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1. 发明申请

US20130109847A1 Detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes 有权
标题翻译：检测或定量所需的靶分子，新型染料，复合染料和寡核苷酸或包含这些染料的多核苷酸
公开(公告)号：US20130109847A1
公开(公告)日：2013-05-02
申请号：US12456514
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C07D417/14 , C07K16/00 , C07H21/00 , C07K14/00 , C07D417/06 , C07H19/10
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。

2. 发明申请

US20120183948A1 Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from epsilon-amino lysine moieties 有权
标题翻译：用于检测从ε-氨基赖氨酸部分去除甲酰基，琥珀酰基，甲基琥珀酰基或肉豆蔻酰基的酶的化合物和方法
公开(公告)号：US20120183948A1
公开(公告)日：2012-07-19
申请号：US12930693
申请日：2011-01-13
申请人： Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
发明人： Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
IPC分类号： C12Q1/00 , C07D493/10 , C07D311/16
CPC分类号： C12Q1/34 , C07D311/16 , C07D493/10 , C12Y305/01098 , G01N2333/98
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
摘要翻译：提供了包含以下结构的化合物：其中SIG是信号分子，R3是甲酰基，琥珀酰基，甲基琥珀酰基或肉豆蔻酰基。还提供了包含上述化合物的试剂盒，其具有用于确定酶的存在的说明书。此外，提供了一种用于确定样品是否具有从赖氨酸的“ - ” - 氨基除去琥珀酰基，甲基琥珀酰基，甲酰基或肉豆蔻酰部分的酶的方法。还提供了确定分子是否抑制从赖氨酸的“ - ” - 氨基除去琥珀酰基，甲基琥珀酰基，甲酰基或肉豆蔻酰部分的酶的方法。

3. 发明申请

US20120122136A1 Self-immolative probes for enzyme activity detection 有权
标题翻译：用于酶活性检测的自发性探针
公开(公告)号：US20120122136A1
公开(公告)日：2012-05-17
申请号：US12927497
申请日：2010-11-16
申请人： Maciej Szczepanik , Irina V. Lebedeva , Yuejun Xiang , Praveen Pande , Wayne Forrest Patton
发明人： Maciej Szczepanik , Irina V. Lebedeva , Yuejun Xiang , Praveen Pande , Wayne Forrest Patton
IPC分类号： C12Q1/26 , C07D491/22 , G01N21/75 , C07D493/10 , C07D413/14 , C07D237/32 , C07D311/08
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound comprising the structure: (SIG)-(SI-MOD)m. In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.
摘要翻译：提供了包含以下结构的化合物：（SIG） - （SI-MOD）m。在该化合物中，SIG是信号分子，SI是与SIG结合的自消除结构，使得SIG相对于没有SI的SIG的信号具有降低的信号，MOD是与SI结合的部分，其经受活化剂，m为1至约10的整数。用该化合物，当MOD被活化剂修饰时，SI是不稳定的并且从SIG自分离，使得SIG产生增加的信号。还提供了使用上述化合物来确定样品是否包含活化剂的方法。另外提供了使用上述硝基还原酶是活化剂的化合物来确定细胞是否包含硝基还原酶的方法。还提供了使用上述硝基还原酶是活化剂的化合物来确定哺乳动物细胞是否缺氧的方法。还提供了使用上述硝基还原酶为活化剂的化合物检测包含硝基还原酶的微生物的方法。还提供了使用上述硝酸还原酶是活化剂的化合物来鉴定样品中的硝基还原酶的方法。

