310/0088 , A61F2310/0097 , A61L27/306
摘要： A medical implant has a microscopically rough outer coating that serves to bond the implant to animal tissue. The coating is applied to the implant by physical vapor deposition. The coating preferable is applied via a generally oblique coating flux or a low energy coating flux. In some embodiments, the coating has pores. The pores can contain a drug, which can diffuse over a period of time. The coating may be partially nonporous to protect the implant from corrosion. The coating can have an outer porous layer that can bond with animal tissue easily.
摘要翻译：医疗植入物具有显微粗糙的外涂层，其用于将植入物结合到动物组织。通过物理气相沉积将涂层施加到植入物上。优选的涂层通过大体上倾斜的涂层焊剂或低能量涂层焊剂施加。在一些实施方案中，涂层具有孔。毛孔可以含有药物，其可以在一段时间内扩散。涂层可能是部分无孔的，以保护植入物免受腐蚀。涂层可以具有能够容易地与动物组织结合的外部多孔层。

2. 发明申请

US20070106374A1 Radiopaque coating for biomedical devices 审中-公开
标题翻译：用于生物医学装置的不透射线涂层
公开(公告)号：US20070106374A1
公开(公告)日：2007-05-10
申请号：US11586836
申请日：2006-10-26
申请人： David Glocker , Mark Romach
发明人： David Glocker , Mark Romach
IPC分类号： A61F2/02 , A61F2/82 , C23C14/32
CPC分类号： A61L31/088 , A61F2/86 , A61L31/18 , C23C30/00
摘要： A medical device has a porous metallic coating that can withstand the high strains inherent in the use of such devices without delamination. A coating of the metal is applied to a medical device, such as a stent, by vapor deposition so that the thermomechanical properties of the stent are not adversely affected. The coating preferable has high emissivity. The coating is applied via a generally oblique coating flux or a low energy coating flux.
摘要翻译：医疗装置具有多孔金属涂层，可以承受使用这种装置固有的高应变而不发生分层。通过气相沉积将金属涂层施加到诸如支架的医疗装置上，使得支架的热机械性能不受不利影响。该涂层优选具有高发射率。通过大体上倾斜的涂层焊剂或低能量涂层焊剂施加涂层。

3. 发明申请

US20040149575A1 System for unbalanced magnetron sputtering with AC power 审中-公开
标题翻译：交流电源不平衡磁控溅射系统
公开(公告)号：US20040149575A1
公开(公告)日：2004-08-05
申请号：US10720602
申请日：2003-11-24
申请人： Isoflux, Inc.
发明人： David A. Glocker , Mark Romach
IPC分类号： C23C014/35
CPC分类号： C23C14/352
摘要： An array of unbalanced magnetrons arranged around a centrally-located space for sputter coating of material from target electrodes in the magnetrons onto a substrate disposed in the space. The electrodes are powered in pairs by an alternating voltage and current source. The unbalanced magnetrons, which may be planar, cylindrical, or conical, are arranged in mirror configuration such that like poles are opposed across the substrate space or are adjacent on the same side of the substrate space. The magnetrons are all identical in magnetic polarity, such that there is no magnetic coupling between either opposed or adjacent magnetrons. A positive plasma potential produced by the AC driver prevents electrons from escaping to ground along the unclosed field lines, increasing plasma density in the background working gas and thereby improving the quality of coating being deposited on the substrate.
摘要翻译：一个不平衡磁控管阵列，其布置在中心位置的空间周围，用于将材料从磁控管中的目标电极溅射到设置在该空间中的衬底上。电极通过交流电压和电流成对地供电。可以是平面的，圆柱形的或圆锥形的不平衡磁控管被布置成镜面结构，使得类似的极在衬底空间上相对或者在衬底空间的同一侧相邻。磁控管在磁极性方面都是相同的，使得在相对或相邻的磁控管之间不存在磁耦合。由AC驱动器产生的正等离子体电位器防止电子沿着未闭合的场线逸出到地面，增加背景工作气体中的等离子体密度，从而提高沉积在基片上的涂层质量。

