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1. 发明申请

US20130267483A1 Hydroxy Acid Complexes for Skin Antiaging, Acne, and Skin Whitening 审中-公开
标题翻译：用于皮肤抗衰老，痤疮和皮肤美白的羟基酸配合物
公开(公告)号：US20130267483A1
公开(公告)日：2013-10-10
申请号：US13760276
申请日：2013-02-06
申请人： SHYAM K GUPTA
发明人： SHYAM K GUPTA
IPC分类号： C07F3/06 , C07F3/02 , C07F1/08
CPC分类号： C07F3/06 , A61K8/19 , A61K8/27 , A61K8/365 , A61K8/368 , A61K8/44 , A61K8/4933 , A61K2800/58 , A61Q5/006 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/08 , C07F1/005 , C07F1/08 , C07F3/003 , C07F3/02
摘要： This invention relates to complexes of certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including molybdenum, having a hydroxy acid [HA] and an amino acid [AA] moiety concurrently bound to a single said metal and having a spirocyclic, bidentate chelate structure of formula (I). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation. The said metal complexes are useful for topical conditions that includes dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, age spots, dark circles around eyes, skin pigmentation, topical inflammation, liver spots, pigmented spots, wrinkles, blemishes, skin lines, oily skin, acne, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, dandruff, bacterial infection, fungal infection, wound healing, body odor, and skin changes associated with aging;
摘要翻译：本发明涉及元素周期表第一至第Ⅵ族第一转化系列的某些二价和多价d轨金属的络合物，包括具有羟基酸[HA]和氨基酸[AA] 部分同时与单个所述金属结合并具有式（I）的螺环，二齿螯合结构。在局部应用时，金属络合物经历增强的皮肤渗透，而不会引起皮肤刺激。所述金属络合物可用于包括干性皮肤，干燥症，鱼鳞病，头皮屑，褐斑，角化病，黑斑病，斑点，老年斑，眼睛周围的黑眼圈，皮肤色素沉着，局部炎症，肝斑，色斑，皱纹等局部病症皮肤线，油性皮肤，痤疮，疣，湿疹，瘙痒皮肤，牛皮癣，炎性皮肤病，受干扰的角质化，头皮屑，细菌感染，真菌感染，伤口愈合，身体气味和与老化相关的皮肤变化;

2. 发明申请

US20120189567A1 Artemisinin Derivatives with Natural Amino Acids, Peptides, and Amino Sugars for Skin Imperfections and Infection in Mammals 失效
标题翻译：具有天然氨基酸，肽和氨基糖的青蒿素衍生物，用于皮肤缺陷和哺乳动物感染
公开(公告)号：US20120189567A1
公开(公告)日：2012-07-26
申请号：US13440446
申请日：2012-04-05
申请人： SHYAM K GUPTA
发明人： SHYAM K GUPTA
IPC分类号： A61K31/357 , A61K31/4178 , A61K31/404 , A61P17/00 , A61Q19/08 , A61P17/10 , A61P17/18 , A61P17/12 , A61K8/49 , A61Q19/02 , A61P17/06 , A61P29/00 , A61P17/04 , A61P33/00 , A61P31/00 , C07D493/18
CPC分类号： A61K8/49 , A61K8/498 , A61K31/205 , A61K31/357 , A61K31/404 , A61K31/4178 , A61K31/60 , A61K31/7008 , A61K31/728 , A61K2800/28 , A61Q5/006 , A61Q19/008 , A61Q19/02 , C07D493/18 , A61K2300/00
摘要： The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars and salts thereof (formula I). The compounds of the present invention possess wide-spectrum antibacterial and antifungal biological activity suitable for topical or oral application for the treatment of infections and topical ailments in mammals, including acne, rosacea, topical wounds, infections, dandruff, skin disfigurements caused by infection, skin discoloration, age spots, wrinkles, excess facial oil, and veterinary problems including canine infections;
摘要翻译：本发明公开了青蒿素的某些衍生物和含有氨基酸，肽，氨基糖及其盐的蒿提取物中的活性成分（式I）。本发明的化合物具有广泛的抗菌和抗真菌生物活性，适用于局部或口服施用以治疗哺乳动物感染和局部疾病，包括痤疮，酒渣鼻，局部创伤，感染，头皮屑，由感染引起的皮肤损伤，皮肤变色，老年斑，皱纹，多余面部油脂和兽医问题，包括犬类感染;

