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1. 发明申请

US20120103817A1 DIELECTRIC CYTOMETRIC APPARATUS AND DIELECTRIC-CYTOMETRIC CELL SORTING METHOD 有权
标题翻译：介电细胞仪和电介质细胞分选方法
公开(公告)号：US20120103817A1
公开(公告)日：2012-05-03
申请号：US13278749
申请日：2011-10-21
申请人： Shinji Omori , Kazumasa Sato , Yoichi Katsumoto , Tomoyuki Umetsu , Yoshihito Hayashi
发明人： Shinji Omori , Kazumasa Sato , Yoichi Katsumoto , Tomoyuki Umetsu , Yoshihito Hayashi
IPC分类号： C25B15/00 , G01N27/447
CPC分类号： G01N15/12 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B03C5/005 , B03C5/028 , G01N2015/1081
摘要： Disclosed herein is a dielectric cytometric apparatus capable of analyzing cells and sorting the cells without adopting an optical analysis method and provides a dielectric cytometric cell sorting method for the apparatus. A stenosis channel allowing a single cell to flow is created on a cell injection section of a micro flow channel device used as a portion of the dielectric cytometric apparatus. A pair of measurement electrodes is created on the stenosis channel and an analyzer connected to the measurement electrodes measures the complex dielectric constant of for every cell passing through the stenosis channel. A electric-field application section provided on the downstream side of the stenosis channel applies an electric field for changing the flow of the cells inside a flow channel on the basis of information on the measured complex dielectric constants so that the cells can be sorted by making use of branch channels.
摘要翻译：本文公开了一种能够分析细胞并分选细胞而不采用光学分析方法并提供该装置的介质细胞计数细胞分选方法的介质细胞计数装置。在用作介电细胞仪器的一部分的微流通道装置的细胞注射部分上产生允许单细胞流动的狭窄通道。在狭窄通道上产生一对测量电极，连接到测量电极的分析仪测量通过狭窄通道的每个细胞的复合介电常数。设置在狭窄通道的下游侧的电场应用部根据关于测定的复介电常数的信息，施加用于改变流路内的细胞的流动的电场，使得可以通过制作细胞来分选细胞使用分支渠道。

2. 发明授权

US08478546B2 Method for measuring physical property values of a cell 有权
标题翻译：测量细胞物理性质值的方法
公开(公告)号：US08478546B2
公开(公告)日：2013-07-02
申请号：US12733031
申请日：2008-07-28
申请人： Yoichi Katsumoto , Yoshihito Hayashi
发明人： Yoichi Katsumoto , Yoshihito Hayashi
IPC分类号： G01N33/48
CPC分类号： G01N33/5044 , G01N27/026 , G01N33/48728
摘要： The present invention relates to a method for measuring physical property values of a cell based on dielectric spectroscopy and based on modeling electrical characteristics such as electric conductivity, electric permittivity, dielectric constant change, and dielectric relaxation expressions in order to obtain membrane capacitance and cytoplasmic conductivity values of the cell.
摘要翻译：本发明涉及一种基于介电光谱测量电池的物理性质值的方法，并且基于电导率，介电常数变化和介电弛豫表达等电特性的模拟，以获得膜电容和细胞质电导率单元格的值。

3. 发明申请

US20120048732A1 SAMPLE CARTRIDGE AND DEVICE FOR MEASURING ELECTRICAL CHARACTERISTICS OF LIQUID SAMPLE 有权
标题翻译：用于测量液体样品电气特性的样品盒和装置
公开(公告)号：US20120048732A1
公开(公告)日：2012-03-01
申请号：US13217918
申请日：2011-08-25
申请人： Yoshihito Hayashi , Yoichi Katsumoto
发明人： Yoshihito Hayashi , Yoichi Katsumoto
IPC分类号： G01N27/30 , G01N33/86
CPC分类号： G01N33/4905 , G01N27/026 , G01N33/86
摘要： A sample cartridge for measuring the electrical characteristics of a liquid sample, which is made by forming an insulating material into a tubular body and is capable of holding the liquid sample in a region that is constituted by the surfaces of electrodes that are respectively inserted from openings of both ends into an inner cavity and the surface of the inner cavity, and in which a narrowing portion located between two facing electrodes and having a narrowed inner cavity is provided in the region.
摘要翻译：一种用于测量液体样品的电特性的样品盒，其通过将绝缘材料形成为管状体而能够将液体样品保持在由从开口分别插入的电极表面构成的区域中两端分别设置在内腔和内腔的表面之间，并且在该区域中设置有位于两个面对电极之间并具有变窄的内腔的变窄部分。

