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1. 发明申请

US20140179801A1 Inhibition of the Survival of Lymphoma by Cyclohexenone Compounds from Antrodia Camphorata 审中-公开
标题翻译：抑制樟芝中环己烯酮化合物对淋巴瘤的生存
公开(公告)号：US20140179801A1
公开(公告)日：2014-06-26
申请号：US14195534
申请日：2014-03-03
申请人： Golden Biotechnology Corporation
发明人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
IPC分类号： C07C49/753
CPC分类号： C07C49/753 , A61K31/122
摘要： The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3 -dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6, 10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of lymphoma cells and be used as a pharmaceutical composition to inhibit the lymphoma tumor growth.
摘要翻译：本发明涉及化合物的新应用。本发明的化合物4-羟基-2,3-二甲氧基-6-甲基-5-（3,7,11-三甲基 - 十二-2,6,10-三烯基） - 环己-2-烯酮被分离和纯化来自樟芝的提取物，其可用于抑制淋巴瘤细胞的存活并用作抑制淋巴瘤肿瘤生长的药物组合物。

2. 发明申请

US20110060055A1 Inhibition of the Survival of Lymphoma by Cyclohexenone Compounds from Antrodia Camphorata 审中-公开
标题翻译：抑制樟芝中环己烯酮化合物对淋巴瘤的生存
公开(公告)号：US20110060055A1
公开(公告)日：2011-03-10
申请号：US12871321
申请日：2010-08-30
申请人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
发明人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
IPC分类号： A61K31/122 , A61P35/00
CPC分类号： C07C49/753 , A61K31/122
摘要： The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of lymphoma cells and be used as a pharmaceutical composition to inhibit the lymphoma tumor growth.
摘要翻译：本发明涉及化合物的新应用。本发明化合物4-羟基-2,3-二甲氧基-6-甲基-5-（3,7,11-三甲基 - 十二-2,6,10-三烯基） - 环己-2-烯酮被分离和纯化来自樟芝的提取物，其可用于抑制淋巴瘤细胞的存活并用作抑制淋巴瘤肿瘤生长的药物组合物。

3. 发明申请

US20110059122A1 Inhibition of the Survival of Oral Cavity Cancer by Cyclohexenone Compounds from Antrodia Camphorata 审中-公开
标题翻译：抑制樟芝中环己烯酮化合物对口腔癌的生存
公开(公告)号：US20110059122A1
公开(公告)日：2011-03-10
申请号：US12876498
申请日：2010-09-07
申请人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
发明人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
IPC分类号： A61K31/122 , A61K31/133 , A61K31/145 , A61K36/07 , A61P35/00
CPC分类号： A61K31/122 , A61K9/0095 , A61K9/2004 , A61K9/5005 , A61K36/07
摘要： The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of oral cavity cancer cells and be used as a pharmaceutical composition to inhibit the oral cavity tumor growth.
摘要翻译：本发明涉及化合物的新应用。本发明化合物4-羟基-2,3-二甲氧基-6-甲基-5-（3,7,11-三甲基 - 十二-2,6,10-三烯基） - 环己-2-烯酮被分离和纯化来自樟芝的提取物，其可以用于抑制口腔癌细胞的存活并用作抑制口腔肿瘤生长的药物组合物。

4. 发明申请

US20110009495A1 Inhibition of the Survival of Bone Cancer by Cyclohexenone Compounds from Antrodia Camphorata 审中-公开
标题翻译：抑制来自樟芝的环己烯酮化合物对骨癌的生存
公开(公告)号：US20110009495A1
公开(公告)日：2011-01-13
申请号：US12832624
申请日：2010-07-08
申请人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
发明人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
IPC分类号： A61K31/122 , A61P35/00
CPC分类号： A61K36/07 , A61K31/122
摘要： The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of bone cancer cells and be used as a pharmaceutical composition to inhibit the bone tumor growth.
摘要翻译：本发明涉及化合物的新应用。本发明化合物4-羟基-2,3-二甲氧基-6-甲基-5-（3,7,11-三甲基 - 十二-2,6,10-三烯基） - 环己-2-烯酮被分离和纯化可以用于抑制骨癌细胞存活的Anticonia樟脑提取物，并用作抑制骨肿瘤生长的药物组合物。

5. 发明授权

US07501454B2 Cyclohexenone compounds from Antrodia camphorata to treat autoimmune diseases 有权
标题翻译：来自樟芝的环己烯酮化合物治疗自身免疫性疾病
公开(公告)号：US07501454B2
公开(公告)日：2009-03-10
申请号：US11882196
申请日：2007-07-31
申请人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
发明人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
IPC分类号： A61K31/12 , C07C49/543
CPC分类号： C07C403/02 , A61K31/122 , C07C2601/16
摘要： The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.
摘要翻译：本发明涉及一种用于治疗自身免疫性疾病的樟芝（Antigdia camphorata）化合物，特别涉及一种提取物，4-羟基-2,3-二甲氧基-6-甲基-5（3,7,11-三甲基 - 十二烷-2） 6,10-三烯基） - 环己-2-烯酮，其用于缓解自身免疫疾病如系统性红斑狼疮（SLE）的症状。根据本发明的环己烯酮化合物有助于降低SLE哺乳动物中的蛋白尿水平和抗核抗体滴度，以减轻肾脏炎症和疾病，以及由抗核抗体引起的自身损伤。然后可以实现通过天然的副作用游离物质预防和治疗自身免疫疾病和肾脏疾病的目的。

