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1. 发明申请

US20080131889A1 Novel human genes and gene expression products: II 审中-公开
公开(公告)号：US20080131889A1
公开(公告)日：2008-06-05
申请号：US11799463
申请日：2007-04-30
申请人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam
发明人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57419
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

2. 发明授权

US07211398B2 Human genes and gene expression products: II 有权
标题翻译：人类基因和基因表达产物：II
公开(公告)号：US07211398B2
公开(公告)日：2007-05-01
申请号：US10280403
申请日：2002-10-25
申请人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
发明人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57419
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

3. 发明授权

US07198929B2 14790, a novel protein kinase molecule and uses therefor 失效
标题翻译： 14790，一种新的蛋白激酶分子，并用于此
公开(公告)号：US07198929B2
公开(公告)日：2007-04-03
申请号：US10892276
申请日：2004-07-15
申请人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
发明人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
IPC分类号： C12N9/12 , C07K1/00 , C12P21/06 , C12Q1/48 , C12N15/00 , C12N5/00 , C12N1/20 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C12Y207/01037
摘要： The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了编码新型蛋白激酶的分离的核酸分子，命名为激酶核酸分子。本发明还提供反义核酸分子，含有激酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了激酶基因的非人类转基因动物。本发明还进一步提供分离的14790蛋白，融合蛋白，抗原肽和抗激酶抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

4. 发明申请

US20060172946A1 Human bikunin 失效
公开(公告)号：US20060172946A1
公开(公告)日：2006-08-03
申请号：US11390775
申请日：2006-03-27
申请人： Paul Tamburini , Gary Davis , Katherine Delaria , Christopher Marlor , Daniel Muller
发明人： Paul Tamburini , Gary Davis , Katherine Delaria , Christopher Marlor , Daniel Muller
IPC分类号： A61K38/54 , C12N9/99
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.

5. 发明授权

US07037671B2 25312, a novel human agmatinase-like homolog 失效
公开(公告)号：US07037671B2
公开(公告)日：2006-05-02
申请号：US10460138
申请日：2003-06-12
申请人： William James Cook , Rory A. J. Curtis , Frank Spaltmann
发明人： William James Cook , Rory A. J. Curtis , Frank Spaltmann
IPC分类号： C12Q1/34 , C12N9/14 , C12N5/00 , C07K1/00 , C07H21/04
CPC分类号： C12N9/78
摘要： The present invention relates to a newly identified human agmatinase-like arginase, designated “25312”. The invention also relates to polynucleotides encoding the agmatinase-like arginase. The invention further relates to methods using the agmatinase-like polypeptides and polynucleotides as a target for diagnosis and treatment in disorders mediated by or related to the agmatinase-like arginase. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to agonists and antagonists identified by drug screening methods with the polypeptides and polynucleotides as a target.

6. 发明授权

US07019123B2 Human bikunin 失效
标题翻译：人类bikunin
公开(公告)号：US07019123B2
公开(公告)日：2006-03-28
申请号：US09974026
申请日：2001-10-10
申请人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
发明人： Paul P. Tamburini , Gary Davis , Katherine A. Delaria , Christopher W. Marlor , Daniel K. Muller
IPC分类号： C07H21/04
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof
摘要翻译：本发明提供蛋白质，多肽，核酸序列，构建体，表达载体，宿主细胞，药物组合物和使用人胎盘bikunin，丝氨酸蛋白酶抑制物结构域及其片段的方法

7. 发明申请

US20050221436A1 Human neuropeptide Y-like G protein-coupled receptor 审中-公开
公开(公告)号：US20050221436A1
公开(公告)日：2005-10-06
申请号：US11133283
申请日：2005-05-20
申请人： Leonid Zhelnin , Brian Bloomquist
发明人： Leonid Zhelnin , Brian Bloomquist
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12P21/04 , C07H21/04 , C12N15/09
CPC分类号： C07K14/70571 , A61K38/00 , C07K2319/00
摘要： Reagents which regulate human neuropeptide Y-like G protein-coupled receptor (NPY-like GPCR) protein and reagents which bind to human NPY-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma, ganglioneuroblastoma, Huntington's disease, Alzheimer's disease, and Parkinson's disease.

