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1. 发明授权

US06846508B1 Method for adhering substrates using adhesive devices containing silicone gels 失效
标题翻译：使用含有硅胶的粘合剂粘合基材的方法
公开(公告)号：US06846508B1
公开(公告)日：2005-01-25
申请号：US09304393
申请日：1999-05-04
申请人： Andre Rudolf Louis Colas , Gary Lord , Marie Therese Valencia , Xavier Thomas
发明人： Andre Rudolf Louis Colas , Gary Lord , Marie Therese Valencia , Xavier Thomas
IPC分类号： A61L24/00 , A61L15/58 , A61L24/04 , A61L31/06 , C08L83/04 , C09J5/00 , C09J7/04 , A61L27/00 , C09J7/02
CPC分类号： C09J5/00 , A61L15/58 , A61L24/046 , A61L31/06 , C08L83/04 , C09J7/21 , C09J7/38 , C09J2201/128 , C09J2201/606 , C09J2483/00 , Y10T428/2852 , Y10T428/31663 , Y10T442/2754 , Y10T442/60
摘要： A method for adhering a first substrate to a second substrate using a double sided adhesive device based on silicone gels. The method is particularly useful for adhering a medical prosthesis to a human or animal body.
摘要翻译：使用基于有机硅凝胶的双面粘合装置将第一基板粘附到第二基板的方法。该方法对于将医疗假体粘附到人或动物身体特别有用。

2. 发明授权

US5145933A Organosiloxane gel-forming compositions and use thereof 失效
标题翻译：有机硅氧烷凝胶形成组合物及其用途
公开(公告)号：US5145933A
公开(公告)日：1992-09-08
申请号：US665855
申请日：1991-03-07
申请人： Bernard F. R. Grisoni , David Pocknell
发明人： Bernard F. R. Grisoni , David Pocknell
IPC分类号： A61L26/00 , A61L27/18 , C08L83/04
CPC分类号： A61L26/0019 , A61L26/008 , A61L27/18 , C08L83/04 , C08G77/12 , C08G77/20 , C08G77/70
摘要： Non-friable siloxane gels which can be used for gel dressings and in medical prostheses are made from compositions comprising (A) alkenyl-containing polydiorganosiloxanes; (B) hydrosilicon compounds having at least 3 Si-H groups; (C) SiH end-blocked polydiorganosiloxanes and (D) a catalyst. These compositions cure rapidly at room temperature having a ratio (RHAlk) of SiH:Si-Alkenyl of from 3:1 to 20:1, the percentage of silicon-bonded H atoms provided by (C) not being less than 81.36-(3.6.times.RHAlk) and having a value of from 10% to 90%.
摘要翻译：可用于凝胶敷料和医用假体的非易碎硅氧烷凝胶由包含（A）含链烯基的聚二有机硅氧烷的组合物制成; （B）具有至少3个Si-H基团的氢硅氧烷化合物; （C）SiH封端聚二有机硅氧烷和（D）催化剂。这些组合物在室温下快速固化，其中SiH:Si-烯基的比率（RHAlk）为3：1至20：1，由（C）提供的硅键合H原子的百分比不低于81.36-（3.6 xRHAlk），其值为10％至90％。

3. 发明授权

US6120791A Methods for making controlled release devices for pharmaceuticals 失效
标题翻译：制备药物控制释放装置的方法
公开(公告)号：US6120791A
公开(公告)日：2000-09-19
申请号：US113636
申请日：1998-07-10
申请人： Louis Michel Jacques Aguadisch , Patrick Robert Peignot , Alain Etienne , Frederic Jean Claude Goutte
发明人： Louis Michel Jacques Aguadisch , Patrick Robert Peignot , Alain Etienne , Frederic Jean Claude Goutte
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0092 , A61K9/2095
摘要： The invention relates to a process for making a controlled release device suitable for introduction into a human or animal body. The process comprises coextruding a continuous external body comprising a silicone elastomer and one or more elements comprising a synthetic pharmaceutical agent within the continuous external body.
摘要翻译：本发明涉及一种制备适合引入人或动物体内的控制释放装置的方法。该方法包括在连续的外部体内共挤出包含硅氧烷弹性体的连续外体和包含合成药剂的一种或多种元素。

4. 发明授权

US5788977A Method of making controlled release devices 失效
标题翻译：制造控释装置的方法
公开(公告)号：US5788977A
公开(公告)日：1998-08-04
申请号：US803739
申请日：1997-02-21
申请人： Louis Aguadisch , Magali Barbaroux , Frederic Dalle
发明人： Louis Aguadisch , Magali Barbaroux , Frederic Dalle
IPC分类号： A61M37/00 , A61K9/00 , A61K9/52 , C08L83/04 , C08L83/06 , A61F13/00
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0036 , A61K9/0039 , A61K9/0085
摘要： A process is disclosed for making devices which release active material, e.g. a drug, at a controlled rate, which device comprises a closed container and the active material. The device is made by first making a hollow envelope, e.g. by extrusion or moulding, followed by introducing the active material into the void of the envelope. The device may have a ring or cylindrical form.
摘要翻译：公开了一种制造释放活性材料的装置的方法，例如，药物，以受控的速率，该装置包括密闭容器和活性物质。该装置通过首先制造中空包络线，例如通过挤出或模制，然后将活性材料引入到信封的空隙中。该装置可以具有环形或圆柱形形式。

