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1. 发明申请

US20050107604A1 Reagent for determining the absolute configuration of chiral compound and determination method 有权
标题翻译：用于确定手性化合物的绝对构型的试剂和测定方法
公开(公告)号：US20050107604A1
公开(公告)日：2005-05-19
申请号：US10505906
申请日：2003-01-10
申请人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
发明人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
IPC分类号： G01N21/77 , C07D487/22 , C07D519/00 , C07F3/02 , G01N21/19 , G01N33/00
CPC分类号： C07D519/00 , G01N21/19 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/20
摘要： The present invention relates to a reagent for determining the absolute configuration of a chiral compound containing as an active ingredient a metalloporphyrin dimer, wherein the metalloporphyrin dimer has an alkaline-earth metal ion as a central metal and has a carbon chain-crosslinked structure in which at least one of the two porphyrin rings has a substituent bulkier than methyl at at least one of the second carbon atoms from a carbon atom bonded to the crosslinking carbon chain along the outer periphery of the porphyrin ring and a method for determining the absolute configuration of an asymmetric carbon atom of the chiral compound using the reagent.
摘要翻译：本发明涉及一种用于测定含有金属卟啉二聚体作为活性成分的手性化合物的绝对构型的试剂，其中金属卟啉二聚体具有碱土金属离子作为中心金属并具有碳链交联结构，其中两个卟啉环中的至少一个在与卟啉环的外周键合到交联碳链上的碳原子的至少一个第二碳原子上具有比甲基更大的取代基，并且确定绝对构型的方法使用该试剂的手性化合物的不对称碳原子。

2. 发明授权

US06420553B1 Method for preparing metal complex of porphyrin 有权
标题翻译：卟啉金属络合物的制备方法
公开(公告)号：US06420553B1
公开(公告)日：2002-07-16
申请号：US09646448
申请日：2000-10-31
申请人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
发明人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
IPC分类号： C07D48722
CPC分类号： C07D487/22 , C07D519/00
摘要： A process for producing a metalloporphyrin containing a transition metal inserted into the porphyrin ring which comprises dissolving a porphyrin compound and a transition metal salt each in an independent solvent, combining the solutions, and carrying out the reaction in the presence of a basic substance. By this process a metalloporphyrin containing a transition metal inserted into the porphyrin ring can be synthesized easily under mild conditions and with high selectivity.
摘要翻译：一种制备含有插入到卟啉环中的过渡金属的金属卟啉的方法，其包括将卟啉化合物和过渡金属盐各自溶解在独立的溶剂中，将该溶液混合，并在碱性物质的存在下进行反应。通过该方法，可以在温和条件下以高选择性容易地合成含有插入卟啉环中的过渡金属的金属卟啉。

3. 发明授权

US07648841B2 Reagent for determining the absolute configuration of chiral compound and determination method 有权
标题翻译：用于确定手性化合物的绝对构型的试剂和测定方法
公开(公告)号：US07648841B2
公开(公告)日：2010-01-19
申请号：US10505906
申请日：2003-01-10
申请人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
发明人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
IPC分类号： G01N33/00 , C07D487/22
CPC分类号： C07D519/00 , G01N21/19 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/20
摘要： The present invention relates to a reagent for determining the absolute configuration of a chiral compound containing as an active ingredient a metalloporphyrin dimer, wherein the metalloporphyrin dimer has an alkaline-earth metal ion as a central metal and has a carbon chain-crosslinked structure in which at least one of the two porphyrin rings has a substituent bulkier than methyl at least one of the second carbon atoms from a carbon atom bonded to the crosslinking carbon chain along the outer periphery of the porphyrin ring and a method for determining the absolute configuration of an asymmetric carbon atom of the chiral compound using the reagent.
摘要翻译：本发明涉及一种用于测定含有金属卟啉二聚体作为活性成分的手性化合物的绝对构型的试剂，其中金属卟啉二聚体具有碱土金属离子作为中心金属并具有碳链交联结构，其中两个卟啉环中的至少一个具有比甲基更大的取代基，该取代基来自沿着卟啉环的外周键合到交联碳链的碳原子的至少一个第二碳原子，以及用于测定卟啉环的绝对构型的方法使用该试剂的手性化合物的不对称碳原子。

