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1. 发明授权

US08965093B2 Method for registering functional MRI data 有权
标题翻译：功能性MRI数据记录方法
公开(公告)号：US08965093B2
公开(公告)日：2015-02-24
申请号：US13806509
申请日：2011-12-21
申请人： Yong Fan , Di Jiang , Tianzi Jiang
发明人： Yong Fan , Di Jiang , Tianzi Jiang
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/33 , G06T2200/04 , G06T2207/10088 , G06T2207/30016
摘要： A method for registering functional MRI data, comprising: computing the functional connectivity pattern for every voxel in its given spatial neighborhood for every fMRI image; extracting features invariant to spatial location of the neighboring voxels based on the functional connectivity patterns; constructing similarity metric between voxels of different images based on the extracted features, and using fluid-like demons registration model to spatial normalize the fMRI data. The present invention tries to exploit the multi-range functional connectivity information of the fMRI data, and to register functional MR images based on the extracted spatial-location-invariant features. The present invention is robust against local spatial perturbations and does not depend on the assumption that functional signals of different subjects are synchronic, hence can be applied to resting-state fMRI data, and can achieve a statistically significant improvement in functional consistency across subjects.
摘要翻译：一种用于登记功能性MRI数据的方法，包括：为每个fMRI图像计算其给定空间邻域中的每个体素的功能连接性模式; 基于功能连通性模式提取不相邻体素空间位置的特征; 基于提取的特征构建不同图像的体素之间的相似性度量，并使用流体样恶魔注册模型对fMRI数据进行空间归一化。本发明试图利用fMRI数据的多范围功能连接性信息，并且基于所提取的空间位置不变特征来注册功能性MR图像。本发明对于局部空间扰动是鲁棒的，并且不依赖于不同主体的功能信号是同步的假设，因此可以应用于静息状态的fMRI数据，并且可以实现主体之间的功能一致性的统计学显着的改善。

2. 发明申请

US20130177228A1 METHOD FOR REGISTERING FUNCTION MRI DATA 有权
标题翻译：注册功能MRI数据的方法
公开(公告)号：US20130177228A1
公开(公告)日：2013-07-11
申请号：US13806509
申请日：2011-12-21
申请人： Yong Fan , Di Jiang , Tianzi Jiang
发明人： Yong Fan , Di Jiang , Tianzi Jiang
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/33 , G06T2200/04 , G06T2207/10088 , G06T2207/30016
摘要： A method for registering functional MRI data, comprising: computing the functional connectivity pattern for every voxel in its given spatial neighborhood for every fMRI image; extracting features invariant to spatial location of the neighboring voxels based on the functional connectivity patterns; constructing similarity metric between voxels of different images based on the extracted features, and using fluid-like demons registration model to spatial normalize the fMRI data. The present invention tries to exploit the multi-range functional connectivity information of the fMRI data, and to register functional MR images based on the extracted spatial-location-invariant features. The present invention is robust against local spatial perturbations and does not depend on the assumption that functional signals of different subjects are synchronic, hence can be applied to resting-state fMRI data, and can achieve a statistically significant improvement in functional consistency across subjects.
摘要翻译：一种用于登记功能性MRI数据的方法，包括：为每个fMRI图像计算其给定空间邻域中的每个体素的功能连接性模式; 基于功能连通性模式提取不相邻体素空间位置的特征; 基于提取的特征构建不同图像的体素之间的相似性度量，并使用流体样恶魔注册模型对fMRI数据进行空间归一化。本发明试图利用fMRI数据的多范围功能连接性信息，并且基于所提取的空间位置不变特征来注册功能性MR图像。本发明对于局部空间扰动是鲁棒的，并且不依赖于不同主体的功能信号是同步的假设，因此可以应用于静息状态的fMRI数据，并且可以实现主体之间的功能一致性的统计学显着的改善。