8. 发明授权

US06881380B1 Cup handling subsystem for an automated clinical chemistry analyzer system 失效
标题翻译：用于自动化临床化学分析仪系统的杯子处理子系统
公开(公告)号：US06881380B1
公开(公告)日：2005-04-19
申请号：US09626066
申请日：2000-07-26
申请人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
发明人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
IPC分类号： B65G59/06 , B65G59/10 , G01N35/04 , G01N29/00
CPC分类号： G01N35/04 , B65G59/062 , B65G59/105 , G01N2035/0427 , G01N2035/0465 , Y10T436/11 , Y10T436/113332
摘要： The present invention relates to a cup handling subsystem for an automated clinical chemistry analyzer system which includes a nestable sample cup for holding sample mixtures, a cup dispenser mechanism for holding and dispensing a supply of the cups into a sample shuttle for transporting them, and an incubator for controlling the temperature of the cup and its contents. In one embodiment, the cups include a conical lower portion and a cylindrical upper portion having a top flange, a bottom flange and a groove formed therebetween. An apparatus is provided for holding and dispensing a plurality of such cups including a supply tube for holding the cups in a stack wherein the stack has a bottom-most cup and a next-bottom-most cup located above the bottom-most cup. The apparatus also includes an escapement located at a lower end of the supply tube which includes a disk having an aperture formed therein, a first leaf attached to a top side of the disk and a second leaf attached to a bottom side of the disk. The disk is movable between a first position in which the second leaf engages the bottom flange of the bottom-most cup and a second position in which the first leaf is inserted into the groove of the next-bottom-most cup and engages the top flange of the next-bottom-most cup and in which the second leaf no longer engages the bottom flange of the bottom-most cup. In the second position, the bottom-most cup is free to fall through the aperture formed in the disk.
摘要翻译：本发明涉及一种用于自动临床化学分析仪系统的杯子处理子系统，其包括用于保持样品混合物的可嵌套样品杯，用于保持和分配杯子供应到用于运输它们的样品梭中的杯分配器机构，以及用于控制杯子及其内容物的温度的培养箱。在一个实施例中，杯包括锥形下部和具有顶部凸缘，底部凸缘和在其间形成的凹槽的圆柱形上部。提供了一种用于保持和分配多个这样的杯子的装置，其包括用于将杯子保持在堆叠中的供给管，其中所述烟囱具有最底部的杯子和位于最下面的杯子上方的下一个最下面的杯子。该装置还包括位于供应管的下端处的擒纵机构，其包括具有形成在其中的孔的盘，附接到盘的顶侧的第一叶片和附接到盘的底侧的第二叶片。盘可以在其中第二叶片接合最底部杯的底部凸缘的第一位置和第二位置之间移动，第二位置中第一叶片插入下一个最下面的杯子的凹槽中并且接合顶部凸缘的下一个最下面的杯子，其中第二个叶子不再接合最底部的杯子的底部凸缘。在第二位置，最下面的杯子可自由地落入通过形成在盘中的孔。

9. 发明授权

US06864078B2 14790, novel protein kinase molecule and uses therefor 失效
标题翻译： 14790，新型蛋白激酶分子及其用途
公开(公告)号：US06864078B2
公开(公告)日：2005-03-08
申请号：US09515806
申请日：2000-02-29
申请人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
发明人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , C12N5/00 , C12N15/00 , C12P21/06 , C12Q1/48
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C12Y207/01037
摘要： The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了编码新型蛋白激酶的分离的核酸分子，命名为激酶核酸分子。本发明还提供反义核酸分子，含有激酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了激酶基因的非人类转基因动物。本发明还进一步提供分离的14790蛋白，融合蛋白，抗原肽和抗激酶抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

US20040200720A1 ELECTROCHEMICAL-SENSOR DESIGN 有权
标题翻译：电化学传感器设计
公开(公告)号：US20040200720A1
公开(公告)日：2004-10-14
申请号：US09861437
申请日：2001-05-21
申请人： Bayer Corporation
发明人： Matthew K. Musho , J. Oakey Noell , Andrew J. Edelbrock , Dijia Huang
IPC分类号： G01N027/327
CPC分类号： C12Q1/001 , G01N27/3274
摘要： Disclosed is an improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working electrode has a reaction layer on its surface which contains an enzyme capable of reacting with an analyte to produce electrons which are received by the working electrode. The base is mated with a cover to form a capillary space into which the test fluid is drawn. The improvement involves configuring the working and counter electrodes so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode. This configuration provides the sensor with the capability of sending a greatly reduced electrical signal to the device's detecting element in the event that the capillary space is incompletely filled with test fluid. This reduced signal can be manipulated to produce an error signal which affirmatively apprises the device's user that such incomplete filling has occurred.
摘要翻译：公开了一种改进的电化学传感器，其具有承载工作和反电极的基座，其提供用于流体测试样品的流动路径。工作电极在其表面上具有含有能够与分析物反应以产生由工作电极接收的电子的酶的反应层。基座与盖子配合以形成毛细管空间，测试流体被拉入其中。改进之处在于配置工作电极和对电极，使得对电极的主要部分位于来自工作电极的流动路径的下游，除了与电极电连接的对电极的小子元件之外并且位于工作电极的上游。这种配置使得传感器能够在毛细管空间不完全填充测试流体的情况下将大大减小的电信号发送到装置的检测元件。该减小的信号可以被操纵以产生一个误差信号，该误差信号肯定地认识到设备的用户已经发生了这样的不完全填充。

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