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1. 发明授权

US10646565B2 Treatment of alzheimer'S disease (AD) with an aluminum salt 有权
公开(公告)号：US10646565B2
公开(公告)日：2020-05-12
申请号：US15307714
申请日：2015-04-29
申请人： AFFIRIS AG
发明人： Markus Mandler , Achim Schneeberger , Frank Mattner , Walter Schmidt
IPC分类号： A61K39/39 , A61K39/00 , A61K33/06 , A61K9/00 , A61K47/02 , A61K33/08 , A61K38/03
摘要： Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.

2. 发明授权

US10576131B2 IL-23-p19 vaccines 有权
公开(公告)号：US10576131B2
公开(公告)日：2020-03-03
申请号：US15569303
申请日：2016-06-03
申请人： AFFIRIS AG
发明人： Guenther Staffler , Dorian Winter
IPC分类号： C07K14/54 , C07K7/06 , C07K7/08 , C07K9/00 , C07K17/00 , A61K38/08 , A61K38/10 , A61K38/20 , A61K39/00 , A61K38/16 , A61P37/00
摘要： Disclosed is a vaccine, preferably for use in the prevention or treatment of an interleukin 23 (IL-23) related disease, that includes a peptide bound to a pharmaceutically acceptable carrier, wherein the peptide is QPEGHHWETQQIPSLS (SEQ ID No. 103; p8322), GHHWETQQIPSLSPSQPWQRL QPEGHHWETQ (SEQ ID No. 98; p8461), TQQIPSLSPSQ (SEQ ID No. 99; p8400), QPEGHHWETQQIPSLSPSQ (SEQ ID No. 100; p9269), QPEGHHWETQQIPSLSPS (SEQ ID No. 101; p9269-C1), or QPEGHHWETQQIPSLSP (SEQ ID No. 102; p9269-C2), especially QPEGHHWETQQIPSLS (SEQ ID No. 103; p8322) and wherein the IL-23 related disease is one or more of psoriasis, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, diabetes, preferably type 1 diabetes, atherosclerosis, inflammatory bowel disease (IBD)/M. Crohn, multiple sclerosis, Behcet disease, ankylosing spondylitis, Vogt-Koyanagi-Harada disease, chronic granulomatous disease, hidratenitis suppurtiva, anti-neutrophil cytoplasmic antibodies (ANCA-) associated vasculitides, neurodegenerative diseases, preferably M. Alzheimer or multiple sclerosis, atopic dermatitis, graft-versus-host disease, cancer, preferably Oesophagal carcinoma colorectal carcinoma, lung adenocarcinoma, small cell carcinoma, and squamous cell carcinoma of the oral cavity, especially psoriasis, neurodegenerative diseases or IBD.

3. 发明申请

US20180186896A1 VACCINES FOR THE TREATMENT AND PREVENTION OF IGE MEDIATED DISEASES 审中-公开
公开(公告)号：US20180186896A1
公开(公告)日：2018-07-05
申请号：US15738759
申请日：2016-07-07
申请人： AFFIRIS AG
发明人： Oskar SMRZKA , Benjamin VIGL
IPC分类号： C07K16/42 , A61K39/00
CPC分类号： C07K16/4291 , A61K39/0005 , A61K2039/505 , A61K2039/6081 , A61K2039/627 , A61K2039/70 , C07K16/00 , C07K2317/21 , C07K2317/34
摘要： Disclosed is a vaccine for use in the prevention or treatment of an Immunoglobulin E (IgE-) related disease, comprising a peptide bound to a pharmaceutically acceptable carrier, wherein said peptide is selected from the group of QQQGLPRAAGG (SEQ ID No. 109; p9347), QQLGLPRAAGG (SEQ ID No. 110; p8599), QQQGLPRAAEG (SEQ ID No. I11; p8600), QQLGLPRAAEG (SEQ ID No. 112; p8601), QQQGLPRAAG (SEQ ID No. 113; p9338), QQLGLPRAAG (SEQ ID No. 114; p9041), QQQGLPRAAE (SEQ ID No. 115; p9042), QQLGLPRAAE (SEQ ID No. 116; p9043), HSGQQQGLPRAAGG (SEQ ID No. 117; p7575), HSGQQLGLPRAAGG (SEQ ID No. 118; p8596), HSGQQQGLPRAAEG (SEQ ID No. 119; p8597), HSGQQLGLPRAAEG (SEQ ID No. 120; p8598), QSQRAPDRVLCHSG (SEQ ID No. 121; p7580), GSAQSQRAPDRVL (SEQ ID No. 122; p7577), and WPGPPELDV (SEQ ID No. 125; p7585).

