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1. 发明授权

US5438201A Method and apparatus for restraining finger motion in blood analyte optical measurement 失效
标题翻译：用于抑制血液分析物光学测量中手指运动的方法和装置
公开(公告)号：US5438201A
公开(公告)日：1995-08-01
申请号：US195654
申请日：1994-02-15
申请人： Robert D. Rosenthal , Ryoichi Yabe
发明人： Robert D. Rosenthal , Ryoichi Yabe
IPC分类号： A61B5/00 , A61B5/024 , G01N21/35 , G01N33/487
CPC分类号： A61B5/1455 , A61B5/02433 , A61B5/14532 , A61B5/14552 , G01N21/359
摘要： A method and apparatus for preventing undesirable index finger rotational motion within a non-invasive quantitative blood analyte measurement instrument includes placing at least the middle finger or the thumb into proper alignment with the index finger when inserted in the instrument to prevent the index finger from rotating with respect to the instrument's optical axis. The natural pincer-type relationship of the thumb and index finger is used to align the index finger in the optical axis by the positioning of the thumb and the positioning of the middle finger is used to hinder the rotation of the finger toward the thumb away from the optical axis. Conductive material is provided in grooves formed on the instrument housing to dissipate EMI energy from the test subject.
摘要翻译：用于防止非侵入式定量血液分析物测量仪器内的不期望的食指旋转运动的方法和装置包括：当插入仪器中时，至少将中指或拇指与食指对准，以防止食指旋转相对于仪器的光轴。拇指和食指的自然夹子型关系用于通过拇指的定位使食指在光轴上对准，并且中指的定位用于阻止手指朝向拇指的旋转远离光轴。导电材料设置在形成在仪器壳体上的凹槽中，以从测试对象消散EMI能量。

2. 发明授权

US5204532A Method for providing general calibration for near infrared instruments for measurement of blood glucose 失效
标题翻译：提供用于测量血糖的近红外仪器的一般校准的方法
公开(公告)号：US5204532A
公开(公告)日：1993-04-20
申请号：US717198
申请日：1991-06-18
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： G01N21/35 , A61B5/00 , A61N5/06 , G01N21/27 , G01N21/31 , G01N33/483 , G01N33/487
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61N5/06 , G01N21/274 , G01N21/314 , G01N2201/129
摘要： A method is disclosed for accurately providing general calibration of near-infrared quantitative analysis instruments for almost any individual user. The general calibration method comprises comparing an individual's near-infrared spectrum to a plurality of near-infrared spectral clusters. Each near-infrared spectral cluster has a set of calibration constants associated therewith. The calibration constants of the spectral cluster most closely associated with the individual spectra are used to custom calibrate the near-infrared analysis measurement instrument.
摘要翻译：公开了一种用于准确地为几乎任何个体用户提供近红外定量分析仪的一般校准的方法。一般校准方法包括将个体的近红外光谱与多个近红外光谱簇进行比较。每个近红外光谱簇具有与之相关联的一组校准常数。与各个光谱最密切相关的光谱簇的校准常数用于定制校准近红外分析测量仪器。

3. 发明授权

US4928014A Near-infrared apparatus and method for determining percent fat in a body 失效
标题翻译：用于确定身体脂肪百分比的近红外线装置和方法
公开(公告)号：US4928014A
公开(公告)日：1990-05-22
申请号：US252548
申请日：1988-10-03
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： A61B5/00
CPC分类号： A61B5/4872 , A61B5/0059 , A61B2560/0233
摘要： Method and simplified, lower cost apparatus for determining percent fat in a body wherein near-infrared radiation from at least one, and preferably a single pair of IREDs is transmitted into the body to achieve optical interactance between the body and the near-infrared radiation. Optical absorption by the body at only one bandwidth of the near-infrared radiation is measured. The measured absorption at the one bandwidth of near-infrared radiation is utilized to quantitatively determine the fat content of the body. Data on a plurality of physical parameters of the body, such as height, weight, exercise level, sex, race, waist-to-hip measurement and arm circumference, can be utilized along with the measured near-infrared absorption in the quantitative determination of body fat content. Advantageously, there is no need for labor-intensive factory calibration of each production unit.
摘要翻译：用于确定身体中脂肪百分比的方法和简化的成本较低的装置，其中来自至少一个，优选地一对IRED的近红外辐射被传输到身体中以实现身体和近红外辐射之间的光学相互作用。测量仅在近红外辐射的一个带宽处的身体的光学吸收。利用近红外辐射的一个带宽测量的吸收量来定量测定身体的脂肪含量。关于身体的多个物理参数的数据，例如高度，体重，运动水平，性别，种族，腰围到臀部测量和手臂周长，可以与测量的近红外吸收一起用于定量测定身体脂肪含量。有利的是，不需要每个生产单元的劳动密集型工厂校准。

