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1. 发明申请

US20110200679A1 METHOD FOR MANUFACTURING SUSTAINED RELEASE MICROSPHERE BY SOLVENT FLOW EVAPORATION METHOD 审中-公开
标题翻译：通过溶剂流动蒸发方法制造持续释放微球的方法
公开(公告)号：US20110200679A1
公开(公告)日：2011-08-18
申请号：US13061389
申请日：2009-08-28
申请人： Nak Hyun Lim , Sung Geun Kim , Se Yeon Kim , Hyung Joon Jung , Kyung Hoi Cha
发明人： Nak Hyun Lim , Sung Geun Kim , Se Yeon Kim , Hyung Joon Jung , Kyung Hoi Cha
IPC分类号： A61K9/14 , A61K38/09 , A61P5/24
CPC分类号： A61K9/1647 , A61K9/1694
摘要： The present invention relates to a method for preparing a sustained-release microsphere which can control the long-term release of a drug. More particularly, as the preparation of a microsphere in which a drug is loaded in a carrier comprising a biodegradable polymer, the present invention relates to a method for preparing a sustained-release microsphere wherein a solvent intra-exchange evaporation method by means of co-solvent is used for suppressing the initial burst release of physiologically active substance, to release the physiologically active substance in the body continuously and uniformly.
摘要翻译：本发明涉及可以控制药物长期释放的缓释微球的制备方法。更具体地，作为其中将药物负载在包含可生物降解的聚合物的载体中的微球的制备，本发明涉及一种制备缓释微球的方法，其中通过共 - 溶剂用于抑制生理活性物质的初始爆发释放，以连续均匀地释放身体中的生理活性物质。

2. 发明申请

US20100272820A1 Preparation Method of Sustained-Release Microcapsules Having Good Initial Burst Inhibiting Property and the Microcapsules Thereby 有权
标题翻译：具有良好的初始突发抑制性能的缓释微胶囊的制备方法和微胶囊
公开(公告)号：US20100272820A1
公开(公告)日：2010-10-28
申请号：US12516275
申请日：2007-11-21
申请人： Nak-Hyun Lim , Jung-Kwoun Kim , Hyung-Joon Jung , Se-Yeon Kim , Goo-Young Jung , Kyung-Hoi Cha , Mork-Soon Park
发明人： Nak-Hyun Lim , Jung-Kwoun Kim , Hyung-Joon Jung , Se-Yeon Kim , Goo-Young Jung , Kyung-Hoi Cha , Mork-Soon Park
IPC分类号： A61K9/50 , A61K38/31 , A61P5/02
CPC分类号： B01J13/02
摘要： Disclosed is a method for preparing a longer sustained-release formulation containing bioactive substances. More particularly, the present invention provides a method for preparing longer sustained-release microcapsules comprising: adding an emulsion including bioactive substances, biocompatible polymer and polyvinylpyrrolidone to an aqueous solution.
摘要翻译：公开了一种制备含有生物活性物质的较长持续释放制剂的方法。更具体地说，本发明提供了一种制备更长时间的缓释微胶囊的方法，包括：向水溶液中加入包括生物活性物质，生物相容性聚合物和聚乙烯吡咯烷酮的乳液。

3. 发明授权

US08575344B2 Process for preparing voriconazole by using new intermediates 有权
标题翻译：使用新中间体制备伏立康唑的方法
公开(公告)号：US08575344B2
公开(公告)日：2013-11-05
申请号：US13577055
申请日：2011-02-01
申请人： Hyuk Chul Kwon , Man Dong Rho , Kyung Hoi Cha
发明人： Hyuk Chul Kwon , Man Dong Rho , Kyung Hoi Cha
IPC分类号： C07D403/06
CPC分类号： C07D403/04 , C07D239/34 , C07D403/08
摘要： Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.
摘要翻译：提供一种用化学式1表示的伏立康唑的制备方法。更具体地说，制备化学式1的伏立康唑的方法包括：进行化学式4的酮衍生物与化学式的嘧啶衍生物之间的Reformatsky型偶联反应得到化学式3的化合物; 使取代基卤代和氧基磺酰基与氢供体反应，得到化学式2的外消旋伏立康唑; 并通过向其中加入足够的光学活性酸进行外消旋的伏立康唑的光学分离，得到具有高成本效率和高产率的高光学纯度的伏立康唑。