3. 发明授权

US09310375B2 Luminophore-labeled molecules coupled with particles for microarray-based assays 有权
标题翻译：发光标记分子与颗粒偶联用于基于微阵列的测定
公开(公告)号：US09310375B2
公开(公告)日：2016-04-12
申请号：US13877320
申请日：2010-10-27
申请人： Huafang Gao , Guangxin Xiang , Di Jiang , Wanli Xing , Jing Cheng
发明人： Huafang Gao , Guangxin Xiang , Di Jiang , Wanli Xing , Jing Cheng
IPC分类号： G01N33/58 , C12Q1/68 , C40B30/04 , G01N33/543
CPC分类号： G01N33/582 , C12Q1/6816 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C40B30/04 , G01N33/54333 , G01N33/54386 , C12Q2563/103 , C12Q2565/501
摘要： A microarray-based assay is provided, which is used for analyzing molecular interactions, including polynucleotides, polypeptides, antibodies, small molecule compounds, peptides and carbohydrates. Such method comprises labeling a target molecule with a luminophore, coupling the target molecule to a particle, and binding to a probe molecule on microarray. In particular, multiplexed genetic analysis of nucleic acid fragments can be implemented. Specific genes, single nucleotide polymorphisms or gene mutations, such as deletions, insertions, and indels, can be identified. This technology, with high sensitivity, enables the detection and interpretation of molecular interactions in an efficient way.
摘要翻译：提供基于微阵列的测定法，其用于分析分子相互作用，包括多核苷酸，多肽，抗体，小分子化合物，肽和碳水化合物。这种方法包括用发光体标记目标分子，将靶分子偶联到颗粒上，并在微阵列上结合探针分子。特别地，可以实现核酸片段的多重遗传分析。可以鉴定特异性基因，单核苷酸多态性或基因突变，例如缺失，插入和插入。该技术具有高灵敏度，能够以有效的方式检测和解释分子相互作用。

4. 发明申请

US20090239758A1 METHODS, MICROARRAY, AND KITS FOR DETECTION OF DRUG RESISTANCE GENES IN GRAM-NEGATIVE BACTERIA 有权
标题翻译：用于检测抗菌细菌中耐药基因的方法，微阵列和试剂盒
公开(公告)号：US20090239758A1
公开(公告)日：2009-09-24
申请号：US12097237
申请日：2007-01-18
申请人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
发明人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/04 , C40B40/08 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.
摘要翻译：本发明提供了包含用于扩增用于检测药物抗性基因的药物抗性基因和/或探针的引物对的试剂盒和微阵列。还提供了使用本文所述的试剂盒和微阵列检测药物抗性基因的方法。

5. 发明申请

US20130267436A1 LUMINOPHORE-LABELED MOLECULES COUPLED WITH PARTICLES FOR MICROARRAY-BASED ASSAYS 有权
标题翻译：与基于微量元素测定的颗粒偶联的荧光标记分子
公开(公告)号：US20130267436A1
公开(公告)日：2013-10-10
申请号：US13877320
申请日：2010-10-27
申请人： Huafang Gao , Guangxin Xiang , Di Jiang , Wanli Xing , Jing Cheng
发明人： Huafang Gao , Guangxin Xiang , Di Jiang , Wanli Xing , Jing Cheng
IPC分类号： G01N33/58 , C12Q1/68
CPC分类号： G01N33/582 , C12Q1/6816 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C40B30/04 , G01N33/54333 , G01N33/54386 , C12Q2563/103 , C12Q2565/501
摘要： A microarray-based assay is provided, which is used for analyzing molecular interactions, including polynucleotides, polypeptides, antibodies, small molecule compounds, peptides and carbohydrates. Such method comprises labeling a target molecule with a luminophore, coupling the target molecule to a particle, and binding to a probe molecule on microarray. In particular, multiplexed genetic analysis of nucleic acid fragments can be implemented. Specific genes, single nucleotide polymorphisms or gene mutations, such as deletions, insertions, and indels, can be identified. This technology, with high sensitivity, enables the detection and interpretation of molecular interactions in an efficient way.
摘要翻译：提供基于微阵列的测定法，其用于分析分子相互作用，包括多核苷酸，多肽，抗体，小分子化合物，肽和碳水化合物。这种方法包括用发光体标记目标分子，将靶分子偶联到颗粒上，并在微阵列上结合探针分子。特别地，可以实现核酸片段的多重遗传分析。可以鉴定特异性基因，单核苷酸多态性或基因突变，例如缺失，插入和插入。该技术具有高灵敏度，能够以有效的方式检测和解释分子相互作用。