4. 发明授权

US07354771B2 Method of determining absolute configuration of chiral compound 有权
标题翻译：确定手性化合物绝对构型的方法
公开(公告)号：US07354771B2
公开(公告)日：2008-04-08
申请号：US10148652
申请日：2000-12-04
申请人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
发明人： Yoshihisa Inoue , Victor Borovkov , Juha Lintuluoto
IPC分类号： G01N21/00
CPC分类号： C07D487/22 , C09B47/00 , Y10T436/145555 , Y10T436/173845 , Y10T436/174614
摘要： The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site, and (ii) analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon based on the sign of the Cotton effect. The chiral compound has an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group.
摘要翻译：手性化合物的绝对构型通过以下方式确定：（i）将手性化合物与具有碳链交联的卟啉二聚体结构的金属卟啉配位，其中两个卟啉环中的一个至少具有至少一个乙基或取代基至少一个乙基，在碳链交联位点处碳原子的第二外周碳原子之一，（ii）通过圆二色性分光光度法分析得到的配位化合物，以基于棉花效应的符号确定不对称碳的绝对构型。手性化合物具有与能够与金属卟啉二聚体的另一卟啉环的金属配位的碱性基团或与键合到碱性基团的碳原子相邻的不对称碳原子键合的不对称碳。

5. 发明申请

US20060148091A1 Method for determination of absolute configuration of chiral compounds 有权
标题翻译：手性化合物绝对构型测定方法
公开(公告)号：US20060148091A1
公开(公告)日：2006-07-06
申请号：US10544496
申请日：2004-02-05
申请人： Yoshihisa Inoue , Victor Borovkov , Guy Hembury
发明人： Yoshihisa Inoue , Victor Borovkov , Guy Hembury
IPC分类号： G01N33/00
CPC分类号： G01N21/19 , Y10T436/145555 , Y10T436/173845 , Y10T436/174614 , Y10T436/203332
摘要： The present invention provides a simple, highly sensitive, and highly precise method for determining the absolute configuration of a chiral compound such as a diamine or an amino alcohol. The present invention is directed to a method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy.
摘要翻译：本发明提供了用于确定手性化合物如二胺或氨基醇的绝对构型的简单，高灵敏度和高度精确的方法。本发明涉及一种通过分析含有手性化合物和卟啉二聚体的溶液通过圆二色光谱法测定手性化合物的不对称碳的绝对构型的方法。

6. 发明申请

US20090198454A1 STANDARD SAMPLE FOR TEST AND /OR CALIBRATION OF CIRCULAR DICHROISM DISPERSION METER AND UV-VISIBLE SPECTROPHOTOMETER 审中-公开
标题翻译：循环二色散射计和紫外可见分光光度计的测试和/或校准标准样品
公开(公告)号：US20090198454A1
公开(公告)日：2009-08-06
申请号：US12064786
申请日：2006-02-22
申请人： Yoshihisa Inoue , Victor Borovkov , Akio Wada
发明人： Yoshihisa Inoue , Victor Borovkov , Akio Wada
IPC分类号： G01J1/10 , G06F19/00 , C07D487/22
CPC分类号： G01N21/278 , G01N21/19
摘要： A principal object of the present invention is to provide a standard sample that allows accurate testing and calibration of a circular dichroism spectrometer, and which can also be applied to testing and calibration of a UV-visible spectrophotometer. The present invention relates to a standard sample for use in testing and/or calibrating a circular dichroism spectrometer and a UV-visible spectrophotometer, which standard sample comprising: a chlorin dimer represented by Chemical Formula (I): wherein A is CnH2n (n is an integer of 0 or more); and R1, R2, R3R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 are the same or different, and are each a hydrogen atom, a saturated hydrocarbon group, an aryl group that may be substituted, a heteroaryl group that may be substituted, or an aralkyl group that may be substituted; or a metal chlorin dimer represented by Chemical Formula (II): wherein M2+ is a divalent metal ion; and A, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 are the same as defined above. Each of the chlorin dimer and the metal chlorin dimer exhibits at least two peaks in an ultraviolet to visible region of a circular dichroism spectrum and a UV-visible absorption spectrum thereof.
摘要翻译：本发明的主要目的是提供一种允许对圆二色性光谱仪进行精确测试和校准的标准样品，其也可应用于UV可见分光光度计的测试和校准。本发明涉及用于测试和/或校准圆形二色性光谱仪和紫外 - 可见分光光度计的标准样品，该标准样品包含：由化学式（I）表示的二氢卟酚二聚体：其中A是C n H 2n（n是 0以上的整数）; R1，R2，R3R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15和R16可以相同或不同，分别为氢原子，饱和烃基，可被取代的芳基，可被取代的杂芳基或可被取代的芳烷基; 或由化学式（II）表示的金属二氢卟酚二聚体：其中M2 +是二价金属离子; 并且A，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15和R16与上述定义相同。二氢卟酚二聚物和金属二氢卟酚二聚体中的每一个在圆二色性光谱的紫外到可见区和其可见光吸收光谱中表现出至少两个峰。

