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    • 1. 发明授权
    • Filter methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses
    • 用于从用于单层沉积,分析或其他用途的样品悬浮液中捕获所需量的材料的过滤方法
    • US07341669B2
    • 2008-03-11
    • US11010897
    • 2004-12-13
    • Gary W. Ferguson
    • Gary W. Ferguson
    • G01N1/28
    • G01N15/0618B01D61/22G01N1/2813G01N1/4077Y10T436/25375
    • The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs sensors to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow. Typically, pressure is used to provide a means to cause the sample suspension to flow through the filter, which is preferably a membrane filter for monolayer deposition. In some embodiments a novel syringe provides this pressure, functioning as a vacuum source. The filter apparatus may be further automated to process a plurality of samples, simultaneously.
    • 本发明是一种具有捕获悬浮在液体或气体中用于单层沉积,分析或其它用途的所需量的材料的方法的过滤装置。 采用新颖的过滤装置来捕获可用于各种样品组分的纯化或富集的材料,或者可以观察或分析捕获的材料。 或者,颗粒材料可以用作蛋白质或化学品的运输机制,其又可以被评估或使用。 过滤装置使用传感器来感测压力并调节,停止或以其他方式控制样品流。 压力传感器基本上监测通过过滤器的样品悬浮液的流速,通常在与在过滤器上捕获所需量的材料相关联的预定压力下进行响应。 与压力传感器集成的单独的阀门或阀门提供了一种调节样品流量的方法。 通常,使用压力来提供使样品悬浮液流过过滤器的手段,过滤器优选是用于单层沉积的膜过滤器。 在一些实施方案中,新颖的注射器提供这种作为真空源的压力。 过滤装置可以进一步自动化以同时处理多个样品。
    • 2. 发明授权
    • Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
    • 识别和评估生物细胞中DNA嗜铬蛋白的方法,用于检测疾病,监测健康,评估生物活性和筛选药物代谢
    • US07153691B2
    • 2006-12-26
    • US10293609
    • 2002-11-13
    • Gary William Ferguson
    • Gary William Ferguson
    • G01N33/52
    • C12Q1/6841C12Q1/68
    • The present invention is a method of identifying and assessing DNA euchromatin in biological cells. The amount and/or distribution of DNA euchromatin generally relates to RNA/protein synthesis, which may change in certain conditions, such as disease, and/or cellular response to environmental and/or chemical agents. The present invention detects the potential presence of disease by assessing DNA euchromatin in ostensibly normal cells and similarly provides means to monitor and assess treatment response. The present invention may also be used to assess how application (or removal) of influences, such as environment, radiation, chemical agents, medications, herbs, vitamins, etc., interact to effect cells, establishing uses in monitoring wellness and pharmacological screening. Additional uses include assessing age related disorders, allergies, infections, Alzheimer's disease, ‘Time of Death’, chronic fatigue syndrome, etc. The method may be advantageously applied to biological cells including micro-organisms, plants, animals, or cultured cells, alone or in conjunction with other markers.
    • 本发明是鉴定和评估生物细胞中DNA复合物的方法。 DNA泛素的量和/或分布通常涉及RNA /蛋白质合成,其可在某些条件下变化,例如疾病和/或细胞对环境和/或化学试剂的反应。 本发明通过在表面上正常细胞中评估DNA嗜铬蛋白来检测潜在的疾病存在,并且类似地提供监测和评估治疗反应的手段。 本发明还可以用于评估如环境,辐射,化学试剂,药物,草药,维生素等的影响的应用(或去除)如何相互影响细胞,建立用于监测健康和药理学筛选的用途。 额外的用途包括评估年龄相关疾病,过敏症,感染,阿尔茨海默病,“死亡时间”,慢性疲劳综合征等。该方法可有利地应用于包括微生物,植物,动物或培养细胞在内的生物细胞 或与其他标记结合使用。
    • 3. 发明授权
    • Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses
    • 用于从用于单层沉积,分析或其它用途的样品悬浮液中捕获所需量的材料的过滤装置和方法
    • US06905594B2
    • 2005-06-14
    • US10269220
    • 2002-10-11
    • Gary William Ferguson
    • Gary William Ferguson
    • B01D61/22G01N1/28G01N15/06B01L11/00
    • G01N15/0618B01D61/22G01N1/2813G01N1/4077Y10T436/25375
    • The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs sensors to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow. Typically, pressure is used to cause the sample suspension to flow through the filter, which is preferably a membrane filter for monolayer deposition. In some embodiments a novel syringe provides this pressure, functioning as a vacuum source. The filter apparatus may be further automated to process a plurality of samples, simultaneously.
