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1. 发明授权

US4923437A Process for applying a localized magnetic or electric field 失效
标题翻译：施加局部磁场或电场的方法
公开(公告)号：US4923437A
公开(公告)日：1990-05-08
申请号：US250821
申请日：1988-09-27
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61K41/00 , A61N2/00 , A61N2/10 , G01N33/532 , G01N33/553
CPC分类号： A61N2/00 , A61K41/0019 , G01N33/532 , G01N33/553
摘要： The process includes applying a localized static, magnetic or electric field to neurological or neuromuscular tissue to aid in the intracellular uptake and energy absorption of electric or magnetic dipoles present in the tissue and the cells. Before the applying step dipoles can be introduced in the tissues or cells. Also, after or during the applying step, an alternating, oscillating or pulsed electromagnetic field can be applied to the tissue to enhance the intracellular uptake of energy, and the energy absorption responsiveness in the tissue and/or the energy absorption of the dipoles in the tissue. The process can utilize a constant magnetic field through the interaction with the intracellular dipoles in the tissue. Further, an external electromagnetic field can be applied to the tissue to excite the particles and raise the energy level of the tissue to destroy the cells and modify their behavior to decrease the degenerative process. Additionally, particles can be introduced into the extracellular environment of the tissue to alter membrane events and potentiate energy delivery to the diseased inflammatory or reactive cells or reduce energy delivery to the normal cells.
摘要翻译：该方法包括将局部静态，磁场或电场施加到神经或神经肌肉组织，以帮助存在于组织和细胞中的电或磁偶极子的细胞内吸收和能量吸收。在施用步骤之前，可将偶极子引入组织或细胞中。此外，在施加步骤之后或期间，可以将交替的，振荡的或脉冲的电磁场施加到组织以增强细胞内的能量摄取，并且组织中的能量吸收反应性和/或偶极子的能量吸收在组织。该过程可以通过与组织中细胞内偶极子的相互作用来利用恒定的磁场。此外，可以对组织施加外部电磁场以激发颗粒并提高组织的能量水平以破坏细胞并改变其行为以减少退行过程。另外，颗粒可以被引入到组织的细胞外环境中以改变膜事件并且增强能量递送到患病的炎症或反应性细胞或减少向正常细胞的能量递送。

2. 发明授权

US4731239A Method for enhancing NMR imaging; and diagnostic use 失效
标题翻译：增强核磁共振成像的方法和诊断用途
公开(公告)号：US4731239A
公开(公告)日：1988-03-15
申请号：US916350
申请日：1986-10-07
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： G01R33/28 , A61K49/00 , A61B5/05 , A61B6/00
CPC分类号： G01R33/5601 , Y10S436/806 , Y10T436/24
摘要： An improvement in NMR imaging techniques is disclosed, whereby the image is "shadowed" to intensify and contrast the image generated by the NMR sensitive nuclei, as a consequence of the introduction to the examined locus, e.g., human tissue of ferromagnetic, diamagnetic or paramagnetic particles. The intensified and clarified image is itself diagnostically valuable, in accordance with art recognized methods but also provides an improved information base for establishing and controlling treatment modes, especially in determining spatial density and distribution of particles by comparing standard and enhanced images. According to a preferred embodiment, metabolizable particles are employed, whereby the change and rate of change with metabolic time can be imaged, compared, and correlated with various metabolic diseases or malignant states.
摘要翻译：公开了NMR成像技术的改进，由此，作为引入检查的轨迹的结果，例如人体铁磁性，抗磁性或顺磁性的组织，图像被“阴影化”以增强和对比由NMR敏感核产生的图像粒子。加强和澄清的图像本身在诊断上是有价值的，根据艺术公认的方法，但也提供了改进的信息库，用于建立和控制治疗模式，特别是通过比较标准和增强图像来确定颗粒的空间密度和分布。根据优选实施方案，可以使用可代谢的颗粒，由此与代谢时间的变化和变化率可被成像，比较并与各种代谢疾病或恶性状态相关联。

