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1. 发明授权

US11272874B2 Contingent cardio-protection for epilepsy patients 有权
公开(公告)号：US11272874B2
公开(公告)日：2022-03-15
申请号：US16729689
申请日：2019-12-30
申请人： Flint Hills Scientific, L.L.C.
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/08 , A61B5/11 , A61B5/113 , A61B5/318 , A61B5/021 , A61N1/36 , A61B5/026 , A61B5/0245 , A61N1/365 , A61B5/024 , A61B5/0531 , A61B7/04 , A61B8/08 , A61B5/389
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

2. 发明申请

US20200375525A1 DETECTING OR VALIDATING A DETECTION OF A STATE CHANGE FROM A TEMPLATE OF HEART RATE DERIVATIVE SHAPE OR HEAT BEAT WAVE COMPLEX 审中-公开
公开(公告)号：US20200375525A1
公开(公告)日：2020-12-03
申请号：US16996335
申请日：2020-08-18
申请人： Ivan Osorio , Mark Frei
发明人： Ivan Osorio , Mark Frei
IPC分类号： A61B5/00 , A61B5/024 , A61N1/36 , A61B5/0452 , A61B5/0468 , A61B5/04 , A61B5/0456 , A61B5/0245
摘要： Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.

3. 发明申请

US20200324115A1 CONTINGENT CARDIO-PROTECTION FOR EPILEPSY PATIENTS 审中-公开
公开(公告)号：US20200324115A1
公开(公告)日：2020-10-15
申请号：US16911592
申请日：2020-06-25
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61N1/36
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

4. 发明授权

US10682515B2 Contingent cardio-protection for epilepsy patients 有权
公开(公告)号：US10682515B2
公开(公告)日：2020-06-16
申请号：US15437155
申请日：2017-02-20
申请人： FLINT HILLS SCIENTIFIC, L.L.C.
发明人： Ivan Osorio
IPC分类号： A61N1/36 , A61N1/05
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

5. 发明授权

US10172550B2 Systems approach to disease state and health assessment 有权
公开(公告)号：US10172550B2
公开(公告)日：2019-01-08
申请号：US14581662
申请日：2014-12-23
申请人： Flint Hills Scientific, LLC
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61B5/16 , A61B5/11 , A61B5/0205 , A61B5/0488 , G06F19/00 , G16H50/30 , G16H50/70 , G16H50/20 , A61B5/01 , A61B5/053 , A61B5/08
摘要： Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

6. 发明申请

US20180296155A1 PARAMETRIC SEIZURE DETECTION 审中-公开
公开(公告)号：US20180296155A1
公开(公告)日：2018-10-18
申请号：US16015713
申请日：2018-06-22
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61B5/00 , A61B5/024 , A61B5/0205 , G06F19/00
摘要： We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

7. 发明申请

US20180140246A1 AUTOMATED MEANS TO CONTROL RESPONSES TO REPETITIVE ELECTRICAL STIMULATION AND IMPROVE THERAPEUTIC EFFICACY 审中-公开
公开(公告)号：US20180140246A1
公开(公告)日：2018-05-24
申请号：US15863941
申请日：2018-01-07
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61B5/00 , A61N1/36 , A61B5/0484
CPC分类号： A61B5/4094 , A61B5/0484 , A61N1/36064 , A61N1/36139
摘要： We report a method for optimizing the therapeutic efficacy of evoked responses elicited by one or more electrical impulses delivered to a neural structure, comprising: comparing a test evoked response to an evoked response elicited by therapeutically efficacious electrical stimulation; adjusting at least one parameter of the electrical impulses in response to a determination that said test evoked response is not similar to the therapeutic evoked response; determining that the test evoked response resembles the therapeutic evoked response after performing at least one of said adjustments; and saving to memory at least one adjusted parameter that increased the similarity between the test evoked response and the therapeutic evoked response. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

8. 发明申请

US20170150916A1 DETECTING, QUANTIFYING, AND/OR CLASSIFYING SEIZURES USING MULTIMODAL DATA 审中-公开
公开(公告)号：US20170150916A1
公开(公告)日：2017-06-01
申请号：US15387417
申请日：2016-12-21
申请人： FLINT HILLS SCIENTIFIC L.L.C.
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/36 , A61B5/0205
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/0245 , A61B5/026 , A61B5/0402 , A61B5/0488 , A61B5/0531 , A61B5/0816 , A61B5/1117 , A61B5/113 , A61B5/4266 , A61B5/686 , A61B5/7264 , A61B5/746 , A61B7/04 , A61B8/0883 , A61B2562/0219 , A61N1/36064 , A61N1/36135 , A61N1/36139 , A61N1/36585
摘要： A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.

9. 发明申请

US20170143273A1 SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING A WAVELET TRANSFORM MAXIMUM MODULUS ALGORITHM 审中-公开
公开(公告)号：US20170143273A1
公开(公告)日：2017-05-25
申请号：US15377922
申请日：2016-12-13
申请人： FLINT HILLS SCIENTIFIC, L.L.C.
发明人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/02055 , A61B5/0205 , A61B5/024 , A61B5/04001 , A61B5/0476 , A61B5/048 , A61B5/0816 , A61B5/0833 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/165 , A61B5/4094 , A61B5/4836 , A61B5/726 , A61B5/746
摘要： Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method.

10. 发明申请

US20170035368A1 DETECTING, ASSESSING AND MANAGING A RISK OF DEATH IN EPILEPSY 有权
标题翻译：检测，评估和管理死亡风险
公开(公告)号：US20170035368A1
公开(公告)日：2017-02-09
申请号：US15333802
申请日：2016-10-25
申请人： FLINT HILLS SCIENTIFIC, L.L.C.
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/365 , A61N1/36 , G06F19/00 , A61F7/00 , A61B5/16 , A61B5/0452 , A61N1/39 , A61M5/172
CPC分类号： A61B5/746 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02455 , A61B5/0452 , A61B5/0826 , A61B5/1118 , A61B5/162 , A61B5/4094 , A61B5/4836 , A61B5/4839 , A61B5/7275 , A61F7/00 , A61M5/1723 , A61M2230/06 , A61M2230/20 , A61M2230/201 , A61M2230/208 , A61M2230/30 , A61M2230/42 , A61M2230/63 , A61N1/36064 , A61N1/36139 , A61N1/36142 , A61N1/36514 , A61N1/36585 , A61N1/37247 , A61N1/37258 , A61N1/3987 , G06F19/00 , G16H50/30
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
摘要翻译：提供了一种用于确定和响应于与癫痫患者相关的死亡风险增加的实时方法。该方法包括接收心脏数据并基于心脏数据确定心脏指数。该方法包括确定如果指数极端，与癫痫相关的死亡风险增加，发出与死亡风险增加有关的死亡风险增加和记录信息的警告。还提出了用于确定和响应于与癫痫患者相关的死亡风险增加的第二种方法，其包括接收觉醒数据，响应性数据或感知数据中的至少一个，并且确定觉醒指数，响应指数或意识指数，其中指数分别基于觉醒数据，响应性数据或意识数据。第二种方法包括确定与癫痫相关的死亡风险增加，如果指标是极端值，发出与死亡风险增加有关的死亡风险增加警报。还提供了一种计算机可读程序存储装置。还提供了一种用于接收身体数据，确定心脏，唤醒，反应性或动力学指标的方法，在与癫痫患者相关的第一时间窗口中确定增加或增加的死亡风险并发出警告和记录相关信息。

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