3. 发明授权

US08193376B2 Artemisinin derivatives with natural amino acids, peptides, and amino sugars for the treatment of infection and topical condition in mammals 失效
标题翻译：具有天然氨基酸的青蒿素衍生物，肽和氨基糖，用于治疗哺乳动物的感染和局部病症
公开(公告)号：US08193376B2
公开(公告)日：2012-06-05
申请号：US12957598
申请日：2010-12-01
申请人： Shyam K Gupta
发明人： Shyam K Gupta
IPC分类号： C07D323/00 , C07D309/00 , C07D313/00 , C07D321/00
CPC分类号： A61Q19/02 , A61K8/49 , A61K8/498 , A61K31/205 , A61K31/357 , A61K31/60 , A61K31/7008 , A61K31/728 , A61K2800/28 , A61Q5/006 , A61Q19/008 , A61K2300/00
摘要： The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars, and isomers and salts thereof (formula I). The compounds of the present invention possess wide-spectrum antibacterial and antifungal biological activity suitable for topical or oral application for the treatment of infections and topical ailments in mammals, including acne, rosacea, topical wounds, infections, dandruff, skin disfigurements caused by infection, skin discoloration, age spots, wrinkles, excess facial oil, and veterinary problems including canine infections;
摘要翻译：本发明公开了青蒿素的某些衍生物和含有氨基酸，肽和氨基糖的艾蒿提取物及其异构体和盐（式I）中的活性成分。本发明的化合物具有广泛的抗菌和抗真菌生物活性，适用于局部或口服施用以治疗哺乳动物感染和局部疾病，包括痤疮，酒渣鼻，局部创伤，感染，头皮屑，由感染引起的皮肤损伤，皮肤变色，老年斑，皱纹，多余面部油脂和兽医问题，包括犬类感染;

4. 发明申请

US20110077193A1 Artemisinin Derivatives with Natural Amino Acids, Peptides, and Amino Sugars for the Treatment of Infection and Topical Condition in Mammals 失效
标题翻译：具有天然氨基酸，肽和氨基糖的青蒿素衍生物用于治疗哺乳动物的感染和局部状况
公开(公告)号：US20110077193A1
公开(公告)日：2011-03-31
申请号：US12957598
申请日：2010-12-01
申请人： Shyam K. Gupta
发明人： Shyam K. Gupta
IPC分类号： A61K38/02 , C07D493/16 , C07K2/00 , C07H5/06 , C07D491/153 , A61K31/357 , A61K31/7008 , A61P33/00 , A61P35/00 , A61P3/10 , A61P17/06 , A61P17/04 , A61P29/00 , A61P17/00 , A61P17/10 , A61P17/12 , A61Q19/08 , A61Q19/00 , A61P31/04 , A61P31/10 , A61P33/02
CPC分类号： A61Q19/02 , A61K8/49 , A61K8/498 , A61K31/205 , A61K31/357 , A61K31/60 , A61K31/7008 , A61K31/728 , A61K2800/28 , A61Q5/006 , A61Q19/008 , A61K2300/00
摘要： The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars, and isomers and salts thereof (formula I). The compounds of the present invention possess wide-spectrum antibacterial and antifungal biological activity suitable for topical or oral application for the treatment of infections and topical ailments in mammals, including acne, rosacea, topical wounds, infections, dandruff, skin disfigurements caused by infection, skin discoloration, age spots, wrinkles, excess facial oil, and veterinary problems including canine infections;
摘要翻译：本发明公开了青蒿素的某些衍生物和含有氨基酸，肽和氨基糖的艾蒿提取物及其异构体和盐（式I）中的活性成分。本发明的化合物具有广泛的抗菌和抗真菌生物活性，适用于局部或口服施用以治疗哺乳动物感染和局部疾病，包括痤疮，酒渣鼻，局部创伤，感染，头皮屑，由感染引起的皮肤损伤，皮肤变色，老年斑，皱纹，多余面部油脂和兽医问题，包括犬类感染;