3. 发明授权

US4662359A Use of magnetic susceptibility probes in the treatment of cancer 失效
标题翻译：使用磁化率探针治疗癌症
公开(公告)号：US4662359A
公开(公告)日：1987-05-05
申请号：US535390
申请日：1983-09-23
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61K9/50 , A61K41/00
CPC分类号： A61K9/5094 , A61K41/0052
摘要： Described is a process for the treatment of cancer in at least one region of host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising:providing to a host organism minute particles capable of being inductively heated and of size capable of being absorbed into cancer cells,determining, after a period of metabolic time, the magnetic susceptibility of the particles with said region,subjecting the organism to an alternating electromagnetic field to inductively heat said particles at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cell and normal cells within said region occurs, andcontinuing the inductive heating of said particles to attain an increase in intracellular temperature to selectively kill the cancer cells.
摘要翻译：描述了在含有癌细胞和正常细胞的宿主生物体的至少一个区域中治疗癌症的过程，而没有实质损害生命正常细胞的方法，包括：向宿主生物体提供能够感应加热并且能够被吸收的大小的微小颗粒在一段时间的代谢时间之后，确定具有所述区域的颗粒的磁化率，使生物进行交变的电磁场，以在代谢时间点在该点感应加热所述颗粒，当磁化率的最大差异在发生所述区域内的癌细胞和正常细胞，并继续感应加热所述颗粒以获得细胞内温度的升高以选择性地杀死癌细胞。

4. 发明授权

US4622952A Cancer treatment method 失效
标题翻译：癌症治疗方法
公开(公告)号：US4622952A
公开(公告)日：1986-11-18
申请号：US681697
申请日：1984-12-14
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61N1/40 , A61N1/42
CPC分类号： A61N1/406
摘要： A process for the treatment of cancer by the application of external electromagnetic energy capable of achieving biophysical alterations in the intracellular structure of cancer cells in living tissue, including stimulation of intracellular production of interferon. The process accomplishes these biophysical alterations by tuning an external electromagnetic energy to the resonant energy absorption frequencies of the intracellular structure of the selected cells and then exposing the subject to this tuned electromagnetic energy field. Alternatively, the field can be tuned to the frequency which has been calculated to be closest to the resonant frequency of the cancer cells and furthest from the resonant frequency of the normal cells. The process may be further enhanced by the intracellular absorption of selected materials designed to alter the magnetic susceptibility and therefore the resonant energy absorption frequency of the intracellular structure.
摘要翻译：一种通过应用能够实现活体组织中癌细胞的细胞内结构的生物物理学改变的外部电磁能来治疗癌症的方法，包括刺激细胞内产生干扰素。该过程通过将外部电磁能调谐到所选择的细胞的细胞内结构的共振能量吸收频率，然后将受试者暴露于该调谐的电磁能场来实现这些生物物理学改变。或者，该场可被调谐到被计算为最接近癌细胞的谐振频率并且最远离正常细胞的共振频率的频率。通过细胞内吸收所设计的改变磁化率和因此细胞内结构的共振能量吸收频率的材料，可以进一步增强该过程。

5. 发明授权

US4359453A Atherosclerosis treatment method 失效
标题翻译：动脉粥样硬化治疗方法
公开(公告)号：US4359453A
公开(公告)日：1982-11-16
申请号：US894504
申请日：1978-04-07
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61K9/50 , A61K33/26 , A61K41/00 , A61K49/00 , A61K43/00 , G01T1/00
CPC分类号： A61K49/00 , A61K33/26 , A61K41/0052 , A61K9/5094 , A61K2121/00
摘要： A treatment of atherosclerosis by the application of external electromagnetic energy capable of the generation of heat and biophysical alterations in intracellular particles and particles within atherosclerotic plaques to induce resolution of the atherosclerotic plaques. This process allows for the selective treatment of the atherosclerotic plaque without damaging the normal blood vessel by the compartmentalized alteration of biophysical properties within the atherosclerotic lesion.The process comprises introducing minute particles into the interior of atherosclerotic plaques and the cells involved in the lesion. These particles being injected intravenously while suspended in an appropriate solution are of a size generally having a diameter of approximately 1 micron or less and one of a material with properties such as ferromagnetic, paramagnetic or diamagnetic so as to be inductively heated when subjected to a high frequency alternating electromagnetic field. Introducing the particles as described the patient is thereafter subjected to an alternating electromagnetic field to inductively heat the particles sufficiently to raise the temperature of the atherosclerotic lesion and destroy the atherosclerotic lesion without harming the normal artery or intima.
摘要翻译：通过应用能够在动脉粥样硬化斑块内产生热和生物物理变化的细胞内颗粒和颗粒的外部电磁能来诱导动脉粥样硬化的治疗以诱导动脉粥样硬化斑块的分解。该过程允许选择性地治疗动脉粥样硬化斑块，而不会通过在动脉粥样硬化病变中的生物物理性质的划分改变而损害正常血管。该方法包括将微小颗粒引入到动脉粥样硬化斑块和涉及病变的细胞的内部。悬浮在合适溶液中时静脉注射的这些颗粒的尺寸通常为约1微米或更小的直径，以及具有铁磁性，顺磁性或抗磁性等特性的材料之一，以便当受到高的感应加热时频率交替电磁场。如上所述，引入颗粒，患者随后进行交变电磁场，以充分感应加热颗粒以升高动脉粥样硬化病变的温度并破坏动脉粥样硬化病变而不损害正常动脉或内膜。

