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1. 发明授权

US11602515B2 Pharmaceutical compositions comprising dimethyl fumarate 有权
公开(公告)号：US11602515B2
公开(公告)日：2023-03-14
申请号：US16625092
申请日：2018-06-25
申请人： Almirall, S.A.
发明人： Jorge Aubets Mir
IPC分类号： A61K31/225 , A61P17/06 , A61K9/00 , A61K9/20 , A61K9/28
摘要： Pharmaceutical compositions are described comprising (a) dimethyl fumarate, (b) a diluent selected from monosaccharides, disaccharides, starch and starch derivatives, calcium and magnesium inorganic salts, sugar alcohols, and mixtures thereof, (c) microcrystalline cellulose and (d) croscarmellose sodium, wherein the dimethyl fumarate is not covered with a gastroresistant coating. These compositions are intended for the treatment of some inflammatory autoimmune diseases or disorders.

2. 发明申请

US20210220368A1 COMPOSITIONS COMPRISING TIMOLOL AND THEIR USE IN THE TREATMENT OF ROSACEA BY TOPICAL ADMINISTRATION 有权
公开(公告)号：US20210220368A1
公开(公告)日：2021-07-22
申请号：US16309808
申请日：2017-06-15
申请人： Almirall, S.A.
发明人： Bernat Vidal Juan , Maria Victoria Revilla Sanchez , Gema Tarrason Encuentra
IPC分类号： A61K31/5377 , A61P17/00 , A61K9/00 , A61K9/06
摘要： The present invention relates to the use of timolol in treating rosacea, and to pharmaceutical compositions comprising timolol.

3. 发明授权

US10005771B2 Bicyclic derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities 有权
公开(公告)号：US10005771B2
公开(公告)日：2018-06-26
申请号：US15514294
申请日：2015-09-25
申请人： Almirall, S.A.
发明人： Carlos Puig Duran , Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quiñones
IPC分类号： C07D453/02 , A61K31/439
CPC分类号： C07D453/02 , C07D401/12
摘要： The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

4. 发明授权

US09737520B2 Aclidinium for use in improving the quality of sleep in respiratory patients 有权
公开(公告)号：US09737520B2
公开(公告)日：2017-08-22
申请号：US15161531
申请日：2016-05-23
申请人： Almirall, S.A.
发明人： Maria Esther Garcia Gil , Gonzalo De Miquel Serra , Maria Jose Sala Peinado
IPC分类号： A61K31/439 , A61K45/06 , A61K9/00
CPC分类号： A61K31/439 , A61K9/0073 , A61K9/0075 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the quality of sleep in respiratory patients.

5. 发明授权

US09643961B2 Cyclohexylamine derivatives having β2 adrenergic antagonist and M3 muscarinic antagonist activities 有权
公开(公告)号：US09643961B2
公开(公告)日：2017-05-09
申请号：US15068926
申请日：2016-03-14
申请人： Almirall, S.A.
发明人： Maria Prat Quinones , Silvia Fonquerna Pou , Carlos Puig Duran , Wenceslao Lumeras Amador , Jose Aiguade Bosch , Juan Francisco Caturla Javaloyes
IPC分类号： C07D215/26 , C07D409/14 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D413/14
CPC分类号： C07D409/14 , A61K31/4709 , C07D215/26 , C07D405/12 , C07D409/12 , C07D413/14
摘要： The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

6. 发明申请

US20140373838A1 INHALATION DEVICE FOR POWDERED DRUGS 审中-公开
标题翻译：用于粉剂的吸入装置
公开(公告)号：US20140373838A1
公开(公告)日：2014-12-25
申请号：US14373572
申请日：2013-01-17
申请人： Almirall, S.A.
发明人： Martin Herder , Gerhard Ludanek , Ingo Mett , Joachim Schmidt
IPC分类号： A61M15/00
摘要： The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. The inhalation device further comprises an advancing mechanism for advancing a counter means each time the inhalation device has been activated by the patient so that a powder dose has been released into the powder channel. The counter means comprises a mechanical index coupled to a locking mechanism blocking the dosage key (5) and/or the activating device and/or the transportation mechanism after a predetermined number of metering cycles after detection of the index. Moreover, the locking mechanism includes a locking lever (7) for positive engagement with the dosage key (5) and/or the activating device and/or the transportation mechanism in the blocked condition. The inhalation device (1) is characterized in that the locking lever includes signaling means integrally formed therewith engaging the index after said predetermined number of metering cycles.
摘要翻译：本发明涉及一种由吸入引起的气流由患者接收的粉末药物的吸入装置，其包括至少一个粉末储存器，用于从贮存器反复计量粉末剂量的计量装置，用于移动所述计量从填充位置的装置，用于将粉末剂量接收到用于将所述粉末剂量释放到粉末通道中的排空位置，用于由患者手动操作的至少一个致动装置，所述致动装置可操作地连接到所述运输机构，使得在操作正在计量单一粉剂量，所述活化装置包括当由患者按压时作用在所述运输机构上的剂量密钥（5）。吸入装置还包括一个推进机构，用于在每次吸入装置已被患者激活时推进计数器装置，从而将粉末剂量释放到粉末通道中。计数器装置包括机械指标，其耦合到锁定机构，该锁定机构在检测到索引之后经过预定数量的计量循环之后阻止剂量密钥（5）和/或启动装置和/或运输机构。此外，锁定机构包括用于与封闭状态下的剂量密钥（5）和/或启动装置和/或运输机构正接合的锁定杆（7）。吸入装置（1）的特征在于，锁定杆包括在所述预定数量的计量循环之后与所述索引一体形成的信号装置。