4. 发明授权

US6134458A Light probe for a near-infrared body chemistry measurement instrument 有权
标题翻译：用于近红外线身体化学测量仪器的光探针
公开(公告)号：US6134458A
公开(公告)日：2000-10-17
申请号：US210950
申请日：1998-12-15
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： A61B5/00
CPC分类号： A61B5/0059
摘要： A light probe method and apparatus is provided for an infrared body chemistry measurement instrument. The light probe includes an illumination ring of a light-conducting material, having facets on an exterior circumferential surface, and an inner circumferential surface at about a forty-five degree angle, infrared light emitting devices positioned at each facet, a coaxially located optical detector, a shielding ring coaxially located between the optical detector and the illumination ring, and a cover having a central opening which exposes the optical detector, the shielding ring, and the illumination ring, wherein a length dimension of the light probe is less than a diameter dimension. The method includes radially illuminating an illumination ring with infrared light, redirecting the infrared light to an axial direction perpendicular to the radially inward direction, conducting the infrared light through the illumination ring and into a body part under test, and receiving reflected and scattered light in an optical detector concentric with the illumination ring.
摘要翻译：提供了一种用于红外线体化学测量仪器的光探针方法和装置。光探测器包括导光材料的照明环，在外圆周表面上具有小平面，在大约四十五度角处具有内圆周表面，位于每个刻面处的红外发光器件，同轴定位的光学检测器，同轴地位于光学检测器和照明环之间的屏蔽环，以及具有暴露光学检测器，屏蔽环和照明环的中心开口的盖，其中光探针的长度尺寸小于直径尺寸。该方法包括用红外线径向照射照明环，将红外光重定向到与径向向内方向垂直的轴向，将红外光穿过照明环并进入被测体内，并将反射和散射光与照明环同心的光学检测器。

5. 发明授权

US5365066A Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments 失效
标题翻译：低成本意味着增加LED / IRED近红外仪器的测量灵敏度
公开(公告)号：US5365066A
公开(公告)日：1994-11-15
申请号：US980272
申请日：1992-11-23
申请人： Don E. Krueger, Jr. , Robert D. Rosenthal
发明人： Don E. Krueger, Jr. , Robert D. Rosenthal
IPC分类号： A61B5/00 , A61B5/024 , G01N21/31 , G01N21/35 , G01N33/487
CPC分类号： A61B5/02433 , A61B5/14532 , A61B5/14552 , G01N21/314 , G01N21/359
摘要： A low cost means for increasing measurement sensitivity in LED near-infrared instruments is disclosed which utilizes a current modification means for modifying the driving current supplied to each IRED as a function of the opacity of the particular sample being measured. The current modification means is part of the processing means and comprises means for measuring a signal level for each IRED at an analog-to-digital converter. Based upon the signal level detected for each IRED, the current modification means modifies the current to each IRED to a value that is as high as possible without saturating the analog-to-digital converter. Thus, by modifying the driving current of each IRED to such a maximal value, the analytical instrument of the present invention provides high resolution without the use of expensive electronic circuitry. Also provided is a system for generating and storing an optical signature of a particular user, thus further insuring the accuracy of measurements taken by the instrument.
摘要翻译：公开了用于提高LED近红外仪器的测量灵敏度的低成本手段，其利用当前修改装置来修改提供给每个IRED的驱动电流作为被测量的特定样品的不透明度的函数。当前的修改装置是处理装置的一部分，并且包括用于在模数转换器处测量每个IRED的信号电平的装置。基于为每个IRED检测到的信号电平，当前修改装置将对每个IRED的电流修改为尽可能高的值，而不使模数转换器饱和。因此，通过将每个IRED的驱动电流修改为这样的最大值，本发明的分析仪器在不使用昂贵的电子电路的情况下提供高分辨率。还提供了一种用于生成和存储特定用户的光学签名的系统，从而进一步确保了仪器所进行的测量的准确性。

6. 发明授权

US5218207A Using led harmonic wavelengths for near-infrared quantitative 失效
标题翻译：使用led谐波波长进行近红外定量
公开(公告)号：US5218207A
公开(公告)日：1993-06-08
申请号：US795997
申请日：1991-11-22
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： A61B5/145 , A61B5/00 , A61B5/024 , A61B5/107 , A61B5/1455 , G01N21/31 , G01N21/35 , G01N33/487
CPC分类号： G01N21/359 , A61B5/02433 , A61B5/107 , A61B5/14532 , A61B5/1455 , G01N21/314 , A61B5/6826 , G01N2201/0621
摘要： A near-infrared quantitative analysis instrument for measuring a constituent of a sample material is disclosed which effectively utilizes energy in the 1200 to 1800 nanometer wavelengths regions by isolating and employing harmonic wavelengths emitted by typical, low cost commercially available light emitting diodes (LEDs) or infrared emitting diodes (IREDs). The analysis instrument utilizes these very desirable wavelength regions for quantitative analysis measurements by interposing suitable narrow bandpass filters which permit passage of only the selected harmonic wavelengths.
摘要翻译：公开了一种用于测量样品材料的组成的近红外定量分析仪器，其通过隔离并采用由典型的低成本市售发光二极管（LED）发射的谐波波长，有效地利用1200至1800纳米波长区域中的能量红外发射二极管（IRED）。分析仪器利用这些非常理想的波长区域进行定量分析测量，通过插入允许仅通过所选择的谐波波长的合适的窄带通滤波器。