5. 发明申请

US20080254130A1 Skin Antiaging & Brightening via Multi-function Treatment of Enzyme Dysfunction 审中-公开
标题翻译：通过多功能治疗酶功能障碍的皮肤抗衰老和增白
公开(公告)号：US20080254130A1
公开(公告)日：2008-10-16
申请号：US12139462
申请日：2008-06-14
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K9/14 , A61K31/12 , A61K31/47 , A61K31/435 , A61K31/428 , A61K31/44 , A61K31/40 , A61K31/4164 , A61P17/00 , A61K31/426 , A61K31/505 , A61K31/404 , A61K31/5415 , A61K31/4965 , A61K31/517 , A61K8/18
CPC分类号： A61K8/498 , A61K8/35 , A61K2800/522 , A61K2800/78 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a topical method of treatment for dysfunction of certain dermal enzymes, and the treatment of skin condition or disorder caused by said dysfunction. The said method of treatment consists of (i) an extra-cellular, matrix metalloprotease regulating agent, and (ii) an intra-cellular ubiquitin—proteasome regulating agent, and (iii) an epidermal melanocyte-regulating agent; and, wherein, said extra-cellular agent, said intracellular agent, and said epidermal agent can, surprisingly and unexpectedly, be a single multi-function compound having chemical formula (I). Additionally, the method of the present invention provides treatment of skin condition or disorder caused by dysfunction of said dermal enzymes; wherein said skin disorder is skin aging, skin wrinkles, dark skin, age spots, acne, skin inflammation, loss of cellular antioxidants, loss of collagen, loss of skin pliability, loss of skin suppleness, oily skin, or a combination thereof:
摘要翻译：本发明涉及局部用于某些真皮酶的功能障碍的治疗方法，以及由所述功能障碍引起的皮肤状况或障碍的治疗。所述治疗方法包括（i）细胞外基质金属蛋白酶调节剂和（ii）细胞内泛素 - 蛋白酶体调节剂，和（iii）表皮黑素细胞调节剂; 并且其中，所述细胞外试剂，所述细胞内试剂和所述表皮剂可以令人惊奇地和出人意料地是具有化学式（I）的单一多功能化合物。此外，本发明的方法提供了由所述皮肤酶的功能障碍引起的皮肤状况或障碍的治疗; 其中所述皮肤病症是皮肤老化，皮肤皱纹，黑皮肤，老年斑，痤疮，皮肤炎症，细胞抗氧化剂丧失，胶原损失，皮肤柔韧性丧失，皮肤柔软度丧失，油性皮肤或其组合：

6. 发明申请

US20070237834A1 Zinc Zeolite for the Treatment for Diaper Rash (Diaper Dermatitis) 审中-公开
标题翻译：锌沸石治疗尿布疹（尿布皮炎）
公开(公告)号：US20070237834A1
公开(公告)日：2007-10-11
申请号：US11760466
申请日：2007-06-08
申请人： SHYAM GUPTA
发明人： SHYAM GUPTA
IPC分类号： A61K33/06 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61P17/00
CPC分类号： A61K33/30 , A61K8/26 , A61K8/27 , A61K33/06 , A61K33/24 , A61K33/32 , A61K33/34 , A61K2800/58 , A61K2800/75 , A61K2800/782 , A61Q17/00 , A61K2300/00
摘要： The present invention provides treatment of infants and incontinent adults related to diaper rash, also known as diaper dermatitis, by the application of divalent metal complexes of zeolites, such as zinc zeolite, and compositions thereof.
摘要翻译：本发明提供了通过应用沸石的二价金属络合物如锌沸石及其组合物治疗与尿布疹相关的婴儿和失禁成年人，也称为尿布性皮炎。

7. 发明申请

US20070041924A1 Sebum Control Compositions Based on Saponins and Sapogenins 审中-公开
标题翻译：基于皂苷和皂苷元的皮脂控制组合物
公开(公告)号：US20070041924A1
公开(公告)日：2007-02-22
申请号：US11161856
申请日：2005-08-19
申请人： Shyam Gupta
发明人： Shyam Gupta
IPC分类号： A61K8/63 , A61K8/60
CPC分类号： A61K8/63 , A61K2800/782 , A61Q1/14 , A61Q5/006 , A61Q5/02 , A61Q19/00 , A61Q19/008 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： The present invention discloses compositions based on certain furostanol saponins and sapogenins that reduce sebum production. These compounds are useful for the reduction of excess sebum associated with dermatological disorders such as acne, dandruff, and body malodor.
摘要翻译：本发明公开了基于减少皮脂产生的某些呋甾醇皂苷和皂角蛋白的组合物。这些化合物可用于减少与皮肤病如痤疮，头皮屑和身体恶臭相关的过量皮脂。

