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1. 发明授权

US08717569B2 Apparatus and method for improved optical detection of particles in fluid 有权
标题翻译：用于改善流体中颗粒的光学检测的装置和方法
公开(公告)号：US08717569B2
公开(公告)日：2014-05-06
申请号：US13605925
申请日：2012-09-06
申请人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
发明人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
IPC分类号： G01N21/00
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体光子学装置，采用这种装置的系统以及这些装置的相关操作和制造方法。在至少一些实施方案中，装置可以用作流式细胞术装置和/或使用微流体通道。此外，在至少一些实施例中，装置是采用流体通道和能够接收和/或传送光的一个或多个波导的流体 - 光子学集成电路（FPIC）装置，并且可以使用聚合材料制造。至少一些实施例中的流体光子学装置能够具有诸如片上激发，飞行时间测量等功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，器件采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关过程。

2. 发明授权

US08270781B2 Apparatus and method for improved optical detection of particles in fluid 有权
标题翻译：用于改善流体中颗粒的光学检测的装置和方法
公开(公告)号：US08270781B2
公开(公告)日：2012-09-18
申请号：US12091414
申请日：2006-10-27
申请人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
发明人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
IPC分类号： G02B6/00
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体光子学装置，采用这种装置的系统以及这些装置的相关操作和制造方法。在至少一些实施方案中，装置可以用作流式细胞术装置和/或使用微流体通道。此外，在至少一些实施例中，装置是采用流体通道和能够接收和/或传送光的一个或多个波导的流体 - 光子学集成电路（FPIC）装置，并且可以使用聚合材料制造。至少一些实施例中的流体光子学装置能够具有诸如片上激发，飞行时间测量等功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，器件采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关过程。

3. 发明申请

US20130004987A1 APPARATUS AND METHOD FOR IMPROVED OPTICAL DETECTION OF PARTICLES IN FLUID 有权
标题翻译：改进流体中颗粒的光学检测的装置和方法
公开(公告)号：US20130004987A1
公开(公告)日：2013-01-03
申请号：US13605925
申请日：2012-09-06
申请人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
发明人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
IPC分类号： G01N21/64 , G01N21/53 , G01J1/58 , G01N21/49
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体光子学装置，采用这种装置的系统以及这些装置的相关操作和制造方法。在至少一些实施方案中，装置可以用作流式细胞术装置和/或使用微流体通道。此外，在至少一些实施例中，装置是采用流体通道和能够接收和/或传送光的一个或多个波导的流体 - 光子学集成电路（FPIC）装置，并且可以使用聚合材料制造。至少一些实施例中的流体光子学装置能够具有诸如片上激发，飞行时间测量等功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，器件采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关过程。

4. 发明申请

US20090155832A1 Apparatus and Method for Improved Optical Detection of Particles in Fluid 有权
标题翻译：改进流体中颗粒光学检测的装置和方法
公开(公告)号：US20090155832A1
公开(公告)日：2009-06-18
申请号：US12091414
申请日：2006-10-27
申请人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
发明人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
IPC分类号： C12Q1/02 , C12M1/34 , B29C69/00 , H05K3/00 , G01N21/53 , G01J1/58
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfiuidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体光子学装置，采用这种装置的系统以及这些装置的相关操作和制造方法。在至少一些实施方案中，该装置可以用作流式细胞术装置和/或使用微流体通道。此外，在至少一些实施例中，装置是采用流体通道和能够接收和/或传送光的一个或多个波导的流体 - 光子学集成电路（FPIC）装置，并且可以使用聚合材料制造。至少一些实施例中的流体光子学装置能够具有诸如片上激发，飞行时间测量等功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，器件采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关过程。

5. 发明授权

US09134221B2 Fluidic flow cytometry devices and particle sensing based on signal-encoding 有权
标题翻译：基于信号编码的流式流式细胞术装置和粒子感测
公开(公告)号：US09134221B2
公开(公告)日：2015-09-15
申请号：US13254851
申请日：2010-03-10
申请人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
发明人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/1459 , G01N15/1484 , G01N2015/0065 , G01N2015/1006 , G01N2015/1415 , G01N2015/1447 , G01N2015/145 , G01N2015/149
摘要： Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.
摘要翻译：与流体中颗粒分选有关的微流体装置，系统和技术，包括细胞计量装置和化学或生物测试和诊断测量中的技术和应用。

6. 发明申请

US20120078531A1 FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING 有权
标题翻译：基于信号编码的流体流式细胞仪装置和颗粒感测
公开(公告)号：US20120078531A1
公开(公告)日：2012-03-29
申请号：US13254851
申请日：2010-03-10
申请人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
发明人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
IPC分类号： G06F19/00 , G01N21/00
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/1459 , G01N15/1484 , G01N2015/0065 , G01N2015/1006 , G01N2015/1415 , G01N2015/1447 , G01N2015/145 , G01N2015/149
摘要： Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.
摘要翻译：与流体中颗粒分选有关的微流体装置，系统和技术，包括细胞计量装置和化学或生物测试和诊断测量中的技术和应用。

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