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1. 发明公开

US20230218901A1 COGNITIVE FUNCTION WITHIN A HUMAN BRAIN 审中-公开
公开(公告)号：US20230218901A1
公开(公告)日：2023-07-13
申请号：US17989637
申请日：2022-11-17
申请人： Functional Neuromodulation, Inc.
发明人： Andres M. Lozano
IPC分类号： A61N1/36 , A61M5/142 , A61N1/05 , A61K45/06 , G16Z99/00 , A61M27/00 , A61M5/172
CPC分类号： A61N1/36092 , A61M5/14276 , A61N1/0531 , A61K45/06 , G16Z99/00 , A61M5/142 , A61N1/36082 , A61M27/006 , A61M5/172 , A61M2210/0693
摘要： Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.

2. 发明公开

US20230173257A1 INDUCING NEUROGENESIS WITHIN A HUMAN BRAIN 审中-公开
公开(公告)号：US20230173257A1
公开(公告)日：2023-06-08
申请号：US17863345
申请日：2022-07-12
申请人： Functional Neuromodulation, Inc.
发明人： Andres M. Lozano , Hiroki Toda
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0534 , A61N1/3605 , A61N1/36082
摘要： Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

3. 发明授权

US10384053B2 Inducing neurogenesis within a human brain 有权
公开(公告)号：US10384053B2
公开(公告)日：2019-08-20
申请号：US14081229
申请日：2013-11-15
申请人： Functional Neuromodulation Inc.
发明人： Andres M. Lozano , Hiroki Toda
IPC分类号： A61N1/05 , A61N1/36
摘要： Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

4. 发明申请

US20180071519A9 INDUCING NEUROGENESIS WITHIN A HUMAN BRAIN 审中-公开
公开(公告)号：US20180071519A9
公开(公告)日：2018-03-15
申请号：US14081229
申请日：2013-11-15
申请人： Functional Neuromodulation Inc.
发明人： Andres M. Lozano , Hiroki Toda
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/3605 , A61N1/36082
摘要： Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

5. 发明申请

US20170368354A1 COGNITIVE FUNCTION WITHIN A HUMAN BRAIN 审中-公开
公开(公告)号：US20170368354A1
公开(公告)日：2017-12-28
申请号：US15400700
申请日：2017-01-06
申请人： Functional Neuromodulation Inc.
发明人： Andres M. Lozano
IPC分类号： A61N1/36 , A61M5/142 , A61K45/06 , A61N1/05 , A61M27/00 , A61M5/172
CPC分类号： A61N1/36092 , A61K45/06 , A61M5/142 , A61M5/14276 , A61M5/172 , A61M27/006 , A61M2210/0693 , A61N1/0531 , A61N1/36082 , G06F19/00 , G16Z99/00
摘要： Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.

6. 发明申请

US20160030666A1 METHOD OF TREATING COGNITIVE DISORDERS USING NEUROMODULATION 审中-公开
标题翻译：使用神经修复治疗认知障碍的方法
公开(公告)号：US20160030666A1
公开(公告)日：2016-02-04
申请号：US14586849
申请日：2014-12-30
申请人： Functional Neuromodulation, Inc.
发明人： Andres M. Lozano , Helen S. Mayberg
IPC分类号： A61M5/142 , A61N1/36 , A61N1/05
CPC分类号： A61M5/14276 , A61N1/0534 , A61N1/36071 , A61N1/36082
摘要： The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat a cognitive impairment and/or disorder. More particularly, the method comprises surgically implanting an electrode and/or catheter that is in communication with a predetermined site which is coupled to a pulse generating source and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the cognitive disorder and/or enhancing the cognitive ability.
摘要翻译：本发明涉及一种使用电刺激和/或化学刺激来治疗认知障碍和/或病症的方法和系统。更具体地，该方法包括手术植入与预定部位相通的电极和/或导管，该预定部位与脉冲产生源和/或输注泵联接，所述脉冲发生源和/或输注泵释放电信号和/或药物，导致刺激从而治疗认知障碍和/或提高认知能力。