6. 发明授权

US08124382B2 Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria 有权
标题翻译：用于检测革兰氏阴性菌耐药基因的方法，微阵列和试剂盒
公开(公告)号：US08124382B2
公开(公告)日：2012-02-28
申请号：US12097237
申请日：2007-01-18
申请人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
发明人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
IPC分类号： C12P19/34
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.
摘要翻译：本发明提供了包含用于扩增用于检测药物抗性基因的药物抗性基因和/或探针的引物对的试剂盒和微阵列。还提供了使用本文所述的试剂盒和微阵列检测药物抗性基因的方法。

7. 发明申请

US20120038639A1 PRESENTATION-ENHANCED SOLID MECHANICAL SIMULATION 审中-公开
标题翻译：介绍 - 增强的固体机械模拟
公开(公告)号：US20120038639A1
公开(公告)日：2012-02-16
申请号：US12854336
申请日：2010-08-11
申请人： Vincent Mora , Di Jiang , Rupert Brooks , Sébastien Delorme
发明人： Vincent Mora , Di Jiang , Rupert Brooks , Sébastien Delorme
IPC分类号： G06T17/00
CPC分类号： G06T19/20 , G06T15/04 , G06T17/20 , G06T2219/2021
摘要： In a solid mechanics simulation of a deformable object having: a model representing a condition of the deformable object; a rendering module for presenting an image of the object in response to states of the elements of the object according to an oriented view; and a user interface for a user to mechanically interact with the model to deform the modeled object; an enhancement is provided that effectively supplies a refined rendering of the set of elements of the object in view, without adding elements to the model, so that the image is of an object defined locally to a higher degree than that of the model.
摘要翻译：在可变形物体的固体力学模拟中，具有：表示可变形物体的状态的模型; 渲染模块，用于根据定向视图响应对象的元素的状态呈现对象的图像; 以及用户界面，用于与模型机械地交互以使模拟对象变形; 提供了一种增强，其有效地提供视觉上的对象的元素集合的精细呈现，而不向模型添加元素，使得图像是在本地定义为比模型更高的程度定义的对象。

8. 发明授权

US08783196B2 AC plasma ejection gun, the method for supplying power to it and pulverized coal burner 有权
标题翻译：交流等离子体喷枪，为其供电的粉煤燃烧器的方法
公开(公告)号：US08783196B2
公开(公告)日：2014-07-22
申请号：US12824953
申请日：2010-06-28
申请人： Hujun Zhao , Bin Li , Di Jiang , Guangrong Chen , Zhaojun Zhang , Dezhe Nan
发明人： Hujun Zhao , Bin Li , Di Jiang , Guangrong Chen , Zhaojun Zhang , Dezhe Nan
IPC分类号： F23D1/00 , F23C99/00 , H05H1/42 , H05H1/36 , H05H1/34
CPC分类号： H05H1/42 , F23C99/001 , F23C2900/99005 , F23D1/00 , H05H1/36 , H05H2001/3431
摘要： An AC plasma ejection gun, a method for supplying power to the gun, and a pulverized coal burner are provided. The ejection gun comprising a front electrode and a rear electrode. There is a gap between the electric rear electrode and said front electrode. The ejection gun can work with small current and large power, so that the life of the plasma ejection gun is prolonged.
摘要翻译：提供AC等离子体喷枪，向枪供电的方法和粉煤燃烧器。喷射枪包括前电极和后电极。电后电极和前电极之间存在间隙。喷枪可以以较小的电流和大功率工作，从而延长等离子体喷枪的使用寿命。

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