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1. 发明授权

US3852353A Oral hypoglycemic aminophenylsulfonyl-hydrocarbylbiguanides 失效
标题翻译：口服超高效氨基磺酰氟 - 乙酰胆碱
公开(公告)号：US3852353A
公开(公告)日：1974-12-03
申请号：US31454572
申请日：1972-12-12
申请人： HEAPHY C
发明人： HEAPHY C
IPC分类号： A61K31/27 , C07C317/36 , C07C133/10
CPC分类号： C07C317/36 , A61K31/27 , Y10S514/866
摘要： An oral hypoglycemic compound for use in the treatment of diabetes mellitus having the general formula

AND WHICH IS ONE OF THE GROUP CONSISTING OF: A. THE COMPOUND WHEREIN R1 is an aliphatic series containing 2 to 8 carbon atoms; B. THE COMPOUND WHEREIN R2 R3 and is a member of the group consisting of hydrogen, aliphatic, and aromatic radicals; and C. THE COMPOUND WHEREIN X represents an amino or a substituted amino radical. The compound is prepared by synthesizing p-amino benzenesulfonamide through the chlorsulfonation of acetanilide and placing a radical group in the para position of the benzene ring. The compound may be incorporated with therapeutically acceptable carriers to make compositions adapted to be administered orally in the treatment of diabetes mellitus. The compound is intended to aid in the regulation of metabolic disturbance in diabetes mellitus not only by stimulating the production and release of insulin but also by functioning as a substitute for insulin in this regulatory process.
摘要翻译：用于治疗具有通式的糖尿病的口服降血糖化合物，其为本组中的一个：

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