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1. 发明公开

US20230226087A1 PHOSPHOLIPIDS AND PHOSPHOLIPID METABOLITES FOR TREATING VIRAL AND BACTERIAL PNEUMONIA AND SEPSIS 审中-公开
公开(公告)号：US20230226087A1
公开(公告)日：2023-07-20
申请号：US17996370
申请日：2021-04-16
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： ULRICH MASSING
IPC分类号： A61K31/685 , A61K9/00 , A61K45/06
CPC分类号： A61K31/685 , A61K9/0053 , A61K45/06
摘要： The invention relates to lyso-phosphatidylcholine (LysoPC), or a suitable precursor or derivative thereof, or a composition containing LysoPC and/or one or more suitable precursors or derivatives thereof, for use in the treatment and aftercare of inflammatory diseases in humans that involve lowering of the LysoPC level, including the treatment, prevention or support of treatment and aftercare of viral and bacterial pneumonias and sepsis, including pneumonia and sepsis as a consequence of influenza, Covid-19, ARDS, cancer, for supporting immunotherapy in cancer in view of effectiveness and for reducing side-effects, such as pneumonitis, colitis or hepatitis, and for reducing undesirable vaccination responses. The invention further relates to alpha-glycerophosphocholine (alpha-GPC), or a variant thereof, or a composition containing alpha-GPC and/or one or more variants thereof, for use in the treatment and aftercare of cancers and tumor cachexia.

2. 发明授权

US11307210B2 Conveying device 有权
公开(公告)号：US11307210B2
公开(公告)日：2022-04-19
申请号：US16086589
申请日：2017-03-16
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： Klaus-Guenter Eberle
IPC分类号： G01N35/00 , C12M1/22 , C12M1/00 , C12M3/00 , C12M1/26 , C12M1/36 , G01N35/04
摘要： The invention relates to a conveying device (IO) for positioning and providing laboratory vessels (12; 12a, 12b, 12c) for nutrient media, samples, microorganisms, cell cultures, or the like for analysis, sample preparation, and/or sample manipulation at an associated apparatus (64), comprising at least one first conveying unit (32) for conveying the laboratory vessels (12) between an initial region (30) and a provision region (60), where the laboratory vessel (12) is held for the analysis or preparation. According to the invention, a plurality of conveying units is present, which perform only a translational motion of the laboratory vessel (12) along an axis, wherein the first conveying unit (32) vertically conveys the laboratory vessel (12) from the initial region (30) to a predetermined height region (50) and vice versa, and a second conveying unit (56) is provided, which horizontally conveys the laboratory vessel (12) from the height region (50) to the provision region and vice versa.

3. 发明申请

US20210245174A1 Centrifuge 有权
公开(公告)号：US20210245174A1
公开(公告)日：2021-08-12
申请号：US16973429
申请日：2019-06-11
申请人： Andreas Hettich GmbH & Co. KG
发明人： Matthias HORNEK , Andreas HOELDERLE , Rainer PRILLA , Robert HEGELE , Klaus-Guenter EBERLE
IPC分类号： B04B9/08 , B04B7/02 , B04B9/12
摘要： The invention relates to a centrifuge (10), having a drive shaft (12), a rotor (14), which is mounted on the drive shaft (12) and is axially removable in a removal direction (26), a quick closure (20), which operates between the rotor (14) and the drive shaft (12) and by means of which the rotor (14) can be fixed relative to the drive shaft (12) in the removal direction (26), a thrust bearing (44) connected to the drive shaft (12), a locking bearing (24) connected to the rotor (14), at least one blocking element (38), which, when activated, fixes the rotor (14) relative to the drive shaft (12) and operates between the locking bearing (24) of the rotor (14) and the thrust bearing (44) of the drive shaft (12). The pivot axis (38b) is aligned perpendicular to a straight line parallel to the drive shaft (12) and the blocking element (38) has a cardan shaft (38a), which is rotatable about the pivot axis (38b), and is connected to a bearing (40) via the cardan shaft (38a).