4. 发明申请

US20120115169A1 HYDROXYCHOLESTEROL IMMUNOASSAY 有权
标题翻译：羟吗啉酮免疫
公开(公告)号：US20120115169A1
公开(公告)日：2012-05-10
申请号：US12927206
申请日：2010-11-09
申请人： Michael C. Mullenix , Robert Elliot Zipkin , Jeffrey Kroll Adams , Wayne Forrest Patton , James J. Donegan
发明人： Michael C. Mullenix , Robert Elliot Zipkin , Jeffrey Kroll Adams , Wayne Forrest Patton , James J. Donegan
IPC分类号： G01N33/53 , C07J9/00 , C07K14/00 , C07J43/00 , G01N33/566 , C07K16/44
CPC分类号： G01N33/92 , C07J9/00 , C07J43/003 , C07K16/18 , C07K16/44 , C07K2317/21 , G01N33/5308 , G01N33/56966 , G01N2800/2835 , G01N2800/285 , G01N2800/52
摘要： Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective.
摘要翻译：提供了22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的衍生物。还提供了与上述衍生物结合的蛋白质。进一步提供了包含特异性结合22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的抗体的抗体组合物。此外，提供了制备特异性结合22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的抗体的方法。此外，提供了测定22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的方法。另外提供了用于检测22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的试剂盒。还提供了检测在II期药物代谢中使用的酶或酶的方法。此外，提供了检测合成22-羟基胆固醇，24S-羟基胆固醇，25-羟基胆固醇，26-羟基胆固醇或27-羟基胆固醇的酶的方法。进一步提供评估患者多发性硬化症进展的方法。还提供了确定患者多发性硬化症的治疗是否有效的方法。此外，提供了评价患者中亨廷顿病进展的方法。另外提供了一种确定患者亨廷顿氏病的治疗是否有效的方法。

5. 发明申请

US20110098441A1 Label target and labeling reagents comprising backbones with at least two consecutive peptide bonds 有权
标题翻译：标记靶标和标记试剂，其包含具有至少两个连续肽键的骨架
公开(公告)号：US20110098441A1
公开(公告)日：2011-04-28
申请号：US10763104
申请日：2004-01-22
申请人： Jannis G. Stavrianopoulos , Flazar Rabbani
发明人： Jannis G. Stavrianopoulos , Flazar Rabbani
IPC分类号： C07K5/103 , C07H19/10 , C07K9/00 , C07K19/00 , C07H21/00 , C07K16/46 , C08B37/00 , C07D403/06 , C07D311/82 , C07D491/16
CPC分类号： C07H21/00 , C09B23/02 , C09B47/00 , C09B57/00 , Y10S436/80
摘要： This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
摘要翻译：本发明提供标记试剂，标记的靶标和制备标记试剂的方法。标记试剂可以采用花青染料，呫吨染料，卟啉染料，香豆素染料或复合染料的形式。这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。这些试剂可用于基于蛋白质和基于核酸探针的测定。它们也适用于实时检测过程。

6. 发明申请

US20110028692A1 Multisignaling oligomeric or polymeric compositions comprising labeled moieties and binding partners 有权
标题翻译：包含标记部分和结合配偶体的多重信号低聚或聚合物组合物
公开(公告)号：US20110028692A1
公开(公告)日：2011-02-03
申请号：US12803354
申请日：2010-06-24
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan
IPC分类号： C07H21/00 , C07K14/765 , C07K14/00
CPC分类号： C07H21/04
摘要： The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties.
摘要翻译：本发明提供多信号标记试剂，并且它们可用于许多生化应用，包括生物分子探针的制备及其在检测或扩增分析物特异性部分中的用途。

7. 发明申请

US20100324268A1 Multi-oligomeric or multi--polymeric compositions comprising labeled moieties and binding partners 有权
标题翻译：包含标记部分和结合配偶体的多聚体或多聚合物组合物
公开(公告)号：US20100324268A1
公开(公告)日：2010-12-23
申请号：US12803355
申请日：2010-06-24
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan
IPC分类号： C07K14/765 , C07H21/04
CPC分类号： C07H21/04
摘要： The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties.
摘要翻译：本发明提供多信号标记试剂，并且它们可用于许多生化应用，包括生物分子探针的制备及其在检测或扩增分析物特异性部分中的用途。

8. 发明授权

US07737281B2 Purine based fluorescent dyes 有权
标题翻译：基于嘌呤的荧光染料
公开(公告)号：US07737281B2
公开(公告)日：2010-06-15
申请号：US11177923
申请日：2005-07-07
申请人： Maciej Szczepanik
发明人： Maciej Szczepanik
IPC分类号： C07D215/38
CPC分类号： C07D401/14 , C07D405/14 , C07D417/06 , C07D417/14 , C07D473/00 , C07F9/65616 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/6816 , C12Q2563/107
摘要： The present invention provides novel purine-based fluorescent dyes that may be used for staining, localizing and otherwise labeling target molecules, such as nucleic acids, for detection, amplification and quantification.
摘要翻译：本发明提供了新的基于嘌呤的荧光染料，其可用于染色，定位和以其他方式标记用于检测，扩增和定量的靶分子，例如核酸。