7. 发明申请

US20150142089A1 INDUCING NEUROGENESIS WITHIN A HUMAN BRAIN 审中-公开
标题翻译：在人脑中诱导神经发生
公开(公告)号：US20150142089A1
公开(公告)日：2015-05-21
申请号：US14081229
申请日：2013-11-15
申请人： Functional Neuromodulation Inc.
发明人： Andres M. Lozano , Hiroki Toda
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/3605 , A61N1/36082
摘要： Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.
摘要翻译：用于诱导人类神经发生的方法和装置。本发明利用可植入信号发生器将高频刺激传递给深部脑组织元件。植入的装置向大脑递送治疗疗法，从而诱导人的神经发生。传感器可用于检测神经系统发现的各种症状。然后，微处理器算法可以分析来自传感器的输出，以调节传递给大脑的刺激和/或药物治疗。

8. 发明授权

US08868191B2 Regulation of neurotrophins 有权
标题翻译：调节神经营养因子
公开(公告)号：US08868191B2
公开(公告)日：2014-10-21
申请号：US13747237
申请日：2013-01-22
申请人： Andres M. Lozano
发明人： Andres M. Lozano
IPC分类号： A61N1/18 , A61N1/36 , A61N1/32 , A61N1/05
CPC分类号： A61N1/36121 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/326 , A61N1/3605 , A61N1/36082
摘要： Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.
摘要翻译：公开了用于调节人体内神经营养因子水平的方法。本发明利用可植入信号发生器将刺激递送至神经组织元件。或者，可以使用可植入泵来递送一种或多种药物。植入的装置向神经组织递送治疗疗法，从而改变由受影响的神经组织表达的神经营养因子如BDNF的水平。传感器可用于检测神经系统疾病的各种症状。然后，微处理器算法可以分析来自传感器的输出，以调节递送到身体的治疗疗法。本发明描述了一种调节神经营养因子内在水平的新方法，可用于治疗患有神经和认知障碍的患者。

9. 发明申请

US20140025133A1 COGNITIVE FUNCTION WITHIN A HUMAN BRAIN 审中-公开
标题翻译：人脑中的认知功能
公开(公告)号：US20140025133A1
公开(公告)日：2014-01-23
申请号：US14034336
申请日：2013-09-23
申请人： Functional Neuromodulation Inc.
发明人： Andres M. Lozano
IPC分类号： A61N1/36
CPC分类号： A61N1/36092 , A61K45/06 , A61M5/142 , A61M5/14276 , A61M5/172 , A61M27/006 , A61M2210/0693 , A61N1/0531 , A61N1/36082 , G06F19/00 , G16Z99/00
摘要： Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.
摘要翻译：改善人类认知功能的方法和手段。本发明利用诸如可植入信号发生器或可植入泵的植入装置来影响人脑Papez电路中的组织元件以及Papez电路上游或下游的组织。植入装置提供治疗疗法，从而改善人的认知功能。传感器可用于检测认知障碍的各种症状。微处理器算法然后可以分析来自传感器的输出以调节刺激和/或药物治疗的递送。

10. 发明授权

US10576283B2 Brain stimulation system including multiple stimulation modes 有权
公开(公告)号：US10576283B2
公开(公告)日：2020-03-03
申请号：US15431569
申请日：2017-02-13
申请人： Functional Neuromodulation Inc.
发明人： J. Christopher Flaherty , Daniel J. O'Connell , Todd Langevin , R. Maxwell Flaherty
IPC分类号： A61N1/36 , A61N5/06 , A61N1/05 , A61B6/03 , A61B6/00 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/053 , A61B5/11 , A61B5/145 , A61B5/00 , A61B5/021 , A61B5/055 , A61N2/00 , A61N7/00
摘要： A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

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