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1. 发明授权

US11446336B2 Compositions comprising bacterial strains 有权
公开(公告)号：US11446336B2
公开(公告)日：2022-09-20
申请号：US17325502
申请日：2021-05-20
申请人： 4D Pharma Research Limited
发明人： Imke Elisabeth Mulder , Anna Ettorre , Suaad Ahmed , Parthena Fotiadou
IPC分类号： A61K35/74
摘要： The invention provides a composition comprising a bacterial strain of the genus Parabacteroides, for use in a method of treating or preventing cancer in a subject; wherein the cancer comprises oncogenic ERK signalling.

3. 发明申请

US20220257668A1 COMPOSITIONS COMPRISING BACTERIAL STRAINS 有权
公开(公告)号：US20220257668A1
公开(公告)日：2022-08-18
申请号：US17586968
申请日：2022-01-28
申请人： 4D Pharma Research Limited
发明人： Alex STEVENSON
IPC分类号： A61K35/74 , C12N1/20 , A61P37/00 , A61P11/06 , A61P19/02 , A61K9/19
摘要： The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.

4. 发明申请

US20220080003A1 LACTIC ACID BACTERIAL STRAINS 有权
公开(公告)号：US20220080003A1
公开(公告)日：2022-03-17
申请号：US17232871
申请日：2021-04-16
申请人： 4D Pharma Research Limited
发明人： Denise Kelly
IPC分类号： A61K35/747 , A23L33/135 , C12N1/20 , A23K10/18
摘要： A first aspect of the invention relates to a porcine lactic acid bacterial strain, wherein said bacterial strain is characterised by one or more of the following characteristics: (i) the ability to exhibit antimicrobial activity against E. coli; (ii) the ability to exhibit antimicrobial activity against S. enteritidis; (iii) the ability to suppress inflammation in IPEC cells induced by 12-O-tetradecaboylphorbol-13-acetate (PMA); (iv) the ability to block the attachment or invasion of IPEC cells by S. enteritidis; (v) the ability to block the attachment or invasion of IPEC cells by E. coli; (vi) the absence of antibiotic resistance to one or more antibiotics selected from the following: ampicillin; cefotaxime; chloramphenicol; erythromycin; gentamicin; tetracycline; vancomycin; metronizadole; nalidixic acid; and kanamycin; and (vii) the ability to exhibit heat stability when subjected to three cycles of heating, each cycle comprising heating at a temperature of 70° C. for a period of 15 minutes. Further aspects of the invention relate to compositions comprising said bacterial strains, and therapeutic uses of said bacterial strains.

5. 发明申请

US20220016184A1 COMPOSITIONS COMPRISING BACTERIAL STRAINS 有权
公开(公告)号：US20220016184A1
公开(公告)日：2022-01-20
申请号：US17382426
申请日：2021-07-22
申请人： 4D Pharma Research Limited
发明人： Helene SAVIGNAC , Imke Elisabeth MULDER , Alexander James STEVENSON
IPC分类号： A61K35/74 , A61P25/28 , A61P25/22 , A61P25/18 , A61P25/24 , A61P25/16 , A61P25/00 , A61K9/00 , A61K35/741 , A61K9/48
摘要： The invention provides compositions comprising bacterial strains for treating and preventing brain injury.

6. 发明申请

US20210275607A1 COMPOSITIONS COMPRISING BACTERIAL STRAINS 有权
公开(公告)号：US20210275607A1
公开(公告)日：2021-09-09
申请号：US17149990
申请日：2021-01-15
申请人： 4D Pharma Research Limited
发明人： Imke MULDER , Alexander STEVENSON , Helene SAVIGNAC
IPC分类号： A61K35/741 , A61P11/00
摘要： The invention provides compositions comprising bacterial strains for treating and preventing lung injury or lung disease.

7. 发明申请

US20210214676A1 COMPOSITION 有权
公开(公告)号：US20210214676A1
公开(公告)日：2021-07-15
申请号：US17089370
申请日：2020-11-04
申请人： 4D Pharma Research Limited
发明人： Samantha YUILLE , Nicole REICHARDT
IPC分类号： C12N1/20 , C12Q1/02 , G01N33/50
摘要： The invention provides compositions, processes and kits for determining the metabolic properties of cells of interest in vitro.

8. 发明授权

US11013773B2 Lactic acid bacterial strains 有权
公开(公告)号：US11013773B2
公开(公告)日：2021-05-25
申请号：US16206250
申请日：2018-11-30
申请人： 4D Pharma Research Limited
发明人： Denise Kelly
IPC分类号： A61K35/747 , A23L33/135 , C12R1/225 , C12R1/23 , C12R1/25 , C12N1/20 , A23K10/18
摘要： A first aspect of the invention relates to a porcine lactic acid bacterial strain, wherein said bacterial strain is characterised by one or more of the following characteristics: (i) the ability to exhibit antimicrobial activity against E. coli; (ii) the ability to exhibit antimicrobial activity against S. enteritidis; (iii) the ability to suppress inflammation in IPEC cells induced by 12-0-tetradecaboylphorbol-13-acetate (PMA); (iv) the ability to block the attachment or invasion of IPEC cells by S. enteritidis; (v) the ability to block the attachment or invasion of IPEC cells by E. coli; (vi) the absence of antibiotic resistance to one or more antibiotics selected from the following: ampicillin; cefotaxime; chloramphenicol; erythromycin; gentamicin; tetracycline; vancomycin; metronizadole; nalidixic acid; and kanamycin; and (vii) the ability to exhibit heat stability when subjected to three cycles of heating, each cycle comprising heating at a temperature of 70° C. for a period of 15 minutes. Further aspects of the invention relate to compositions comprising said bacterial strains, and therapeutic uses of said bacterial strains.

9. 发明申请

US20210138058A1 COMPOSITIONS 有权
公开(公告)号：US20210138058A1
公开(公告)日：2021-05-13
申请号：US17025706
申请日：2020-09-18
申请人： 4D Pharma Research Limited
发明人： Imke Elisabeth MULDER , Emma RAFTIS , Emma Elizabeth Clare HENNESSY , Delphine Louise Claudette LAUTE-CALY , Philip COWIE
IPC分类号： A61K39/09
摘要： The invention provides compositions comprising flagellin polypeptides from bacterial strains and the use of such compositions in the treatment of disease.

10. 发明授权

US10987387B2 Compositions comprising bacterial strain 有权
公开(公告)号：US10987387B2
公开(公告)日：2021-04-27
申请号：US16691136
申请日：2019-11-21
申请人： 4D Pharma Research Limited
发明人： Imke Elisabeth Mulder , Emma Raftis , Delphine Louise Claudette Caly , Emma Elizabeth Clare Hennessy
IPC分类号： A61K35/744 , A61P35/00 , A61K9/00
摘要： The invention provides compositions comprising bacterial strains for treating and preventing cancer.

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