4. 发明授权

US10085941B2 Pharmaceutical composition for parenteral administration, containing donepezil 有权
公开(公告)号：US10085941B2
公开(公告)日：2018-10-02
申请号：US14782276
申请日：2014-04-02
申请人： DONGKOOK PHARMACEUTICAL CO., LTD.
发明人： Deok Keun Lee , Sung Jin Ko , Shin Eom , Kyung Hoi Cha
IPC分类号： A61K9/16 , A61K31/445 , A61K9/00
摘要： The present invention relates to a composition for parenteral administration, containing donepezil as an active ingredient, and a preparation method therefor. Donepezil, which has been conventionally used for oral or transdermal administration, is prepared as microparticles comprising a biodegradable and biocompatible polymer and a release controller so as to be provided as a pharmaceutical composition for sustained release parenteral administration, thereby enabling in vivo sustained release continuously for 2-12 weeks or more. Therefore, it is possible to reduce the frequency of administration to a patient and maintain an effective concentration in the blood for a long time.

5. 发明授权

US09168282B2 Method for treating neuronal damage and neurological diseases 有权
标题翻译：治疗神经元损伤和神经系统疾病的方法
公开(公告)号：US09168282B2
公开(公告)日：2015-10-27
申请号：US14035967
申请日：2013-09-25
申请人： DONGKOOK PHARMACEUTICAL CO., LTD.
发明人： Jae-Hoon Jung , Hyung-Ryong Moon
IPC分类号： A61K31/685 , A61K36/886 , A61K9/00 , A61K9/107 , A61K31/661 , A61K31/688
CPC分类号： A61K36/886 , A61K9/0014 , A61K9/107 , A61K31/661 , A61K31/685 , A61K31/688
摘要： Disclosed is a method of treating pain. The method includes administering a lecithin as an active ingredient to a mammal to treat the pain, wherein the pain is caused by at least one of herpes zoster, post-herpetic neuralgia, and diabetic neuropathic pain. The method further includes administering at least one selected from the group consisting of vegetable gel, a vegetable resin, and a synthetic resin, wherein the vegetable gel, vegetable resin, and synthetic resin is selected from the group consisting of aloe gel; a seaweed extract selected from the group consisting of kelp extract, agar extract, and Fucoidan; and a mixture thereof.
摘要翻译：公开了一种治疗疼痛的方法。该方法包括将卵磷脂作为活性成分施用于哺乳动物以治疗疼痛，其中所述疼痛由带状疱疹带状疱疹后，疱疹后神经痛和糖尿病性神经性疼痛中的至少一种引起。该方法还包括给予选自植物凝胶，植物性树脂和合成树脂中的至少一种，其中所述植物凝胶，植物树脂和合成树脂选自芦荟凝胶; 选自海带提取物，琼脂提取物和岩藻依聚糖的海藻提取物; 及其混合物。

6. 发明授权

US08541030B2 Preparation method of sustained-release microcapsules having initial burst inhibiting property and the microcapsules thereby 有权
标题翻译：具有初始爆发抑制性能的缓释微胶囊的制备方法和由此产生的微胶囊
公开(公告)号：US08541030B2
公开(公告)日：2013-09-24
申请号：US12516275
申请日：2007-11-21
申请人： Nak-Hyun Lim , Jung-Kwoun Kim , Hyung-Joon Jung , Se-Yeon Kim , Goo-Young Jung , Kyung-Hoi Cha , Mork-Soon Park
发明人： Nak-Hyun Lim , Jung-Kwoun Kim , Hyung-Joon Jung , Se-Yeon Kim , Goo-Young Jung , Kyung-Hoi Cha , Mork-Soon Park
IPC分类号： A61K9/50
CPC分类号： B01J13/02
摘要： Disclosed is a method for preparing a longer sustained-release formulation containing bioactive substances. More particularly, the present invention provides a method for preparing longer sustained-release microcapsules comprising: adding an emulsion including bioactive substances, biocompatible polymer and polyvinylpyrrolidone to an aqueous solution.
摘要翻译：公开了一种制备含有生物活性物质的较长持续释放制剂的方法。更具体地说，本发明提供了一种制备更长时间的缓释微胶囊的方法，包括：向水溶液中加入包括生物活性物质，生物相容性聚合物和聚乙烯吡咯烷酮的乳液。

