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1. 发明授权

US06920356B2 Tachycardia rate hysteresis for dual-chambered cardiac stimulators 有权
标题翻译：双腔心脏刺激器的心动过速速度滞后
公开(公告)号：US06920356B2
公开(公告)日：2005-07-19
申请号：US10321049
申请日：2002-12-16
申请人： Randolph Kerry Armstrong , Douglas Jason Cook
发明人： Randolph Kerry Armstrong , Douglas Jason Cook
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3622
摘要： It has been determined that certain dual-chambered cardiac stimulators may operate in a region in which an atrial pacing event may obscure the detection of a ventricular tachyarrhythmia. Various exemplary techniques may be used to improve the ability of dual-chamber cardiac stimulators to detect such ventricular events. In accordance with one technique, it is determined whether a ventricular event should be classified as a ventricular tachyarrhythmia. If not, the VA interval is restarted as usual. However, if the ventricular event may be classified as a ventricular tachyarrhythmia, it is determined whether the ventricular event falls within the region in which an atrial pacing event may obscure its detection. If not, then the VA interval is restarted as usual. However, if the ventricular event falls within this region, the VA interval is restarted with the VT rate detection boundary. This has the effect of lengthening the VA interval and the AA interval in this region so that atrial pacing events will not obscure the sensing and treatment of ventricular tachyarrhythmias in the region.
摘要翻译：已经确定某些双腔心脏刺激器可能在心房起搏事件可能会遮蔽心室快速性心律失常检测的区域中运作。可以使用各种示例性技术来改善双室心脏刺激器检测这种心室事件的能力。根据一种技术，确定心室事件是否应被分类为室性快速性心律失常。如果没有，则按照平常重新启动VA间隔。然而，如果心室事件可能被分类为室性快速性心律失常，则确定心室事件是否落入心房起搏事件可能使其检测模糊的区域内。如果没有，则平均重新启动VA间隔。然而，如果心室事件落在该区域内，则使用VT速率检测边界重新开始VA间隔。这具有延长该区域的VA间隔和AA间隔的作用，使得心房起搏事件不会掩盖该区域的心室快速性心律失常的感测和治疗。

2. 发明申请

US20050022181A1 Implantable device and programmer system which permits multiple programmers 失效
标题翻译：可植入设备和程序员系统，允许多个程序员
公开(公告)号：US20050022181A1
公开(公告)日：2005-01-27
申请号：US10919553
申请日：2004-08-17
申请人： James Fox , William Rottenberg , Bryan Thome
发明人： James Fox , William Rottenberg , Bryan Thome
IPC分类号： A61N1/372 , G06F9/445
CPC分类号： A61N1/37252 , A61N1/37 , G06F19/00
摘要： A multiprogrammer system, for monitoring and optimizing implant performance, includes at least two programmers and an implant. Each programmer may perform inquiry and programming operations on the implant. In an inquiry operation, the programmer retrieves some or all of the configuration parameters from the implant. In a programming operation, the programmer provides one or more modified parameters to the implant. As part of the programming operation, the programmer is configured to verify that it is aware of the implant's current parameters before sending modified parameters. The current programmer verifies that the implant's parameters have not been altered since the current programmer's last interaction with the implant. If the parameters have been altered, the current programmer aborts the programming operation and provides notification. The verification may be performed by the implant, i.e., it may verify that the programmer is aware of the current device parameters before the implant accepts modified parameters.
摘要翻译：用于监测和优化植入物性能的多重程序设计系统至少包括两个程序员和植入物。每个程序员可以对植入物进行查询和编程操作。在查询操作中，程序员从植入物检索一些或全部配置参数。在编程操作中，编程器为植入物提供一个或多个修改的参数。作为编程操作的一部分，编程器被配置为在发送修改的参数之前验证其是否知道植入物的当前参数。当前的程序员验证植入物的参数自从当前程序员最后与植入物的相互作用以来没有被改变。如果参数被更改，当前程序员将中止编程操作并提供通知。该验证可以通过植入来执行，即它可以在植入物接受修改的参数之前验证编程器是否知道当前的器件参数。

