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1. 发明申请

US20060258946A1 Method and apparatus for assessing vascular endothelial function 有权
标题翻译：评估血管内皮功能的方法和装置
公开(公告)号：US20060258946A1
公开(公告)日：2006-11-16
申请号：US11485972
申请日：2006-07-14
申请人： Junichiro Hayano , Toshihiko Ogura
发明人： Junichiro Hayano , Toshihiko Ogura
IPC分类号： A61B5/02
CPC分类号： A61B5/02007 , A61B5/0285
摘要： Vascular endothelial function in terms of flow-mediated dilation (FMD) of peripheral arteries can be assessed reliably by measuring beat-to-beat pulse-wave conduction time (PCT) simultaneously for two symmetric segments of arteries locating on the right and left sides of body. When reactive hyperemia is induced in the peripheral tissues on one side, the time dependent changes in PCT caused by FMD on that side can be detected as the beat-to-beat differences in PCT between two sides (ΔPCT). ΔPCT would provide a sensitive and specific assessment of the FMD response, because the influences of the systemic changes in hemodynamic and neurohumoral factors common to both sides are subtracted out. In addition, measurement of PCT requires no skillful technique and is advantageous in that the apparatus is inexpensive.
摘要翻译：通过测量位于左右两侧的动脉对称段同时测量搏动脉搏波导通时间（PCT），可以可靠地评估外周动脉血流内皮扩张（FMD）方面的血管内皮功能。身体。当在一侧的外周组织中诱导反应性充血时，由该侧FMD引起的PCT的时间依赖性变化可以被检测为双侧（DeltaPCT）之间的PCT中的搏动间差异。 DeltaPCT将对FMD反应进行敏感和具体的评估，因为减少了双方共同的血液动力学和神经体液因素的全身变化的影响。此外，PCT的测量不需要熟练的技术，并且是有利的，因为该设备是便宜的。

2. 发明授权

US07097621B2 Filter for use with pulse-wave sensor and pulse wave analyzing apparatus 失效
标题翻译：滤波器用于脉波传感器和脉波分析仪
公开(公告)号：US07097621B2
公开(公告)日：2006-08-29
申请号：US10760582
申请日：2004-01-21
申请人： Kiyoyuki Narimatsu , Akira Tampo , Takashi Honda
发明人： Kiyoyuki Narimatsu , Akira Tampo , Takashi Honda
IPC分类号： A61B5/00
CPC分类号： A61B5/0285 , A61B5/022
摘要： A pulse wave analyzing apparatus including a cuff 12 for detecting a pulse wave from a living subject, a pressure sensor 16 for converting the pulse wave detected by the cuff 12, into an electric signal, i.e., a pulse wave signal SM, a plurality of band-pass filters 62 (BPF(1), BPF(2), . . . , BPF(n)) that have respective low-side cuff-off frequency bands differing from each other and each receive the pulse wave signal SM, a provisional rising point determining device 64 for determining respective times PS of respective provisional rising points of respective pulse waves represented by respective secondary pulse wave signals SM2 that have passed through the band-pass filters 62, and a proper rising point determining device 66 for comparing the respective times PS of respective provisional rising points with each other and thereby determining a time AS of a proper rising point based on the respective times PS of respective provisional rising points.
摘要翻译：一种脉波分析装置，包括用于检测来自活体的脉搏波的袖带12，将由袖带12检测出的脉搏波转换成电信号的压力传感器16，即脉波信号SM，多个带通滤波器62（BPF（1），BPF（2），...，BPF（n）），它们各自具有彼此不同的低侧克隆截止频带，并且各自接收脉波信号SM，a 临时上升点确定装置64，用于确定由通过带通滤波器62的各个辅助脉冲波信号SM 2表示的各个脉搏波的各个临时上升点的各个时间PS，以及用于比较的适当的上升点确定装置66 相应的临时上升点的时间PS，从而基于各个临时上升点的各个时间PS来确定适当上升点的时间AS。

