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1. 发明授权

US4663478A Process for producing a para-substituted phenol derivative 失效
标题翻译：对位取代苯酚衍生物的制备方法
公开(公告)号：US4663478A
公开(公告)日：1987-05-05
申请号：US725360
申请日：1985-04-18
申请人： Hidefuni Hirai , Makoto Komiyama , Izuru Sugiura
发明人： Hidefuni Hirai , Makoto Komiyama , Izuru Sugiura
IPC分类号： C07C37/11 , C07C37/18 , C07C45/00 , C07C45/51 , C07C45/74 , C07C51/00 , C07C51/093 , C07C65/04
CPC分类号： C07C51/00 , C07C45/00 , C07C45/008 , C07C45/512 , C07C45/74 , C07C51/093
摘要： By reacting a phenol compound with an organic halide selected from the group consisting of a haloform, a carbon tetrahalide and a substituted or unsubstituted allyl halide in the presence of an alkali metal hydroxide, using as a catalyst a fixed cyclodextrin having hydroxyl groups crosslinked with a bivalent hydrocarbon group having free valences at its both ends, said hydrocarbon group having at least one hydrogen atom substituted or unsubstituted with a member selected from the group consisting of an alkyl group, a halogen atom and a hydroxyl group and containing or not containing at least one combination of two neighboring carbon atoms having therebetween at least one member selected from the group consisting of an oxygen atom, a sulfur atom and a phenylene, various useful para-substituted phenol derivatives can be advantageously obtained. The fixed cyclodextrin which has been used as the catalyst can be extremely easily separated from the reaction system without any loss of the fixed cyclodextrin, and the recovered fixed cyclodextrin can be used repeatedly as a catalyst in the process of the present invention without lowering in yield of and selectivity for para-substituted phenol derivatives.
摘要翻译： PCT No.PCT / JP85 / 00057 Sec。 371日期：1985年4月18日 102（e）日期1985年4月18日PCT提交1985年2月13日PCT公布。公开号WO85 / 03701 1985年8月29日。在碱金属氢氧化物的存在下，使苯酚化合物与选自卤代甲酰基，四卤化碳和取代或未取代的烯丙基卤的有机卤化物反应，使用固定具有在其两端与具有游离价的二价烃基交联的羟基的环糊精，所述烃基具有至少一个被选自烷基，卤素原子和羟基的成员所取代或未取代的氢原子并且含有或不包含两个相邻碳原子的至少一个组合，其间具有选自氧原子，硫原子和亚苯基中的至少一个的成员，可以有利地获得各种有用的对位取代的酚衍生物。已经用作催化剂的固定的环糊精可以非常容易地从反应体系中分离出来，而没有固定的环糊精的任何损失，并且回收的固定的环糊精可以在本发明的方法中作为催化剂反复使用，而不降低产率的对位取代的苯酚衍生物的选择性。

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