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1. 发明授权

US09142145B2 Medical training systems and methods 有权
公开(公告)号：US09142145B2
公开(公告)日：2015-09-22
申请号：US14616409
申请日：2015-02-06
申请人： VIRTAMED AG , EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH
发明人： Stefan Tuchschmid , Daniel Bachofen , Matthias Harders , Jonas Spillman
IPC分类号： G09B23/28 , A61B19/00
CPC分类号： G09B23/28 , A61B34/20 , G06F19/00
摘要： Simulation systems and methods may enable virtual imaging. A data processing unit may receive data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to a physical model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the physical model. The data processing unit may generate a virtual image using the data from the position and orientation sensor and the data from the calibration unit. The data processing unit may render the virtual image to a display.

2. 发明授权

US08992230B2 Medical training systems and methods 有权
标题翻译：医疗培训体系和方法
公开(公告)号：US08992230B2
公开(公告)日：2015-03-31
申请号：US13732899
申请日：2013-01-02
申请人： Virtamed AG , Eidgenossische Technische Hochschule Zurich
发明人： Stefan Tuchschmid , Daniel Bachofen , Matthias Harders , Jonas Spillmann
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , A61B34/20 , G06F19/00
摘要： Simulation systems and methods may enable virtual imaging. A data processing unit may receive data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to a physical model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the physical model. The data processing unit may generate a virtual image using the data from the position and orientation sensor and the data from the calibration unit. The data processing unit may render the virtual image to a display.
摘要翻译：仿真系统和方法可以实现虚拟成像。数据处理单元可以从校准单元接收指示相对于物理模型的位置和方向传感器的位置和/或取向的数据。数据处理单元还可以从位置和方向传感器接收指示物理模型的位置和/或取向的数据。数据处理单元可以使用来自位置和方向传感器的数据和来自校准单元的数据来生成虚拟图像。数据处理单元可以将虚拟图像呈现给显示器。

3. 发明申请

US20140133745A1 OBJECT RECOGNITION DEVICE 有权
标题翻译：对象识别装置
公开(公告)号：US20140133745A1
公开(公告)日：2014-05-15
申请号：US14126690
申请日：2012-06-14
申请人： Nima Razavi , Juergen Gall , Luc Van Gool , Ryuji Funayama
发明人： Nima Razavi , Juergen Gall , Luc Van Gool , Ryuji Funayama
IPC分类号： G06K9/62 , G06K9/00
CPC分类号： G06K9/6267 , G06K9/00791 , G06K9/00805 , G06K9/4633 , G06K9/6219 , G06K9/6282 , G06K2209/27
摘要： A learning unit 4 generates a function table indicating the relationship between the class number and position information of an object and the probability of appearance of the object for each small area image pattern of a code book, calculates a sharing matrix indicating the commonality of a feature amount between the classes, makes a tree diagram in which the classes with a similar feature amount are clustered, and calculates the weight of each node in the tree diagram for each small area image pattern. The recognition processing unit 7 compares image data captured by a camera 2 with the code book, selects the closest small area image pattern among a plurality of small area image patterns, extracts the class related to the node with the smallest weight among the nodes with a weight equal to or greater than a threshold value for the selected small area image pattern, and votes the position information of the small area image pattern for the class, thereby recognizing the object.
摘要翻译：学习单元4生成指示对象的类号和位置信息之间的关系的函数表以及代码本的每个小区域图像图案的对象的出现概率，计算表示特征的共性的共享矩阵这些类之间的数量构成树图，其中具有相似特征量的类被聚类，并且为每个小区域图像模式计算树图中每个节点的权重。识别处理单元7将照相机2拍摄的图像数据与码本进行比较，选择多个小区域图像图案中最接近的小区域图像图案，从而在节点之间提取与节点中具有最小权重的节点相关的类别权重等于或大于所选择的小区域图像图案的阈值，并且对该类别的小区域图像图案的位置信息进行投票，从而识别该对象。

