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1. 发明授权

US5281210A Accumulator for implantable pump 失效
标题翻译：可植入泵的蓄能器
公开(公告)号：US5281210A
公开(公告)日：1994-01-25
申请号：US946848
申请日：1992-09-18
申请人： Paul F. Burke , Samir F. Idriss
发明人： Paul F. Burke , Samir F. Idriss
IPC分类号： A61M5/142 , A61M31/00
CPC分类号： A61M5/14276 , A61M5/16881
摘要： An accumulator for an implantable infusion system employs a pair of separated diaphragms movable in unison by a transfer fluid disposed therebetween. A first chamber receives infusate in metered amounts and dispenses the contents as a function of toggled valve operation. During filling, the first diaphragm deflects upward and by pressure transfer causes a corresponding deflection in the second diaphragm. The second diaphragm is biased by springs, gas under pressure or the like. Hence, when the outlet valve opens, the pressure differential across the diaphragm causes downward deflection. No mechanical stops are needed in the infusate chamber for the first diaphragm since its movement is controlled by the pressure differential across the second diaphragm.
摘要翻译：用于植入式输注系统的蓄能器采用一对分离的隔膜，其可通过设置在其间的输送流体一致地移动。第一腔室以计量量接收输液，并将内容物分配为切换阀门操作的功能。在填充期间，第一隔膜向上偏转并且通过压力传递引起第二隔膜中相应的偏转。第二隔膜由弹簧，气体在压力下等施加偏压。因此，当出口阀打开时，横跨隔膜的压力差导致向下偏转。在第一隔膜的输注腔室中不需要机械止动件，因为其运动由跨过第二隔膜的压力差来控制。

2. 发明授权

US5067943A Pressure regulator for implantable pump 失效
标题翻译：可压缩泵的压力调节器
公开(公告)号：US5067943A
公开(公告)日：1991-11-26
申请号：US412376
申请日：1989-09-26
申请人： Paul Burke
发明人： Paul Burke
IPC分类号： A61M5/14 , A61M5/142 , A61M5/168 , A61M37/00
CPC分类号： A61M5/14276 , A61M5/16881 , Y10S128/12
摘要： An implantable pump system employing a flow regulator isolates the regulator sensing chamber from the path of drug flow. This is accomplished by establishing either an independent sensing chamber in the regulator or coupling it to the propellant chamber of the pump. Additionally, a downstream restrictor may be used to provide an additional pressure drop between the regulator and the outlet catheter.

3. 发明授权

US5088983A Pressure regulator for implantable pump 失效
标题翻译：用于植入式泵的压力调节器
公开(公告)号：US5088983A
公开(公告)日：1992-02-18
申请号：US724032
申请日：1991-07-01
申请人： Paul Burke
发明人： Paul Burke
IPC分类号： A61M5/14 , A61M5/142 , A61M5/168 , A61M37/00
CPC分类号： A61M5/14276 , A61M5/16881 , Y10S128/12
摘要： An implantable pump system employing a flow regulator isolates the regulator sensing chamber from the path of drug flow. This is accomplished by establishing either an independent sensing chamber in the regulator or coupling it to the propellant chamber of the pump. Additionally, a downstream restrictor may be used to provide an additional pressure drop between the regulator and the outlet catheter.
摘要翻译：使用流量调节器的可植入泵系统将调节器感测室与药物流动的路径隔离开。这通过在调节器中建立独立的感测室或将其耦合到泵的推进剂室来实现。另外，可以使用下游限流器来在调节器和出口导管之间提供额外的压降。

