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1. 发明申请

US20130133516A1 FINE PARTICLES FOR CHROMATOGRAPHY AND CHROMATOGRAPHY USING SAME 审中-公开
标题翻译：用于色谱和色谱的精细颗粒
公开(公告)号：US20130133516A1
公开(公告)日：2013-05-30
申请号：US13816051
申请日：2011-08-19
申请人： Yoshimichi Okano , Akira Takaragi , Tomoki Kitagawa , Atsushi Ohnishi , Shouji Miyamoto
发明人： Yoshimichi Okano , Akira Takaragi , Tomoki Kitagawa , Atsushi Ohnishi , Shouji Miyamoto
IPC分类号： C08F118/04
CPC分类号： C08F118/04 , B01D15/40 , B01D53/025 , B01D2253/106 , B01D2253/202 , B01D2253/25 , B01J20/28061 , B01J20/28073 , B01J20/28083 , B01J20/28085 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3278 , Y10T428/2982
摘要： The present invention provides a polymer brush-type filler which contains polymer chains at a high density and with a broad molecular weight distribution. Specifically, the present invention provides fine particles for chromatography comprising graft polymer chains obtained by grafting polymer chains via polymerization initiating groups on the surface of solid particles, wherein the graft polymer chains include specific repeating units, have a specific number average molecular weight and a specific molecular weight distribution and also have a high density of 0.03 chains/nm2 or more and 0.70 chains/nm2 or less.
摘要翻译：本发明提供一种聚合物刷型填料，其包含高密度聚合物链并具有宽分子量分布。具体地说，本发明提供了用于色谱的细颗粒，其包括通过聚合引发基团在固体颗粒表面上接枝聚合物链而获得的接枝聚合物链，其中接枝聚合物链包括特定的重复单元，具有特定的数均分子量和特定的数均分子量并且还具有0.03个链/ nm 2以上且0.70个链/ nm 2以下的高密度的高密度。

2. 发明授权

US07758753B2 Method of analyzing optical isomers or method of resolving the same 失效
标题翻译：分析光学异构体的方法或其拆分方法
公开(公告)号：US07758753B2
公开(公告)日：2010-07-20
申请号：US12226855
申请日：2007-07-22
申请人： Atsushi Ohnishi , Akito Ichida
发明人： Atsushi Ohnishi , Akito Ichida
IPC分类号： B01D15/08
CPC分类号： G01N30/34 , G01N30/02 , G01N30/8665 , G01N30/8693 , G01N2030/8877 , B01D15/3833 , B01D15/426
摘要： Provided are a method of quickly and simply confirming the success or failure of resolution of optical isomers with the use of a column for resolving optical isomers and a method of simply designing the conditions of the eluent composition under isocratic elution conditions. In resolving optical isomers, the success or failure of the resolution can be simply and quickly confirmed by employing an HPLC gradient elution analysis method with the use of a column for resolving optical isomers. When the resolution is successfully conducted, the eluent composition under isocratic elution conditions can be estimated from the elution time in the gradient elution analysis.
摘要翻译：提供了一种快速简单地确认光学异构体的拆分成功或失败的方法，其中使用用于拆分光学异构体的色谱柱以及在等度洗脱条件下简单地设计洗脱组合物的条件的方法。在旋光异构体的拆分中，通过使用用于拆分光学异构体的色谱柱的HPLC梯度洗脱分析方法，可以简单且快速地确认分辨率的成败。当分辨率成功地进行时，洗脱组分在等度洗脱条件下可以从梯度洗脱分析中的洗脱时间估算。