3. 发明申请

US20030088288A1 Tachycardia rate hysteresis for dual-chambered cardiac stimulators 有权
标题翻译：双腔心脏刺激器的心动过速速度滞后
公开(公告)号：US20030088288A1
公开(公告)日：2003-05-08
申请号：US10321049
申请日：2002-12-16
申请人： Intermedics Inc.
发明人： Randolph Kerry Armstrong , Douglas Jason Cook
IPC分类号： A61N001/365
CPC分类号： A61N1/3622
摘要： It has been determined that certain dual-chambered cardiac stimulators may operate in a region in which an atrial pacing event may obscure the detection of a ventricular tachyarrhythmia. Various exemplary techniques may be used to improve the ability of dual-chamber cardiac stimulators to detect such ventricular events. In accordance with one technique, it is determined whether a ventricular event should be classified as a ventricular tachyarrhythmia. If not, the VA interval is restarted as usual. However, if the ventricular event may be classified as a ventricular tachyarrhythmia, it is determined whether the ventricular event falls within the region in which an atrial pacing event may obscure its detection. If not, then the VA interval is restarted as usual. However, if the ventricular event falls within this region, the VA interval is restarted with the VT rate detection boundary. This has the effect of lengthening the VA interval and the AA interval in this region so that atrial pacing events will not obscure the sensing and treatment of ventricular tachyarrhythmias in the region.
摘要翻译：已经确定某些双腔心脏刺激器可能在心房起搏事件可能会遮蔽心室快速性心律失常检测的区域中运作。可以使用各种示例性技术来改善双室心脏刺激器检测这种心室事件的能力。根据一种技术，确定心室事件是否应被分类为室性快速性心律失常。如果没有，则按照平常重新启动VA间隔。然而，如果心室事件可能被分类为室性快速性心律失常，则确定心室事件是否落入心房起搏事件可能使其检测模糊的区域内。如果没有，则平均重新启动VA间隔。然而，如果心室事件落在该区域内，则使用VT速率检测边界重新开始VA间隔。这具有延长该区域的VA间隔和AA间隔的作用，使得心房起搏事件不会掩盖该区域的心室快速性心律失常的感测和治疗。

4. 发明申请

US20020035384A1 Implantable device and programmer system which permits multiple programmers 有权
标题翻译：可植入设备和程序员系统，允许多个程序员
公开(公告)号：US20020035384A1
公开(公告)日：2002-03-21
申请号：US09981972
申请日：2001-10-16
申请人： Intermedics Inc.
发明人： James K. Fox , William B. Rottenberg , Bryan J. Thome
IPC分类号： A61N001/362
CPC分类号： A61N1/37252 , A61N1/37 , G06F19/00
摘要： A multiprogrammer system for monitoring and optimizing implantable device performance. In one embodiment, the system includes at least two programming devices and an implantable device. Each of the programming devices may be used to perform inquiry and programming operations on the implantable device. In an inquiry operation, the programming device retrieves some or all of the configuration parameters from the implantable device. In a programming operation, the programming device provides one or more modified parameters to the implantable device. As part of the programming operation, the programming device is configured to verify that it is aware of the implantable device's current parameters before sending the modified parameters. In other words, the current programming device verifies that the implantable device's parameters have not been altered by another programming device since the current programming device's last interaction with the implantable device. If the parameters have been altered, the current programming device aborts the programming operation and notifies the operator. In alternate embodiments, the verification may be performed by the implantable device, i.e. the implantable device may verify that the programming device is aware of the current device parameters before the implantable device accepts the modified parameters.
摘要翻译：用于监测和优化植入式设备性能的多程序设计系统。在一个实施例中，该系统包括至少两个编程装置和可植入装置。每个编程设备可用于在可植入设备上执行查询和编程操作。在查询操作中，编程设备从可植入设备检索部分或全部配置参数。在编程操作中，编程设备向可植入设备提供一个或多个修改的参数。作为编程操作的一部分，编程设备被配置为在发送修改的参数之前验证其是否知道可植入设备的当前参数。换句话说，当前编程设备验证可植入设备的参数由于当前编程设备与可植入设备的最后交互而未被另一编程设备改变。如果参数被更改，当前的编程设备中止编程操作并通知操作员。在替代实施例中，验证可以由可植入装置执行，即可植入装置可以验证编程装置在可植入装置接受修改的参数之前是否知道当前的装置参数。