4. 发明授权

US5045064A Constant pressure implantable pump reservoir 失效
标题翻译：恒压可植入式水泵
公开(公告)号：US5045064A
公开(公告)日：1991-09-03
申请号：US531592
申请日：1990-06-01
申请人： Samir F. Idriss
发明人： Samir F. Idriss
IPC分类号： A61M37/00 , A61M1/36 , A61M5/142
CPC分类号： A61M5/14276 , A61M2205/0266 , Y10S128/12
摘要： An implantable device uses shape memory alloy (SMA) as the driver to compress a reservoir thereby providing a constant pressure source fluid delivery device. The SMA may form either the reservoir itself by appropriate shaped sheets or it may form bands around a flexible reservoir member. The reservoir may also be formed of rigid members pivoted or clamped using SMA actuators to bias the rigid members together.
摘要翻译：可植入装置使用形状记忆合金（SMA）作为驱动器来压缩储存器，从而提供恒定的压力源流体输送装置。 SMA可以通过适当的成形片材形成储存器本身，或者可以围绕柔性储存器构件形成带。储存器也可以由使用SMA致动器枢转或夹紧的刚性构件形成，以将刚性构件偏置在一起。

5. 发明授权

US5207666A Passive shuttle metering device for implantable drug delivery system 失效
标题翻译：用于可植入式药物输送系统的被动式按钮式计量装置
公开(公告)号：US5207666A
公开(公告)日：1993-05-04
申请号：US752798
申请日：1991-08-30
申请人： Samir F. Idriss , Joshua Makower
发明人： Samir F. Idriss , Joshua Makower
IPC分类号： A61M1/36 , A61M5/00 , A61M5/168 , A61M37/00 , G01F11/04 , G01F11/16
CPC分类号： G01F11/16 , A61M5/16809 , G01F11/04 , Y10S128/12
摘要： A fluid metering device useful in implantable drug delivery systems is coupled between a pressurized fluid source and an outlet conduit to provide discrete flow pulses at a predetermined rate. The metering device consists of a first movable member constrained within a housing and a second movable member retained in a cavity by the first. Alternate positioning of the first member simultaneously fills and empties the cavity in which the second resides, discharging fluid through the conduit. The first movable member can be a planar slider, an axially translatable cylinder or a rotatable cylinder. The second movable member may be a flat shuttle, a sliding bar or a diaphragm.
摘要翻译：可用于可植入药物递送系统的流体计量装置联接在加压流体源和出口导管之间，以预定的速率提供离散的流动脉冲。计量装置由限制在壳体内的第一可动构件和通过第一可动构件保持在空腔中的第二可移动构件组成。第一构件的替代定位同时填充并排空第二构件所在的空腔，通过导管排出流体。第一可移动构件可以是平面滑块，可轴向平移的气缸或可旋转气缸。第二可动构件可以是平滑梭，滑杆或隔膜。

6. 发明授权

US5092849A Implantable device 失效
标题翻译：植入式装置
公开(公告)号：US5092849A
公开(公告)日：1992-03-03
申请号：US469895
申请日：1990-01-24
申请人： Edward J. Sampson
发明人： Edward J. Sampson
IPC分类号： A61M39/02
CPC分类号： A61M39/0208
摘要： A device that is implantable to provide access to multiple body sites for the administration or withdrawal of fluids. A hollow port has a self sealing septum on one end and an outlet at an opposite end. A catheter is connected to the outlet. The septum and outlet are positioned to be substantially in-line.
摘要翻译：可植入以提供对多个体部位进行流体管理或取出的装置。中空端口在一端具有自密封隔膜，在相对端具有出口。导管连接到出口。隔膜和出口被定位成基本上是直列的。