7. 发明申请

US20140373837A1 INHALATION DEVICE FOR POWDERED DRUGS 审中-公开
标题翻译：用于粉剂的吸入装置
公开(公告)号：US20140373837A1
公开(公告)日：2014-12-25
申请号：US14373568
申请日：2013-01-17
申请人： Almirall, S.A.
发明人： Martin Herder , Gerhard Ludanek , Ingo Mett , Joachim Schmidt
IPC分类号： A61M15/00
摘要： The invention refers to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when actuated by the patient. According to the invention, said transportation mechanism furthermore comprises a dosage lever (6) acting on said metering means, said dosage lever (6) being locked in the inhalation position of said metering means after said dosage key (5) has been properly pressed down by the patient. The dosage lever (6) in the inhalation position engages a trigger member and is releasable by actuation of the trigger member. The trigger member comprises at least one cam surface and the dosage lever (6) engages the cam surface tangentially in said locked inhalation position.
摘要翻译：本发明涉及一种用于通过吸入引起的空气流由患者接受的粉末药物的吸入装置，其包括至少一个粉末储存器，用于从储存器反复计量粉末剂量的计量装置，用于移动所述计量用于从用于将粉末剂量接收到排空位置以将所述粉末剂量释放到粉末通道中的填充位置的装置，用于由患者手动操作的至少一个激活装置，其可操作地连接到所述运输机构，使得在操作时单一粉末剂量所述激活装置包括当由患者致动时作用在所述运送机构上的剂量密钥（5）。根据本发明，所述运送机构还包括作用在所述计量装置上的剂量控制杆（6），所述剂量控制杆（6）在所述剂量键（5）被适当地按压之后被锁定在所述计量装置的吸入位置由病人吸入位置中的剂量杆（6）接合触发构件，并且通过触发构件的致动可释放。所述触发器构件包括至少一个凸轮表面，并且所述剂量杆（6）在所述锁定的吸入位置中切向地接合所述凸轮表面。

8. 发明授权

US08865728B2 Combinations comprising methotrexate and DHODH inhibitors 有权
标题翻译：组合包括甲氨蝶呤和DHODH抑制剂
公开(公告)号：US08865728B2
公开(公告)日：2014-10-21
申请号：US12999698
申请日：2009-06-18
申请人： Nuria Godessart Marina , Maria Pilar Pizcueta Lalanza
发明人： Nuria Godessart Marina , Maria Pilar Pizcueta Lalanza
IPC分类号： A01N43/90 , A61K31/59 , A61K31/455 , A61K31/519 , A61K45/06
CPC分类号： A61K45/06 , A61K31/455 , A61K31/519 , Y02A50/411 , A61K2300/00
摘要： The present disclosure relates to combinations comprising (a) methotrexate, and (b) a DHODH inhibitor and their uses.
摘要翻译：本公开涉及包含（a）甲氨蝶呤和（b）DHODH抑制剂及其用途的组合。

9. 发明授权

US08802699B2 Quinuclidine derivatives and medicinal compositions containing the same 有权
标题翻译：奎宁环衍生物和含有它们的药物组合物
公开(公告)号：US08802699B2
公开(公告)日：2014-08-12
申请号：US13939742
申请日：2013-07-11
申请人： Almirall, S.A.
发明人： Maria Dolors Fernandez Forner , Maria Prat Quinones , Maria Antonia Buil Albero
IPC分类号： A61K31/439 , A61K31/56 , A61K45/06 , A61K31/4745 , C07D453/02
CPC分类号： A61K31/439 , A61K9/0073 , A61K9/0075 , A61K31/4745 , A61K31/56 , A61K45/06 , A61K47/26 , C07D453/02 , Y10S514/826 , A61K2300/00
摘要： Provided is a pharmaceutical composition comprising: (i) 3-(2-hydroxy-2,2-dithien-2- ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X−with a single negative charge is associated with the positive charge of the nitrogen atom; and (ii) a phosphodiesterase IV inhibitor and methods of using the same.
摘要翻译：本发明提供的药物组合物包含：（i）3-（2-羟基-2,2-二噻吩-2-基乙酰氧基）-1-（3-苯氧基丙基）-1-氮鎓二环[2.2.2]辛烷或对映异构体，对映异构体或其外消旋体的混合物，其中具有单个负电荷的阴离子X与氮原子的正电荷相关联; 和（ii）磷酸二酯酶IV抑制剂及其使用方法。

10. 发明申请

US20140005178A1 AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS 审中-公开
标题翻译：作为DHODH抑制剂的亚氨基苯甲酸苯甲酸衍生物
公开(公告)号：US20140005178A1
公开(公告)日：2014-01-02
申请号：US13964181
申请日：2013-08-12
申请人： Almirall, S.A.
发明人： Julio Cesar CASTRO PALOMINO LARIA , Emma Terricabras Belart , Montserrat Erra Sola , Eloisa Navarro Romero , Siliva Fonquerna Pou , Aranzazu Cardus Figueras , Maria Estrella Lozoya Toribio
IPC分类号： C07D213/74 , A61K31/5377 , A61K31/505 , A61K31/47 , C07D413/10 , A61K31/444 , A61K31/44 , C07D239/42 , C07D215/38 , A61K45/06 , A61K31/55 , A61K31/4545
CPC分类号： C07D213/74 , A61K31/44 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D215/38 , C07D239/42 , C07D401/04 , C07D401/10 , C07D413/10
摘要： The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).
摘要翻译：本公开涉及式（I）的新的氮杂二苯胺基苯甲酸衍生物; 以及它们的制备方法，包含它们的药物组合物及其在治疗中作为脱氢山梨醇二氢化酶（DHODH）抑制剂的用途。

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