4. 发明授权

US08501421B2 Method for high throughput peptide/protein assay generation and assays generated therewith 有权
标题翻译：用于生成高通量肽/蛋白质测定法的方法和由此产生的测定法
公开(公告)号：US08501421B2
公开(公告)日：2013-08-06
申请号：US12994093
申请日：2009-05-20
申请人： Rudolf Aebersold , Paola Picotti , Oliver Rinner , Johan Malmstroem
发明人： Rudolf Aebersold , Paola Picotti , Oliver Rinner , Johan Malmstroem
IPC分类号： G01N31/00 , G01N33/53
CPC分类号： G01N33/6848
摘要： The invention relates to a method for the determination of an MRM or SRM assay for a protein of interest, a peptide of interest, or a group of proteins/peptides of interest or a whole proteome. It essentially includes the following steps: (1) a list of proteins of interest is selected and for each member at least one or a list of candidate proteotypic peptides is derived (2) this at least one peptide is synthesized/generated essentially without subsequent purification; (3) this at least one unpurified peptide is analyzed by selected reaction monitoring (SRM) preferably coupled to liquid chromatography (LC-SRM) or analogous techniques; (4) validation and/or optimisation of the corresponding assay of the at least one peptide with determination of the SRM coordinates for a peptide/protein of interest and/or of a regulator of interest is achieved. A protein sample of interest is enzymatically digested and can then be analyzed in SRM mode or time-constrained SRM mode, using elution times to trigger acquisition of the set of selected SRM traces, thus drastically increasing the throughput. The analysis allows to detect and quantify the set of peptides/proteins of interest. The method additionally relates to a tagging strategy to achieve absolute quantification of the peptides/proteins of interest at low-budget and high-throughput.
摘要翻译：本发明涉及用于确定感兴趣的蛋白质，目标肽或感兴趣的蛋白质/肽组或整个蛋白质组的MRM或SRM测定法的方法。它基本上包括以下步骤：（1）选择目的蛋白的列表，并且对于每个成员，导出候选蛋白多肽的至少一个或一个或多个列表（2）该基因上没有随后的纯化合成/生成至少一种肽 ; （3）通过优选与液相色谱法（LC-SRM）偶联的选择性反应监测（SRM）或类似技术来分析至少一种未纯化的肽。（4）通过确定感兴趣的肽/ /蛋白质和/或感兴趣的调节剂的SRM坐标来确定和/或优化至少一种肽的相应测定。感兴趣的蛋白质样品被酶消化，然后可以以SRM模式或时间受限的SRM模式进行分析，使用洗脱时间来触发所选择的SRM迹线的采集，从而大大增加产量。该分析允许检测和定量所组合的肽/蛋白质。该方法另外涉及在低预算和高通量下实现目标肽/蛋白质的绝对定量的标记策略。

5. 发明授权

US08496836B2 Method and device for chromatographic purification 有权
标题翻译：色谱纯化方法和装置
公开(公告)号：US08496836B2
公开(公告)日：2013-07-30
申请号：US12916367
申请日：2010-10-29
申请人： Lars Aumann , Massimo Morbidelli
发明人： Lars Aumann , Massimo Morbidelli
IPC分类号： B01D15/08 , C02F1/28
CPC分类号： G01N30/468 , B01D15/1828 , B01D15/1864
摘要： A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent(s). The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (α,β,γ,δ). After or within a switch time (t*) the last column from the first section (α) is moved to the first position of the second section (β), the last column of the second section (β) is moved to the first position of the third section (γ), the last column of the third section (γ) is moved to the first position of the fourth section (δ) and the last column of the fourth section (δ) is moved to become the first column of the first section (α).
摘要翻译：通过单独的色谱柱连续或准连续纯化多组分混合物（F）的方法，混合物通过其通过至少一种溶剂进料。多组分混合物（F）至少包含轻质杂质（A），待纯化的中间产物（B）和重杂质（C），并且将列分成至少四个部分（α，β，γ，三角洲）。在切换时间（t *）之后或之内，来自第一部分（α）的最后一列被移动到第二部分（β）的第一位置，第二部分（β）的最后一列被移动到第一部分（γ）的第三部分（γ）的最后一列移动到第四部分（delta）的第一位置，并且第四部分（delta）的最后一列被移动成为第第一部分（alpha）。

6. 发明申请

US20130189663A1 MEDICAL TRAINING SYSTEMS AND METHODS 有权
公开(公告)号：US20130189663A1
公开(公告)日：2013-07-25
申请号：US13732899
申请日：2013-01-02
申请人： VIRTAMED AG , EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH
发明人： STEFAN TUCHSCHMID , DANIEL BACHOFEN , MATTHIAS HARDERS , JONAS SPILLMANN
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , A61B34/20 , G06F19/00
摘要： Simulation systems and methods may enable virtual imaging. A data processing unit may receive data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to a physical model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the physical model. The data processing unit may generate a virtual image using the data from the position and orientation sensor and the data from the calibration unit. The data processing unit may render the virtual image to a display.

7. 发明申请

US20120314017A1 Transparent Autostereoscopic Image Display Apparatus and Method 有权
标题翻译：透明自动立体图像显示装置及方法
公开(公告)号：US20120314017A1
公开(公告)日：2012-12-13
申请号：US13510192
申请日：2010-11-16
申请人： Markus Gross
发明人： Markus Gross
IPC分类号： H04N7/14 , G06T15/00
CPC分类号： G02B27/2214 , H04N13/315 , H04N13/363
摘要： An image display apparatus includes a display layer and an image separation layer. The image separation layer is adapted to separate a displayed image on the display layer into a first image for a left eye of an observer and into a second image for a right eye of an observer. This renders the image display apparatus autostereoscopic. In order to improve the appearance of the displayed image, the apparatus is adapted to activate the display layer and the image separation layer substantially only within a given two-dimensional silhouette and to remain substantially transparent outside of the silhouette. In other aspects, the apparatus may be adapted to dynamically adjust an observation angle between the first image and the second image by controlling the distance between the display layer and the image separation layer by an actuator. The apparatus may be mounted on a robotic unit.
摘要翻译：图像显示装置包括显示层和图像分离层。图像分离层适于将显示层上的显示图像分离成用于观察者的左眼的第一图像和用于观察者右眼的第二图像。这使得图像显示装置自动立体。为了改善显示图像的外观，该装置适于基本上仅在给定的二维轮廓内激活显示层和图像分离层，并且在轮廓外部保持基本透明。在其他方面，该装置可以适于通过致动器控制显示层和图像分离层之间的距离来动态地调整第一图像和第二图像之间的观察角度。该装置可以安装在机器人单元上。

