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1. 发明授权

US4567302A Polymeric quaternary ammonium salts possessing antimicrobial activity and methods for preparation and use thereof 失效
标题翻译：具有抗微生物活性的聚合季铵盐及其制备和使用方法
公开(公告)号：US4567302A
公开(公告)日：1986-01-28
申请号：US632819
申请日：1984-07-20
申请人： Kallidaikurichi N. Sivaramakrishnan
发明人： Kallidaikurichi N. Sivaramakrishnan
IPC分类号： A01N35/02 , A01N43/32 , A61K31/335 , A61K31/357 , A61K31/785 , A61P31/04 , C07C67/00 , C07C213/00 , C07C217/08 , C07D319/06 , C08G4/00 , C08G65/48 , C07C93/04
CPC分类号： A01N35/02 , A01N43/32 , C07D319/06 , C08G4/00
摘要： Quaternary ammonium salts exhibiting strong antimicrobial activity are disclosed along with the method of using them as antimicrobial agents. The salts having the formulas I or II: ##STR1## wherein R is C.sub.1-20 alkyl, C.sub.5-7 cycloalkyl or an aralkyl group, R.sup.1 is methyl or ethyl, and X is a halogen, are prepared by the method comprising the steps of:(a) initially reacting 2-nitro-2-methyl-1,3-propanediol or 2-nitro-2-ethyl-1,3-propanediol or a mixture thereof and trioxane in a solvent containing an acid to obtain a first product;(b) reducing said first product by dissolving said first product in a solvent and maintaining the resulting solution under a hydrogen atmosphere in the presence of a reduction catalyst to obtain a second product;(c) alkylating said second product by maintaining said second product under a hydrogen atmosphere in the presence of a formaldehyde solution, a solvent and an alkylation catalyst to obtain a third product; and(d) quaternizing said third product by reacting said third product with a halogenated hydrocarbon in the presence of a solvent to obtain quaternary ammonium salts.
摘要翻译：公开了表现出强抗微生物活性的季铵盐以及将其用作抗微生物剂的方法。具有式I或II的盐：其中R是C 1-20烷基，C 5-7环烷基或芳烷基，R 1是甲基或乙基，X是卤素，通过包括以下步骤的方法制备：（a）使2-硝基-2-甲基-1,3-丙二醇或2-硝基-2-乙基-1,3-丙二醇或其混合物和三恶烷在含有酸的溶剂得到第一产物; （b）通过将所述第一产物溶解在溶剂中并将所得溶液在还原催化剂的存在下在氢气氛下保持以得到第二产物，从而还原所述第一产物; （c）在甲醛溶液，溶剂和烷基化催化剂的存在下，在氢气氛下保持所述第二产物，烷基化所述第二产物，得到第三产物; 和（d）通过使所述第三产物与卤代烃在溶剂存在下反应季铵化所述第三产物，得到季铵盐。

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