7. 发明授权

US08168436B2 Method for determining quantity of peptide compound having phenylalanine residue at N-terminus 失效
标题翻译：确定N-末端具有苯丙氨酸残基的肽化合物的量的方法
公开(公告)号：US08168436B2
公开(公告)日：2012-05-01
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N33/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

8. 发明申请

US20100238969A1 METHOD FOR DETERMINING QUANTITY OF PEPTIDE COMPOUND HAVING PHENYLALANINE RESIDUE AT N-TERMINUS 失效
标题翻译：用于确定N-末端苯丙氨酸残基的肽类化合物的数量的方法
公开(公告)号：US20100238969A1
公开(公告)日：2010-09-23
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N25/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

9. 发明授权

US07736902B2 Method for determination of absolute configuration of chiral compounds 有权
标题翻译：手性化合物绝对构型测定方法
公开(公告)号：US07736902B2
公开(公告)日：2010-06-15
申请号：US10544496
申请日：2004-02-06
申请人： Yoshihisa Inoue , Victor V. Borovkov , Guy A. Hembury
发明人： Yoshihisa Inoue , Victor V. Borovkov , Guy A. Hembury
IPC分类号： G01N21/19 , G01N33/00
CPC分类号： G01N21/19 , Y10T436/145555 , Y10T436/173845 , Y10T436/174614 , Y10T436/203332
摘要： The present invention provides a simple, highly sensitive, and highly precise method for determining the absolute configuration of a chiral compound such as a diamine or an amino alcohol.The present invention is directed to a method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy.
摘要翻译：本发明提供了用于确定手性化合物如二胺或氨基醇的绝对构型的简单，高灵敏度和高度精确的方法。本发明涉及一种通过分析含有手性化合物和卟啉二聚体的溶液通过圆二色光谱法测定手性化合物的不对称碳的绝对构型的方法。

10. 发明授权

US07652096B2 Rubber composition for tire tread 有权
标题翻译：轮胎胎面橡胶组合物
公开(公告)号：US07652096B2
公开(公告)日：2010-01-26
申请号：US10495485
申请日：2003-12-03
申请人： Naoya Amino , Yoshihisa Inoue
发明人： Naoya Amino , Yoshihisa Inoue
IPC分类号： C08K3/04
CPC分类号： B60C1/0016 , C08K3/04 , C08L21/00
摘要： A rubber composition for a tire tread including 100 parts by weight of a diene-based rubber and 5 to 150 parts by weight of carbon black having a nitrogen adsorption specific area N2SA (m2/g) of 80 to 150 and satisfying a relationship between a TINT (%) and dibutyl phthalate absorption DBPA (ml/100 g) of TINT (%)>1.4 DBPA (ml/100 g) and capable of increasing the frictional force without impairing the hysteresis loss.
摘要翻译：一种轮胎胎面用橡胶组合物，其包含100重量份的二烯系橡胶和5〜150重量份的氮吸附比面积N2SA（m 2 / g）为80〜150的炭黑，满足下述关系： TINT（％）和邻苯二甲酸二丁酯吸收DBPA（ml / 100g）TINT（％）> 1.4 DBPA（ml / 100g），能够增加摩擦力而不损害磁滞损耗。

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