7. 发明申请

US20130005973A1 PROCESS FOR PREPARING VORICONAZOLE BY USING NEW INTERMEDIATES 有权
标题翻译：通过使用新的中间体制备五唑酮的方法
公开(公告)号：US20130005973A1
公开(公告)日：2013-01-03
申请号：US13577055
申请日：2011-02-01
申请人： Hyuk Chul Kwon , Man Dong Rho , Kyung Hoi Cha
发明人： Hyuk Chul Kwon , Man Dong Rho , Kyung Hoi Cha
IPC分类号： C07D403/06
CPC分类号： C07D403/04 , C07D239/34 , C07D403/08
摘要： Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.
摘要翻译：提供一种用化学式1表示的伏立康唑的制备方法。更具体地说，制备化学式1的伏立康唑的方法包括：进行化学式4的酮衍生物与化学式的嘧啶衍生物之间的Reformatsky型偶联反应得到化学式3的化合物; 使取代基卤代和氧基磺酰基与氢供体反应，得到化学式2的外消旋伏立康唑; 并通过向其中加入足够的光学活性酸进行外消旋的伏立康唑的光学分离，得到具有高成本效率和高产率的高光学纯度的伏立康唑。

8. 发明授权

US5484712A Method for producing aclacinomycins A, B, Y using Strepomyces lavendofoliae DKRS 失效
标题翻译：使用枸杞子链霉菌DKRS生产阿卡霉素A，B，Y的方法
公开(公告)号：US5484712A
公开(公告)日：1996-01-16
申请号：US369375
申请日：1995-01-06
申请人： Won T. Cho , Wan S. Kim , Myung K. Kim , Jin K. Park , Hak R. Kim , Sang K. Rhee , A. G. Domracheva , T. B. Panichkina , L. A. Saburoba , L. M. Nobikoba , Y. E. Bartochevichi
发明人： Won T. Cho , Wan S. Kim , Myung K. Kim , Jin K. Park , Hak R. Kim , Sang K. Rhee , A. G. Domracheva , T. B. Panichkina , L. A. Saburoba , L. M. Nobikoba , Y. E. Bartochevichi
IPC分类号： A61K31/65 , A61K31/655 , A61P35/00 , C12N1/20 , C12N15/00 , C12N15/09 , C12P15/00 , C12P19/56 , C12P19/58 , C12P19/60 , C12R1/465 , C07H17/04 , C07H15/244
CPC分类号： C12R1/56 , C12P15/00 , C12P19/56 , C12P19/60 , Y10S435/886
摘要： Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS(KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.
摘要翻译：本文公开了一种新型链霉菌菌株，以及通过培养它们来生产阿克拉霉素A，B，Y及其糖苷配基的方法。本发明的枸杞子链霉菌DKRS（KCTC 0092BP）能够以更高的产率生产阿奇霉素A，B，Y和糖苷配基。此外，可以通过将醋酸链霉菌DKRS的培养肉汤的pH分别用醋酸盐缓冲液或盐酸调节至4.4或4.6来选择性地产生阿克拉霉素A或Y。

9. 发明授权

US5468637A S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins A, B, Y and aglycones 失效
标题翻译：薰衣草酵母DKRS细胞培养产生抗肿瘤阿曲酸霉素A，B，Y和糖苷配基
公开(公告)号：US5468637A
公开(公告)日：1995-11-21
申请号：US192165
申请日：1994-02-04
申请人： Won T. Cho , Wan S. Kim , Myung K. Kim , Jin K. Park , Hak R. Kim , Sang K. Rhee , A. G. Domracheva , T. B. Panichkina , L. A. Saburoba , L. M. Nobikoba , Y. E. Bartochevichi
发明人： Won T. Cho , Wan S. Kim , Myung K. Kim , Jin K. Park , Hak R. Kim , Sang K. Rhee , A. G. Domracheva , T. B. Panichkina , L. A. Saburoba , L. M. Nobikoba , Y. E. Bartochevichi
IPC分类号： A61K31/65 , A61K31/655 , A61P35/00 , C12N1/20 , C12N15/00 , C12N15/09 , C12P15/00 , C12P19/56 , C12P19/58 , C12P19/60 , C12R1/465 , C07H17/04 , C07H15/244
CPC分类号： C12R1/56 , C12P15/00 , C12P19/56 , C12P19/60 , Y10S435/886
摘要： Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.
摘要翻译：本文公开了一种新型链霉菌菌株，以及通过培养它们来生产阿克拉霉素A，B，Y及其糖苷配基的方法。本发明的枸杞子链霉菌DKRS（KCTC 0092BP）能够以更高的产率生产阿奇霉素A，B，Y和糖苷配基。此外，可以通过将醋酸链霉菌DKRS的培养肉汤的pH分别用醋酸盐缓冲液或盐酸调节至4.4或4.6来选择性地产生阿克拉霉素A或Y。

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