8. 发明授权

US08309518B2 Drug delivery matrices to enhance wound healing 有权
标题翻译：药物递送基质以增强伤口愈合
公开(公告)号：US08309518B2
公开(公告)日：2012-11-13
申请号：US12845354
申请日：2010-07-28
申请人： Jason C. Schense , Hugo Schmoekel , Jeffrey A. Hubbell , Franz Weber
发明人： Jason C. Schense , Hugo Schmoekel , Jeffrey A. Hubbell , Franz Weber
IPC分类号： A61K38/18 , A61K38/36 , C07K14/495 , C07K14/51
CPC分类号： A61L31/046 , A61L24/0015 , A61L24/106 , A61L27/225 , A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45
摘要： Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.
摘要翻译：生物活性分子被包埋在基质内，用于受控递送这些化合物用于治疗性愈合应用。基质可以由天然或合成的化合物形成。捕获生物活性分子的主要方法是通过体外或体内在基质凝胶化过程中沉淀生物活性分子。生物活性分子可以被修饰以降低其在基质中的有效溶解度，以便在基质内更有效地保留生物活性分子，例如通过胱氨酸结生长因子超家族内，特别是在TGF-bgr内的成员的去糖基化; 超家族可以修饰基质以包括对不同生物活性分子具有结合亲和力的位点，例如用于肝素结合的位点。

9. 发明授权

US08097254B2 Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis 有权
标题翻译：用于闪烁扫描的特异性结合分子，含有它们的缀合物和用于治疗血管发生的治疗方法
公开(公告)号：US08097254B2
公开(公告)日：2012-01-17
申请号：US10821930
申请日：2004-04-12
申请人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
发明人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
IPC分类号： A61K39/00 , A61K39/395 , A61K51/00 , A61K38/39 , C07K14/515
CPC分类号： C07C63/04 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/622
摘要： The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
摘要翻译：本发明涉及对纤连蛋白的ED-B结构域的特征性表位具有亚纳摩尔亲和力的抗体，血管发生的标志物。此外，它涉及放射性标记的高亲和力抗ED-B抗体用于检测体内新形成血管的用途以及包含所述抗体的诊断试剂盒。此外，它涉及包含所述抗体和合适的光活性分子（例如适当选择的光敏剂或放射性核素）的缀合物，以及它们用于选择性光介导的新血管阻塞的用途。

10. 发明申请

US20110233472A1 POROUS CERAMIC CATALYSTS AND METHODS FOR THEIR PRODUCTION AND USE 审中-公开
标题翻译：多孔陶瓷催化剂及其生产和使用方法
公开(公告)号：US20110233472A1
公开(公告)日：2011-09-29
申请号：US13003239
申请日：2009-07-06
申请人： Nico Hotz , Dimos Poulikakos , André Studart , Ludwig Gauckler , Anja Bieberle-Hutter
发明人： Nico Hotz , Dimos Poulikakos , André Studart , Ludwig Gauckler , Anja Bieberle-Hutter
IPC分类号： C01B3/26 , B01J31/18
CPC分类号： B01J35/04 , B01J23/42 , B01J23/44 , B01J23/63 , B01J35/0013 , B01J37/0009 , B01J37/0215 , B01J37/0236 , B01J37/349 , C01B3/40 , C01B2203/0233 , C01B2203/0261 , C01B2203/0283 , C01B2203/1064 , C01B2203/107 , C01B2203/1082 , C01B2203/1241 , C01B2203/1247 , Y02P20/52
摘要： A method of producing a rigid catalytically active porous ceramic is disclosed. Catalyst particles comprising a catalytically active material or a precursor thereof are mixed with a chemical additive, a ceramic binder, a carrier liquid and, optionally, substantially inert carrier particles to obtain a slurry having a gel-or paste-like consistency. The slurry may be transported to a substrate, e.g., by printing, or to a reactor cavity by a suitable flow method. The slurry is then heated to substantially evaporate said carrier liquid to obtain a rigid, catalytically active porous ceramic in situ. A catalyst obtainable by such a method and the use of such a catalyst are also disclosed.
摘要翻译：公开了一种制备刚性催化活性多孔陶瓷的方法。包含催化活性材料或其前体的催化剂颗粒与化学添加剂，陶瓷粘合剂，载体液体和任选的基本上惰性的载体颗粒混合，以获得具有凝胶或糊状稠度的浆料。可以通过适当的流动方法将浆料例如通过印刷或转移到反应器腔中来运输到基底。然后将浆料加热以使所述载体液体基本蒸发，以便原位获得刚性的催化活性多孔陶瓷。还公开了通过这种方法获得的催化剂和这种催化剂的用途。

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