5. 发明申请

US20020035319A1 Cardiac lead with minimized inside diameter of sleeve 有权
标题翻译：心脏导线，套筒内径最小
公开(公告)号：US20020035319A1
公开(公告)日：2002-03-21
申请号：US09994389
申请日：2001-11-26
申请人： Intermedics Inc.
发明人： Paul R. Spehr , Elmar R. Fischer, SR. , James E. Machek
IPC分类号： A61B005/04
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/058
摘要： A lead assembly adapted for endocardial fixation to a human heart is provided. The lead assembly includes a lead body that has a proximal end provided with a connector for electrical connection to a cardiac stimulator. The cardiac stimulator may be a pacemaker, a cardioverter/defibrillator, or a sensing instrument. The distal end of the lead body is connected to a tubular electrode housing. The lead body consists of one or more noncoiled conductor cables surrounded by a coextensive insulating sleeve. Each conductor cable consists of a conducting element covered by a coextensive insulating sleeve. The conducting element may be a single filament wire or a plurality of individual conductor wires. In contrast to conventional leads, the lead body of the present invention does not require coiled conductor wires. Lead body diameters of 1.04 mm or smaller are possible.
摘要翻译：提供了一种适用于心脏内固定于人心脏的引导组件。引线组件包括引线本体，其具有设置有用于与心脏刺激器电连接的连接器的近端。心脏刺激器可以是起搏器，心律转复器/除颤器或感测器械。引线主体的远端连接到管状电极壳体。引线体由一个或多个非共线导体电缆组成，包括一个共同的绝缘套管。每个导体电缆由一个由共同延伸绝缘套管覆盖的导电元件组成。导电元件可以是单丝线或多根独立的导线。与传统的引线相比，本发明的引线体不需要卷绕导线。铅体直径可达1.04mm以下。

6. 发明授权

US6167314A Cardiac pacemaker lead with pacemaker connector 失效
标题翻译：心脏起搏器带起搏器连接器
公开(公告)号：US6167314A
公开(公告)日：2000-12-26
申请号：US59975
申请日：1998-04-14
申请人： Elmar R. Fischer, Sr. , Hans Gerstmann
发明人： Elmar R. Fischer, Sr. , Hans Gerstmann
IPC分类号： A61N1/05 , A61N1/375 , A61N1/04
CPC分类号： A61N1/056 , A61N1/3752
摘要： A cardiac stimulator lead connector is provided. The connector includes a pin member that has a distal end and a first insulating sleeve coupled to the pin member. An annular member is coupled to the first insulating sleeve. A conductor sleeve is coupled to the annular member and a second insulating sleeve is coupled to the conductor sleeve. One or more conductor wires running from distal electrodes in a lead may be welded to the connector. The connector eliminates crimping as a mechanism to secure lead conductors to lead connectors.
摘要翻译：提供心脏刺激器引线连接器。连接器包括具有远端的销构件和联接到销构件的第一绝缘套筒。环形构件联接到第一绝缘套筒。导体套筒联接到环形构件，并且第二绝缘套筒联接到导体套管。从引线中的远端电极延伸的一根或多根导线可以焊接到连接器。该连接器消除了作为将导线固定到引线连接器的机构的压接。