3. 发明授权

US06736967B2 Separating agent for enantiomeric isomers 有权
标题翻译：对映体异构体分离剂
公开(公告)号：US06736967B2
公开(公告)日：2004-05-18
申请号：US10162128
申请日：2002-06-04
申请人： Atsushi Ohnishi , Shinsuke Suzuki , Masato Sakai
发明人： Atsushi Ohnishi , Shinsuke Suzuki , Masato Sakai
IPC分类号： B01D1508
CPC分类号： B01J20/29 , B01D15/3833 , B01J20/286 , B01J20/3204 , B01J20/3272 , B01J20/328 , C07B57/00
摘要： A separating agent for enantiomeric isomers has an enantiomerically active polymer compound supported thereon. The polymer compound has an exothermic peak before a decomposition temperature of the polymer compound supported is reached in a differential calorimetric curve obtained in a process of temperature elevation in differential scanning calorimetry (DSC) on the separating agent. Also, disclosed is a method of evaluating asymmetry recognition ability of a separating agent for enantiomeric isomers. The method includes performing the differential scanning calorimetry (DSC) of a separating agent for enantiomeric isomers having supported thereon an enantiomerically active polymer compound to obtain a differential calorimetric curve in a process of temperature elevation therein, and observing presence or absence of an exothermic peak of the polymer compound in the differential calorimetric curve before a decomposition temperature of the supported polymer compound is reached. The evaluation method provides a simpler method for the evaluation of asymmetry recognition ability and thus provides a separating agent for enantiomeric isomers having higher ability of recognizing asymmetry.
摘要翻译：对映体异构体的分离剂具有负载在其上的对映体活性聚合物化合物。在分离剂的差示扫描量热法（DSC）中的温度升高过程中获得的差示量热曲线达到在所加载的高分子化合物的分解温度之前，高分子化合物具有放热峰。此外，公开了评价对映异构体的分离剂的不对称识别能力的方法。该方法包括对对映异构体异构体进行差示扫描量热法（DSC）的对映体异构体的负载在其上的对映异构体活性聚合物化合物，以获得其升温过程中的差示量热曲线，观察是否存在放热峰在达到负载型高分子化合物的分解温度之前的差示量热曲线中的高分子化合物。评价方法提供了用于评价不对称识别能力的更简单的方法，从而提供了具有较高识别不对称性的对映体异构体的分离剂。

4. 发明申请

US20130165632A1 METHOD FOR SEPARATING WATER-SOLUBLE BIOLOGICAL SUBSTANCES 审中-公开
标题翻译：分离水溶性生物物质的方法
公开(公告)号：US20130165632A1
公开(公告)日：2013-06-27
申请号：US13820898
申请日：2011-09-09
申请人： Atsushi Ohnishi , Ryota Hamasaki
发明人： Atsushi Ohnishi , Ryota Hamasaki
IPC分类号： C08B15/00 , C08B37/00 , C08B33/00 , C07K1/20
CPC分类号： B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3219 , B01J20/3221 , B01J20/3272 , B01J20/3274 , B01J2220/54 , C13K1/02 , C13K11/00 , C13K13/00 , C13K13/002 , G01N2030/8836
摘要： Provided is a novel method for separating water-soluble biological substances. A separating agent is composed by bonding a polysaccharide such as cellulose or amylose to the surface of a carrier by chemical bonding, and water-soluble biological substances are separated from a mixture of two or more types of water-soluble biological substances by chromatography using the separating agent.
摘要翻译：提供了一种分离水溶性生物物质的新方法。分离剂是通过化学键合将纤维素或直链淀粉等多糖与载体的表面结合而成的，通过色谱法将水溶性生物物质从两种以上的水溶性生物物质的混合物中分离出来，分离剂。