8. 发明申请

US20050048008A1 Antiaging Cosmetic Delivery Systems 失效
标题翻译：抗衰老化妆品运送系统
公开(公告)号：US20050048008A1
公开(公告)日：2005-03-03
申请号：US10604999
申请日：2003-08-29
申请人： Shyam Gupta
发明人： Shyam Gupta
IPC分类号： A61K8/44 , A61K8/64 , A61K8/97 , A61Q3/00 , A61Q5/00 , A61Q5/02 , A61Q19/08 , A61K7/42 , A61K7/00
CPC分类号： A61K8/97 , A61K8/447 , A61K8/64 , A61K2800/522 , A61K2800/70 , A61Q3/00 , A61Q5/00 , A61Q5/02 , A61Q19/08
摘要： The present invention provides a comprehensive solution to the problems associated with natural topical aging via the incorporation of: (i) An Extra-cellular antioxidant or Free-radical neutralizing composition, and (ii) An Intra-cellular antioxidant or Free-radical neutralizing composition, and (iii) An Anti-inflammatory composition, and (iv) A collagen or fibrin boosting composition. It is preferred to also have the above incorporated in a suitable carrier base or topical delivery system for skin, nail, and hair beneficial applications.
摘要翻译：本发明通过以下方式提供了与天然局部老化相关的问题的综合解决方案：（i）细胞外抗氧化剂或自由基中和组合物，和（ii）细胞内抗氧化剂或自由基中和组合物，和（iii）抗炎组合物，和（iv）胶原或纤维蛋白增强组合物。优选还将上述化合物掺入合适的载体基质或用于皮肤，指甲和毛发有益应用的局部递送系统中。

9. 发明申请

US20090269291A1 Protection of Skin from UV and Peroxide 失效
标题翻译：保护皮肤免受紫外线和过氧化物的侵害
公开(公告)号：US20090269291A1
公开(公告)日：2009-10-29
申请号：US12497662
申请日：2009-07-04
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K8/49 , C07F13/00 , A61Q17/04
CPC分类号： A61K8/19 , A61K8/4946 , A61K2800/58 , A61Q17/04 , A61Q19/004 , A61Q19/08
摘要： The present invention discloses certain heterocyclic complexes of metals of formula (I), especially those of manganese, which enhance the safety and efficacy of sunscreens via urocanate pathway modulation. The present invention also discloses a method for topical application of said complexes, which causes the reduction of topical peroxide including hydrogen peroxide, the reduction of topical inflammation including sunburn, increased sun protection of skin, comprehensive protection from UVA, UVB, and UVC, reduction of radiation-initiated inflammation, the reduction of skin wrinkles, acne, and overall treatment of skin damaged from natural aging and exposure to sun:
摘要翻译：本发明公开了一些式（I）金属的杂环络合物，特别是锰的杂环络合物，其通过尿素途径调节增强了防晒剂的安全性和有效性。本发明还公开了一种用于局部施用所述复合物的方法，其导致包括过氧化氢在内的局部过氧化物的还原，包括晒伤的局部炎症的减少，皮肤的增加的防晒，对UVA，UVB和UVC的综合保护，还原辐射引发的炎症，减少皮肤皱纹，痤疮，以及从自然老化和暴露于阳光下损坏的皮肤的整体治疗：

10. 发明申请

US20090042846A1 Topical Delivery System for Phytosterols 失效
标题翻译：植物甾醇的局部输送系统
公开(公告)号：US20090042846A1
公开(公告)日：2009-02-12
申请号：US12210266
申请日：2008-09-15
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K8/63 , C07J71/00 , C07J53/00 , A61Q19/00 , A61Q19/08 , C07J9/00
CPC分类号： A61K8/63 , A61K2800/782 , A61Q1/14 , A61Q5/006 , A61Q5/02 , A61Q19/00 , A61Q19/008 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof; Wherein, n=0, 1, 2, or 3; and R=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; and R1=Substituent selected from a sapogenin, steroid, or terpenoid.
摘要翻译：本发明涉及式（I）的植物甾醇的某些糖酯。这些酯可用于局部应用，并用于治疗皮肤状况，包括老年斑，痤疮，细胞抗氧化剂的丧失，胶原蛋白损失，皮肤柔韧性丧失，皮肤柔软度的丧失，包括细纹在内的皮肤皱纹，氧化，辐射，基质金属蛋白酶的故障，酪氨酸酶的故障，自由基的损伤，紫外线，皮肤干燥，干癣病，鱼鳞病，头皮屑，褐斑，角化病，黑斑病，斑点，肝斑，色素斑点，皮肤色素沉着，包括皮肤变黑，瑕疵，油性皮肤，疣，湿疹，瘙痒皮肤，牛皮癣，炎性皮肤病，局部炎症，受干扰的角质化，与老化有关的皮肤变化，需要清洁剂的指甲或皮肤，调理或治疗，以及需要洗发或调理，及其组合; 其中n = 0,1,2或3; 并且R = H，-CH 2 OH，-CH（OH）-CH 2 OH，-CH（OH）-CH（OH）-CH 2 OH; R1 =选自皂甙元，类固醇或萜类化合物的取代基。

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