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1. 发明授权

US08821859B2 Methods and articles for the delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的方法和物品
公开(公告)号：US08821859B2
公开(公告)日：2014-09-02
申请号：US10849498
申请日：2004-05-19
申请人： Yi-Yan Yang , Yong Wang , Cherng-wen Tan , Jackie Y. Ying
发明人： Yi-Yan Yang , Yong Wang , Cherng-wen Tan , Jackie Y. Ying
IPC分类号： A61K38/43 , C12N9/00 , C12N5/00
CPC分类号： A61K9/5153 , A61K9/1075 , A61K47/6935 , A61K48/0025 , A61K48/0041 , B82Y5/00 , C08G63/6856 , C08G63/916 , C08L2207/53
摘要： Articles and methods for the delivery of drugs and/or nucleic acids. Articles including a nanoparticle are provided that may be used for the delivery of a drug, a nucleic acid, or both, to a subject. The articles may be of polymeric material and may self-assemble.
摘要翻译：用于递送药物和/或核酸的制品和方法。提供了包括纳米颗粒的制品，其可用于向受试者递送药物，核酸或两者。制品可以是聚合材料并且可以自组装。

2. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

3. 再颁专利

USRE44820E1 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production 有权
标题翻译：纳米晶磷灰石和复合材料，并入其中的假体及其生产方法
公开(公告)号：USRE44820E1
公开(公告)日：2014-04-01
申请号：US13536924
申请日：2012-06-28
申请人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
发明人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
IPC分类号： A61F2/28 , C01B15/16
CPC分类号： A61L27/12 , A61F2/30767 , A61F2310/00239 , A61F2310/00293 , A61F2310/00796 , A61L27/32 , A61L2400/12 , B82Y30/00 , C01B25/32 , C03C4/0007 , C03C14/00 , C04B35/117 , C04B35/447 , C04B35/46 , C04B35/488 , C04B35/6262 , C04B35/62675 , C04B35/645 , C04B2235/3212 , C04B2235/3217 , C04B2235/3225 , C04B2235/3232 , C04B2235/3244 , C04B2235/3246 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/549 , C04B2235/608 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/668 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9653 , F16C2240/64 , Y10S977/776
摘要： Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density.Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
摘要翻译：提出了纳米晶磷灰石的合成方法，以及一系列具体的反应参数，可以根据具体方式调整回收产物的特性。提供平均晶体尺寸小于150nm的颗粒状磷灰石组合物。产品还可以具有至少40m 2 / g的表面积，并且可以具有高密度。详细研究了羟基磷灰石材料。本发明的组合物可以用作假体植入物和用于假体植入物的涂层。

4. 发明申请

US20130295637A1 FIBROUS SUBSTRATES FOR CELL PROPAGATION AND DIFFERENTIATION 审中-公开
标题翻译：纤维基质用于细胞传播和分化
公开(公告)号：US20130295637A1
公开(公告)日：2013-11-07
申请号：US13814501
申请日：2011-08-05
申请人： Hongfang Lu , Andrew Chwee Aun Wan , Jackie Y. Ying , Karthikeyan Narayanan
发明人： Hongfang Lu , Andrew Chwee Aun Wan , Jackie Y. Ying , Karthikeyan Narayanan
IPC分类号： C12N11/04
CPC分类号： C12N11/04 , C12N5/0012 , C12N5/0606 , C12N2533/72 , C12N2533/74
摘要： The present invention relates to a method of releasably encapsulating pluripotent embryonic stem cells in a degradable continuous polyionic fiber for tissue culture, wherein the encapsulated embryonic stem cells are able to maintain a pluripotent phenotype in tissue culture; the method comprising (a) contacting an aqueous solution of a polyanion with an aqueous solution of a polycation to form an interface between the aqueous solution of polyanion and the aqueous solution of polycation, and wherein the aqueous solution of polyanion or the aqueous solution of polycation or both the aqueous solution of polyanion and the aqueous solution of polycation comprises a suspension of pluripotent embryonic stem cells; (b) drawing a continuous polyionic fiber which comprises encapsulated pluripotent embryonic stem cells from the interface; (c) passing the continuous polyionic fiber comprising encapsulated pluripotent embryonic stem cells in a continuous process through a solution which reduces secondary complexation of the components of the polyionic fiber.
摘要翻译：本发明涉及一种将多能胚胎干细胞可释放地包封在用于组织培养的可降解连续聚离子纤维中的方法，其中包封的胚胎干细胞能够在组织培养中保持多能表型; 该方法包括（a）将聚阴离子的水溶液与聚阳离子水溶液接触以形成聚阴离子水溶液与聚阳离子水溶液之间的界面，并且其中聚阴离子水溶液或聚阳离子水溶液或聚阴离子水溶液和聚阳离子水溶液两者均包含多能胚胎干细胞的悬浮液; （b）从界面绘制包含多能胚胎干细胞的连续聚离子纤维; （c）使包含多能胚胎干细胞的连续聚离子纤维在连续过程中通过减少聚离子纤维组分的次级络合的溶液。

5. 发明申请

US20130189604A1 NANOCOMPOSITES 有权
公开(公告)号：US20130189604A1
公开(公告)日：2013-07-25
申请号：US13522944
申请日：2011-03-30
申请人： Jackie Y. Ying , Jun Yang
发明人： Jackie Y. Ying , Jun Yang
IPC分类号： H01M4/92 , H01M4/88 , H01M4/96 , H01M4/86
CPC分类号： H01M4/921 , B01J23/50 , B01J27/045 , B01J35/002 , B01J35/004 , B01J35/006 , H01M4/8657 , H01M4/8842 , H01M4/926 , H01M4/96
摘要： The invention pertains to heterogenous noble metal nanostructures comprising silver salts and different noble metals, and methods for synthesis and use of various nanocomposite materials having silver salts and different noble metals.
摘要翻译：本发明涉及包含银盐和不同贵金属的异质贵金属纳米结构体，以及合成和使用具有银盐和不同贵金属的各种纳米复合材料的方法。

