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1. 发明授权

US10723570B2 Pallet changing system for a machine tool 有权
公开(公告)号：US10723570B2
公开(公告)日：2020-07-28
申请号：US15962855
申请日：2018-04-25
申请人： FIDIA S.p.A.
发明人： Giuseppe Morfino , Giacomo Bene
IPC分类号： B65G65/00 , B23Q7/14 , B65G1/04 , B23Q1/52
摘要： The pallet changing system comprises a pallet deposition and pick-up station and a pallet loading and unloading station, horizontally spaced from one another along a first horizontal direction (A-A), as well as a pallet handling unit. The pallet handling unit includes: horizontal guide means extending along the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station; a pair of motorized uprights, which are jointly movable in a controlled manner in the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station, each upright being provided with a respective motorized lifting carriage vertically movable in a controlled manner, each lifting carriage being provided with a pair of gripping devices which are horizontally spaced from one another and selectively or jointly controllable to engage a corresponding end of a pallet (P) so as to allow rotation of the pallet (P) about a first horizontal axis; a pair of motorized auxiliary carriages, which are jointly movable in the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station, and are provided each with a gripping device arranged to engage a corresponding end of the pallet (P) facing the pallet deposition and pick-up station, so as to allow rotation of the pallet (P) about the first horizontal axis; and a motorized transporting carriage which is arranged to transport, in a vertical attitude, the pallet (P) with the workpiece (WP) connected thereto, and is movable between the pallet loading and unloading station and a working area (SW) of the machine tool (MT) in a second horizontal direction (B-B) forming an angle with respect to the first horizontal direction (A-A).

2. 发明授权

US09645217B2 System and method for error correction for CNC machines 有权
公开(公告)号：US09645217B2
公开(公告)日：2017-05-09
申请号：US13856044
申请日：2013-04-03
申请人： Fidia S.p.A.
发明人： Giuseppe Morfino , Augusto Mignani
IPC分类号： G01C17/38 , G01R35/00 , B25J9/16 , G05B19/401 , G01B21/04 , G01D5/244
CPC分类号： G01R35/00 , B25J9/1692 , G01B21/042 , G01D5/2448 , G05B19/4015 , G05B2219/39007 , G05B2219/39024 , G05B2219/50026
摘要： A method of determining a positioning error of a CNC machine is provided and an system thereof. A calibration element is placed within the CNC machine. A first sensor reading is taken of the calibration element. A second sensor reading is taken and the sensor is moved in a manner that the difference between the first and second sensor data decreases until the difference becomes less or equal to a pre-determined threshold value. A positioning error of the tool head is determined based on the movement of the sensor.

3. 发明授权

US5795869A Sulfated lyso-ganglioside derivatives 失效
标题翻译：硫酸溶解性神经节苷脂衍生物
公开(公告)号：US5795869A
公开(公告)日：1998-08-18
申请号：US530267
申请日：1995-11-02
申请人： Aurelio Romeo , Gunter Kirschner , Carlo Chizzolini , Hari Manev , Laura Facci
发明人： Aurelio Romeo , Gunter Kirschner , Carlo Chizzolini , Hari Manev , Laura Facci
IPC分类号： C07H15/10 , A61K31/70 , C07H15/00
CPC分类号： C07H15/10
摘要： Semisynthetic analogues of gangliosides selected from the group consisting of N-sulfo-, N-hydrocarbyl-sulfonyl- and N-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N'-acyl derivatives thereof, N'-sulfo-, N'-hydrocarbylsulfonyl- and N'-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N-acyl derivatives thereof, N,N'-di or polysulfo-N,N'-di- or poly-lyso-gangliosides, N,N'-di- or polyhydrocarbylsulfonyl-N,N'-di- or poly-lyso-gangliosides and N,N'-di- or polyhydrocarbyloxy-N,N'-di- or poly-lyso-gangliosides, and functional derivatives thereof, and salts of these compounds, have protective activity against neurotoxicity induced by excitatory amino acids and are foreseen to be used in therapy in the nervous system and in modulating of the expression of determinants such as CD.sub.4 on the surface of human cells in the immune system.
摘要翻译： PCT No.PCT / US94 / 01966 Sec。 371日期：1995年11月2日 102（e）1995年11月2日日期PCT 1994年3月4日PCT公布。出版物WO94 / 20516 PCT 日期1994年9月15日选自N-磺基 - ，N-烃基 - 磺酰基 - 和N-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N'-酰基衍生物的神经节苷脂的合成类似物， N' - 磺基 - ，N'-烃基磺酰基 - 和N'-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N-酰基衍生物，N，N'-二或多磺基-N，N'-二 - 或多溶解神经节苷脂，N，N'-二 - 或多烃基磺酰基-N，N'-二 - 或多赖氨酸神经节苷脂和N，N'-二 - 或多羟基氧基-N，N'-二 - 或多元神经节苷脂及其功能衍生物和这些化合物的盐具有对兴奋性氨基酸诱导的神经毒性的保护作用，并且预期用于神经系统的治疗和调节诸如CD4 在免疫系统中的人类细胞表面。

