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1. 发明申请

US20110245747A1 Splint for treatment of musculoskeletal injury of the hand 审中-公开
标题翻译：夹板用于治疗手骨的肌肉骨骼损伤
公开(公告)号：US20110245747A1
公开(公告)日：2011-10-06
申请号：US12929877
申请日：2011-02-22
申请人： Ronit Wollstein , Thomas Ogden , Jonathan Pearlman , Rory A. Cooper , David White , Miriam Zisook
发明人： Ronit Wollstein , Thomas Ogden , Jonathan Pearlman , Rory A. Cooper , David White , Miriam Zisook
IPC分类号： A61F5/00
CPC分类号： A61F5/10 , A61F5/05875 , A61F2005/0197
摘要： A splint for treatment of a joint including a generally longitudinal body including first and second portions forming inner and outer splint layers, with the second portion being rollable onto the first portion to form the splint. The outer splint layer may include a longitudinal cavity for insertion of a stay, and/or may include a fluted section for permitting insertion of a stay between the inner and outer splint layers. The longitudinal body may be linear or curved. The first and second portions may include areas having different thicknesses for adding rigidity to the splint structure at a predetermined location. The splint may include a cutout for exposing a predetermined portion of a user's finger. The splint may be made of a flexible material such as rubber, silicone and/or urethane. The splint may include a reduced friction surface layer for minimizing sticking of the splint during donning.
摘要翻译：一种用于治疗关节的夹板，包括大体上纵向的主体，包括形成内部和外部夹板层的第一和第二部分，第二部分可滚动到第一部分上以形成夹板。外夹板层可以包括用于插入支柱的纵向腔，和/或可以包括用于允许在内夹板和外夹板层之间插入支柱的带槽部分。纵向体可以是线性的或弯曲的。第一和第二部分可以包括具有不同厚度的区域，用于在预定位置向夹板结构增加刚度。夹板可以包括用于暴露用户手指的预定部分的切口。夹板可以由诸如橡胶，硅树脂和/或聚氨酯的柔性材料制成。夹板可以包括减少的摩擦表面层，以最小化穿戴期间夹板的粘附。

2. 发明申请

US20070110734A9 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs 审中-公开
标题翻译：使用细胞免疫测定剂和糖缀合物将细胞靶向组织和器官的方法和组合物
公开(公告)号：US20070110734A9
公开(公告)日：2007-05-17
申请号：US10940691
申请日：2005-02-01
申请人： Catherine Phillips
发明人： Catherine Phillips
IPC分类号： A61K38/17 , A61K48/00 , A61K35/14
CPC分类号： A61K35/17 , A61K35/28 , A61K35/34 , A61K35/50 , A61K35/51 , A61K38/1741 , A61K47/549 , A61K47/64 , Y10S514/885 , A61K2300/00
摘要： The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering lymphoid cells such as natural killer (NK) cells activated with interleukin-2 (IL-2), lymphokine-activated killer (LAK) cells and/or tumor-infiltrating lymphocytes (TILs) and/or cytotoxic lymphocytes (CTLs), or stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
摘要翻译：本发明涉及使用糖缀合物将细胞递送至哺乳动物中的靶组织以将细胞运送到哺乳动物中所需器官的方法。根据本发明的方法特别适用于施用淋巴细胞，例如用白细胞介素-2（IL-2），淋巴因子激活的杀伤（LAK）细胞和/或肿瘤浸润淋巴细胞（TILs）激活的天然杀伤（NK）细胞）和/或细胞毒性淋巴细胞（CTLs）或干细胞，例如衍生自骨髓或来自脐带组织的细胞。所述方法还可用于通过将含有目的基因的细胞导入哺乳动物的哺乳动物的组织靶向感兴趣的基因，并给予哺乳动物的糖缀合物。

3. 发明授权

US07348305B2 Inhibitor of cardiac tachyarrhythmias 有权
公开(公告)号：US07348305B2
公开(公告)日：2008-03-25
申请号：US10927616
申请日：2004-08-26
申请人： David C. Kem , Eugene Patterson
发明人： David C. Kem , Eugene Patterson
IPC分类号： A61K38/00
CPC分类号： A61K38/20 , A01K2267/0375 , A61K38/06 , A61K38/1793 , A61K2300/00
摘要： Methods of preventing sustained monomorphic ventricular tachycardia following myocardial ischemia, decreasing infarct size and/or decreasing the incidence and/or maximum intrinsic rate of very rapid ventricular triplets following myocardial ischemia is disclosed. The methods involve administering an effective amount of a composition that inhibits substantial loss of beta-adrenergic receptor kinase (β-ARK) activity and/or β-ARK expression.

4. 发明申请

US20060171934A1 Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs 审中-公开
标题翻译：使用细胞免疫测定剂和糖缀合物将细胞靶向组织和器官的方法和组合物
公开(公告)号：US20060171934A1
公开(公告)日：2006-08-03
申请号：US10940691
申请日：2005-02-01
申请人： Catherine Phillips
发明人： Catherine Phillips
IPC分类号： A61K38/17 , A61K48/00 , A61K35/14
CPC分类号： A61K35/17 , A61K35/28 , A61K35/34 , A61K35/50 , A61K35/51 , A61K38/1741 , A61K47/549 , A61K47/64 , Y10S514/885 , A61K2300/00
摘要： The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering lymphoid cells such as natural killer (NK) cells activated with interleukin-2 (IL-2), lymphokine-activated killer (LAK) cells and/or tumor-infiltrating lymphocytes (TILs) and/or cytotoxic lymphocytes (CTLs), or stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
摘要翻译：本发明涉及使用糖缀合物将细胞递送至哺乳动物中的靶组织以将细胞运送到哺乳动物中所需器官的方法。根据本发明的方法特别适用于施用淋巴细胞，例如用白细胞介素-2（IL-2），淋巴因子激活的杀伤（LAK）细胞和/或肿瘤浸润淋巴细胞（TILs）激活的天然杀伤（NK）细胞）和/或细胞毒性淋巴细胞（CTLs）或干细胞，例如衍生自骨髓或来自脐带组织的细胞。所述方法还可用于通过将含有目的基因的细胞导入哺乳动物的哺乳动物的组织靶向感兴趣的基因，并给予哺乳动物的糖缀合物。

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