4. 发明授权

US08002822B2 Radiopaque coating for biomedical devices 有权
标题翻译：用于生物医学装置的不透射线涂层
公开(公告)号：US08002822B2
公开(公告)日：2011-08-23
申请号：US11087909
申请日：2005-03-23
申请人： David A. Glocker , Mark M. Romach
发明人： David A. Glocker , Mark M. Romach
IPC分类号： A61F2/82
CPC分类号： C23C30/00 , A61F2/86 , A61L31/088 , A61L31/146 , A61L31/18
摘要： A medical device has a porous radiopaque coating that can withstand the high strains inherent in the use of such devices without delamination. A coating of Ta is applied to a medical device, such as a stent, by vapor deposition so that the thermomechanical properties of the stent are not adversely affected. The coating preferable has high emissivity.
摘要翻译：医疗装置具有多孔的不透射线涂层，可以承受使用这种装置固有的高应变而不会分层。通过气相沉积将Ta的涂层施加到诸如支架的医疗装置上，使得支架的热机械性能不受不利影响。该涂层优选具有高发射率。

5. 发明申请

US20080299337A1 Method for the formation of surfaces on the inside of medical devices 审中-公开
标题翻译：在医疗器械内部形成表面的方法
公开(公告)号：US20080299337A1
公开(公告)日：2008-12-04
申请号：US12221612
申请日：2008-08-05
申请人： David A. Glocker , Brent C. Bell
发明人： David A. Glocker , Brent C. Bell
IPC分类号： B32B3/26 , B05D5/00 , H05H1/00
CPC分类号： A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/86 , A61F2002/0086 , A61F2002/2821 , A61F2002/30321 , A61F2002/3084 , A61F2002/30925 , A61F2002/3093 , A61F2002/30968 , A61F2002/3098 , A61F2250/0025 , A61F2310/00023 , A61F2310/00395 , A61F2310/00568 , A61F2310/00598 , A61F2310/00604 , A61F2310/00616 , A61F2310/00622 , A61F2310/0064 , A61F2310/00646 , A61F2310/00856 , A61L27/06 , A61L27/306 , B82Y30/00 , C23C14/046 , C23C14/5826 , C23C14/5873 , C23F4/00 , Y10T428/13 , Y10T428/24802 , Y10T428/249953 , Y10T428/265
摘要： A method of manufacturing a medical device having interior and exterior surfaces, the method including the steps of: a) shielding the exterior surface; and, b) exposing the interior surface to a plasma, wherein the shielding of the exterior surface substantially prevents exposure of the exterior surface to the plasma.
摘要翻译：一种制造具有内表面和外表面的医疗装置的方法，所述方法包括以下步骤：a）屏蔽所述外表面; 以及b）将所述内表面暴露于等离子体，其中所述外表面的屏蔽基本上防止所述外表面暴露于所述等离子体。

6. 发明申请

US20070184257A1 Formation of nanoscale surfaces for the atttachment of biological materials 审中-公开
标题翻译：形成用于生物材料接触的纳米级表面
公开(公告)号：US20070184257A1
公开(公告)日：2007-08-09
申请号：US11704650
申请日：2007-02-09
申请人： David A. Glocker , Mark Romach
发明人： David A. Glocker , Mark Romach
IPC分类号： B32B3/26 , B05D5/00 , B05D3/00 , G11B11/105
CPC分类号： C23F4/00 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2002/0086 , A61F2002/2821 , A61F2002/30321 , A61F2002/3084 , A61F2002/30925 , A61F2002/3093 , A61F2002/30968 , A61F2002/3098 , A61F2250/0025 , A61F2310/00023 , A61F2310/00395 , A61F2310/00568 , A61F2310/00598 , A61F2310/00604 , A61F2310/00616 , A61F2310/00622 , A61F2310/0064 , A61F2310/00646 , A61F2310/00856 , A61L27/06 , A61L27/306 , B82Y30/00 , C23C14/04 , C23C14/5826 , C23C14/5873 , Y10T428/249953 , Y10T428/25 , Y10T428/26
摘要： An inhomogeneous surface is formed on a substrate, such as an orthopedic implant or other surface upon which cell growth is desired, by depositing a discontinuous coating of atoms on the substrate and etching the substrate. The difference in etch rates between the coating and the substrate will produce structures in the nanometer scale. Deposition and etch conditions can be chosen to create structures of a specific size to preferentially bind to specific biological materials.
摘要翻译：通过在衬底上沉积不连续的原子涂层并蚀刻衬底，在诸如整形外科植入物或期望细胞生长的其它表面的基底上形成不均匀的表面。涂层和基材之间的蚀刻速率差异将产生纳米尺度的结构。可以选择沉积和蚀刻条件以产生特定尺寸的结构以优先结合特定的生物材料。

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