4. 发明授权

US08828212B2 Dielectric cytometric apparatus and dielectric-cytometric cell sorting method 有权
标题翻译：介电细胞仪和介电细胞分选法
公开(公告)号：US08828212B2
公开(公告)日：2014-09-09
申请号：US13278749
申请日：2011-10-21
申请人： Shinji Omori , Kazumasa Sato , Yoichi Katsumoto , Tomoyuki Umetsu , Yoshihito Hayashi
发明人： Shinji Omori , Kazumasa Sato , Yoichi Katsumoto , Tomoyuki Umetsu , Yoshihito Hayashi
IPC分类号： B03C5/02 , B03C5/00 , B01L3/00 , G01N15/12 , G01N15/10
CPC分类号： G01N15/12 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B03C5/005 , B03C5/028 , G01N2015/1081
摘要： Disclosed herein is a dielectric cytometric apparatus capable of analyzing cells and sorting the cells without adopting an optical analysis method and provides a dielectric cytometric cell sorting method for the apparatus. A stenosis channel allowing a single cell to flow is created on a cell injection section of a micro flow channel device used as a portion of the dielectric cytometric apparatus. A pair of measurement electrodes is created on the stenosis channel and an analyzer connected to the measurement electrodes measures the complex dielectric constant of for every cell passing through the stenosis channel. A electric-field application section provided on the downstream side of the stenosis channel applies an electric field for changing the flow of the cells inside a flow channel on the basis of information on the measured complex dielectric constants so that the cells can be sorted by making use of branch channels.
摘要翻译：本文公开了一种能够分析细胞并分选细胞而不采用光学分析方法并提供该装置的介质细胞计数细胞分选方法的介质细胞计数装置。在用作介电细胞仪器的一部分的微流通道装置的细胞注射部分上产生允许单细胞流动的狭窄通道。在狭窄通道上产生一对测量电极，连接到测量电极的分析仪测量通过狭窄通道的每个细胞的复合介电常数。设置在狭窄通道的下游侧的电场应用部根据关于测定的复介电常数的信息，施加用于改变流路内的细胞的流动的电场，使得可以通过制作细胞来分选细胞使用分支渠道。

5. 发明申请

US20120238026A1 BLOOD COAGULATION SYSTEM ANALYZING METHOD AND BLOOD COAGULATION SYSTEM ANALYZING DEVICE 有权
标题翻译：血液凝固系统分析方法和血液凝聚系统分析装置
公开(公告)号：US20120238026A1
公开(公告)日：2012-09-20
申请号：US13403652
申请日：2012-02-23
申请人： Yoshihito Hayashi , MarcAurele Brun , Shinji Omori , Yoichi Katsumoto , Kazumasa Sato
发明人： Yoshihito Hayashi , MarcAurele Brun , Shinji Omori , Yoichi Katsumoto , Kazumasa Sato
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N27/221 , G01N33/4905
摘要： A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.
摘要翻译：血液凝固系统分析方法包括：基于在血液的凝固过程中测定的复合介电常数谱中产生的变化，获取与血液凝固性相关的信息，这是由于加入活化或灭活血小板的物质引起的。

6. 发明授权

US09366663B2 Sample cartridge and device for measuring electrical characteristics of liquid sample 有权
标题翻译：用于测量液体样品电气特性的样品盒和装置
公开(公告)号：US09366663B2
公开(公告)日：2016-06-14
申请号：US13217918
申请日：2011-08-25
申请人： Yoshihito Hayashi , Yoichi Katsumoto
发明人： Yoshihito Hayashi , Yoichi Katsumoto
IPC分类号： G01N27/07 , G01N27/403 , G01N33/49 , G01N33/86 , G01N27/02
CPC分类号： G01N33/4905 , G01N27/026 , G01N33/86
摘要： A sample cartridge for measuring the electrical characteristics of a liquid sample, which is made by forming an insulating material into a tubular body and is capable of holding the liquid sample in a region that is constituted by the surfaces of electrodes that are respectively inserted from openings of both ends into an inner cavity and the surface of the inner cavity, and in which a narrowing portion located between two facing electrodes and having a narrowed inner cavity is provided in the region.
摘要翻译：一种用于测量液体样品的电特性的样品盒，其通过将绝缘材料形成为管状体而能够将液体样品保持在由从开口分别插入的电极表面构成的区域中两端分别设置在内腔和内腔的表面之间，并且在该区域中设置有位于两个面对电极之间并具有变窄的内腔的变窄部分。