6. 发明授权

US5612019A Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles 失效
标题翻译：使用磁性金属转铁蛋白颗粒诊断和治疗HIV病毒感染
公开(公告)号：US5612019A
公开(公告)日：1997-03-18
申请号：US195070
申请日：1994-02-14
申请人： David Gordon, deceased , by Eunice Gordon, legal representative , Robert T. Gordon
发明人： David Gordon, deceased , by Eunice Gordon, legal representative , Robert T. Gordon
IPC分类号： A61B5/055 , A61K9/50 , A61K31/295 , A61K33/00 , A61K33/24 , A61K33/26 , A61K41/00 , A61K49/18 , G01N33/569
CPC分类号： A61K9/5094 , A61K31/295 , A61K33/00 , A61K33/24 , A61K33/26 , A61K41/0052 , A61K49/1818 , A61K49/183 , G01N33/56988 , Y10T436/24
摘要： This invention provides methods of treatment and/or diagnosis and/or siting of viruses including the AIDS virus and others as well as the cells which they infect. The method comprises introducing near, into or onto the virus or the cell which the virus infects, or both, minute particles. These particles possess ferromagnetic, paramagnetic or diamagnetic properties. After being localized near, in or on the virus or the viral-infected cell, the particles are inductively heated by application of an alternating electromagnetic field. The inductive heating is continued for a period of time sufficient to bring about a temperature rise to a minimum necessary to kill the virus or cell or to desirably alter the behavior of the virus or infected cell. Prior to, during or after treatment, these particles can be used diagnostically to locate and/or map the virus in the living tissue.
摘要翻译：本发明提供了治疗和/或诊断和/或选择病毒的方法，所述病毒包括AIDS病毒和其他病毒以及它们感染的细胞。该方法包括在病毒或病毒感染的细胞附近或之上或之外引入微量颗粒。这些颗粒具有铁磁性，顺磁性或抗磁性。在被定位在病毒或病毒感染细胞附近或之上时，通过施加交变电磁场感应加热颗粒。感应加热持续一段时间，足以使温度上升到杀死病毒或细胞所需的最低限度，或者期望地改变病毒或感染细胞的行为。在治疗之前，期间或之后，这些颗粒可以在诊断上用于在病毒组织中定位和/或映射病毒。

7. 发明授权

US5087438A Method for affecting intracellular and extracellular electric and magnetic dipoles 失效
标题翻译：影响细胞内和细胞外电磁偶极子的方法
公开(公告)号：US5087438A
公开(公告)日：1992-02-11
申请号：US221991
申请日：1988-07-20
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61B19/00 , A61K31/00 , A61K41/00
CPC分类号： A61K41/0052 , A61K31/00 , A61B2090/3925
摘要： A treatment of infectious diseases and enhancement of genetic engineering processes is described comprising the use of external electromagnetic energy to alter electric and magnetic dipoles intracellularly.The process comprises introducing minute particles into the interior of cells in a host organism. These particles are capable of affecting the intracellular conductivity, dielectric properties, dipole content and membrane characteristics of the cell and nucleus. The particles are introduced intravenously, intra-arterially, and/or intra-lymphatically and the organism is then exposed to an alternating electromagnetic field to introduce energy into the cells.
摘要翻译：描述了感染性疾病的治疗和基因工程过程的增强，其包括使用外部电磁能来在细胞内改变电和磁偶极子。该方法包括将微小颗粒引入宿主生物体内的细胞内。这些颗粒能够影响细胞和细胞核的细胞内电导率，介电特性，偶极子含量和膜特性。静脉内，动脉内和/或淋巴内引入颗粒，然后将生物体暴露于交替电磁场以将能量引入细胞。