5. 发明授权

US07306734B2 Method for separation of enantiomeric isomers by simulated moving bed chromatography 失效
标题翻译：通过模拟移动床层析分离对映体异构体的方法
公开(公告)号：US07306734B2
公开(公告)日：2007-12-11
申请号：US10943436
申请日：2004-09-17
申请人： Atsushi Ohnishi , Koichi Murazumi
发明人： Atsushi Ohnishi , Koichi Murazumi
IPC分类号： B01D15/08
CPC分类号： B01J20/3272 , B01D15/1821 , B01D15/206 , B01D15/22 , B01D15/3833 , B01J20/286 , B01J20/29 , B01J20/328 , B01J2220/54 , G01N2030/565
摘要： The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: TS coefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR, (I) wherein Vc (cm3): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected.
摘要翻译：本发明提供了一种通过模拟移动床色谱法制备分离的高生产率的方法。也就是说，在通过模拟移动床层析法的对映体异构体分离的填料中，其具有在其上载有多糖衍生物的多孔载体并且TS系数在0.55至1.20的范围内，TS系数由下表所示的式（I），并通过使用用于模拟移动床层析的对映体异构体分离柱，其中通过浆料填充方法将填料填充在柱管中获得：<？在线公式描述=“在线配方”末端 =“lead”？> TS系数= [Vc- [t（TS）-t（空白）] xFR] / [t（TS）-t（空白）] xFR，（I） =“直线公式”end =“tail”？>其中Vc（cm 3）：柱体积; FR（ml / min）：流速; t（TS）（分钟）：四（三甲基甲硅烷基）硅烷（= TS）的洗脱时间; 和t（空白）（分钟）：在未连接色谱柱的状态下TS的洗脱时间。

6. 发明申请

US20060219639A1 Novel separation agent for separating optical isomer and method for preparation thereof 失效
标题翻译：用于分离光学异构体的新型分离剂及其制备方法
公开(公告)号：US20060219639A1
公开(公告)日：2006-10-05
申请号：US11444726
申请日：2006-06-01
申请人： Atsushi Ohnishi
发明人： Atsushi Ohnishi
IPC分类号： B01D15/08
CPC分类号： B01J20/285 , B01D15/3833 , B01J20/103 , B01J20/24 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3257 , B01J20/3268 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/328 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C12N9/6418
摘要： A method of producing a novel separating agent for separating enantiomeric isomers, characterized by including: a step of supporting an optically active polymer compound and a compound having an asymmetric structure of a molecular weight of 1,000 or less on a carrier using a solvent; a step of removing the solvent; and a step of removing the compound having the asymmetric structure of the molecular weight of 1,000 or less by washing.
摘要翻译：一种制备用于分离对映异构体的新型分离剂的方法，其特征在于包括：使用溶剂在载体上负载光学活性聚合物化合物和分子量为1000以下的不对称结构的化合物的步骤; 除去溶剂的步骤; 以及通过洗涤除去分子量为1000以下的不对称结构的化合物的工序。

7. 发明申请

US20050054878A1 Method for separation of enantiomeric isomers by simulated moving bed chromatography 失效
标题翻译：通过模拟移动床层析分离对映体异构体的方法
公开(公告)号：US20050054878A1
公开(公告)日：2005-03-10
申请号：US10943436
申请日：2004-09-17
申请人： Atsushi Ohnishi , Koichi Murazumi
发明人： Atsushi Ohnishi , Koichi Murazumi
IPC分类号： B01J20/291 , B01D15/00 , B01D15/08 , B01D15/18 , B01D15/20 , B01D15/22 , B01D15/38 , B01J20/281 , B01J20/283 , B01J20/29 , B01J20/32 , C07B57/00 , G01N30/04 , G01N30/26 , G01N30/46 , G01N30/56 , G01N30/74 , G01N30/88 , C07C51/573
CPC分类号： B01J20/3272 , B01D15/1821 , B01D15/206 , B01D15/22 , B01D15/3833 , B01J20/286 , B01J20/29 , B01J20/328 , B01J2220/54 , G01N2030/565
摘要： The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: TS coefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR (I),wherein Vc (cm3): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected.
摘要翻译：本发明提供了一种通过模拟移动床色谱法制备分离的高生产率的方法。也就是说，在通过模拟移动床层析法的对映体异构体分离的填料中，其具有在其上载有多糖衍生物的多孔载体并且具有在0.55至1.20范围内的TS系数，TS系数由下表所示的式（I），通过使用用于模拟移动床层析的对映体异构体分离柱，其中通过浆料填充方法将填料填充在柱管中获得：TS系数= [Vc- [t（TS）-t（空白） ] xFR] / [t（TS）-t（空白）] xFR（I），其中Vc（cm 3）：柱体积; FR（ml / min）：流速; t（TS）（分钟）：四（三甲基甲硅烷基）硅烷（= TS）的洗脱时间; 和t（空白）（分钟）：在未连接色谱柱的状态下TS的洗脱时间。