5. 发明授权

US5480653A Formulations for sustained release dressings and their use 失效
标题翻译：持续释放敷料及其用途的配方
公开(公告)号：US5480653A
公开(公告)日：1996-01-02
申请号：US890334
申请日：1992-05-26
申请人： Louis M. J. Aguadisch , Alain Etienne
发明人： Louis M. J. Aguadisch , Alain Etienne
IPC分类号： A61K9/70 , A61K9/00 , A61K9/20 , A61K9/22 , A61K47/34 , A61L26/00 , A61K9/10 , A61L15/26
CPC分类号： A61K9/2036 , A61K9/006 , Y10S514/947
摘要： The invention concerns a sustained release formulation comprising an agent (A) which is to be released and a vehicle (B) therefor.The vehicle comprises a hydrophilic component such as a polyhydroxylated organic substance such as a polyethylene glycol, glycerol, sorbitol, mannitol or lactose and curable silicone composition which is capable of curing at ambient temperature and contains a polysiloxane having alkylhydrogen units, a polysiloxane having unsaturated groups and a platinum or rhodium catalyst. The formulation may be applied to the human or animal body or a cavity in the latter to cure in situ to give a dressing capable of sustained release of the therapeutic or diagnostic agent (A) to the body.The invention is applicable in the field of pharmacy.
摘要翻译：本发明涉及包含待释放的药剂（A）和其用途的载体（B）的持续释放制剂。载体包含亲水性成分如多羟基化有机物质如聚乙二醇，甘油，山梨糖醇，甘露糖醇或乳糖，以及可在环境温度下固化并含有具有烷基氢单元的聚硅氧烷的可固化有机硅组合物，具有不饱和基团的聚硅氧烷和铂或铑催化剂。制剂可以施用于人体或动物体或后者中的空腔，以便原位固化，以产生能够将治疗剂或诊断剂（A）持续释放到身体的敷料。本发明适用于药学领域。

6. 发明授权

US5153231A Silicone foams 失效
标题翻译：硅胶粉丝
公开(公告)号：US5153231A
公开(公告)日：1992-10-06
申请号：US849855
申请日：1992-03-12
申请人： Philippe L. Bouquet , David Pocknell
发明人： Philippe L. Bouquet , David Pocknell
IPC分类号： A61C9/00 , A61L26/00 , B65D81/32 , C08J9/02 , C08K5/06 , C08K5/5419 , C08L83/04 , C08L83/05 , C08L83/06 , C08L83/07
CPC分类号： C08J9/02 , A61C5/064 , A61C9/0026 , A61L26/0019 , A61L26/0085 , B65D81/325 , C08L83/04 , C08J2383/04
摘要： A multi-component foamable silicone composition is described and claimed which is capable of curing quickly at 20.degree. C. to provide a low density foamed mass. The composition comprises (A) one or more polydiorganosiloxanes having not less than three alkyl-hydrogensiloxane units per molecule, (B) one or more polydiorganosiloxanes having not less than two alkenyl-siloxane units (C) a liquid alcohol, (D) a fluorinated silicone foam stabilizing material and (E) a platinum catalyst for promoting reaction between the components. The composition may be packaged as two or more individually stable parts of substantially equal volume and viscosity each in a receptacle of material which is adapted to be opened by rupture so as to release the components for admixture. The composition is intended for use in forming a foam medical dressing by dispensing onto a surface e.g. an open wound and allowing the composition to cure at room temperature.
摘要翻译：描述和要求保护的多组分可发泡硅氧烷组合物，其能够在20℃下快速固化以提供低密度发泡团块。该组合物包含（A）每分子具有不少于三个烷基 - 氢硅氧烷单元的一种或多种聚二有机硅氧烷，（B）一种或多种具有不少于2个烯基 - 硅氧烷单元的聚二有机硅氧烷（C）液体醇，（D）氟化硅氧烷泡沫稳定材料和（E）促进组分之间的反应的铂催化剂。组合物可以作为两个或更多个单独稳定的部分包装，每个部分具有基本上相同的体积和粘度，每个在容器的容器中，其适于通过破裂而打开，以便释放用于混合的组分。该组合物旨在用于通过分配到表面上形成泡沫医疗敷料，例如，开放的伤口并使组合物在室温下固化。