4. 发明授权

US11059007B2 Rotor of a dual centrifuge 有权
公开(公告)号：US11059007B2
公开(公告)日：2021-07-13
申请号：US15539131
申请日：2015-11-24
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： Jovan Dobos , Anke Lenz , Ulrich Massing , Klaus-Guenter Eberle
IPC分类号： B01F9/00 , B04B5/02 , B04B9/12
摘要： The invention relates to a rotor (10) of a dual centrifuge wherein the rotor has a rotor head (12) and an additional rotational mechanism for at least one rotational unit (22) which is provided in the rotor head (12) and comprises a bearing unit (70) and a rotational head (24) that is connected to the bearing unit (70) which is rotatably mounted and can be driven relative to the rotor head (12) by an additional rotational mechanism, an opening (16) for the rotational unit (22) being provided in which the rotational unit is accommodated and by means of which the bearing (70) is arranged such that it is fixed relative to the rotor head (12). The invention is characterized in that the rotational unit (22) has a housing (26) in which the bearing unit (70) is accommodated and in which the rotational head (24) engages, and in that the housing (26) and the rotational head (24) form, with bearing unit (70), a structural unit, the housing (26) being mounted such that it cannot rotate relative to the rotor head (12) and such that it can be detached from the rotor head.

5. 发明申请

US20210032918A1 HOLDING AND OPENING MECHANISM 有权
公开(公告)号：US20210032918A1
公开(公告)日：2021-02-04
申请号：US16940706
申请日：2020-07-28
申请人： Andreas Hettich GmbH & Co. KG
发明人： Timo Liebermann , Klaus-Guenter Eberle
IPC分类号： E05F3/18 , E05F3/20
摘要： The invention relates to a holding and opening mechanism for a pivoting element, such as a lid, a cover, a door or the like, which is mounted to be pivotable relative to a supporting element such as a housing, a frame or the like about a first axle via a joint, with a pivoting arm acting between the pivoting element and the supporting element, which arm is pivotally mounted about a second axle that is not the same as the first axle, wherein the free end of the pivoting arm acts, preferably via a roller, on a control surface of a guide element, wherein a torsion spring is provided which acts on the pivoting arm in the direction around the second axle, in order to generate a holding and opening force on the pivoting arm and the control surface, comprising a fixed part and a part pivotable relative thereto, with the one part including the guide element and the other part including the pivoting arm, wherein the pivotable part is adapted to be pivotable relative to the fixed part about the joint and the first axle, the pivotable part is connected to the pivoting arm and the pivoting element and the fixed part is connected to the supporting element, wherein the control surface in cooperation with the torsion spring and the pivoting arm determines the holding and opening force via the pivot angle of the pivoting element. The invention is characterized in that a plurality of pivoting arms, guide elements, joints and fixed and pivotable parts are provided, with the pivoting arms being coupled together by a common torsion spring Spin the second axle.

6. 发明申请

US20170348704A1 ROTATIONAL UNIT FOR A ROTOR OF A DUAL CENTRIFUGE 审中-公开
公开(公告)号：US20170348704A1
公开(公告)日：2017-12-07
申请号：US15541358
申请日：2015-11-24
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： JOVAN DOBOS , KLAUS-GUENTER EBERLE , ULRICH MASSING , ANKE LENZ
IPC分类号： B04B5/02 , B04B5/04
摘要： The invention relates to a rotational unit (10) for a rotor of a dual centrifuge, said rotational unit having a bearing (14) and a rotational head (24) which is connected to the bearing (14), is mounted therein such that it can rotate about an axis of rotation and can be driven relative to the rotor by an additional rotational mechanism of the centrifuge, the rotational head (24) being detachably connected to the receiving unit (40, 80) for conjoint rotation, which receiving unit comprises a sample container receptacle (60, 70, 100, 110) for at least one sample container. The invention is characterized in that the receiving unit (40, 80) and the rotational head (24) are connected by a frictional connection in which some portions of the receiving unit (40, 80) and the rotational head (24) engage in each other in a wedge-like manner, and the frictional connection increases with a movement of the receiving unit (40, 80) along the axis of rotation of the rotational unit (10) in the direction toward the rotational head (24).