8. 发明授权

US4994014A Process for treating diseased cells including the step of raising the subjects blood oxygen level 失效
标题翻译：包括治疗患病细胞的方法，包括提高受试者血氧水平的步骤
公开(公告)号：US4994014A
公开(公告)日：1991-02-19
申请号：US224144
申请日：1988-07-26
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61K33/26 , A61K41/00 , A61N2/04
CPC分类号： A61K33/26 , A61K41/0052
摘要： A process for treating diseased cells in the living tissue of a subject. A solution of ferric oxyhydroxide or other intracellular chemically-generated, energy particles is intravenously injected into the subject. After the particles have been intracellularly absorbed by the diseased cells, the oxygen level in the subject's blood is raised, as by subjecting him to hyperbaric air or oxygen. This increases the rate of the intracellular absorption of oxygen by the diseased cells. This oxygen absorption then together with the intracellularly-absorbed particles increase the rate of oxidation and metabolism of the particles, and thereby raise the subject's intracellular energy. The intracellular production of interleukins and other activators, such as interferons and prostaglandins, is thereby stimulated, and these interleukins and other activators destroy the diseased cells wherever they may be in the subject. This process can be enhanced by then applying an alternating electromagnetic field tuned to a resonant frequency to the subject.
摘要翻译：用于治疗受试者的活组织中的病变细胞的方法。将羟基氧化氢或其他细胞内化学产生的能量粒子的溶液静脉内注射到受试者体内。在颗粒被细胞内细胞吸收之后，受试者的血液中的氧水平升高，因为他受到高压空气或氧气的影响。这增加了患病细胞对细胞内的氧吸收速率。然后，这种氧吸收与细胞内吸收的颗粒一起增加了颗粒的氧化和代谢速率，从而提高了受试者的细胞内能量。因此刺激白细胞介素和其它激活因子如干扰素和前列腺素的细胞内产生，并且这些白细胞介素和其它活化剂破坏患病细胞，无论他们在哪里。然后可以通过将被调谐到谐振频率的交变电磁场施加到被摄体来增强该过程。

9. 发明授权

US4950221A Process for affecting molecules in tissue 失效
标题翻译：影响组织分子的方法
公开(公告)号：US4950221A
公开(公告)日：1990-08-21
申请号：US250824
申请日：1988-09-27
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A61K41/00 , A61N2/00 , A61N2/10 , G01N33/532 , G01N33/553
CPC分类号： A61N2/00 , A61K41/0019 , G01N33/532 , G01N33/553
摘要： A process for affecting molecules in neurological or neuromuscular tissue and cells and subcellular structures in the tissue of a host organism. The process includes introducing particles into the living cells of the tissues and thereby affecting the relative dipole moment and producing direct effects on subcellular structures and molecules in the cells of the tissues. A constant magnetic field can be applied to the tissue to enhance the dipole moment in the neurological or neuromuscular tissue and in their cells, or to enhance the effect of an alternative electromagnetic field applied to the tissue.
摘要翻译：用于影响宿主生物体组织中神经或神经肌肉组织和细胞和亚细胞结构中的分子的方法。该方法包括将颗粒引入组织的活细胞，从而影响相对偶极矩，并且对组织细胞中的亚细胞结构和分子产生直接作用。可以向组织施加恒定的磁场以增强神经或神经肌肉组织及其细胞中的偶极矩，或增强施加到组织的替代电磁场的效果。

10. 发明授权

US4829984A Method for the improvement of transplantation techniques and for the preservation of tissue 失效
标题翻译：改善移植技术和保存组织的方法
公开(公告)号：US4829984A
公开(公告)日：1989-05-16
申请号：US936321
申请日：1986-12-01
申请人： Robert T. Gordon
发明人： Robert T. Gordon
IPC分类号： A01N1/02 , A61B19/00 , A61F7/00 , A61N1/40
CPC分类号： A01N1/0294 , A01N1/0226 , A61B90/00 , A61N1/406 , A61F2007/009
摘要： The present invention relates to a process for improvement and enhancement of transplantation by the introduction of particles to the tissue area where rejection may occur. The tissue is then subjected to a constant magnetic field thereby affecting the metabolism of the cells therein. Also contemplated is the use of a constant magnetic field to effect naturally occurring paramagnetic or ferromagnetic components in the cells of tissue during transplantation.
摘要翻译：本发明涉及通过将颗粒引入可能发生排斥的组织区域来改善和增强移植的方法。然后使组织经受恒定的磁场，从而影响细胞的代谢。还考虑使用恒定的磁场在移植期间在组织细胞中实现天然存在的顺磁性或铁磁性成分。

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