7. 发明授权

US6157859A Upgradable implantable medical device with post-shock pacing and redraw functions 失效
标题翻译：可升级植入式医疗设备，具有后冲击起搏和重绘功能
公开(公告)号：US6157859A
公开(公告)日：2000-12-05
申请号：US37168
申请日：1998-03-09
申请人： Eckhard Alt
发明人： Eckhard Alt
IPC分类号： A61N1/372 , A61N1/39 , G06F9/445
CPC分类号： A61N1/37264 , A61N1/37211 , A61N1/3962 , G06F8/64 , G06F8/65
摘要： An implantable medical interventional device is adapted to provide therapy to a patient in whom the device is implanted to treat cardiac dysrhythmias including tachyarrhythmia. The device performs a plurality of functions corresponding to different levels of therapy for treatment of sensed dysrhythmias, including an electric shock waveform of predetermined energy content for delivery to the patient's heart to terminate at least one type of tachyarrhythmia. In response to cessation of the tachyarrhythmia after delivery of the electric shock waveform, the device promptly thereafter applies post-shock pacing pulses to the heart for a period of time sufficient to allow the heart to recover from the shock and to resume substantially normal sinus rhythm. The device may be upgraded by programming to select among the various functions as necessary to provide designated therapy by suppressing some functions and activating others. The functions include, among others, simulating different conditions of interaction between activity of the heart and the therapies offered by the device, based on stored intrinsic heart beat signals over a respective time period with modified settings of parameters associated with the therapies. The results of the simulated different conditions of interaction can be displayed to show the effectiveness of treatment by the device if the dysrhythmia were actually encountered while the device is programmed with the respective time period and parameter settings.
摘要翻译：植入式医疗介入装置适于向装配有该装置的患者提供治疗以治疗心律失常，包括快速性心律失常。该装置执行对应于治疗感觉到的心律失常的不同程度的治疗的多个功能，包括预定的能量含量的电击波形以递送至患者的心脏以终止至少一种类型的快速性心律失常。响应于在发送电击波形之后停止快速性心律失常，该装置随后立即对心脏施加冲击后起搏脉冲一段足以允许心脏从休克恢复并恢复基本正常窦性心律的时间。可以通过编程来升级设备，以在各种功能中进行选择，以通过抑制一些功能并激活其他功能来提供指定的治疗。功能包括，除了别的以外，基于在相应时间段内存储的固有心跳信号，通过与治疗相关联的参数的修改设置来模拟心脏的活动与设备提供的治疗之间的相互作用的不同条件。可以显示模拟不同的相互作用条件的结果，以便在设备用相应的时间段和参数设置进行编程时，如果实际遇到心律失常，则显示设备治疗的有效性。

8. 发明授权

US6141592A Data transmission using a varying electric field 失效
标题翻译：使用变化电场的数据传输
公开(公告)号：US6141592A
公开(公告)日：2000-10-31
申请号：US36528
申请日：1998-03-06
申请人： Robert L. Pauly
发明人： Robert L. Pauly
IPC分类号： A61N1/372 , A61N1/00
CPC分类号： A61N1/37223
摘要： A system for communicating information between a first medical device and a second medical device. A first transducer is connected to the first medical device. A second transducer is connected to the second medical device. Each of the transducers includes a pair of electrically separated electrodes. A means is provided for imposing an electrical potential across one pair of electrodes of one of the transducers and modulating the electrical potential according to the information to be communicated, to generate a modulated electric field. The other of the transducers is disposed within influence of the modulated electric field. A means is provided having inputs connected to the pair of electrodes of the other of the transducers for amplifying an electrical potential sensed between the pair of electrodes of the other of the transducers.
摘要翻译：一种用于在第一医疗设备和第二医疗设备之间传送信息的系统。第一换能器连接到第一医疗装置。第二换能器连接到第二医疗装置。每个换能器包括一对电分离的电极。提供了一种用于在一个换能器的一对电极上施加电位并根据要传送的信息调制电位的装置，以产生调制的电场。换能器中的另一个设置在调制电场的影响之内。提供了一种装置，其具有连接到另一个换能器的一对电极的输入，用于放大在另一个换能器的一对电极之间感测到的电位。

