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1. 发明授权

US5047428A Expectorant comprising hydroxyalkylcysteine derivative 失效
标题翻译：祛痰剂包含羟基烷基半胱氨酸衍生物
公开(公告)号：US5047428A
公开(公告)日：1991-09-10
申请号：US365368
申请日：1989-06-13
申请人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
发明人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
IPC分类号： A61K31/195 , A61K31/198 , A61P11/10 , C07C323/58
CPC分类号： A61K31/195 , Y10S514/855
摘要： An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

2. 发明授权

US4906665A Hydroxyalkylcysteine derivative and expectorant containing the same 失效
标题翻译：羟基烷基半胱氨酸衍生物和含有它们的祛痰剂
公开(公告)号：US4906665A
公开(公告)日：1990-03-06
申请号：US365371
申请日：1989-06-13
申请人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
发明人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
IPC分类号： A61K31/195 , A61K31/198 , A61P11/10 , C07C323/58
CPC分类号： A61K31/195 , Y10S514/855
摘要： Novel hydroxyalkylcysteine derivatives of the following formula (I) and an expectorant comprising the same are disclosed. ##STR1## wherein n represents an integer of 5 to 24. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

3. 发明授权

US4564615A Immunoactivator 失效
标题翻译：免疫活化剂
公开(公告)号：US4564615A
公开(公告)日：1986-01-14
申请号：US441177
申请日：1982-11-12
申请人： Hideaki Matsuda , Ryohta Tatezaki , Hiroyuki Mizuno , Tatsuhiko Katori
发明人： Hideaki Matsuda , Ryohta Tatezaki , Hiroyuki Mizuno , Tatsuhiko Katori
IPC分类号： C07D513/04 , A61K31/535
CPC分类号： C07D513/04 , Y10S514/825 , Y10S514/885 , Y10S514/892
摘要： An immunoactivator comprising an effective amount of a thiazolobenzoxazine derivative of the formula, or its salt ##STR1## wherein R.sup.1 represents a hydrogen atom, carboxyl group or lower alkoxycarbonyl group, R.sup.2 represents a substituted or unsubstituted phenyl group, lower alkyl group or furyl group, and R.sup.3 represents a hydrogen atom or lower alkoxy group.
摘要翻译：包含有效量的下式的噻唑并恶嗪衍生物或其盐，其中R1表示氢原子，羧基或低级烷氧基羰基，R2表示取代或未取代的苯基，低级烷基或呋喃基，并且R 3表示氢原子或低级烷氧基。

4. 发明授权

US5585511A Platinum complex and malignant tumor treating drug containing the same 失效
标题翻译：铂复合物和恶性肿瘤治疗药物含有相同的药物
公开(公告)号：US5585511A
公开(公告)日：1996-12-17
申请号：US578490
申请日：1995-12-26
申请人： Koichi Yokoi , Kinichi Mogi , Hidehiko Kohya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato , Tadayuki Kuraishi
发明人： Koichi Yokoi , Kinichi Mogi , Hidehiko Kohya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato , Tadayuki Kuraishi
IPC分类号： A61K33/24 , A61K31/28 , A61K31/282 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： A platinum complex represented by the following formula (1): ##STR1## wherein the all symbols are defined in the disclosure; and a malignant tumor treating drug which contains the complex as an active ingredient. The platinum complex is excellent in antitumor effects and safety and is highly soluble in water, and therefore it is useful as an agent for use in the treatment of various malignant tumors.
摘要翻译：由下式（1）表示的铂络合物：其中全部符号在本公开中定义; 和含有复合物作为活性成分的恶性肿瘤治疗药物。铂络合物具有优异的抗肿瘤效果和安全性，并且高度可溶于水，因此可用作治疗各种恶性肿瘤的药剂。

5. 发明授权

US5231101A Benzo[5,6]cyclohepta[1,2-B]pyridine derivatives and antiallergic agents comprising same 失效
标题翻译：苯并（5,6）环辛基（1,2-B）吡啶衍生物和包含其的抗菌剂
公开(公告)号：US5231101A
公开(公告)日：1993-07-27
申请号：US821803
申请日：1992-01-17
申请人： Haruyoshi Honda , Hiroyuki Mizuno , Kinichi Mogi , Yoshikuni Ito , Yasushi Kaneko , Naokata Taido , Susumu Sato , Tadayuki Kuraishi
发明人： Haruyoshi Honda , Hiroyuki Mizuno , Kinichi Mogi , Yoshikuni Ito , Yasushi Kaneko , Naokata Taido , Susumu Sato , Tadayuki Kuraishi
IPC分类号： A61K31/445 , A61K31/4427 , A61P37/08 , A61P43/00 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04
摘要： Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: ##STR1## wherein R.sup.1 represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R.sup.2 represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group ##STR2## or --X--R.sub.4, X being an oxygen or sulfur atom, R.sup.3 standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R.sup.4 being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.