4. 发明授权

US5646129A Method of using low molecular weight hyaluronic acid for stimulating bone formation 失效
标题翻译：使用低分子量透明质酸刺激骨形成的方法
公开(公告)号：US5646129A
公开(公告)日：1997-07-08
申请号：US318804
申请日：1995-01-17
申请人： Lanfranco Callegaro , Aurelio Romeo
发明人： Lanfranco Callegaro , Aurelio Romeo
IPC分类号： C08B37/08 , A61K31/715 , A61K31/728 , A61P19/08 , A61P43/00
CPC分类号： C08B37/0072
摘要： The present invention is drawn to hyaluronic acid fractions having molecular weights in the range of from about 20,000 to about 60,000 daltons, wherein these hyaluronic acid fractions possess osteoinductive activity. The present invention further includes pharmaceutical compositions comprising such hyaluronic acid fractions to be used in the treatment of various types of bone disorders, as well as methods of treating such disorders using the pharmaceutical compositions.
摘要翻译： PCT No.PCT / EP93 / 00932 Sec。 371日期1995年1月17日 102（e）日期1995年1月17日PCT 1993年4月16日PCT公布。出版物WO93 / 20827 日期：1993年10月28日本发明涉及分子量在约20,000至约60,000道尔顿范围内的透明质酸部分，其中这些透明质酸部分具有骨诱导活性。本发明还包括药物组合物，其包含用于治疗各种类型的骨骼疾病的这种透明质酸组分，以及使用该药物组合物治疗此类病症的方法。

5. 发明授权

US5618561A Preparation of highly hydrated self-supporting hyaluronic acid containing films 失效
标题翻译：高水合自支撑透明质酸含膜的制备
公开(公告)号：US5618561A
公开(公告)日：1997-04-08
申请号：US488049
申请日：1995-06-07
申请人： Francesco Della Valle , Alessandro Rastrelli , Gabriella Calderini , Aurelio Romeo
发明人： Francesco Della Valle , Alessandro Rastrelli , Gabriella Calderini , Aurelio Romeo
IPC分类号： A61K9/70 , A61K9/06 , A61L15/22 , A61L15/28 , A61L15/44 , C08L5/04 , C08L5/08 , D01F9/04
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a hyaluronic acid or a derivative thereof, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
摘要翻译：本发明提供了具有高度水合的自支撑膜形式的新凝胶，其制备方法包括一种或多种碱性藻酸盐，碱土藻酸盐，多元醇和透明质酸或其衍生物。这些高度水合的自支撑膜形式的多糖基质凝胶适合用作皮肤损伤和/或病变的覆盖和保护材料，因为它们可以以所需厚度的自支撑形式获得，是透明的，柔性的，具有良好的机械特性，适应于病变表面而不强烈粘附在其上，并且可渗透气体，但不渗透液体和细菌; 一种或多种药理活性物质也可以掺入凝胶中。

6. 发明授权

US5583142A Analgesic and nootropic drugs 失效
标题翻译：止痛药和益智药
公开(公告)号：US5583142A
公开(公告)日：1996-12-10
申请号：US369761
申请日：1995-01-06
申请人： Alessandro Bartolini , Carla Ghelardini , Alberto Giotti , Fulvio Gualtieri , Serena Scapecchi , Gino Toffano
发明人： Alessandro Bartolini , Carla Ghelardini , Alberto Giotti , Fulvio Gualtieri , Serena Scapecchi , Gino Toffano
IPC分类号： A61K31/46 , A61P25/02 , C07D451/04 , C07D451/10 , A61K31/44 , C07D451/02
CPC分类号： C07D451/04 , C07D451/10
摘要： Compounds of general formula: ##STR1## where: Ar=phenyl or beta-naphtyl, or aromatic heterocyclic 6-membered ring containing one or two nitrogen atoms;R.sub.1 =one or more substituents of the Ar nucleus, preferably in para position, and selected out of the group consisting of H, CH.sub.3, CH.sub.2 --CH--(CH.sub.3).sub.2, O--CH.sub.3, Cl, F, Br, CF.sub.3, NH.sub.2, S--CH.sub.3, CN, NO.sub.2 R.sub.2 =H, CH.sub.3, C.sub.2 H.sub.5, CH(CH.sub.3).sub.2 ;R.sub.3 = ##STR2## Where R.sub.4 =H, CH.sub.3, C.sub.2 H.sub.5 R.sub.5 =H, CH.sub.3X=none O, S, NH, NCH.sub.3, --CH=CH--, --C.ident.C--Y=O, NH,both in the racemic Form and in the isomeric enantiomeric forms,which produce a nootropic effect, i.e. memory enhancement and learning facilitation, as well as an analgesic effect.
摘要翻译：通式为：其中：Ar =苯基或β-萘基，或含有一个或两个氮原子的芳香杂环六元环; R1 = Ar核的一个或多个取代基，优选在对位，选自H，CH 3，CH 2 -CH-（CH 3）2，O-CH 3，Cl，F，Br，CF 3，NH 2 ，S-CH 3，CN，NO 2 R 2 = H，CH 3，C 2 H 5，CH（CH 3）2; R3 = 其中R4 = H，CH3，C2H5 R5 = H，CH3 X =无O，S，NH，NCH 3，-CH = CH-，-C = CY = O，NH，均以外消旋形式和在异构体对映异构体形式中，其产生向异性作用，即记忆增强和学习促进作用以及止痛作用。