6. 发明授权

US07468392B1 Anti-fatigue cyclohexenone compounds from antrodia camphorata 有权
标题翻译：来自樟芝的抗疲劳环己烯酮化合物
公开(公告)号：US07468392B1
公开(公告)日：2008-12-23
申请号：US11829745
申请日：2007-07-27
申请人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
发明人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
IPC分类号： A61K31/12 , C07C49/543
CPC分类号： C07C403/02 , C07C2601/16
摘要： The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6-10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80% VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.
摘要翻译：本发明涉及一种用于延缓生理疲劳的樟脑类化合物，特别是涉及从樟芝（Antrodia camphorata）分离的提取物，4-羟基-2,3-二甲氧基-6-甲基-5（3,7,11-三甲基 - 十二-2,6-10-三烯基） - 环己-2-烯酮，并用于延缓疲劳。在80％VO2max高强度排气运动后立即补充本发明化合物可促进人体中磷酸肌酸激酶和血氨的代谢，有利于其恢复，进一步达到延缓生理疲劳的功能。

7. 发明申请

US20080312334A1 CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA TO TREAT AUTOIMMUNE DISEASES 有权
标题翻译：来自天竺葵的CYCLOHEXENONE化合物治疗自身免疫性疾病
公开(公告)号：US20080312334A1
公开(公告)日：2008-12-18
申请号：US11882196
申请日：2007-07-31
申请人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
发明人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
IPC分类号： A61K31/12 , A61P37/00 , C07C49/00
CPC分类号： C07C403/02 , A61K31/122 , C07C2601/16
摘要： The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.
摘要翻译：本发明涉及一种用于治疗自身免疫性疾病的樟芝（Antigdia camphorata）化合物，特别涉及一种提取物，4-羟基-2,3-二甲氧基-6-甲基-5（3,7,11-三甲基 - 十二烷-2） 6,10-三烯基） - 环己-2-烯酮，其用于缓解自身免疫疾病如系统性红斑狼疮（SLE）的症状。根据本发明的环己烯酮化合物有助于降低SLE哺乳动物中的蛋白尿水平和抗核抗体滴度，以减轻肾脏炎症和疾病，以及由抗核抗体引起的自身损伤。然后可以实现通过天然的副作用游离物质预防和治疗自身免疫疾病和肾脏疾病的目的。

8. 发明授权

US07456225B1 Liver protection compounds of the cyclohexenone type from Antrodia camphorata 失效
标题翻译：来自樟芝的环己烯酮类型的肝保护化合物
公开(公告)号：US07456225B1
公开(公告)日：2008-11-25
申请号：US11902599
申请日：2007-09-24
申请人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
发明人： Sheng-Yun Liu , Wu-Che Wen , Mao-Tien Kuo
IPC分类号： A61K31/12 , C07C49/543 , C07C49/557
CPC分类号： A61K36/07 , A61K31/12 , C07C403/02 , C07C2601/16
摘要： The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.
摘要翻译：本发明涉及一种用于肝保护的樟脑类化合物，特别涉及一种提取物，4-羟基-2,3-二甲氧基-6-甲基-5（3,7,11-三甲基 - 十二烷-2,6- ，10-三烯基） - 环己-2-烯酮，其从樟脑中分离。根据本发明的环己烯酮化合物有助于缓解由化学物质引起的肝脏损伤和纤维化，并降低丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的水平。通过增加谷胱甘肽过氧化物酶（GSHPx）和过氧化氢酶（CAT）的含量，环己烯酮进一步降低了肝脏损伤和自由基引起的氧化压力，提高了抗氧化能力，达到了肝脏保护的目的。

9. 发明授权

US11364209B2 Methods and compositions for treating atopic dermatitis 有权
公开(公告)号：US11364209B2
公开(公告)日：2022-06-21
申请号：US16349155
申请日：2017-11-17
申请人： Golden Biotechnology Corporation
发明人： Sheng-Yung Liu , Chih-Ming Chen
IPC分类号： A61K31/122 , A61P17/00 , A61K9/00 , A61K36/07 , C07C403/04 , C07C403/18 , A61K9/48 , C07C403/20 , A61P29/00 , C07C403/02 , C07C403/16 , C07C403/08 , C07C403/14
摘要： The present invention provides methods and compositions for treating atopic dermatitis by cyclohexenone compounds.

10. 发明授权

US09365481B2 Cyclohexenone compositions and process for making thereof 有权
标题翻译：环己烯酮组合物及其制备方法
公开(公告)号：US09365481B2
公开(公告)日：2016-06-14
申请号：US14184954
申请日：2014-02-20
申请人： Golden Biotechnology Corporation
发明人： Sheng-Yung Liu , Wu-Che Wen , Chih-Ming Chen , Hsiu-Yi Cheng
IPC分类号： C07C49/753 , C07D307/20 , C07C45/00 , C07C45/61
CPC分类号： C07C403/02 , C07C45/00 , C07C45/61 , C07C49/753 , C07C403/20 , C07D307/20 , C07D307/33
摘要： Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.
摘要翻译：本文提供了制备用于癌症治疗和/或疾病的环己烯酮化合物的方法。

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