    • 本发明是一种具有捕获悬浮在液体或气体中用于单层沉积,分析或其它用途的所需量的材料的方法的过滤装置。 采用新颖的过滤装置来捕获可用于各种样品组分的纯化或富集的材料,或者可以观察或分析捕获的材料。 或者,颗粒材料可以用作蛋白质或化学品的运输机制,其又可以被评估或使用。 过滤装置使用传感器来感测压力并调节,停止或以其他方式控制样品流。 压力传感器基本上监测通过过滤器的样品悬浮液的流速,通常在与在过滤器上捕获所需量的材料相关联的预定压力下进行响应。 与压力传感器集成的单独的阀门或阀门提供了一种调节样品流量的方法。 通常,使用压力使样品悬浮液流过过滤器,该过滤器优选是用于单层沉积的膜过滤器。 在一些实施方案中,新颖的注射器提供这种作为真空源的压力。 过滤装置可以进一步自动化以同时处理多个样品。
    • 4. 发明授权
    • Syringe device with resistive ridges and methods of use
    • 具有电阻脊的注射器和使用方法
    • US06972006B2
    • 2005-12-06
    • US10246600
    • 2002-09-18
    • Gary William Ferguson
    • Gary William Ferguson
    • A61M5/31A61M5/315A61M5/00
    • A61M5/3129A61M2005/31506A61M2205/582
    • A syringe device incorporating ridges that cause resistive changes to the movement of the syringe gasket or plunger, thereby providing user feedback as to the position and speed of plunger movement. Such user feedback may be useful in stressful situations, under poor lighting conditions or in other unfavorable circumstances. Additionally, in certain embodiments these ridges may aid in accurate dispension or allow the syringe to derive additional functionality, such as performing as a vacuum source. Ridges can be protrusions such as tabs, bubbles or continuous rings for single or repeated use or these ridges may be formed as indentations. Ridges may be formed in patterns, in various sizes and shapes or these ridges may be mixed and matched as required or desired. Ridges may also be formed from a soluble material and the resistive change may itself provide indication that the material has been substantially dissolved and dispensed. In some embodiments these ridges are formed primarily within the barrel portion of the syringe. In other embodiments these ridges may be formed on the plunger stem of the syringe. Ridges may be constructed to provide one type of resistive change during the aspiration stroke and a different resistive change to motion in the opposite direction.
    • 一种注射器装置,其包含引起对注射器垫圈或柱塞的移动的电阻变化的脊,由此提供关于柱塞移动的位置和速度的用户反馈。 这种用户反馈可能在紧张情况下,在不良照明条件下或其他不利情况下有用。 另外,在某些实施例中,这些脊可以有助于准确地分配,或允许注射器导出附加的功能,诸如作为真空源执行。 脊可以是用于单次或重复使用的突起,例如突片,气泡或连续环,或者这些脊可以形成为凹陷。 脊可以形成为各种尺寸和形状的图案,或者这些脊可以根据需要或需要进行混合和匹配。 脊也可以由可溶性材料形成,并且电阻变化本身可以提供材料已被基本上溶解并分配的指示。 在一些实施例中,这些脊主要形成在注射器的筒部内。 在其它实施例中,这些脊可以形成在注射器的柱塞杆上。 脊可以被构造成在抽吸冲程期间提供一种类型的电阻变化,并且在相反方向上提供不同的电阻变化。
    • 5. 发明授权
    • Filter device to capture a desired amount of material
    • 过滤装置捕获所需量的材料
    • US06884341B2
    • 2005-04-26
    • US10263129
    • 2002-10-02
    • Gary W. Ferguson
    • Gary W. Ferguson
    • G01N1/28G01N1/40G01N15/06B01D29/60
    • G01N1/2813G01N1/405G01N1/4077G01N15/0618G01N2001/2826Y10T137/8122Y10T436/25375
    • A filter device is used to capture a desired amount of material suspended in a liquid or gas. The device includes a planar filter 530 mounted in a chamber defined by a body member having an upper body 510, a lower body 520, an inlet port 525, and an outlet port 515. The filter includes porous portions 540 and 545. Porous portion 545 is centrally arranged and is more restrictive to flow than portion 540. The filter is designed such that upon portion 540 capturing a desired amount of material, a predetermined pressure change exists across the filter. The predetermined pressure change causes the filter to deform and conform against an inner surface of the upper body resulting in all suspension flowing through the apparatus to flow through the more restrictive second portion 545.
    • 过滤装置用于捕获悬浮在液体或气体中的所需量的材料。 该装置包括安装在由具有上主体510,下体520,入口端口525和出口515的主体构件限定的室中的平面过滤器530。 过滤器包括多孔部分540和545。 多孔部分545居中布置,并且比部分540更加限制流动。 过滤器设计成使得在部分540捕获期望量的材料时,过滤器上存在预定的压力变化。 预定的压力变化导致过滤器变形并且抵抗上部主体的内表面,导致流过设备的所有悬浮液流过更严格的第二部分545。