3. 发明授权

US07029449B2 Arteriosclerosis inspecting apparatus 失效
公开(公告)号：US07029449B2
公开(公告)日：2006-04-18
申请号：US10356602
申请日：2003-02-03
申请人： Toshihiko Ogura
发明人： Toshihiko Ogura
IPC分类号： A61B5/00
CPC分类号： A61B5/02007 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/02225 , A61B2562/0247 , A61B2562/043
摘要： An arteriosclerosis inspecting apparatus including an information obtaining device which obtains information that is related to a velocity at which a pulse wave propagates in a living subject, a blood-pressure measuring device which measures a blood pressure of the subject, a heart-rate measuring device which measures a heart rate of the subject, a pre-ejection-period measuring device which measures a pre-ejection period from a time of starting of contraction of the heart of the subject to a time of starting of ejection of blood from the heart, an ejection-time measuring device which measures an ejection time from the time of starting of ejection of blood from the heart to a time of ending of ejection of blood from the heart, and an arteriosclerosis-inspection-related-augmentation-index determining means for determining an arteriosclerosis-inspection-related augmentation index of the subject, based on the obtained pulse-wave-velocity-related information, the measured blood pressure, the measured heart rate, the measured pre-ejection period, and the measured ejection time, according to a predetermined relationship between (A) (a1) pulse-wave-velocity-related information, (a2) blood pressure, (a3) heart rate, (a4) pre-ejection period and (a5) ejection time, and (B) arteriosclerosis-inspection-related augmentation index.

4. 发明授权

US07022084B2 Heart-sound detecting apparatus and heart-sound detecting method 失效
公开(公告)号：US07022084B2
公开(公告)日：2006-04-04
申请号：US11027994
申请日：2005-01-04
申请人： Toshihiko Ogura
发明人： Toshihiko Ogura
IPC分类号： A61B5/02
CPC分类号： A61B5/0285 , A61B5/02233 , A61B5/6843 , A61B7/00 , A61B2562/0247 , A61B2562/043
摘要： An apparatus for detecting a heart sound of a living subject, including a pressure-pulse-wave sensor which is adapted to be worn on a body portion of the subject that is distant from a chest of the subject, detects a pressure pulse wave produced by an artery of the body portion, and generates a pressure-pulse-wave signal representing the detected pressure pulse wave; and a heart-sound extracting device for extracting, from the pressure-pulse-wave signal generated by the pressure-pulse-wave sensor, a heart-sound component representing the heart sound of the subject.

5. 发明授权

US06976966B2 Arteriosclerosis evaluating apparatus 失效
标题翻译：动脉硬化评估仪
公开(公告)号：US06976966B2
公开(公告)日：2005-12-20
申请号：US10724086
申请日：2003-12-01
申请人： Kiyoyuki Narimatsu
发明人： Kiyoyuki Narimatsu
IPC分类号： A61B5/02 , A61B5/022 , A61B5/0245
CPC分类号： A61B5/022
摘要： An arteriosclerosis evaluating apparatus for evaluating an arteriosclerosis of a living subject based on a form of a pulse wave detected from the subject, the apparatus including an inflatable cuff which is adapted to be worn on a body portion of the subject, a cuff-pressure changing device which changes a pressure in the cuff, a cuff-pulse-wave detecting device which detects a cuff pulse wave as a pressure oscillation that is transmitted from the subject to the cuff, and an output device which outputs the cuff pulse wave detected by the cuff-pulse-wave detecting device in a state in which the pressure of the cuff is made higher than a systolic blood pressure of the body portion of the subject by the cuff-pressure changing device.
摘要翻译：一种动脉硬化评估装置，其用于根据从被检体检测出的脉搏波的形式来评价活体的动脉硬化，所述装置包括适于佩戴在被检体的身体部位的充气袖带，袖带压变化改变袖带压力的装置，检测袖带脉波作为从被检体发送到袖带的压力振荡的袖带脉波检测装置，以及输出装置，其输出由袖口检测到的袖带脉波袖带脉波检测装置，其通过袖带压力改变装置使袖带的压力高于被检体的身体部分的收缩压。

6. 发明授权

US06969355B2 Arteriostenosis diagnosing apparatus 失效
标题翻译：动脉粥样硬化诊断仪
公开(公告)号：US06969355B2
公开(公告)日：2005-11-29
申请号：US10780574
申请日：2004-02-19
申请人： Kiyoyuki Narimatsu
发明人： Kiyoyuki Narimatsu
IPC分类号： A61B5/02 , A61B5/021 , A61B5/022 , A61B5/0245 , A61B5/0285
CPC分类号： A61B5/0285 , A61B5/021 , A61B5/02125
摘要： An arteriostenosis diagnosing apparatus which measures an ankle blood pressure at an ankle 12 of a patient and a brachium blood pressure at a brachium 14, so that the measured ankle and brachium blood pressure values are used to calculate an ankle and brachium blood pressure index ABI, and additionally measures a first pulse wave propagation velocity PWV1 with respect to the ankle 12 as a first measuring point and the brachium 14 as a second measuring point, and a second pulse wave propagation velocity PWV2 with respect to the patient's heart and the brachium 14. The arteriostenosis diagnosing apparatus includes an arteriostenosis judging device 100 which judges, even if the index ABI may fall in a prescribed normal range or a prescribed alert range and the first velocity PWV1 falls in a prescribed normal range, that there is a possibility that an inferior limb including the ankle 12 at which the ankle blood pressure has been measured, may have arteriostenosis, if the second velocity PWV2 falls in a prescribed abnormal range.
摘要翻译：一种动脉狭窄诊断装置，其测量患者脚踝12处的踝血压和胎ium 14处的肱骨血压，使得测量的踝和肱高血压值用于计算踝和肱高血压指数ABI，并且另外测量相对于作为第一测量点的脚踝12的第一脉搏波传播速度PWV 1和作为第二测量点的臂14和相对于患者心脏和肱二头体的第二脉搏波传播速度PWV 2 14。动脉狭窄诊断装置包括：动脉狭窄判断装置100，即使指标ABI可能落在规定的正常范围或规定的警报范围内，并且第一速度PWV 1落在规定的正常范围内，则存在以下可能性：如果第二速度PWV 2处于规定的异常范围，则包括测量了踝部血压的脚踝12的下肢可能具有动脉狭窄。