9. 发明授权

US07220854B1 Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides 失效
标题翻译：糖部分标记的核苷酸，以及寡核苷酸或多核苷酸，以及包含这种糖部分标记的核苷酸的其它组合物
公开(公告)号：US07220854B1
公开(公告)日：2007-05-22
申请号：US08486066
申请日：1995-06-07
申请人： Dean Engelhardt , Elazar Rabbani , Stanley Kline , Jannis G. Stavrianopoulos , Dollie Kirtikar
发明人： Dean Engelhardt , Elazar Rabbani , Stanley Kline , Jannis G. Stavrianopoulos , Dollie Kirtikar
IPC分类号： C07H19/04
CPC分类号： C07H19/04
摘要： The present invention provides a nucleotide having the formula, wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to SM at a position independently selected from the 2′, 3′, and 5′ positions of SM when the nucleotide is a ribonucleotide, and at a position independently selected from the 3′ and 5′ positions when the nucleotide is a deoxyribonucleotide. BASE is attached to the 1′ position of SM from the N1 position when BASE is a pyrimidine, or the N9 position when BASE is a purine or 7-deazapurine. Sig is a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such sugar moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminal ligated or attached to the oligo- or polynucleotide. The sugar moiety labeled nucleotide, and the oligo- or polynucleotides and other compositions comprising such nucleotides, are useful as diagnostic tools for detecting analytes and as therapeutic agents.
摘要翻译：本发明提供了具有下式的核苷酸，其中PM是磷酸酯部分，SM是核糖或脱氧核糖糖部分，BASE是嘧啶，嘌呤或7-脱氮嘌呤部分。当核苷酸是核糖核苷酸时，PM与独立地选自SM的2'，3'和5'位置的位置连接，并且当该核苷酸为脱氧核糖核苷酸当BASE是嘧啶时，BASE从N 1位置连接到SM的1'位置，或当BASE是嘌呤或7-脱氮嘌呤时，BASE被连接到N 9的位置。 Sig是直接或通过连接基共价连接到SM的可检测部分。还提供了包含至少一个这样的糖部分标记的核苷酸的寡核苷酸或多核苷酸，以及其他组合物，包括其中多肽是末端连接或连接到寡核苷酸或多核苷酸的那些。标记核苷酸的糖部分和包含这种核苷酸的寡核苷酸和多核苷酸和其它组合物可用作检测分析物和作为治疗剂的诊断工具。

10. 发明授权

US07064197B1 System, array and non-porous solid support comprising fixed or immobilized nucleic acids 失效
标题翻译：系统，阵列和无孔固体支持物，其包含固定或固定的核酸
公开(公告)号：US07064197B1
公开(公告)日：2006-06-20
申请号：US08486070
申请日：1995-06-07
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , Dollie Kirtikar , Kenneth H. Johnston , Barbara E. Thalenfeld
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , Dollie Kirtikar , Kenneth H. Johnston , Barbara E. Thalenfeld
IPC分类号： C07H21/04 , C12N16/11
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q1/6834 , G01N33/535 , G01N33/552 , G01N33/581 , Y10S435/81 , Y10S436/80 , Y10S436/81 , Y10T436/143333
摘要： Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions are useful for nucleic acid analyses and a host of applications, including, for example, detection, mutational analysis and quantification. The non-porous solid supports can be transparent or translucent, and the surfaces can be treated with agents to fix or immobilize the nucleic acids. Such agents include, for example, amine providing compounds, epoxy compounds and acid solutions. The fixed or immobilized nucleic acids can be unlabeled, or labeled with at least one non-radioactive signaling moiety, such as the case when the nucleic acids are double-stranded.
摘要翻译：核酸被固定或固定在无孔固体支持物（底物）上，并且包括含有固定或固定核酸的载体和阵列的体系。这些组合物可用于核酸分析和许多应用，包括例如检测，突变分析和定量。无孔固体支持物可以是透明或半透明的，并且表面可以用试剂处理以固定或固定核酸。这些试剂包括例如胺提供化合物，环氧化合物和酸溶液。固定或固定的核酸可以是未标记的，或用至少一个非放射性信号传导部分标记，例如当核酸是双链的情况。

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