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1. 发明授权

US07247300B1 Therapeutic use of soluble CD39L3 有权
标题翻译：可溶性CD39L3的治疗用途
公开(公告)号：US07247300B1
公开(公告)日：2007-07-24
申请号：US10703780
申请日：2003-11-07
申请人： Ridong Chen , Soon S. Jeong , Timothy A. Mitsky
发明人： Ridong Chen , Soon S. Jeong , Timothy A. Mitsky
IPC分类号： A61K38/46
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of thrombotic disorders in mammals administered with soluble forms of CD39L3 polypeptides.
摘要翻译：本发明提供可溶形式的CD39L3多肽和组合物，以及用于抑制血小板活化和募集用于治疗和预防用可溶性形式的CD39L3多肽施用的哺乳动物血栓形成障碍的方法。

2. 发明申请

US20130142775A1 THERAPEUTIC APYRASE CONSTRUCTS, APYRASE AGENTS, AND PRODUCTION METHODS 有权
标题翻译：治疗APYRASE建议，APYRASE代理和生产方法
公开(公告)号：US20130142775A1
公开(公告)日：2013-06-06
申请号：US13522311
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： C12N9/14 , C12N15/85 , A61K38/46 , C12N5/10
CPC分类号： C12N9/14 , C07K14/70596
摘要： This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.
摘要翻译：本发明提供了一类具有优异的药代动力学，药效学和药物化学性质的增强的apyrases（EN-apyrases），并且可以使用简化的程序纯化。本发明进一步提供了用于转化细胞以产生这些EN-磷酸酶的构建体。 EN-脱酰酶构建体包含编码信号序列，接头和可溶性apyrase的序列。还提供了apyrases的制剂和在培养细胞中产生apyrase的方法和其纯化。

3. 发明申请

US20130028880A1 APYRASE THERAPY FOR BLEEDING CONDITIONS 有权
标题翻译：用于治疗条件的APYRASE治疗
公开(公告)号：US20130028880A1
公开(公告)日：2013-01-31
申请号：US13522310
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46 , A61P7/04
CPC分类号： A61K38/46 , C12Y306/01005
摘要： This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are patho-physiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
摘要翻译：本发明提供了治疗由于血管损伤而出现或有出血风险的受试者，特别是微血管和/或血小板脱敏的新方法。由apyrase试剂有效治疗的损伤的实例是病理生理学条件，缺血再灌注损伤，药理学试剂如抗凝血剂，抗血小板剂，抗血栓药，溶血栓剂和/或免疫抑制剂的损伤以及由移植引起的损伤。当所述器官移植到同种异体受体中时，阿魏酸酶剂也可用于维持器官功能。

4. 发明申请

US20050215505A1 Design and therapeutic use of adpase enhanced apyrases 有权
标题翻译：设计和治疗使用adpase增强的apyrases
公开(公告)号：US20050215505A1
公开(公告)日：2005-09-29
申请号：US11069543
申请日：2005-02-28
申请人： Soon Jeong , Ridong Chen , Timothy Mitsky
发明人： Soon Jeong , Ridong Chen , Timothy Mitsky
IPC分类号： A61K48/00 , C07H21/04 , C12N9/02 , C12N9/12 , C12N9/14 , C12N15/00 , C12Q1/44
CPC分类号： C12N9/14 , A61K48/00 , C12Y306/01005
摘要： The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
摘要翻译：本发明提供了用于预防和逆转血小板聚集和募集用于治疗和预防哺乳动物血管疾病的ADP酶增强多肽，药物组合物和方法的设计和治疗应用。

5. 发明申请

US20170333532A1 ADP'ASE-ENHANCED APYRASE THERAPY FOR WOUNDS, MICROBIAL INFECTION, SEPSIS, AND HETEROTOPIC OSSIFICATION 审中-公开
公开(公告)号：US20170333532A1
公开(公告)日：2017-11-23
申请号：US15522766
申请日：2015-10-29
申请人： APT THERAPEUTICS, INC
发明人： Ridong CHEN , JEONG Seog Soon
IPC分类号： A61K38/46 , A61K38/12
CPC分类号： A61K38/46 , A61K31/795 , A61K38/12 , A61K45/06 , C12Y306/01005 , A61K2300/00
摘要： This invention provides composition and methods of treating subjects with microbial infection, sepsis, wounds, heterotopic ossification, or combination thereof. In each case, the treatment methods of the present invention comprise administering ADPase-enhanced apyrase agents, alone or in combination with an antimicrobial.