7. 发明授权

US06843772B2 Inferior-and-superior-limb blood-pressure-index measuring apparatus 失效
标题翻译：下肢血压指数测定装置
公开(公告)号：US06843772B2
公开(公告)日：2005-01-18
申请号：US10300824
申请日：2002-11-21
申请人： Tomohiro Nunome , Kiyoyuki Narimatsu , Toshihiko Ogura
发明人： Tomohiro Nunome , Kiyoyuki Narimatsu , Toshihiko Ogura
IPC分类号： A61B5/022 , A61B5/0245 , A61B5/0285 , A61B5/02
CPC分类号： A61B5/02116 , A61B5/022 , A61B5/0285
摘要： An apparatus for measuring an inferior-and-superior-limb blood-pressure index of a patient, including an inferior-limb blood-pressure measuring device, a superior-limb blood-pressure measuring device, an index determining device for determining the inferior-and-superior-limb blood-pressure index, based on a blood pressure of an inferior limb measured by the inferior-limb blood-pressure measuring device and a blood pressure of a superior limb measured by the superior-limb blood-pressure measuring device, an inferior-limb-pulse-wave-propagation-velocity-related-information, obtaining device which obtains inferior-limb-pulse-wave-propagation-velocity-related information, an upper-half-body-pulse-wave-propagation-velocity-related-information obtaining device which obtains upper-half-body-pulse-wave-propagation-velocity-related information, and an evaluation-information obtaining device for obtaining, based on the inferior-limb-pulse-wave-propagation-velocity-related information and the upper-half-body-pulse-wave-propagation-velocity-related information, evaluation information that is related to evaluation of reliability of the inferior-and superior-limb blood-pressure index.
摘要翻译：一种用于测量患者的下肢和上肢血压指数的装置，包括下肢血压测量装置，上肢血压测量装置，用于确定下肢血压的指标确定装置，基于由下肢血压测定装置测定的下肢血压和上肢血压测定装置测定的上肢血压，测定上肢血压指数，下肢脉搏波传播速度相关信息获取装置，其获得下肢脉搏波传播速度相关信息，上半身脉搏波传播速度获取上半身脉搏波传播速度相关信息的相关信息获取装置，以及基于下肢脉搏波传播速度相关信息的评估信息获取装置，相关信息和upp 呃半体脉搏波传播速度相关信息，与下肢和上肢血压指数的可靠性的评价相关的评价信息。

8. 发明申请

US20040171940A1 Arteriostenosis diagnosing apparatus 失效
标题翻译：动脉粥样硬化诊断仪
公开(公告)号：US20040171940A1
公开(公告)日：2004-09-02
申请号：US10780574
申请日：2004-02-19
申请人： COLIN MEDICAL TECHNOLOGY CORPORATION
发明人： Kiyoyuki Narimatsu
IPC分类号： A61B005/02
CPC分类号： A61B5/0285 , A61B5/021 , A61B5/02125
摘要： An arteriostenosis diagnosing apparatus which measures an ankle blood pressure at an ankle 12 of a patient and a brachium blood pressure at a brachium 14, so that the measured ankle and brachium blood pressure values are used to calculate an ankle and brachium blood pressure index ABI, and additionally measures a first pulse wave propagation velocity PWV1 with respect to the ankle 12 as a first measuring point and the brachium 14 as a second measuring point, and a second pulse wave propagation velocity PWV2 with respect to the patient's heart and the brachium 14. The arteriostenosis diagnosing apparatus includes an arteriostenosis judging device 100 which judges, even if the index ABI may fall in a prescribed normal range or a prescribed alert range and the first velocity PWV1 falls in a prescribed normal range, that there is a possibility that an inferior limb including the ankle 12 at which the ankle blood pressure has been measured, may have arteriostenosis, if the second velocity PWV2 falls in a prescribed abnormal range.
摘要翻译：一种动脉狭窄诊断装置，其测量患者脚踝12处的踝血压和胎ium 14处的肱骨血压，使得测量的踝和肱高血压值用于计算踝和肱高血压指数ABI，并且另外测量相对于作为第一测量点的踝12的第一脉搏波传播速度PWV1和作为第二测量点的brachium 14以及相对于患者心脏和腋窝14的第二脉搏波传播速度PWV2。动脉狭窄诊断装置包括：动脉狭窄判断装置100，即使指标ABI可能落在规定的正常范围或者规定的警报范围内，并且第一速度PWV1落在规定的正常范围内，则认为有可能劣等包括测量踝血压的脚踝12的肢体可能具有动脉狭窄，如果第二速度P WV2处于规定的异常范围。