7. 发明申请

US20170209874A1 CENTRIFUGE 审中-公开
公开(公告)号：US20170209874A1
公开(公告)日：2017-07-27
申请号：US15326470
申请日：2015-07-24
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： MATTHIAS HORNEK , KLAUS-GUENTER EBERLE
IPC分类号： B04B15/02
CPC分类号： B04B15/02
摘要： The invention relates to a centrifuge (10) having a centrifuge housing, a safety vessel (14) arranged in the centrifuge housing, an interior space (16) at least partially bounded by the safety vessel (14), a rotor arranged in the interior space (16), and a cooling system, arranged in the centrifuge housing, for cooling the interior space (16), having a compressor (22), a condenser (24) and an evaporator (26), which are connected together via line means. The invention is distinguished by the fact that the cooling system has a primary circuit (52) with primary line means (29) and a secondary circuit (62) with secondary line means (34), wherein the primary circuit (52) comprises the compressor (22), the condenser (24) and the evaporator (26), which is part of a heat exchanger (30), and wherein the secondary circuit (62) flows through the heat exchanger (30), cools the safety vessel (14) and is provided with a pump (32).

8. 发明申请

US20170056893A1 CENTRIFUGE 审中-公开
标题翻译：离心机
公开(公告)号：US20170056893A1
公开(公告)日：2017-03-02
申请号：US15246354
申请日：2016-08-24
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： KLAUS-GUENTER EBERLE , MATTHIAS HORNEK , ROBERT HEGELE
IPC分类号： B04B15/02 , B04B7/06
CPC分类号： B04B15/02 , B04B7/02 , B04B7/06
摘要： The invention relates to a centrifuge (10) comprising a housing (12), a rotor (32), a safety vessel (26) in which the rotor (32) is supported on a drive shaft (37) extending through the safety vessel (26) and a centrifuge cover (16) limiting an inner space (24) of the housing (12), wherein the safety vessel (26) is provided in the inner space (24), a gaseous coolant enters the inner space (24) via a suction opening (20), flows through the inner space (24), thereby guided laterally past the safety vessel (26) and at least sectionally past the drive motor via the rotor (32), and laterally exits the inner space (24) of the housing (12) through an outlet opening (46). The invention is characterized by a channel (41) being provided for the gaseous coolant, running around the safety vessel (26) at least in part and formed by the safety vessel (26) and at least one flow guidance (40), provided in radial direction.
摘要翻译：本发明涉及一种离心机（10），其包括壳体（12），转子（32），安全容器（26），其中转子（32）支撑在延伸穿过安全容器的驱动轴（37） 26）和限制所述壳体（12）的内部空间（24）的离心机盖（16），其中所述安全容器（26）设置在所述内部空间（24）中，气态冷却剂进入所述内部空间（24）经由吸入口（20）流过内部空间（24），从而横向引导通过安全容器（26）并经由转子（32）至少部分地超过驱动马达，并横向离开内部空间（24））通过出口开口（46）。本发明的特征在于为气态冷却剂提供了一个通道（41），该通道（41）至少部分地由安全容器（26）和至少一个流动引导（40）形成，安全装置径向。