6. 发明授权

US08771683B2 Therapeutic apyrase constructs, apyrase agents, and production methods 有权
标题翻译：治疗性apyrase构建体，apyrase试剂和生产方法
公开(公告)号：US08771683B2
公开(公告)日：2014-07-08
申请号：US13522311
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46
CPC分类号： C12N9/14 , C07K14/70596
摘要： This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.
摘要翻译：本发明提供了一类具有优异的药代动力学，药效学和药物化学性质的增强的apyrases（EN-apyrases），并且可以使用简化的程序纯化。本发明进一步提供了用于转化细胞以产生这些EN-磷酸酶的构建体。 EN-脱酰酶构建体包含编码信号序列，接头和可溶性apyrase的序列。还提供了apyrases的制剂和在培养细胞中产生apyrase的方法及其纯化。

7. 发明授权

US08021866B2 Therapeutic use of ADPase enhanced apyrases 有权
标题翻译：治疗性使用ADPase增强的apyrases
公开(公告)号：US08021866B2
公开(公告)日：2011-09-20
申请号：US12145394
申请日：2008-06-24
申请人： Soon Seog Jeong , Ridong Chen , Timothy A. Mitsky
发明人： Soon Seog Jeong , Ridong Chen , Timothy A. Mitsky
IPC分类号： C12N9/02 , C12N1/20 , C07H21/04
CPC分类号： C12N9/14 , A61K48/00 , C12Y306/01005
摘要： The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
摘要翻译：本发明提供了用于预防和逆转血小板聚集和募集用于治疗和预防哺乳动物血管疾病的ADP酶增强多肽，药物组合物和方法的设计和治疗应用。

8. 发明授权

US08535662B2 Apyrase therapy for bleeding conditions 有权
标题翻译： Apyrase治疗出血情况
公开(公告)号：US08535662B2
公开(公告)日：2013-09-17
申请号：US13522310
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46
CPC分类号： A61K38/46 , C12Y306/01005
摘要： This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are pathophysiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
摘要翻译：本发明提供了治疗由于血管损伤而出现或有出血风险的受试者，特别是微血管和/或血小板脱敏的新方法。由apyrase试剂有效治疗的损伤的实例是病理生理学条件，缺血再灌注损伤，药理学试剂如抗凝血剂，抗血小板剂，抗血栓药，溶栓剂和/或免疫抑制剂的损伤以及由移植引起的损伤。当所述器官移植到同种异体受体中时，阿魏酸酶剂也可用于维持器官功能。

9. 发明授权

US07390485B2 Design and therapeutic use of adpase enhanced apyrases 有权
标题翻译：设计和治疗使用adpase增强的apyrases
公开(公告)号：US07390485B2
公开(公告)日：2008-06-24
申请号：US11069543
申请日：2005-02-28
申请人： Soon S. Jeong , Ridong Chen , Timothy A. Mitsky
发明人： Soon S. Jeong , Ridong Chen , Timothy A. Mitsky
IPC分类号： A61K38/44 , A61K39/00 , C12N9/02
CPC分类号： C12N9/14 , A61K48/00 , C12Y306/01005
摘要： The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
摘要翻译：本发明提供了用于预防和逆转血小板聚集和募集用于治疗和预防哺乳动物血管疾病的ADP酶增强多肽，药物组合物和方法的设计和治疗应用。

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