9. 发明授权

US07128715B2 Pressure-pulse-wave detecting probe of manually-operable type 失效
标题翻译：手动式压力脉波检测探头
公开(公告)号：US07128715B2
公开(公告)日：2006-10-31
申请号：US10759013
申请日：2004-01-20
申请人： Kiyoyuki Narimatsu
发明人： Kiyoyuki Narimatsu
IPC分类号： A61B5/00
CPC分类号： A61B5/02
摘要： A pressure-pulse-wave detecting probe for detecting a pressure pulse wave generated by an artery of a living subject, including: (a) a sensor portion which has at least one pressure detecting element and a press surface that is to be positioned manually by an operator, relative to the artery of the subject, and is to be pressed manually by the operator, against the artery of the subject via a body surface of the subject, such that the pressure pulse wave is detected by the above-described at least one pressure detecting element which is arranged on the press surface; and (b) an indicator which is provided to be integral with the sensor portion, and provides an indication as to whether a value of pressure detected by each of the above-described at least one pressure detecting element is suitable for detecting of the pressure pulse wave or not.
摘要翻译：一种用于检测由生物体的动脉产生的压力脉搏波的压力脉冲波检测探头，包括：（a）传感器部分，其具有至少一个压力检测元件和按压表面，该压力表面将由操作者相对于受试者的动脉，并且被操作者手动地压迫受试者的动脉，经由受试者的身体表面，使得压力脉搏波由上述至少检测到一个压力检测元件设置在压力表面上; 和（b）设置成与传感器部分成一体的指示器，并且提供关于由上述至少一个压力检测元件中的每一个检测到的压力值是否适于检测压力脉冲的指示波还是不

10. 发明授权

US07070567B2 Inflatable cuff for blood pressure measurement 有权
标题翻译：充气袖口血压测量
公开(公告)号：US07070567B2
公开(公告)日：2006-07-04
申请号：US10822812
申请日：2004-04-13
申请人： Toshiya Mizukoshi , Hideo Nishibayashi
发明人： Toshiya Mizukoshi , Hideo Nishibayashi
IPC分类号： A61B5/02
CPC分类号： A61B5/02233
摘要： An inflatable cuff for blood pressure measurement includes a first inflatable bag to press an arterial vessel of a body portion of a living subject for stopping blood flow; a second inflatable bag for sensing a pulse wave propagating along the arterial vessel, which is supported by the inflatable cuff such that the second inflatable bag is located inside a downstream-side portion of the first inflatable bag in the direction of the blood flows; a shielding member disposed between the first inflatable bag and the second inflatable bag so as to prevent an oscillation of the first inflatable bag from propagating to the second inflatable bag; and a slidable separating member disposed between the shielding member and the second inflatable bag so as to prevent generation of a noise caused by a slide contact of the shielding member with the second inflatable bag.
摘要翻译：用于血压测量的可充气袖带包括：第一充气袋，用于按压活体的身体部分的动脉血管以阻止血液流动; 用于感测沿着所述动脉血管传播的脉波的第二可充气袋，其由所述可充气袖带支撑，使得所述第二可充气袋位于所述第一可充气袋的沿所述血液流动方向的下游侧部分的内侧; 设置在所述第一可充气袋和所述第二充气袋之间的屏蔽构件，以防止所述第一可充气袋的振荡传播到所述第二充气袋; 以及设置在所述遮蔽部件与所述第二可充气袋之间的滑动分离部件，以防止由于所述遮蔽部件与所述第二充气袋的滑动接触而引起的噪音的产生。

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