6. 发明授权

US5902826A Platinum (IV) complex and pharmaceutical composition comprising the same 失效
标题翻译：铂（IV）复合物和包含其的药物组合物
公开(公告)号：US5902826A
公开(公告)日：1999-05-11
申请号：US997061
申请日：1997-12-23
申请人： Kinichi Mogi , Hidehiko Koya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato
发明人： Kinichi Mogi , Hidehiko Koya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato
IPC分类号： A61K31/55 , C07F15/00 , A61K31/28
CPC分类号： C07F15/0093
摘要： A diamine-platinum (IV) complex represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 together represent R.sup.5 O--CH(CH.sub.2 NH.sub.2).sub.2 (R.sup.5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C.sub.5-8 1,2-cycloalkanediamine; R.sup.3 and R.sup.4 each represents hydrogen or R.sup.6 CO-- (R.sup.6 represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.
摘要翻译：由下式（1）表示的二胺 - 铂（IV）络合物：其中R1和R2一起表示R5O-CH（CH2NH2）2（R5代表氢，乙酰基，三氟乙酰基，苯甲酰基，环烷基羰基或甲磺酰基）或C5-8 1,2-环烷二胺; R3和R4各自表示氢或R6CO-（R6表示烷基，卤代烷基，环烷基，芳基或芳烷基）; 两个X一起代表丙二酸残基或乙醇酸残基，其可以具有能够通过与式（1）中的铂配位的O，O-配位体或N-酰基氨基酸残基与式（1）中的铂配位的取代基， 1）通过O，N-配位; 以及包含上述二胺 - 铂（IV）络合物作为活性成分的药物组合物。

7. 发明授权

US5498780A Platinum complex and malignant tumor treating drug containing the same 失效
标题翻译：铂复合物和恶性肿瘤治疗药物含有相同的药物
公开(公告)号：US5498780A
公开(公告)日：1996-03-12
申请号：US454825
申请日：1995-05-31
申请人： Koichi Yokoi , Kinichi Mogi , Hidehiko Kohya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato , Tadayuki Kuraishi
发明人： Koichi Yokoi , Kinichi Mogi , Hidehiko Kohya , Mari Ohtsuka , Hiroyuki Mizuno , Susumu Sato , Tadayuki Kuraishi
IPC分类号： A61K33/24 , A61K31/28 , A61K31/282 , A61P35/00 , C07C239/08 , C07F15/00
CPC分类号： C07F15/0093
摘要： A diamine-platinum complex represented by the following formula (1): ##STR1## wherein the all definitions are defined in the disclosure, and a malignant tumor treating drug which contains the above complex as an active ingredient. The diamine-platinum complex has a high water solubility and an excellent antitumor effect.
摘要翻译：由下式（1）表示的二胺 - 铂络合物：其中全部定义在本公开中定义，以及含有上述络合物作为活性成分的恶性肿瘤治疗药物。二胺 - 铂络合物具有高水溶性和优异的抗肿瘤效果。