7. 发明授权

US4931050A Constant pressure variable flow pump 失效
标题翻译：恒压可变流量泵
公开(公告)号：US4931050A
公开(公告)日：1990-06-05
申请号：US180916
申请日：1988-04-13
申请人： Samir F. Idriss
发明人： Samir F. Idriss
IPC分类号： A61M5/168 , A61M5/14 , A61M5/142 , F16L55/027 , G05D7/01
CPC分类号： A61M5/14276 , A61M5/141 , A61M5/16881 , F16L55/027 , G05D7/0186 , A61M2205/3507 , A61M5/16813 , Y10S128/12
摘要： A variable flow constant pressure implantable pump employs an in-line needle restrictor having a variable insertion distance in a capillary. The degree of insertion determines the effective restriction within the capillary. The restrictor may be repositioned following implantation to vary the drug delivery rate by changing the effective restriction in the capillary. Various couplings may be used such that an auxiliary or bolus port delivers infusate directly into the outlet catheter so that medication from the main chamber does not pass through the auxiliary chamber. A combination of double lumen catheters and T-connectors are employed to provide parallel infusion paths.

8. 发明授权

US5176641A Implantable drug infusion reservoir having fluid impelling resilient foam member 失效
标题翻译：具有流体活动性泡沫构件的可浸入式药物输注储存器
公开(公告)号：US5176641A
公开(公告)日：1993-01-05
申请号：US726659
申请日：1991-07-08
申请人： Samir F. Idriss
发明人： Samir F. Idriss
IPC分类号： A61M37/00 , A61M5/142 , A61M5/145
CPC分类号： A61M5/14276 , A61M5/145
摘要： An implantable infusion reservoir having a resilient foam member in a rigid housing to urge fluid to an implantation site. The foam member compresses upon charging and then expands to maintain a predetermined pressure characteristic within the fluid. The foam replaces the previously used two-phase propellent and eliminates the need for a hermetic metal bellows. The foam may be either closed celled or open celled, with or without a barrier skin. The device can be conformal to any desired shape and employ various metering techniques to deliver accurate quantities of fluid.
摘要翻译：一种植入式输液容器，其具有在刚性壳体中的弹性泡沫构件，以将流体推动到植入部位。泡沫构件在充电时压缩，然后膨胀以在流体内保持预定的压力特性。泡沫代替以前使用的两相推进剂，并且不需要密封的金属波纹管。泡沫可以是闭孔的或开孔的，具有或不具有屏障皮肤。该装置可以与任何期望的形状保持一致，并采用各种计量技术来提供精确量的流体。

9. 发明授权

US5061242A Adjustable implantable drug infusion system 失效
标题翻译：可调植入式药物输注系统
公开(公告)号：US5061242A
公开(公告)日：1991-10-29
申请号：US381350
申请日：1989-07-18
申请人： Edward J. Sampson
发明人： Edward J. Sampson
IPC分类号： A61M5/142 , A61M5/168 , A61M31/00 , A61M37/00 , G05D7/01
CPC分类号： A61M5/16881 , G05D7/0113 , A61M2005/14264 , A61M5/14276
摘要： A drug delivery system for implantation into a living body having a pressure actuated infusion pump and an adjustable flow regulator. The regulator comprises a body having a regulator cavity divided by a diaphragm into two chambers. One chamber serves as a pressure sensor and the other as a conduit through which fluid flows. The outlet from the conduit chamber can be sealed by diaphragm movement as a function of pressure increase or the flow restricted. The outlet itself is mounted on an adjustable fitting that is movable relative to the diaphragm. The distance between the outlet and the diaphragm may be set as a calibration of the regulator.

10. 发明授权

US4838887A Programmable valve pump 失效
标题翻译：可编程阀门泵
公开(公告)号：US4838887A
公开(公告)日：1989-06-13
申请号：US133400
申请日：1987-12-15
申请人： Samir F. Idriss
发明人： Samir F. Idriss
IPC分类号： A61M5/142 , G01F11/08
CPC分类号： A61M5/14276 , G01F11/08 , A61M2205/3523 , A61M2206/22 , Y10S128/12
摘要： An implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a drug reservoir maintained a constant pressure vapor. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume spike to an outlet catheter. In order to minimize dead volume and insure complete discharge, the accumulator employs a titanium diaphragm seated in one position by a recessed stop and in the discharge position by a spacer plate having a groove pattern. The unit is externally programmed.

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