7. 发明授权

US4888074A Therapeutic rings 失效
标题翻译：治疗环
公开(公告)号：US4888074A
公开(公告)日：1989-12-19
申请号：US222441
申请日：1988-07-21
申请人： David Pocknell
发明人： David Pocknell
IPC分类号： A61K9/00 , A61K31/565 , A61M31/00
CPC分类号： A61K9/0036 , A61K9/0039 , A61M31/002 , Y10T156/1036 , Y10T156/1062
摘要： The specification describes and claims a method of making therapeutic rings from a curable silicone rubber based composition. The rings are capable of controlled release of the therapeutic agent in the human or animal body. The method includes the steps of:(i) extruding a first composition comprising a therapeutic agent and a first elastomer-forming silicone composition to provide a core;(ii) extruding a second composition comprising a second elastomer-forming silicone composition to provide a sheath enclosing the core;(iii) bringing together end portions of a piece of extruded core and sheath to form a ring,(iv) effecting crosslinking of the extruded core, and(v) effecting crosslinking of the extruded sheath.
摘要翻译：本说明书描述并要求从可固化的硅橡胶基组合物制备治疗环的方法。环能够在人或动物体内控制释放治疗剂。该方法包括以下步骤：（i）挤出包含治疗剂和第一弹性体形成性硅氧烷组合物的第一组合物以提供核心; （ii）挤出包含第二弹性体形成性硅氧烷组合物的第二组合物，以提供包封芯的护套; （iii）将一片挤出的芯和护套的端部组合在一起形成环，（iv）实现挤出的芯的交联，和（v）实现挤出的护套的交联。

8. 发明授权

US4802068A Sealed chambers 失效
标题翻译：密封室
公开(公告)号：US4802068A
公开(公告)日：1989-01-31
申请号：US118930
申请日：1987-11-10
申请人： Pierre Mokry
发明人： Pierre Mokry
IPC分类号： B29C39/02 , B29K83/00 , B29K105/04 , B29L31/30 , F21V31/00 , F21V31/03 , G10K9/12 , G10K9/13 , G10K9/22 , H04R1/00
CPC分类号： G10K9/22 , F21S48/335 , F21V31/03
摘要： The invention relates to chambers which are sealed against ingress of water and are provided with an element through which air may permeate to equalize pressures of air inside and outside the chamber. The element is of a foamed silicone and has a cellular fine pored layer of predominantly open cells having a skin to be contacted by air outside the chamber. Examples of chambers described and claimed are a vehicle horn and a vehicle headlight.

9. 发明授权

US4791149A Methods of making dressings 失效
标题翻译：敷料方法
公开(公告)号：US4791149A
公开(公告)日：1988-12-13
申请号：US929252
申请日：1986-11-10
申请人： David Pocknell
发明人： David Pocknell
IPC分类号： A61L15/44 , A61F13/00 , A61F13/04 , A61L26/00 , C08L83/04
CPC分类号： C08L83/04 , A61F13/04 , A61L26/0019 , A61L26/0061 , C08G77/12 , C08G77/20 , C08G77/70
摘要： The specification is directed to making noncellular dressings such as gelatinous wound dressings. According to the invention medical and surgical dressings are made by use of packages which may be held in the hand, and which contain the components of two part curable polysiloxane compositions in such a manner that the component may be mixed in predetermined proportions and dispensed therefrom under the influence of propellant gas. The method avoids the need for manual mixing of such compositions during production of dressings.
摘要翻译：本说明书旨在制造非细胞敷料，如胶状伤口敷料。根据本发明，医疗和外科敷料通过使用可以保持在手中的包装制成，并且其包含两部分可固化聚硅氧烷组合物的组分，使得组分可以以预定比例混合并从其中分配推进剂气体的影响。该方法避免了在制备敷料期间手动混合这些组合物。

10. 发明授权

US5232935A Composition for enhancing drug permeation 失效
标题翻译：用于增强药物渗透的组合物
公开(公告)号：US5232935A
公开(公告)日：1993-08-03
申请号：US904743
申请日：1992-06-26
申请人： Andre L. R. Colas , Jonathan Hadgraft , Vivien L. C. Moffat , Franck A. D. Renauld
发明人： Andre L. R. Colas , Jonathan Hadgraft , Vivien L. C. Moffat , Franck A. D. Renauld
IPC分类号： A61K47/04 , A61K47/24 , A61K47/34 , C08L83/04
CPC分类号： A61K47/34 , A61K47/24 , A61K9/0014 , Y10S514/947
摘要： A method of accelerating the permeation of drugs in topical and transdermal delivery of a drug in which a drug is applied to the skin in combination with organosilicon compounds which are carboxyalkyl functional polysiloxanes and alkylsulphoxide functional polysiloxanes. The organosilicon compound may be applied to the skin neat or in the form of a solvent solution containing the organosilicon compound.

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