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    • 3. 发明授权
    • 4-(2-Pyridylamino)phenylacetic acid derivatives
    • 4-(2-吡啶基氨基)苯乙酸衍生物
    • US4256753A
    • 1981-03-17
    • US95572
    • 1979-11-19
    • Hitoshi UnoYasutaka NagaiKatsuhiko HinoHideo Nakamura
    • Hitoshi UnoYasutaka NagaiKatsuhiko HinoHideo Nakamura
    • A61K31/44A61K31/4402A61K31/4418A61P25/04A61P29/00C07D213/74
    • C07D213/74
    • Novel 4-(2'-pyridylamino)phenylacetic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, a halogen, a lower alkyl having 1 to 3 carbon atoms, or nitro, R.sub.2 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.3 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.4 is hydrogen or a lower alkyl having 1 to 3 carbon atoms, R.sub.5 is hydrogen or --CH.sub.2 CH.sub.2 OR.sub.6 wherein R.sub.6 is a lower alkyl having 2 or 3 carbon atoms and being substituted with 1 or 2 hydroxy groups, provided that R.sub.1 or R.sub.2 is not 4-halogen, or pharmaceutically acceptable salts thereof, and a process for the preparation thereof, pharmaceutical composition of said compounds, and a method of using said compounds as anti-inflammatory and analgesic agents. They have excellent anti-inflammatory and analgesic activities with an extremely weak ulcerogenicity in the gastrointestinal tract. Some of the compounds have superior inhibitory activity against chronic inflammation mediated by cellular immunity.
    • 下式的新型4-(2'-吡啶基氨基)苯乙酸衍生物:其中R 1是氢,卤素,具有1至3个碳原子的低级烷基或硝基,R 2是氢,卤素或低级 具有1至3个碳原子的烷基,R 3是氢,卤素或具有1至3个碳原子的低级烷基,R 4是氢或具有1至3个碳原子的低级烷基,R 5是氢或-CH 2 CH 2 OR 6,其中R 6是 具有2或3个碳原子并且被1或2个羟基取代的低级烷基,条件是R1或R2不是4-卤素,或其药学上可接受的盐,及其制备方法,所述化合物的药物组合物和 使用所述化合物作为抗炎和止痛剂的方法。 它们具有优异的抗炎和止痛活性,在胃肠道中具有非常弱的溃疡形成能力。 一些化合物对由细胞免疫介导的慢性炎症具有优异的抑制活性。
    • 6. 发明授权
    • Ultrasonic transducer
    • 超声波换能器
    • US4676106A
    • 1987-06-30
    • US805608
    • 1985-12-06
    • Yasutaka NagaiSusumu Enjoji
    • Yasutaka NagaiSusumu Enjoji
    • A61B8/00B06B1/06G01N29/06
    • B06B1/0622A61B8/4494
    • A phased-array ultrasonic transducer for an ultrasonograph is provided in which electrical signals are supplied to ultrasonic transducer elements to generate ultrasonic beams for diagnostic scanning. The ultrasonic transducer comprises a number of ultrasonic transducer elements arranged in the form of an array, a signal electrode plate coupled to the signal-supply side of the transducer elements and connected to a transmitter-receiver circuit by means of signal wires, and an earth electrode plate connected to the earth side of the transducer elements. The earth electrode plate is divided into a plurality of split earth electrode plates corresponding to ultrasonic transducer groups each including a plurality of adjacent transducer elements so that the split earth electrode plates are grounded independently. Thus, clearer and more accurate ultrasonic images can be obtained without undesired signals attributed to any other transducer elements than the transducer element in operation being produced or artifact appearing on the ultrasonic image.
    • 提供了一种用于超声波诊断仪的相控阵超声波换能器,其中电信号被提供给超声换能器元件以产生用于诊断扫描的超声波束。 超声波换能器包括以阵列形式布置的多个超声换能器元件,耦合到换能器元件的信号供给侧的信号电极板,并通过信号线连接到发射机 - 接收机电路,并且接地 电极板连接到换能器元件的接地侧。 接地电极板被分成多个对应于每个包括多个相邻换能器元件的超声波换能器组的分离接地电极板,使得分离接地电极板独立接地。 因此,可以获得更清晰和更准确的超声波图像,而不产生归因于任何其它换能器元件而不是产生运行中的换能器元件或在超声波图像上出现伪像的信号。