9. 发明授权

US6112121A Implantable medical device with positive indication of lead connection and connector therefor 有权
标题翻译：可植入医疗器械，具有引线连接和连接器的正面指示
公开(公告)号：US6112121A
公开(公告)日：2000-08-29
申请号：US150124
申请日：1998-09-09
申请人： Patrick J. Paul , David Prutchi
发明人： Patrick J. Paul , David Prutchi
IPC分类号： A61N1/375
CPC分类号： A61N1/3752
摘要： An implantable medical device including an enclosure and a header portion attached to the enclosure. The header includes a lead cavity into which a lead can be inserted. The lead cavity includes a compression device, such as a spring, for aligning a highly visible indicator plunger at least partially hidden from view inside the volume defined by an annular electrode, or other opaque object, partially surrounding the lead cavity. The plunger includes at least a portion that is easily visible to a surgeon during implantation of the medical device. When a lead is inserted into the lead cavity, the end of the lead pushes against the indicator plunger thereby moving the plunger and compressing the spring. When the lead is fully inserted into the lead cavity, the plunger becomes visible as it is pushed away from the volume defined by the annular electrode. In this way, the plunger provides a positive indication that the lead has been fully inserted into the header. The annular electrode may also include a retaining surface that will contact a corresponding surface on the plunger should the plunger break loose from the spring. This feature helps to keep the plunger from migrating from the header into the body should the plunger break away from the spring.
摘要翻译：一种可植入医疗装置，其包括外壳和附接到外壳的头部部分。头部包括引线腔，引线可插入该引线腔中。引导腔包括诸如弹簧的压缩装置，用于将高度可见的指示器柱塞对准，该高度可见的指示器柱塞至少部分地隐藏在由环形电极或部分围绕引线腔的其它不透明物体限定的体积内。柱塞包括至少一部分，其在植入医疗装置期间对外科医生容易看到。当引线插入引线腔时，引线的端部推压指示器柱塞，从而移动柱塞并压缩弹簧。当引线完全插入引线腔中时，柱塞被从远离由环形电极限定的体积推开时可见。以这种方式，柱塞提供铅指示已被完全插入到头部中的肯定指示。环形电极还可以包括保持表面，该保持表面将在活塞从弹簧松开时接触柱塞上的对应表面。如果柱塞远离弹簧，该功能有助于保持柱塞不会从集管移动到主体内。

10. 发明授权

US6096061A Defibrillator with improved hemodynamic response and enhanced myocardial stability 失效
标题翻译：除颤器具有改善的血液动力学反应和增强的心肌稳定性
公开(公告)号：US6096061A
公开(公告)日：2000-08-01
申请号：US874032
申请日：1997-06-12
申请人： Eckhard Alt , Lawrence J. Stotts
发明人： Eckhard Alt , Lawrence J. Stotts
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/36585
摘要： An implantable medical interventional device responds to detection of any of a plurality of cardiac dysrhythmias in a human patient by performing an appropriate therapy which may include cardiac pacing, cardioversion or defibrillation according to the nature of the detected dysrhythmia. A first sensor detects whether and what type of dysrhythmia is occurring. A generator produces pulses and/or shocks for delivery to the patient's heart according to whether a detected dysrhythmia is bradycardia or slow pathologic tachycardia on the one hand, or fast tachycardia or fibrillation on the other hand. An optimizer in the device at all times maintains a substantial match of the cardiac pacing rate to the hemodynamic needs of the implant patient under conditions of rest and physical activity; including sensing and distinguishing periods of patient physical activity and rest, and generating a signal representative thereof to control the cardiac pacing rate accordingly. In this way, the device focuses on correction of cardiac pacing problems before they become sufficiently aggravated to require more aggressive cardioversion and defibrillation therapies.
摘要翻译：可植入医疗介入装置通过根据检测到的心律失常的性质进行包括心脏起搏，心脏复律或除颤的适当治疗来响应人类患者的多种心律失常中的任何一种的检测。第一个传感器检测是否发生了什么类型的心律失常。发生器根据检测到的心律失常是一方面是心动过缓还是缓慢的病理性心动过速，另一方面产生快速心动过速或颤动，产生脉冲和/或冲击以递送到患者的心脏。在休息和身体活动的条件下，器械中的优化器始终保持心脏起搏速率与植入物患者的血液动力学需求的实质性匹配; 包括感测和区分患者身体活动和休息的周期，以及产生代表其的信号以相应地控制心脏起搏速率。以这种方式，该装置在心脏起搏问题变得充分恶化以前需要进行更积极的心脏复律和除颤疗法，其重点是矫正心脏起搏问题。

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