7. 发明授权

US5134302A Method and means for generating synthetic spectra allowing quantitative measurement in near infrared measuring instruments 失效
标题翻译：用于生成近红外测量仪器中允许定量测量的合成光谱的方法和手段
公开(公告)号：US5134302A
公开(公告)日：1992-07-28
申请号：US588628
申请日：1990-09-26
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： G01J3/427 , A61B5/00 , G01J3/10 , G01N21/25 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , G01J3/108 , G01N21/255 , G01N21/359 , G01N2201/0621
摘要： A method and means for generating synthetic spectra allowing quantitative measurement utilizes dual chip alternatively energized IREDs with optical bandpass filter(s) passing two optical bands which could be combined with curvilinear interpolation to be utilized in a low cost small size quantitative measuring instrument.
摘要翻译：用于产生允许定量测量的合成光谱的方法和装置利用具有通过两个光谱带的光学带通滤光器的双芯片交替供电的IRED，其可以与曲线插值组合以用于低成本小尺寸定量测量仪器中。

8. 发明授权

US06968221B2 Low-cost method and apparatus for non-invasively measuring blood glucose levels 失效
标题翻译：用于非侵入性测量血糖水平的低成本方法和装置
公开(公告)号：US06968221B2
公开(公告)日：2005-11-22
申请号：US10387845
申请日：2003-03-14
申请人： Robert D. Rosenthal
发明人： Robert D. Rosenthal
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B5/743
摘要： A method and apparatus for measuring a blood analyte concentration using an inexpensive, low precision sensor device is provided. One embodiment of the method includes obtaining energy absorption measurement data through a body part of an individual. A plurality of indicator variables are subsequently calculated from the energy absorption measurement data. An indicator variable from the plurality of indicator variables having the highest correlation to blood glucose level is determined, and a first optical term based on the indicator variable with the highest correlation to blood glucose level is allocated to form a regression analysis equation. An estimated value of the blood analyte concentration using the regression analysis equation is calculated.
摘要翻译：提供了一种使用廉价的低精度传感器装置测量血液分析物浓度的方法和装置。该方法的一个实施例包括通过个体的身体部分获得能量吸收测量数据。随后从能量吸收测量数据计算出多个指标变量。确定与血糖水平相关性最高的多个指标变量的指标变量，并且分配基于与血糖水平相关性最高的指标变量的第一光学项，以形成回归分析方程。使用回归分析方程计算血液分析物浓度的估计值。

9. 发明授权

US6151517A Method and apparatus for noninvasive quantitative measurement of blood analytes 有权
标题翻译：用于血液分析物无创定量测量的方法和装置
公开(公告)号：US6151517A
公开(公告)日：2000-11-21
申请号：US235286
申请日：1999-01-22
申请人： David E. Honigs , Robert D. Rosenthal
发明人： David E. Honigs , Robert D. Rosenthal
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A method and apparatus for performing quantitative noninvasive measurement of blood analytes, includes correction for measurement interference caused by pulse beat and changing body chemistry associated with blood circulation through the part of the body being measured as a function of time. A hypoglycemia monitor and alarm is provided which takes advantage of the methods described for separating pulse beat information from the measurement signals.
摘要翻译：用于进行血液分析物的定量非侵入性测量的方法和装置包括校正由脉搏拍摄引起的测量干扰，以及与作为时间的函数测量的身体部分的血液循环相关联的身体化学变化。提供低血糖监测和报警，利用所描述的用于从测量信号中分离脉搏信息的方法。

10. 发明授权

US5574283A Non-invasive near-infrared quantitative measurement instrument 失效
标题翻译：非侵入性近红外定量测量仪器
公开(公告)号：US5574283A
公开(公告)日：1996-11-12
申请号：US243756
申请日：1994-05-17
申请人： Reynaldo Quintana
发明人： Reynaldo Quintana
IPC分类号： A61B5/00 , A61B5/024 , G01N21/35 , G01N33/487 , G01N33/50
CPC分类号： A61B5/1455 , A61B5/02422 , A61B5/02433 , A61B5/14532 , A61B5/14552 , G01N21/359
摘要： An improved near-infrared quantitative analysis instrument includes a number of removable finger inserts each dimensioned for a different finger size, which facilitates properly aligning and fitting an individual user's finger into the optical system of the analysis instrument taking into account the size of the individual's finger. The insert according to the present invention can be also designed to accommodate samples of various substances for quantitative analyte measurement.
摘要翻译：改进的近红外定量分析仪器包括多个可移除的手指插入物，每个可移除的手指插入物尺寸适于不同的手指尺寸，这有助于将单个用户的手指适当地对准和装配到分析仪器的光学系统中，同时考虑到个体手指的尺寸。根据本发明的插入件还可以设计成适应用于定量分析物测量的各种物质的样品。

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