6. 发明授权

US08481316B2 Method for differentiating embryonic stem cells into cells expressing AQP-1 有权
标题翻译：将胚胎干细胞分化成表达AQP-1的细胞的方法
公开(公告)号：US08481316B2
公开(公告)日：2013-07-09
申请号：US12669457
申请日：2008-07-21
申请人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
发明人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C12N5/0686 , A61F2/06 , C12N2501/11 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
摘要翻译：本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。

7. 发明授权

US08450105B2 Mechanically reversible gel 有权
标题翻译：机械可逆凝胶
公开(公告)号：US08450105B2
公开(公告)日：2013-05-28
申请号：US12299199
申请日：2007-05-04
申请人： Jackie Y. Ying , Shona Pek , Andrew C A Wan
发明人： Jackie Y. Ying , Shona Pek , Andrew C A Wan
IPC分类号： C12M1/12 , C12N11/14 , C12N5/00 , C12N5/02
CPC分类号： C08G77/46 , C01B33/14 , C01B33/163 , C08G77/50
摘要： A process for making a gel comprising combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel is capable of being converted to a liquid by application of a mechanical shear force and the liquid is capable of being converted to the gel in the absence of the mechanical shear force.
摘要翻译：一种制备凝胶的方法，其包括每分子组合含有至少两个硅烷醇基团的硅烷醇物质和每分子包含至少两个羟基的亲水羟基物质。该凝胶能够通过施加机械剪切力而转化为液体，并且液体能够在不存在机械剪切力的情况下转化为凝胶。

8. 发明授权

US08398931B2 Recirculating reactor 失效
标题翻译：循环反应器
公开(公告)号：US08398931B2
公开(公告)日：2013-03-19
申请号：US12875737
申请日：2010-09-03
申请人： Jackie Y. Ying , Su Seong Lee , Jaehong Lim , Siti Nurhanna binte Riduan
发明人： Jackie Y. Ying , Su Seong Lee , Jaehong Lim , Siti Nurhanna binte Riduan
IPC分类号： B01J8/00 , B01J8/06
CPC分类号： B01J8/025 , B01J8/0214 , B01J8/20 , B01J8/22 , B01J19/0093 , B01J2208/00867 , B01J2219/00788 , B01J2219/00835 , B01J2219/00873 , B01J2219/00905
摘要： The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid.
摘要翻译：本发明提供一种用于将基材转化成产物的再循环反应器。反应器包括反应室和再循环系统，所述再循环系统包括分离器。反应室包含催化剂，并且包括室主体，室入口和室出口。再循环系统适于将液体从室出口再循环到室入口，并且分离器用于从液体中分离副产物。

9. 发明授权

US08343443B2 Fluid processing and transfer using inter-connected multi-chamber device 有权
标题翻译：使用相互连接的多室装置的流体处理和转移
公开(公告)号：US08343443B2
公开(公告)日：2013-01-01
申请号：US12935576
申请日：2008-06-23
申请人： Jackie Y. Ying , Guolin Xu , Hock Ming Jeremy Loh
发明人： Jackie Y. Ying , Guolin Xu , Hock Ming Jeremy Loh
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N35/1095 , B01L3/5027 , B01L3/50851 , B01L2200/026 , B01L2200/04 , B01L2200/0642 , B01L2200/0647 , B01L2300/0672 , B01L2300/0809 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , Y10T137/0391 , Y10T436/11 , Y10T436/2575
摘要： A micro-fluidic device comprises a body. The body defines pneumatic ports, chambers for receiving liquids, and a connecting conduit. Each port is sealed with a seal and is shaped to couple to a pneumatic conduit through the seal. At least some of the chambers each have a top opening and a bottom opening. The top openings are in fluid communication with corresponding ports. The bottom openings are in fluid communication with one another through the connecting conduit, which is above the bottom openings. Selective application of pneumatic pressures to the chambers through the pneumatic conduits can transfer a liquid from one chamber to another through the connecting conduit, for example, for processing bio-samples within the device.
摘要翻译：微流体装置包括主体。主体定义气动端口，用于接收液体的腔室和连接导管。每个端口用密封件密封，并且成形为通过密封件连接到气动导管。至少一些室各自具有顶部开口和底部开口。顶部开口与相应的端口流体连通。底部开口通过位于底部开口上方的连接导管彼此流体连通。通过气动导管将气压压力选择性地施加到腔室可以将液体从一个腔室传送到另一个腔室，例如通过连接导管，用于处理装置内的生物样品。

10. 发明申请

US20120276016A1 POLYMER COATED MAGNETIC PARTICLES 有权
标题翻译：聚合物包覆磁性颗粒
公开(公告)号：US20120276016A1
公开(公告)日：2012-11-01
申请号：US13504736
申请日：2010-10-28
申请人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
发明人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
IPC分类号： C08G75/04 , C12P7/62 , A61K49/12 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： C08G63/6856 , A61K49/0019 , A61K49/0054 , A61K49/0067 , A61K49/1857 , A61K49/1863 , B82Y5/00 , C08G63/6886
摘要： The invention relates to a polymer comprising a segment of Formula (I): wherein, R is either absent or a linking group, n is an integer greater than 0; and m is an integer from 1 to 6.
摘要翻译：本发明涉及包含式（I）的片段的聚合物：其中R不存在或连接基团，n为大于0的整数; m为1〜6的整数。

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