8. 发明授权

US6060485A Arylacetic amide derivative or salt thereof, and pharmaceutical comprising it 失效
标题翻译：芳酰乙酰胺衍生物或其盐，以及包含它的药物
公开(公告)号：US6060485A
公开(公告)日：2000-05-09
申请号：US181091
申请日：1998-10-28
申请人： Terumitsu Kaihoh , Tomomi Okada , Yoshinori Takahashi , Hiroyuki Mizuno , Haruyoshi Honda , Susumu Sato
发明人： Terumitsu Kaihoh , Tomomi Okada , Yoshinori Takahashi , Hiroyuki Mizuno , Haruyoshi Honda , Susumu Sato
IPC分类号： C07D211/58 , C07D211/94 , C07D401/12 , A61K31/445
CPC分类号： C07D401/12 , C07D211/58 , C07D211/94
摘要： Described is an arylacetic amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents an aryl group or the like, R.sup.2 and R.sup.3 each independently represents an alkyl group, a cycloalkyl group or the like, and R.sup.4 represents an aralkyl group, an alkyl group or the like; or salt thereof. The compound according to the present invention has both excellent anticholinergic action and calcium antagonism and at the same time has high selectivity to bladder, so that it is useful as a preventive or remedy for urinary disorders.
摘要翻译：描述了由下式（1）表示的芳基乙酰胺衍生物：其中R 1表示芳基等，R 2和R 3各自独立地表示烷基，环烷基等，R 4表示芳烷基，烷基等; 或其盐。根据本发明的化合物具有优异的抗胆碱能作用和钙拮抗作用，同时对膀胱具有高选择性，因此可用作尿障碍的预防或治疗方法。

9. 发明授权

US5532371A Piperazine substituted carboxylic acid derivatives for treating hyperlipimia 失效
标题翻译：哌嗪取代的羧酸衍生物用于治疗高脂血症
公开(公告)号：US5532371A
公开(公告)日：1996-07-02
申请号：US377965
申请日：1995-01-25
申请人： Teruo Komoto , Hiroyuki Hirota , Susumu Sato , Mari Ohtsuka , Hidehiko Koya , Hiroyuki Mizuno , Tadayuki Kuraishi
发明人： Teruo Komoto , Hiroyuki Hirota , Susumu Sato , Mari Ohtsuka , Hidehiko Koya , Hiroyuki Mizuno , Tadayuki Kuraishi
IPC分类号： C07D211/22 , C07D211/52 , C07D211/70 , C07D213/82 , C07D295/192 , C07D333/38 , C07D401/06 , C07D405/06 , C07D409/06 , C07D401/10
CPC分类号： C07D213/82 , C07D211/22 , C07D211/52 , C07D211/70 , C07D295/192 , C07D333/38 , C07D401/06 , C07D405/06 , C07D409/06
摘要： An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH.
摘要翻译：式（1）的芳基酰胺衍生物，其盐和含有该衍生物或盐的高脂血症治疗剂：其中Ar表示基团，萘基，吡啶基，呋喃基噻吩基，喹啉基或吲哚基; Y表示基团，Q表示-O-或单键，Z表示亚烷基，R4表示羟基，烷氧基或基团-NH（CH2）mCOOH。

10. 发明授权

US5411972A Arylamide derivatives for treating hyperlipemia 失效
标题翻译：用于治疗高脂血症的芳酰胺衍生物
公开(公告)号：US5411972A
公开(公告)日：1995-05-02
申请号：US158398
申请日：1993-11-29
申请人： Teruo Komoto , Hiroyuki Hirota , Susumu Sato , Mari Ohtsuka , Hidehiko Koya , Hiroyuki Mizuno , Tadayuki Kuraishi
发明人： Teruo Komoto , Hiroyuki Hirota , Susumu Sato , Mari Ohtsuka , Hidehiko Koya , Hiroyuki Mizuno , Tadayuki Kuraishi
IPC分类号： C07D211/22 , C07D211/52 , C07D211/70 , C07D213/82 , C07D295/192 , C07D333/38 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/445 , C07D211/40 , C07D211/74 , C07D295/10
CPC分类号： C07D213/82 , C07D211/22 , C07D211/52 , C07D211/70 , C07D295/192 , C07D333/38 , C07D401/06 , C07D405/06 , C07D409/06
摘要： An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH, useful for the treatment and prevention of hyperlipemia due to their excellent cholesterol reducing action, triglyceride reducing action and high safety.
摘要翻译：式（1）的芳基酰胺衍生物，其盐和含有该衍生物或盐的高脂血症治疗剂：其中Ar表示基团，萘基，吡啶基，呋喃基噻吩基，喹啉基或吲哚基; Y表示，Q表示-O-或单键，Z表示亚烷基，R4表示羟基，烷氧基或-NH（CH2）mCOOH基团，可用于治疗和预防高脂血症由于其优异的胆固醇降低作用，甘油三酯降低作用和高安全性。

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