4. 发明授权

US09964547B2 Method for detecting aSyn-specific antibodies in a biological sample 有权
公开(公告)号：US09964547B2
公开(公告)日：2018-05-08
申请号：US14782078
申请日：2014-04-02
申请人： AFFIRIS AG
发明人： Guenther Staffler , Markus Mandler , Andreas Mairhofer , Arne Von Bonin
IPC分类号： G01N33/68 , G01N33/564
CPC分类号： G01N33/6854 , G01N33/564 , G01N33/6896 , G01N2800/2814
摘要： Disclosed is a method for detecting aSyn-specific antibodies in a biological sample, comprising the following steps: —contacting the sample with aSyn-comprising-aggregates and allowing the aSyn-specific antibodies to bind to the aSyn-comprising-aggregates, and —detecting the aSyn-specific antibodies bound to the aSyn-comprising-aggregates by a single particle detection technique, preferably by fluorescence activated cell sorting (FACS).

5. 发明申请

US20170304384A1 SUBSTANCES AND METHODS FOR THE USE IN PREVENTION AND/OR TREATMENT IN HUNTINGTON'S DISEASE 审中-公开
公开(公告)号：US20170304384A1
公开(公告)日：2017-10-26
申请号：US15324962
申请日：2015-07-10
申请人： AFFIRIS AG
发明人： Oskar SMRZKA , Stefan BARTL
IPC分类号： A61K38/02 , C07K16/28 , A61K39/42 , C07K14/705 , A61K47/42 , A61K48/00
CPC分类号： A61K38/02 , A61K39/0007 , A61K39/42 , A61K47/42 , A61K47/51 , A61K48/00 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/286 , C07K2317/24 , C07K2317/34 , C07K2317/76 , G01N2800/2835
摘要： Disclosed are immunogenic peptides of the HTT protein and HTT specific antibodies for use in the prevention and/or treatment of Huntington's disease.

6. 发明申请

US20170137509A1 VACCINES AND MONOCLONAL ANTIBODIES TARGETING TRUNCATED VARIANTS OF OSTEOPONTIN AND USES THEREOF 审中-公开
公开(公告)号：US20170137509A1
公开(公告)日：2017-05-18
申请号：US15322356
申请日：2015-06-29
申请人： AFFIRIS AG
发明人： Guenther STAFFLER , Christine LANDLINGER , Marie LE BRAS
IPC分类号： C07K16/24 , G01N33/68 , A61K39/00
CPC分类号： C07K16/24 , A61K39/0005 , A61K2039/6081 , C07K14/52 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/52 , G01N2800/044 , G01N2800/52
摘要： The present invention provides monoclonal antibodies specific for one or more truncated variants of human osteopontin and vaccines comprising at least one isolated osteopontin peptide, as well methods for manufacturing said antibodies and vaccines. Furthermore, a diagnostic method making use of said antibodies is provided. Said antibodies and vaccines are used in therapy, especially in treatment and/or prevention of Type-2 diabetes and cardiovascular disease.

7. 发明授权

US09220762B2 PCSK9 peptide combination vaccine and method of use 有权
标题翻译： PCSK9肽组合疫苗及其使用方法
公开(公告)号：US09220762B2
公开(公告)日：2015-12-29
申请号：US14344879
申请日：2012-09-13
申请人： Sylvia Brunner , Gergana Galabova , Bettina Wanko , Markus Windwarder , Gabriele Winsauer , Guenther Staffler , Claudia Juno
发明人： Sylvia Brunner , Gergana Galabova , Bettina Wanko , Markus Windwarder , Gabriele Winsauer , Guenther Staffler , Claudia Juno
IPC分类号： A61K39/00 , A61K39/39 , C12N9/64 , C07K16/40 , A61K39/385
CPC分类号： A61K39/0005 , A61K39/0012 , A61K39/385 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/6081 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/50 , C12N9/6454 , C12Y304/21061
摘要： A vaccine or immunogenic composition comprising at least two fragments of proprotein convertase subtilisin/kexin type 9 (PCSK9) where one fragment contains at least 9 consecutive residues of residues 153 to 165 of PCSK9 and the other fragment contains at least 9 consecutive residues 209 to 222 of the PCSK9 (SEQ ID NO:9). Methods of treatment for hyperlipidemia, hypercholesterolemia, and atherosclerosis involving administering this vaccine.
摘要翻译：包含至少两种前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）的片段的疫苗或免疫原性组合物，其中一个片段含有至少9个连续残基的PCSK9残基153至165，另一个片段含有至少9个连续残基209至222 的PCSK9（SEQ ID NO：9）。涉及施用该疫苗的高脂血症，高胆固醇血症和动脉粥样硬化的治疗方法。