9. 发明申请

US20170050195A1 CENTRIFUGE ROTOR 审中-公开
标题翻译：离心转子
公开(公告)号：US20170050195A1
公开(公告)日：2017-02-23
申请号：US15242006
申请日：2016-08-19
申请人： ANDREAS HETTICH GMBH & CO. KG
发明人： MATTHIAS HORNEK , RAINER PRILLA , ANDREAS HOELDERLE , KLAUS-GUENTER EBERLE
IPC分类号： B04B7/06
CPC分类号： B04B7/06 , B04B5/0414 , B04B7/02 , B04B7/08 , B04B2007/025
摘要： The invention relates to a rotor 10 of a centrifuge 100, having a receiving chamber 18 for samples to be centrifuged, a concentrically mounted seat 20 which is associated with a support 106 of a drive shaft 104 of said centrifuge 100, a lid 40 which limits the receiving chamber 18 at the top, which is mounted concentrically relative to the rotor and which has, on its side remote from the receiving chamber 18, a handle 44 for carrying the rotor and the lid 40, and a locking mechanism 50, 34b of lid 40 and rotor, which locking mechanism 50, 34b comprises a locking element 50 which can be moved between a locking position and an unlocking position thereof. In accordance with the invention, part of the handle 44 is adapted to be movable and is operatively connected to a retaining element 48b, 48c, which retaining element 48b, 48c can be moved, by means of the handle 44, between a first position which prevents actuation of the locking element 50, and a second position which releases the locking element 50.
摘要翻译：本发明涉及离心机100的转子10，其具有用于待离心的样品的接收室18，与所述离心机100的驱动轴104的支撑件106相关联的同心安装的座20，限定位于顶部的接收室18，其相对于转子同心安装，并且在其远离接收室18的一侧具有用于承载转子和盖40的手柄44和用于承载转子和盖40的锁定机构50,34b 盖40和转子，该锁定机构50,34b包括可在锁定位置和解锁位置之间移动的锁定元件50。根据本发明，手柄44的一部分适于可移动并且可操作地连接到保持元件48b，48c，保持元件48b，48c可借助于手柄44在第一位置防止锁定元件50的致动以及释放锁定元件50的第二位置。

10. 发明授权

US09562214B2 Conditioning chamber for storing samples in a time-controlled manner and method for storing samples in a time-controlled manner 有权
标题翻译：用于以时间控制的方式存储样品的调节室和用于以时间控制的方式存储样品的方法
公开(公告)号：US09562214B2
公开(公告)日：2017-02-07
申请号：US13885149
申请日：2011-11-17
申请人： Klaus-Guenter Eberle , Gavin Clarke
发明人： Klaus-Guenter Eberle , Gavin Clarke
IPC分类号： C12M1/00 , C12M3/00 , C12M1/14 , C12M3/04 , C12M1/26 , B01L1/02 , G01N35/00 , C12M1/22 , B01L7/00 , G01N35/02 , G01N35/04
CPC分类号： C12M33/00 , B01L1/025 , B01L7/00 , C12M23/10 , C12M23/48 , C12M23/50 , C12M41/14 , C12M45/22 , G01N35/00 , G01N35/0099 , G01N35/025 , G01N2035/00356 , G01N2035/00445 , G01N2035/0093 , G01N2035/0427 , G01N2035/0441 , G01N2035/0455 , G01N2035/0465
摘要： The invention relates to an air-conditioning space (10) for storing samples in a time-controlled manner, comprising a device (22) for automatically feeding sample containers (18) into a climatically sealed space (12) having at least one wall (43), into which a sample container (18) can be inserted into the climatically sealed space (12) through an opening (40, 42), wherein the feed device (22) has at least one drive and control unit, and an incubator receptacle (30) for receiving the samples (18) is provided inside the climatically sealed space (12). The invention is distinguished by the fact that the feed device has an automatic feed arm (22, 24) which grips a sample container (18) from a receiving position outside the climatically sealed space (12) and deposits the sample container (18) there in a clear deposit position in an incubator receptacle (30).
摘要翻译：本发明涉及一种用于以时间控制的方式存储样品的空调空间（10），包括用于将样品容器（18）自动供给到具有至少一个壁的气候密封空间（12）中的装置（22） 43），其中样品容器（18）可以通过开口（40,42）插入气候密封空间（12）中，其中进料装置（22）具有至少一个驱动和控制单元，以及培养箱设置在气候密封空间（12）内的用于接收样品（18）的容器（30）。本发明的区别在于进料装置具有自动进料臂（22,24），该自动进料臂将样品容器（18）从位于气候密封空间（12）外部的接收位置夹持并将样品容器（18）沉积在那里在培养箱容器（30）中处于清楚的沉积位置。

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