7. 发明申请

US20100136606A1 METHOD OF MEASURING PHYSICAL PROPERTY VALUES OF CELL AND PHYSICAL PROPERTY MEASURING APPARATUS 有权
标题翻译：测量细胞物理属性值和物理性能测量装置的方法
公开(公告)号：US20100136606A1
公开(公告)日：2010-06-03
申请号：US12733031
申请日：2008-07-28
申请人： Yoichi Katsumoto , Yoshihito Hayashi
发明人： Yoichi Katsumoto , Yoshihito Hayashi
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： G01N33/5044 , G01N27/026 , G01N33/48728
摘要： Firstly, a shape of a cell as an object of a measurement is modeled, and a complex electric permittivity response when an AC electric field is applied to the cell is obtained through a numerical analysis (Step S1). A numerical calculation is carried out based on that result while values of a membrane capacitance Cm and a cell cytoplasm electric conductivity κi are changed, thereby calculating a dielectric spectrum (Step S2). The dielectric spectrum thus calculated is revolved to a dielectric relaxation expression, thereby obtaining a rise Δε in relative electric permittivity and relaxation time τ (Step S3). Next, dependency of (Δε, τ) on (Cm, κi) is obtained, thereby creating a regression expression corresponding to the shape of the cell as the object of the measurement (Step S4). A dielectric spectrum of the cell is actually measured, and the resulting values actually measured and the regression expression are compared with each other, thereby obtaining a membrane capacitance Cm, exp and a cell cytoplasm electric conductivity κi, exp of the cell as the object of the measurement (Step 5).
摘要翻译：首先，对作为测量对象的单元的形状进行建模，通过数值分析获得AC电场施加到电池的复电介质响应（步骤S1）。基于该结果进行数值计算，同时改变膜电容Cm和细胞质电导率k的值，从而计算电介质谱（步骤S2）。这样计算的电介质光谱与介电弛豫表达式相反，从而获得上升和下降。相对电容率和弛豫时间τ（步骤S3）。接下来，获得（＆Dgr;＆egr;τ）对（Cm，＆kgr; i）的依赖性，由此创建与作为测量对象的单元格的形状相对应的回归表达式（步骤S4）。实际测量细胞的介电光谱，并将所得值实际测量并且将回归表达式彼此进行比较，从而获得细胞的膜电容Cm，exp和细胞胞质电导率＆kgr; i，exp作为测量对象（步骤5）。

8. 发明授权

US10222314B2 Flow channel device, complex permittivity measuring apparatus, and dielectric cytometry system 有权
公开(公告)号：US10222314B2
公开(公告)日：2019-03-05
申请号：US13142701
申请日：2010-01-07
申请人： Yoichi Katsumoto , Shinji Omori
发明人： Yoichi Katsumoto , Shinji Omori
IPC分类号： G01N15/12 , G01N15/10 , C40B60/14
摘要： A flow channel device, a complex permittivity measuring apparatus, and a dielectric cytometry system are provided which can improve the measurement accuracy. A constriction portion having a constricted space is disposed between an inflow port and an outflow port of a flow channel. Electrodes are arranged between the inflow port and the constriction portion and between the outflow port and the constriction portion. The conductance of the constriction portion at a low-limit frequency is less than the combined conductance of an inflow channel portion and an outflow channel portion. The capacitance of the constriction portion at a high-limit frequency is less than the combined capacitance of the inflow channel portion and the outflow channel portion.

9. 发明授权

US08795497B2 Cell sorter and cell sorting method 有权
标题翻译：细胞分选机和细胞分选方法
公开(公告)号：US08795497B2
公开(公告)日：2014-08-05
申请号：US13272906
申请日：2011-10-13
申请人： Kazumasa Sato , Yoichi Katsumoto
发明人： Kazumasa Sato , Yoichi Katsumoto
IPC分类号： B01D57/02 , G01N27/447 , G01N27/453
CPC分类号： B03C5/026 , B03C5/005
摘要： Disclosed herein is a cell sorter including a measuring electrode, working electrode, detection electrode, and output section. The measuring electrode forms a measuring electric field in a flow path to measure a complex dielectric constant of each cells flowing through the flow path. The working electrode forms, in the flow path, a working electric field to sort the cells by imparting a dielectrophoretic force to the cells and using the flow path. The detection electrode detects the presence of the cell in the fluid flowing through the flow path. The output section acquires a sorting signal based on information about the measured complex dielectric constant and a detection signal indicating the detection of the cell by the detection electrode. The output section outputs a working signal adapted to form the working electric field to the working electrode when the detection signal is acquired if the sorting signal is acquired.
摘要翻译：本文公开了一种电池分选器，包括测量电极，工作电极，检测电极和输出部分。测量电极在流路中形成测量电场，以测量流经流路的每个单元的复介电常数。工作电极在流动路径中形成工作电场，以通过向细胞施加介电电泳力并使用流动路径对细胞进行分类。检测电极检测流过流路的流体中的电池的存在。输出部根据测定的复介电常数的信息和表示检测电极对电池的检测的检测信号，取得分选信号。如果获取分选信号，则当获取检测信号时，输出部分输出适于形成工作电场的工作信号到工作电极。

10. 发明授权

US08735163B2 Blood coagulation system analyzing method and blood coagulation system analyzing device 有权
标题翻译：血液凝固系统分析方法及血液凝固系统分析装置
公开(公告)号：US08735163B2
公开(公告)日：2014-05-27
申请号：US13403652
申请日：2012-02-23
申请人： Yoshito Hayashi , MarcAurele Brun , Shinji Omori , Yoichi Katsumoto , Kazumasa Sato
发明人： Yoshito Hayashi , MarcAurele Brun , Shinji Omori , Yoichi Katsumoto , Kazumasa Sato
IPC分类号： G01N33/86 , G01N33/48
CPC分类号： G01N33/86 , G01N27/221 , G01N33/4905
摘要： A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.
摘要翻译：血液凝固系统分析方法包括：基于在血液的凝固过程中测定的复合介电常数谱中产生的变化，获取与血液凝固性相关的信息，这是由于加入活化或灭活血小板的物质引起的。

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