8. 发明申请

US20150306191A1 VACCINE 有权
标题翻译：疫苗
公开(公告)号：US20150306191A1
公开(公告)日：2015-10-29
申请号：US14418139
申请日：2013-08-28
申请人： AFFIRIS AG
发明人： Sylvia BRUNNER , Gergana GALABOVA , Gabriele WINSAUER , Erika BILCIKOVA , Claudia JUNO , Pola LINZMAYER-HIRT , Birgit SCHUH , Guenther STAFFLER
IPC分类号： A61K39/00 , A61K39/39 , C12N9/64 , A61K39/385
CPC分类号： A61K39/0005 , A61K39/385 , A61K39/39 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/55505 , A61K2039/6081 , C12N9/6424 , C12N9/6454 , C12Y304/21061
摘要： The present invention relates to a vaccine capable to induce the formation of antibodies directed to PCSK9 in vivo.
摘要翻译：本发明涉及能够在体内诱导针对PCSK9的抗体形成的疫苗。

9. 发明申请

US20140147456A1 CETP FRAGMENTS 有权
标题翻译： CETP片
公开(公告)号：US20140147456A1
公开(公告)日：2014-05-29
申请号：US14116075
申请日：2012-06-11
申请人： Sylvia Brunner , Mathias Gebhart , Erika Bilcikova , Claudia Juno , Pola Linzmayer-Hirt , Birgit Schuh
发明人： Sylvia Brunner , Mathias Gebhart , Erika Bilcikova , Claudia Juno , Pola Linzmayer-Hirt , Birgit Schuh
IPC分类号： C07K14/47 , C07K16/18
CPC分类号： C07K14/47 , A61K38/00 , A61K38/04 , A61K38/08 , A61K39/0005 , A61K2039/6081 , C07K9/00 , C07K16/18 , C07K2317/76
摘要： The present invention relates to a peptide consisting of 6 to 20 amino acid residues and being derived from amino acid sequence VFKGTLKYGYTTAWWLGIDQSIDFEIDSAI (SEQ ID No. 23), wherein said peptide comprises amino acid sequence WWLGID (SEQ ID No. 24) and antibodies binding to these peptides.
摘要翻译：本发明涉及由6至20个氨基酸残基组成的肽，其衍生自氨基酸序列VFKGTLKYGYTTAWWLGIDQSIDFEIDSAI（SEQ ID No.23），其中所述肽包含氨基酸序列WWLGID（SEQ ID No.24）和结合这些肽。

10. 发明申请

US20120269836A1 Vaccine 有权
标题翻译：疫苗
公开(公告)号：US20120269836A1
公开(公告)日：2012-10-25
申请号：US13386603
申请日：2010-07-23
申请人： Günther Staffler , Petra Lührs , Andreas Mairhofer , Frank Mattner , Walter Schmidt , Andrea Dolischka
发明人： Günther Staffler , Petra Lührs , Andreas Mairhofer , Frank Mattner , Walter Schmidt , Andrea Dolischka
IPC分类号： A61K39/00 , A61P9/12 , A61P27/02 , A61P13/12 , A61P9/00 , A61P37/04 , A61P9/10
CPC分类号： A61K39/385 , A61K39/0008 , A61K2039/55505 , A61K2039/6037 , A61K2039/6081 , C07K14/435
摘要： Vaccine comprising a peptide bound to a pharmaceutically acceptable carrier, said peptide having the amino acid sequence (Formula I) (SEQ ID NO: 1) (X1)m(X2)n(X3)oX4X5HPX6, for treating and/or preventing a physical disorder associated with the renin-activated angiotensin system, wherein X1 is G or D, X2 is A, P, M, G, or R, X3 is G, A, H, or V, X4 is S, A, D, or Y, X5 is A, D, H, S, N, or I, X6 is A, L or F, wherein m, n and o are independently 0 or 1 under the premise that when o is 0 m and n are 0 and when n is 0 m is 0, and wherein the peptide is not DRVYIHPF (SEQ ID NO:4).
摘要翻译：包含与药学上可接受的载体结合的肽的疫苗，所述肽具有氨基酸序列（式I）（SEQ ID NO：1）（X1）m（X2）n（X3）oX4X5HPX6，用于治疗和/或预防物理与肾素激活的血管紧张素系统相关的疾病，其中X1是G或D，X2是A，P，M，G或R，X3是G，A，H或V，X4是S，A，D或 Y，X5为A，D，H，S，N或I，X6为A，L或F，其中m，n和o分别为0或1，前提是当o为0，n为0时，当n为0时为0，并且其中肽不是DRVYIHPF（SEQ ID NO：4）。

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