7. 发明授权

US5264422A Esters of alginic acid with steroidal alcohols 失效
标题翻译：海藻酸与甾体醇的酯类
公开(公告)号：US5264422A
公开(公告)日：1993-11-23
申请号：US718446
申请日：1991-06-20
申请人： Francesco della Valle , Aurelio Romeo
发明人： Francesco della Valle , Aurelio Romeo
IPC分类号： A61K8/73 , A61K9/00 , A61K47/36 , A61K47/48 , A61L17/10 , A61L27/20 , A61Q19/00 , A61K31/705 , A61K31/72 , C08B37/04
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S128/912 , Y10S514/912 , Y10S623/924
摘要： Partial esters of alginic acid and salts thereof possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译：海藻酸及其盐的部分酯具有重要的生物塑料和药物特性，可用于医疗，外科，化妆品和食品等各个领域。

8. 发明授权

US5260464A Carnitine derivatives, process for their preparation, and their use in human therapy 失效
标题翻译：肉碱衍生物，其制备方法及其在人类治疗中的应用
公开(公告)号：US5260464A
公开(公告)日：1993-11-09
申请号：US518417
申请日：1990-05-03
申请人： Francesco Della Valle , Aurelio Romeo
发明人： Francesco Della Valle , Aurelio Romeo
IPC分类号： A61K31/66 , A61P25/00 , C07F9/09 , C07F9/02
CPC分类号： C07F9/091
摘要： New carnitine derivatives are described having the formula (I): ##STR1## wherein A=H, --(CH.sub.2).sub.n --O--CO--R.sub.1, n being 1 or 2, and B=--(CH.sub.2).sub.m --O--CO--R.sub.2, m being 1, 2, 3, or 4 with the limitation that when A=--(CH.sub.2).sub.n --O--CO--R.sub.1, m is 1 or 2, and in which R.sub.1 and R.sub.2, equal or different are radicals of aliphatic, aromatic, araliphatic, alicyclic or heterocyclic acids.The process for preparing said derivatives is also described and their use in the therapy of human pathologies associated with neuronal damages.

9. 发明授权

US5250541A Kynurenic acid derivatives, their preparation and pharmaceutical compositions containing them 失效
标题翻译：犬尿酸衍生物，其制剂和含有它们的药物组合物
公开(公告)号：US5250541A
公开(公告)日：1993-10-05
申请号：US828927
申请日：1992-02-05
申请人： Flavio Moroni , Roberto Pellicciari
发明人： Flavio Moroni , Roberto Pellicciari
IPC分类号： A61K31/47 , A61P25/00 , C07D215/48 , A01N43/42
CPC分类号： C07D215/48
摘要： Kynurenic acid derivatives useful as therapeutic agents in treating neurological disorders, for example, thiokynurenic acid, 7-chloro-thio-kynurenic acid, 7-trifluoromethyl-thiokynurenic acid, 7-methoxy-thiokynurenic acid and 5-fluoro-thiokynurenic acid.
摘要翻译：可用作治疗神经系统疾病的治疗剂的犬尿酸衍生物，例如硫代鸟嘌呤酸，7-氯 - 硫 - 鸟嘌呤酸，7-三氟甲基 - 硫代鸟嘌呤酸，7-甲氧基 - 硫代鸟嘌呤酸和5-氟 - 硫代鸟嘌呤酸。

10. 发明授权

US5229373A Use of exogenous gangliosides as a protective factor against toxicity by antitumor drug vincristine 失效
标题翻译：外源性抗坏血酸作为抗病毒药物的毒副作用的保护因子的使用
公开(公告)号：US5229373A
公开(公告)日：1993-07-20
申请号：US66248
申请日：1987-06-25
申请人： Francesco della Valle
发明人： Francesco della Valle
IPC分类号： A61K31/70 , A61K31/7028 , A61K33/24 , A61K35/30 , A61P9/12 , C07H15/04 , C07H15/10
CPC分类号： A61K33/24
摘要： An agent for prevention or prophylaxis of general toxic effects or chronic neurotoxic effects which are caused by the administration of antineoplastic agents, which is to be given to patients prior to administration of said antineoplastic agents and which comprises as an active ingredient a mixture of gangliosides GM.sub.1, GD.sub.1a, GD.sub.1b and GT.sub.1b.
摘要翻译：用于预防或预防由施用抗肿瘤剂引起的一般毒性作用或慢性神经毒性作用的药剂，其在施用所述抗肿瘤剂之前给予患者，并且包含神经节苷脂GM1的混合物作为活性成分，GD1a，GD1b和GT1b。

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