8. 发明授权

US08153551B2 Optical isomer separating filler 有权
标题翻译：光学异构体分离填料
公开(公告)号：US08153551B2
公开(公告)日：2012-04-10
申请号：US12449274
申请日：2008-02-22
申请人： Atsushi Ohnishi , Yutaka Isobe
发明人： Atsushi Ohnishi , Yutaka Isobe
IPC分类号： B01J20/22 , B01J20/24 , B01J20/26
CPC分类号： C07B57/00 , B01J20/286 , B01J20/29 , B01J20/3242 , B01J20/3253 , B01J20/328
摘要： An optical isomer separating filler wherein a polysaccharide derivative is chemically bonded onto a support. This optical isomer separating filler is characterized in that the halogen content in the filler is 3.0 to 5.0%.
摘要翻译：光学异构体分离填料，其中多糖衍生物化学键合到载体上。该光学异构体分离填料的特征在于填料中的卤素含量为3.0-5.0％。

9. 发明申请

US20090166292A1 Method of Analyzing Optical Isomers or Method of Resolving the Same 失效
标题翻译：分析光学异构体的方法或其解决方法
公开(公告)号：US20090166292A1
公开(公告)日：2009-07-02
申请号：US12226855
申请日：2007-07-22
申请人： Atsushi Ohnishi , Akito Ichida
发明人： Atsushi Ohnishi , Akito Ichida
IPC分类号： C07B57/00 , B01D15/08 , G01N30/34
CPC分类号： G01N30/34 , G01N30/02 , G01N30/8665 , G01N30/8693 , G01N2030/8877 , B01D15/3833 , B01D15/426
摘要： Provided are a method of quickly and simply confirming the success or failure of resolution of optical isomers with the use of a column for resolving optical isomers and a method of simply designing the conditions of the eluent composition under isocratic elution conditions. In resolving optical isomers, the success or failure of the resolution can be simply and quickly confirmed by employing an HPLC gradient elution analysis method with the use of a column for resolving optical isomers. When the resolution is successfully conducted, the eluent composition under isocratic elution conditions can be estimated from the elution time in the gradient elution analysis.
摘要翻译：提供了一种快速简单地确认光学异构体的拆分成功或失败的方法，其中使用用于拆分光学异构体的色谱柱以及在等度洗脱条件下简单地设计洗脱组合物的条件的方法。在旋光异构体的拆分中，通过使用用于拆分光学异构体的色谱柱的HPLC梯度洗脱分析方法，可以简单且快速地确认分辨率的成败。当分辨率成功地进行时，洗脱组分在等度洗脱条件下可以从梯度洗脱分析中的洗脱时间估算。

10. 发明授权

US07090775B2 Separation agent for separating optical isomer and method for preparation thereof 有权
公开(公告)号：US07090775B2
公开(公告)日：2006-08-15
申请号：US10480398
申请日：2002-07-05
申请人： Atsushi Ohnishi
发明人： Atsushi Ohnishi
IPC分类号： B01D15/08
CPC分类号： B01J20/285 , B01D15/3833 , B01J20/103 , B01J20/24 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3257 , B01J20/3268 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/328 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C12N9/6418
摘要： A method of producing a novel separating agent for separating enantiomeric isomers, characterized by including: a step of supporting an optically active polymer compound and a compound having an asymmetric structure of a molecular weight of 1,000 or less on a carrier using a solvent; a step of removing the solvent; and a step of removing the compound having the asymmetric structure of the molecular weight of 1,000 or less by washing.

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