专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08080542B2 S1P receptor modulating compounds and use thereof 失效
标题翻译： S1P受体调节化合物及其用途
公开(公告)号：US08080542B2
公开(公告)日：2011-12-20
申请号：US12234514
申请日：2008-09-19
申请人： Susana C. Neira , Xiang Yu , Roland Burli , Victor Cee , Brian Lanman
发明人： Susana C. Neira , Xiang Yu , Roland Burli , Victor Cee , Brian Lanman
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D205/04 , C07D401/10
摘要： The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译：本发明涉及具有作为SIP受体调节剂的活性的酰胺和这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

2. 发明授权

US07238341B2 Peptide-based multimeric targeted contrast agents 有权
标题翻译：基于肽的多聚体靶向造影剂
公开(公告)号：US07238341B2
公开(公告)日：2007-07-03
申请号：US10786791
申请日：2004-02-25
申请人： Zhaoda Zhang , John C. Amedio , Peter D. Caravan , Stephane Dumas , Andrew Kolodziej , Thomas J. McMurry
发明人： Zhaoda Zhang , John C. Amedio , Peter D. Caravan , Stephane Dumas , Andrew Kolodziej , Thomas J. McMurry
IPC分类号： A61B5/055
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
摘要翻译：描述了肽和肽靶向多聚体造影剂，以及制造和使用造影剂的方法。

3. 发明申请

US20120088749A1 S1P Receptor Modulating Compounds and Use Thereof 审中-公开
标题翻译： S1P受体调节化合物及其用途
公开(公告)号：US20120088749A1
公开(公告)日：2012-04-12
申请号：US13327951
申请日：2011-12-16
申请人： Susana C. Neira , Xiang Yu , Roland Burli , Victor Cee , Brian Lanman
发明人： Susana C. Neira , Xiang Yu , Roland Burli , Victor Cee , Brian Lanman
IPC分类号： A61K31/397 , C07D401/10 , A61K31/4427 , A61P37/06 , A61P29/00 , A61P35/02 , A61P3/10 , A61P25/00 , A61P17/06 , A61P1/04 , A61P1/00 , C07D205/04 , A61P19/04
CPC分类号： C07D205/04 , C07D401/10
摘要： The present invention relates to amides that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译：本发明涉及具有作为S1P受体调节剂的活性的酰胺和这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

4. 发明申请

US20090082331A1 S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF 失效
标题翻译： S1P受体调节化合物及其用途
公开(公告)号：US20090082331A1
公开(公告)日：2009-03-26
申请号：US12234514
申请日：2008-09-19
申请人： Susana C. Neira , Xiang Yu
发明人： Susana C. Neira , Xiang Yu
IPC分类号： A61K31/397 , C07D205/04 , A61P37/06 , A61P19/02 , A61P3/10 , A61P1/00 , A61P35/02
CPC分类号： C07D205/04 , C07D401/10
摘要： The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译：本发明涉及具有作为SIP受体调节剂的活性的酰胺和这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

5. 发明申请

US20080044360A1 METHODS OF COLLAGEN IMAGING 有权
标题翻译： COLLAGEN成像方法
公开(公告)号：US20080044360A1
公开(公告)日：2008-02-21
申请号：US11618458
申请日：2006-12-29
申请人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
IPC分类号： A61K49/14 , A61K49/06 , A61K49/08 , A61K49/10
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要： Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译：描述用于成像和/或评估胶原的诊断组合物和方法。诊断组合物可以包括胶原结合肽。

6. 发明申请

US20070244316A1 Optically pure and enriched isomers of chelating ligands and contrast agents 有权
标题翻译：光学纯化和富集的螯合配体和造影剂的异构体
公开(公告)号：US20070244316A1
公开(公告)日：2007-10-18
申请号：US11542883
申请日：2006-10-04
申请人： John Amedio , Peter Caravan , Vincent Jacques , Kevin Zhou , Stuart Levy , Shirley Kalogeropoulos , Matthew Greenfield
发明人： John Amedio , Peter Caravan , Vincent Jacques , Kevin Zhou , Stuart Levy , Shirley Kalogeropoulos , Matthew Greenfield
IPC分类号： C07D257/02 , C07K7/06 , C07K7/08
CPC分类号： A61K49/10 , A61K49/085 , A61K49/106 , A61K49/14 , C07D257/02
摘要： Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.
摘要翻译：公开了有机螯合配体，有机螯合配体前体和金属螯合物。还描述了合成它们的方法，包括制备其光学富集或光学纯的组合物的方法。

7. 发明授权

US07186797B2 Polypeptide conjugates with extended circulating half-lives 失效
标题翻译：具有延长的循环半衰期的多肽缀合物
公开(公告)号：US07186797B2
公开(公告)日：2007-03-06
申请号：US10487025
申请日：2002-08-09
申请人： Theodore R. West , Thomas J McMurry , Stephane Dumas , Andrew Kolodziej
发明人： Theodore R. West , Thomas J McMurry , Stephane Dumas , Andrew Kolodziej
IPC分类号： C07K1/113 , C07K2/00 , C07K14/435
CPC分类号： C07F9/091 , A61K38/00 , A61K47/54 , A61K47/548 , C07F9/5537 , C07K1/1077 , C07K14/62
摘要： The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.
摘要翻译：本发明涉及合成化合物的化合物和方法，其中化合物在血液中表现出延长的循环半衰期。循环半衰期的增加通过将多肽与对人血清白蛋白显示高亲和力的结合基团结合而实现。

8. 发明申请

US20070020184A1 Diagnostic imaging contrast agents with extended blood retention 审中-公开
公开(公告)号：US20070020184A1
公开(公告)日：2007-01-25
申请号：US11526302
申请日：2006-09-25
申请人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
发明人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
IPC分类号： A61K49/10 , C07F5/00 , C07D257/02
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

9. 发明授权

US07855193B2 S1P receptor modulating compounds and use thereof 有权
标题翻译： S1P受体调节化合物及其用途
公开(公告)号：US07855193B2
公开(公告)日：2010-12-21
申请号：US11491766
申请日：2006-07-24
申请人： Ashis K. Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert Christian Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker
发明人： Ashis K. Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert Christian Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/4525 , A61K31/4025 , A61K31/343 , C07D411/06 , C07D405/06 , C07D205/04 , C07D307/80
CPC分类号： C07D405/10 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/10 , C07D417/14
摘要： The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译：本发明涉及具有作为S1P受体调节剂的活性的通式（I）的化合物，以及这些化合物用于治疗与不适当的S1P受体活性有关的疾病的用途。这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

10. 发明申请

US20080058636A1 METHODS OF MYOCARDIAL IMAGING 审中-公开
标题翻译：心肌成像方法
公开(公告)号：US20080058636A1
公开(公告)日：2008-03-06
申请号：US11618556
申请日：2006-12-29
申请人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人： Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
IPC分类号： A61B5/055 , A61K38/16
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要： Diagnostic compositions and methods for imaging collagen and/or assessing myocardial perfusion are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译：描述用于胶原成像和/或评估心肌灌注的诊断组合物和方法。诊断组合物可以包括胶原结合肽。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式